Article
Food Science & Technology
Limei Chen, E. Jiang, Yongmei Guan, Pan Xu, Qian Shen, Zhiyong Liu, Weifeng Zhu, Lihua Chen, Hongning Liu, Huanhuan Dong
Summary: This study found that high doses of Puerariae Lobatae Radix water extract are relatively safe for adolescent SD rats, without significant adverse effects.
FOOD SCIENCE & NUTRITION
(2021)
Article
Plant Sciences
Chi-Man Koon, David Wing-Shing Cheung, Pui-Han Wong, Elaine Wat, Sau-Kuen Ng, Wing-Hoi Cheung, Francis Fu-Yuen Lam, Ping Chook, Kwok-Pui Fung, Ping-Chung Leung, Bryan P. Yan
Summary: DG showed positive dose-dependent vasodilatory response in isolated femoral artery via an endothelium-independent mechanism, leading to improved blood perfusion and micro-vessel density in the ischemic limb, as well as positive effects in functional limb recovery.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Luyao Ma, Meiping Huang, Guanghui Sun, Yanke Lin, Danyi Lu, Baojian Wu
Summary: PLR has a significant protective effect against UVB-induced skin aging by reducing skin wrinkles, thickness, and oxidative stress, while increasing levels of antioxidant enzymes. This effect is mediated through the upregulation of BMAL1 and Nrf2 pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Zhenfu Luo, Yuanyuan Zhao, Liming Zeng, Jie Yin, Qinghua Zeng, Xilong Li, Jianhua He, Jing Wang, Bi'e Tan
Summary: This study investigated the effects of fermented Radix puerariae residue (FRPR) on reproductive performance, digestibility of nutrients, and fecal SCFA contents in sows. Results showed that supplementation with 4% FRPR improved weaned piglet numbers and weight, decreased constipation rate, and enhanced nutrient utilization. Maternal supplementation with 4% FRPR also increased serum concentrations of certain immune markers in offspring piglets. Overall, FRPR showed positive effects on fecal characteristics, nutrient utilization, and reproductive performance in sows.
FRONTIERS IN NUTRITION
(2021)
Review
Cell Biology
Yaoyao Ren, Shengtao Qu
Summary: With the increasing aging population worldwide, the incidence of senile cognitive impairment (CI) is rising, posing a serious threat to elderly people's health. Natural preparations derived from plants, such as Pueraria radix, have shown potential therapeutic effects on CI through multiple mechanisms. Isoflavones from Pueraria radix have been found to have neuroprotective effects on multiple models of CI, preventing Aβ aggregation, inhibiting tau hyperphosphorylation, and improving synaptic plasticity. This review contributes to the development of isoflavones as new drug candidates for the treatment of CI.
AGEING RESEARCH REVIEWS
(2023)
Article
Plant Sciences
Huiqiang Hu, Tingting Wang, Yunpeng Wei, Zhenyu Xu, Shiyu Cao, Ling Fu, Huaxing Xu, Xiaobo Mao, Luqi Huang
Summary: In this study, an innovative and efficient method using hyperspectral imaging technology and deep learning is proposed to predict the content of isoflavones and starch in Puerariae Thomsonii Radix. Experimental results show that the deep learning model outperforms traditional methods, demonstrating its potential for enhancing efficiency in quality control within the food industry.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Applied
Qiong Li, Wenjun Liu, Hua Zhang, Chong Chen, Ronghua Liu, Hengwei Hou, Quan Luo, Qinqin Yu, Hui Ouyang, Yulin Feng, Weifeng Zhu
Summary: Radix Puerariae thomsonii, a wild kudzu root, can be used as a food or medicine. Its active component, RPP-2, has been found to improve high-fat diet-induced NAFLD by regulating gut microbiota and metabolites.
CARBOHYDRATE POLYMERS
(2023)
Article
Plant Sciences
Na Guo, Zhengyu Fang, Qingce Zang, Yiqing Yang, Tiegui Nan, Yuping Zhao, Luqi Huang
Summary: This study systematically compared the metabolite differences between P. lobata and P. thomsonii using AFA-DESI-MSI, LC-MS, and biological activity analysis. The results revealed 52 key differential metabolites and showed that P. lobata extracts exhibited a better protective efficacy on H9c2 cells against hypoxia/reoxygenation injury compared to P. thomsonii extracts.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jinming Liu, Haiman Xu, Li Zhang, Shuai Wang, Danyi Lu, Min Chen, Baojian Wu
Summary: Identifying drugs with dosing time-dependent effects and understanding the role of REV-ERB alpha as a drug target can improve drug treatment outcomes. The herbal medicines Puerariae radix and Coptidis rhizoma have demonstrated chronoeffects in mice, with PR alleviating hyperhomocysteinemia and CR attenuating chronic colitis in a dosing time-dependent manner, possibly attributed to diurnal expression of REV-ERB alpha.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Nutrition & Dietetics
Liping Huang, Zhongyu Liu, Peng Wu, Xiaojing Yue, Zhuoshi Lian, Peishi He, Yarui Liu, Ruisi Zhou, Jie Zhao
Summary: Pre-eclampsia (PE) is a serious pregnancy complication, and this study found that Puerariae lobatae Radix (PLR) supplementation could alleviate PE symptoms in a mouse model. PLR improved hypertension, proteinuria, fetal and placental weights, and increased the levels of VEGF and PlGF. It also protected the placenta from oxidative stress and mitigated placental damage by activating a specific pathway. Additionally, PLR supplementation corrected gut dysbiosis and improved the abundance of beneficial bacteria in the intestines. These findings suggest that modulating the gut microbiota through PLR supplementation could be an effective strategy for the treatment of PE.
Article
Nutrition & Dietetics
Yongfei Deng, Han Liu, Qian Huang, Lingyun Tu, Lu Hu, Bisheng Zheng, Huaiqing Sun, Dengjun Lu, Chaowan Guo, Lin Zhou
Summary: In this study, it was found that the fermented supernatant of Schizophyllum commune with added Radix Puerariae (SC-RP) exhibited significant antioxidant activity and could extend the lifespan and healthspan of Caenorhabditis elegans. This effect was achieved by regulating gene expression and increasing antioxidant enzyme activities.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Huan Qin, Wenwen Zhao, Yang Jiao, Haoyi Zheng, Hao Zhang, Jingyu Jin, Qiu Li, Xiuping Chen, Xia Gao, Yantao Han
Summary: The traditional herb pair Salvia miltiorrhiza Bunge-Radix Puerariae (DG) has shown potential in ameliorating osteoporosis by regulating osteoclast differentiation, autophagy, and oxidative stress. This study provides a mechanistic basis for the therapeutic effects of DG on osteoporosis and suggests safe doses for preventing and improving bone diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yu-Shi Liu, Ming-Hao Yuan, Cun-Yan Zhang, Hong-Mei Liu, Juan-Ru Liu, Ai-Ling Wei, Qiang Ye, Bin Zeng, Mei-Feng Li, Yi-Ping Guo, Li Guo
Summary: The study demonstrated that PLR flavonoids and puerarin can alleviate alcohol-induced hepatic steatosis in zebrafish larvae by regulating alcohol and lipid metabolism, which is closely related to the AMPKα-ACC signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Yuan Gao, Mengjia Xu, Hao Wan, Chang Li, Yiqun Wan
Summary: A new method using ultra-high performance liquid chromatography was developed for the simultaneous determination of puerarin, daidzin, daidzein, and genistein in Radix puerariae. The target analytes were extracted using 70% ethylene glycol with ultrasonication, purified with N-propyl ethylenediamine (PSA) absorption, and separated on a Supersil ODS column. This method successfully determined the content of the four compounds in Radix puerariae from 11 different origins, providing fundamental data and technical means for quality control and regulation of Radix puerariae.
Article
Orthopedics
Tzu-Chieh Lin, Pin-Wen Wang, Chun-Teng Lin, Yu-Jun Chang, Ying-Ju Lin, Wen-Miin Liang, Jeff Chien-Fu Lin
Summary: This retrospective cohort study investigated the long-term outcomes of patients over 60 years old who underwent hemiarthroplasty for unstable trochanteric fractures. The study found that with time, the mortality, readmission, and reoperation rates increased gradually. Risk factors for overall mortality included male gender, older age, higher Charlson Comorbidity Index (CCI), and lower insured amount, while older age and higher CCI were risk factors for readmission. Older age was a protective factor for reoperation, likely due to competing death.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cell Biology
Peng-Tai Tien, Chia-Hung Lin, Chih-Sheng Chen, Ching-Yao Chang, Hsiangyu Ku, Dekang Gan, Yi-Yu Tsai, Jamie Jiin-Yi Chen, Hui-Ju Lin, Lei Wan
Summary: The study showed that diacerein has a therapeutic effect on myopia, potentially by regulating the expression of various biomarkers to inhibit the progression of myopia.
MEDIATORS OF INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Cherry Yin-Yi Chang, An-Jen Chiang, Ming-Tsung Lai, Man-Ju Yan, Chung-Chen Tseng, Lun-Chien Lo, Lei Wan, Chia-Jung Li, Kuan-Hao Tsui, Chih-Mei Chen, Tritium Hwang, Fuu-Jen Tsai, Jim Jinn-Chyuan Sheu
Summary: Infection-induced chronic inflammation is common in patients with endometriosis. This study found that the composition of microbial communities in the cervical mucus changed during the development and progression of the disease. Compared to healthy women, patients with endometriosis had increased Lactobacillus, Streptococcus, and decreased Dialister. These changes were frequently associated with advanced disease stages, higher CA125 levels, severe pain, and infertility.
Article
Pharmacology & Pharmacy
Mu-Lin Chiu, Jian-Shiun Chiou, Chao-Jung Chen, Wen-Miin Liang, Fuu-Jen Tsai, Yang-Chang Wu, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Chen-Hsing Chou, Cheng-Wen Lin, Te-Mao Li, Yu-Lung Hsu, Ying-Ju Lin
Summary: This study investigated the efficacy of Chinese herbal medicine (CHM) in reducing mortalities among patients with Hereditary Hemolytic Anemias (HHAs). The results showed that CHM users had significantly reduced risks of overall mortality, diabetes-related mortality, and cardiovascular diseases-related mortality compared to non-CHM users.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ning-Yi Hsia, Li-Yen Wen, Ching-Ying Chou, Cheng-Li Lin, Lei Wan, Hui-Ju Lin
Summary: This study found that children with ptosis have a higher risk of astigmatism, myopia, hyperopia, and amblyopia. Children diagnosed with ptosis at an age older than 3 years have a higher risk of myopia than those diagnosed before the age of 3. However, there is no significant difference in the risk of astigmatism, amblyopia, and hyperopia between different age groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jian-Shiun Chiou, Chi-Fung Cheng, Wen-Miin Liang, Chen-Hsing Chou, Chung-Hsing Wang, Wei-De Lin, Mu-Lin Chiu, Wei-Chung Cheng, Cheng-Wen Lin, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Chang-Hai Tsai, Ying-Ju Lin, Fuu-Jen Tsai
Summary: This study conducted genome-wide association analyses in the Taiwanese Han population and identified hundreds of genetic loci associated with height, contributing to the understanding of genetic features of height and health-related outcomes in individuals of Han Chinese ancestry in Taiwan.
Article
Medicine, Research & Experimental
Yao-Chien Wang, Kuang Ting Chen, Sheng-Chun Lin, Yu-An Hsu, Ching-Yao Chang, En-Shyh Lin, Hui-Ju Lin, Chih-Sheng Chen, Lei Wan
Summary: This study identified Rhizoma Anemarrhenae (RA) as a potential alternative to growth hormone (GH) in promoting growth. RA extracts exhibited transactivation activities that stimulate the activation of STAT5, and can mimic the bioactivity of GH by interacting with GH receptors. RA extracts also increased the height of the tibial growth plate and stimulated the production of insulin-like growth factor 1.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Chung-Hao Li, Chung-Teng Wang, Ying-Ju Lin, Hsin-Yu Kuo, Juei-Seng Wu, Tzu-Chun Hong, Chih-Jen Chang, Hung-Tsung Wu
Summary: Long-term consumption of sorbitol may alter gut microbiome composition and potentially induce glucose intolerance.
Article
Integrative & Complementary Medicine
Chih-Sheng Chen, Chi-Fong Lin, Yung-Lan Chou, Der-Yen Lee, Peng-Tai Tien, Yao-Chien Wang, Ching-Yao Chang, En-Shyh Lin, Jamie Jiin Chen, Ming-Yen Wu, Hsiangyu Ku, Dekang Gan, Yung-Ming Chang, Hui-Ju Lin, Lei Wan
Summary: The aim of this study was to investigate whether acupuncture suppresses myopia progression in form deprived Syrian hamsters by increasing dopamine levels and inhibiting inflammasome activation. The results showed that acupuncture inhibited myopia development by increasing dopamine levels and activating the dopamine D1 receptor signaling pathway. Additionally, the study demonstrated that activation of the D1 receptor signaling pathway suppressed the activation of the NOD-LRR-NLRP3 inflammasome. Therefore, our findings suggest that acupuncture inhibits myopia development by suppressing inflammation initiated by the dopamine-D1 receptor signaling pathway.
ACUPUNCTURE IN MEDICINE
(2023)
Article
Ophthalmology
I Wang, Hui-Ju Lin, Yi-Yu Tsai, Wen-Lu Chen, Chun-Ju Lin, San-Ni Chen, Ming-Chieh Hsieh, Lei Wan, Peng-Tai Tien
Summary: A 23-year-old female experienced sudden blindness after injection of PDLLA at the glabella. After receiving proper and immediate therapies including medication, massage, and hyperbaric oxygen therapy, her vision improved significantly within 2 months. The case highlights the rare but devastating complication of retinal artery occlusion caused by PDLLA.
Article
Pharmacology & Pharmacy
Jian-Shiun Chiou, Chen-Hsing Chou, Mao-Wang Ho, Ni Tien, Wen-Miin Liang, Mu-Lin Chiu, Fuu-Jen Tsai, Yang-Chang Wu, I-Ching Chou, Hsing-Fang Lu, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Te-Mao Li, Ying-Ju Lin
Summary: Living with HIV and/or ART for a long time can lead to neurocognitive impairment, which is a significant issue for HIV/AIDS patients. This impairment affects a large percentage of patients and has negative impacts on work performance, safety, and health outcomes, resulting in a heavy economic burden.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jyun-Lin Lee, Yao-Chien Wang, Yu-An Hsu, Chih-Sheng Chen, Rui-Cian Weng, Yen-Pei Lu, Chun-Yu Chuang, Lei Wan
Summary: Nonalcoholic fatty liver disease is a risk factor for liver fibrosis caused by an imbalance in lipid metabolism and immune response. M2 macrophages play a role in liver fibrosis through the secretion of transforming growth factor-β1. Galectin-12 regulates lipid metabolism and macrophage polarization. This study investigates the role of galectin-12 in the development of nonalcoholic fatty liver disease and fibrosis, finding that galectin-12 balances M1/M2 polarization of Kupffer cells to prevent disease progression.
Article
Integrative & Complementary Medicine
Chih-Sheng Chen, Yu-An Hsu, Chia-Hung Lin, Yao-Chien Wang, En-Shyh Lin, Ching-Yao Chang, Jamie Jiin-Yi Chen, Ming-Yen Wu, Hui-Ju Lin, Lei Wan
Summary: This study investigated the effects of Fallopia Japonica and Prunella vulgaris extracts on myopia caused by monocular form deprivation. The results showed that these extracts reduced inflammation, inhibited myopia-related cytokines, and increased collagen expression. These findings suggest that these extracts could be a potential treatment option for myopia.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Biochemistry & Molecular Biology
Hsiangyu Ku, Jamie Jiin-Yi Chen, Min Hu, Peng-Tai Tien, Hui-Ju Lin, Gezhi Xu, Lei Wan, Dekang Gan
Summary: In this study, the researchers aimed to investigate the role of chronic retinal inflammation in the pathogenesis of form-deprivation myopia using tree shrews as an animal model. The results suggested that chronic inflammation may play a crucial role in the development of form-deprivation myopia in tree shrews.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Pediatrics
Chieh Wang, Jeng-Dau Tsai, Lei Wan, Cheng-Li Lin, Chang-Ching Wei
Summary: This study found a positive association between different concentrations of sulfur dioxide, total hydrocarbon, and methane and the risk of childhood nephrotic syndrome based on data analysis of Taiwanese children.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)