Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Immunology
Qiyu Yang, Jing Ouyang, Damao Pi, Li Feng, Jiadan Yang
Summary: There is accumulating evidence that patients with inflammatory bowel disease (IBD) have a higher risk of developing different cancers, and the presence of Malassezia fungus may worsen the inflammatory response and promote tumorigenesis in these patients. Surveillance and intervention should be taken to minimize the cancer risk in individuals with IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Yijie Song, Man Yuan, Yu Xu, Hongxi Xu
Summary: Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders caused by abnormal immune response. The development of proinflammatory cytokine therapeutic agents, including TNF inhibitors, shows promise for treating IBD. Antagonizing other cytokines has shown advantages in clinical trials and can be used to target anti-TNF therapy failure. Additionally, blocking lymphocyte homing helps alleviate inflammation and tissue damage.
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Martin Maronek, Irene Marafini, Roman Gardlik, Rene Link, Edoardo Troncone, Giovanni Monteleone
Summary: Inflammatory bowel diseases (IBD) refer to chronic inflammatory conditions of the gastrointestinal tract, including Crohn's disease (CD) and ulcerative colitis (UC). Excessive production of matrix metalloproteinases (MMPs) without sufficient inhibition by tissue inhibitors of metalloproteinases (TIMPs) in inflamed tissue of IBD patients contributes significantly to mucosal degradation in IBD-related pathologies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Chris Ho Ching Yeung, C. Mary Schooling
Summary: This study found that systemic inflammatory regulators were not associated with the risk of Alzheimer's disease, but Alzheimer's disease was suggestively associated with certain specific inflammatory regulators.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chao Liu, Yuhong Jiang, Ganglei Liu, Zhushu Guo, Qianqian Jin, Dongju Long, Weihan Zhou, Ke Qian, Hua Zhao, Kuijie Liu
Summary: This study found that PPARGC1A was downregulated in DSS-induced colitis and DSS-stimulated colonic epithelial cells, and PDT treatment could upregulate PPARGC1A expression. Knockdown of PPARGC1A could attenuate the therapeutic effects of PDT on DSS-induced colitis and DSS-stimulated colonic epithelial cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ting Zhang, Xinghui Ji, Gaochen Lu, Faming Zhang
Summary: Akkermansia muciniphila is a promising next-generation probiotic with recognized potential applications in metabolic diseases and tumor immunotherapy. Its safety and therapeutic value in human metabolic diseases have been confirmed in recent clinical trials. Additionally, A. muciniphila shows promise in the treatment of intestinal inflammatory diseases, particularly inflammatory bowel disease (IBD).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Bartolo Tamburini, Marco Pio La Manna, Lidia La Barbera, Leila Mohammadnezhad, Giusto Davide Badami, Mojtaba Shekarkar Azgomi, Francesco Dieli, Nadia Caccamo
Summary: Inflammatory bowel disease (IBD) is a pressing global health problem with increasing incidence worldwide. While the exact etiology is still unclear, a complex interaction of factors, including immune system defects, microbial dysbiosis, genetic predisposition, and environmental factors, contribute to the development of inflammation. This review aims to analyze the intricate balance between these elements in maintaining intestinal homeostasis and preventing or minimizing the adverse effects of IBD on health.
Review
Pharmacology & Pharmacy
Yang Zheng, Yang Yu, Xu-Feng Chen, Sheng-Lan Yang, Xiao-Long Tang, Zheng-Guo Xiang
Summary: Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders, with unclear mechanisms and lack of ideal treatments. Intestinal macrophage autophagy plays an important role in IBD, with potential implications for treatment by regulating inflammation and immune responses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Timon E. Adolph, Jingwan Zhang
Summary: The diet and gut microbiota play a crucial role in gut inflammation in IBD. Specific nutrients in a Western diet can trigger or worsen experimental gut inflammation in genetically susceptible individuals. Nutritional trials provide common grounds for dietary advice in pediatric and adult IBD, with exclusive enteral nutrition showing effectiveness in treating pediatric Crohn's disease.
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Article
Nutrition & Dietetics
Marlijne C. G. de Graaf, Corinne E. G. M. Spooren, Evelien M. B. Hendrix, Martine A. M. Hesselink, Edith J. M. Feskens, Agnieszka Smolinska, Daniel Keszthelyi, Marieke J. Pierik, Zlatan Mujagic, Daisy M. A. E. Jonkers
Summary: The study found that diet quality was lower in patients with IBD and IBS, and was associated with intestinal inflammation and gastrointestinal symptoms to varying degrees.
Article
Gastroenterology & Hepatology
Salvatori Silvia, Marafini Irene, Venuto Chiara, Laudisi Federica, Neri Benedetto, Lavigna Diletta, Franchin Martina, De Cristofaro Elena, Biancone Livia, Calabrese Emma, Giannarelli Diana, Giovanni Monteleone
Summary: Frailty is common in hospitalized patients with inflammatory bowel disease (IBD) and has been associated with an increased risk of adverse outcomes. This prospective study revealed that nearly one-fifth of IBD patients were frail, with active disease being an independent risk factor for the frail phenotype.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Immunology
Xiaowen Zheng, Yi Zhu, Zihan Zhao, Ying Chu, Wenjing Yang
Summary: Inflammation is a characteristic symptom of many diseases, and this review summarizes the changes and mechanisms of amino acids in inflammatory bowel disease and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)