Article
Medicine, Research & Experimental
Yuchong Wang, Xujun Zhang, Kefan Bi, Hongyan Diao
Summary: MicroRNAs play important roles in regulating virus replication and host antiviral response during H1N1 infection, with some defending against the virus and others promoting viral replication. They are involved in host-viral interactions and have versatile functions in this process.
Article
Immunology
Irina Nudelman, Daniil Kudrin, German Nudelman, Raamesh Deshpande, Boris M. M. Hartmann, Steven H. Kleinstein, Chad L. L. Myers, Stuart C. C. Sealfon, Elena Zaslavsky
Summary: The study examined the activation of functional modules in host cells by influenza viruses of varying pathogenicity, revealing a common core response to infection that is temporally shifted for different viruses. Differentially regulated functional modules highlighted unique elements of host responses to different virus strains, providing mechanistic insight into the differences in host response to influenza strains.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Flora De Conto, Francesca Conversano, Sergey Razin, Silvana Belletti, Maria Cristina Arcangeletti, Carlo Chezzi, Adriana Calderaro
Summary: The study showed that influenza virus is able to induce phosphorylation of keratin 8 in A549 cells, enhancing its replicative efficiency.
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Multidisciplinary Sciences
Xiao Huang, Feng Lu, Huanhuan Tian, Haoran Hu, Fangyu Ning, Quanmei Shang, Dong Hao, Weiwei Zhu, Guiqing Kong, Xiaohong Ma, Jiali Feng, Tao Wang, Xiaozhi Wang
Summary: Plasma levels of syndecan-1 and hyaluronan are positively correlated with disease severity in patients with influenza A (H1N1). Elevated syndecan-1 levels may have a potential role in systemic organ dysfunction and could serve as an indicator of disease severity and mortality in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Aleksandr Ianevski, Rouan Yao, Eva Zusinaite, Hilde Lysvand, Valentyn Oksenych, Tanel Tenson, Magnar Bjoras, Denis Kainov
Summary: The study suggests that commonly prescribed drugs can affect host responses to FLUAV infection, potentially contributing to increased morbidity and mortality among patients with influenza virus infections.
Review
Biochemistry & Molecular Biology
Gayan Bamunuarachchi, Samuel Pushparaj, Lin Liu
Summary: Influenza virus infection through seasonal epidemics and occasional pandemics has been a major public health concern for decades. Incomplete protection from vaccination and increased antiviral resistance due to frequent mutations of influenza viruses have led to a continuous need for new therapeutic options. The functional significance of host protein and influenza virus interactions has been established, but relatively less is known about the interaction of host noncoding RNAs, including microRNAs and long noncoding RNAs, with influenza viruses.
Review
Virology
Katarzyna Magdalena Dolata, Gang Pei, Christopher L. Netherton, Axel Karger
Summary: Viral replication relies on host cell machinery and interactions between viral and host proteins. Identifying these interactions provides insights into virus infection and is crucial for antiviral strategies.
Article
Virology
Meng-Ting Huang, Sen Zhang, Ya-Nan Wu, Wei Li, Yu-Chang Li, Chang-Shuai Zhou, Xiao-Ping Kang, Tao Jiang
Summary: This study examined the role of the multifunctional NS1 protein of influenza A virus in modulating host antiviral responses and compared the sequence differences between a seasonal variant and the 2009 pandemic strain. A dual mutation in the NS1 protein was found to selectively inhibit cytokine responses via a mechanism that may not involve CPSF30 binding. This highlights the complexity of host-influenza NS1 protein interactions.
Review
Cell Biology
Etori Aguiar Moreira, Yohei Yamauchi, Patrick Matthias
Summary: Influenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential. Cellular cues contribute to viral conformational changes during host cell entry, aiding in critical events such as fusion with late endosomes and viral genome release into the cytosol.
Article
Virology
Min Dou, Wenjun Song, Yongping Lin, Qigao Chen, Chang Lu, Zhongmin Liu
Summary: The study analyzed clinical characteristics and viral genes in patients with severe pneumonia due to H1N1 influenza virus in Guangzhou in 2019. Risk factors for severe disease were identified as chronic lung disease and cardiovascular disease, with a significant rate of secondary infections in critically ill patients. Furthermore, serum IL-8 levels were significantly higher in critically ill patients compared to nonsevere patients and healthy controls.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Ecology
Chaoyuan Cheng, Marcel Holyoak, Lei Xu, Jing Li, Wenjun Liu, Nils Chr Stenseth, Zhibin Zhang
Summary: This study explores the competition and coexistence patterns between different lineages of the influenza virus. The results demonstrate that lineages infecting the same host experience stronger competition compared to those infecting different hosts. Additionally, lineages with higher cross-region transmission intensity also face stronger competition and extinction pressures.
ECOLOGY AND EVOLUTION
(2022)
Article
Medicine, General & Internal
Hyun-Jong Lee, Gwanghui Ryu, Ki-Il Lee
Summary: This study compared the symptomatic characteristics of influenza A/H3N2 and A/H1N1 subtypes in primary healthcare settings in Korea. The results showed that the H3N2-dominant season had higher average body temperature and more patients with high fever compared to the H1N1-dominant season. On the other hand, symptoms such as myalgia, cough, and sore throat were more common in the H1N1-dominant season. Antiviral drugs were prescribed to the majority of febrile patients in both seasons.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Microbiology
Nelam Sajjad, Song Wang, Ping Liu, Ji-Long Chen, Xiaojuan Chi, Shasha Liu, Shujie Ma
Summary: Non-coding RNAs play significant roles in cell regulation and response to viral infections, particularly influenza A virus (IAV). They are associated with innate immunity and involvement of interferons and their stimulated genes (ISGs) during IAV infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Yueming Wang, Jiwei Huang, Cuijian Zhang, Xiaoyi Hu, Ping Wang, Guohai Shi, Jin Zhang, Wen Kong, Yonghui Chen, Yiran Huang, Dingwei Ye, Dan Xia, Jianming Guo, Zhisong He, Wei Xue
Summary: This retrospective multicenter study analyzed the clinical outcomes and prognostic factors of 85 patients who underwent targeted therapy for local retroperitoneal recurrence (RPR) after radical nephrectomy (RN). The study found that presurgical targeted therapy followed by surgical resection was associated with better cancer-specific survival (CSS) compared to targeted therapy alone. Factors such as risk classification, number of recurrence lesions, and surgical resection were independent predictors of CSS.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Jiwei Huang, Yueming Wang, Cuijian Zhang, Xiaoyi Hu, Ping Wang, Guohai Shi, Liang Dong, Jin Zhang, Wen Kong, Yonghui Chen, Dan Xia, Jianming Guo, Wei Xue, Yiran Huang, Zhisong He
Summary: Patients who underwent RPR surgery had significantly longer CSS than those who received targeted therapy alone.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Oncology
Xinan Sheng, DingWei Ye, Aiping Zhou, Xin Yao, Hong Luo, Zhisong He, Zengjun Wang, Yingchao Zhao, Zhigang Ji, Qing Zou, Chaohong He, Jianming Guo, Xinhua Tu, Ziling Liu, Benkang Shi, Ben Liu, Peng Chen, Qiang Wei, Zhiquan Hu, Yanqiao Zhang, Kui Jiang, Fangjian Zhou, Dapeng Wu, Cheng Fu, Xingya Li, Bin Wu, Lijie Wang, Shukui Qin, Gang Li, Yunpeng Liu, Hongqian Guo, Kehe Chen, Dahong Zhang, Gongxian Wang, Lieming Ding, Yang Wang, Xiaobin Yuan, Jun Guo
Summary: This study aimed to evaluate the efficacy of vorolanib in combination with everolimus or as monotherapy compared to everolimus alone as second-line treatment for metastatic renal cell carcinoma (RCC). The results showed that the combination of vorolanib and everolimus had a significant improvement in progression-free survival (PFS) and objective response rate compared to everolimus alone. However, there was no significant difference in PFS and objective response rate between vorolanib monotherapy and everolimus. Overall, this study offers a better treatment option for patients with metastatic RCC.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Kaiwei Yang, Hailong Hu, Junlong Wu, Huina Wang, Zhaoxia Guo, Wei Yu, Lin Yao, Feng Ding, Tao Zhou, Wang Wang, Yunkai Wang, Lei Liu, Jing Guo, Shuaipeng Zhu, Xinhao Zhang, Shanbo Cao, Feng Lou, Yuanjie Niu, Dingwei Ye, Zhisong He
Summary: Current methods for early detection and MRD monitoring of urothelial carcinoma (UC) are invasive or suboptimal in sensitivity. A new workflow called utLIFE, based on UC-specific mutations and large copy number variations, can detect UC with high sensitivity and specificity. It has been validated in bladder cancer and upper tract urothelial carcinoma cohorts, showing improved sensitivity compared to cytology and fluorescence in situ hybridization (FISH).
Article
Biotechnology & Applied Microbiology
FeiMing Huang, QingLan Ma, JingXin Ren, JiaRui Li, Fen Wang, Tao Huang, Yu-Dong Cai
Summary: Long-term cigarette smoking is associated with various human diseases, and this study used advanced machine learning methods to identify specific isoforms and pathways that play important roles in distinguishing smokers from former smokers. The study evaluated multiple feature selection algorithms and utilized a decision tree approach to establish high-performance classification models. The identified isoforms and classification rules were validated through previous research. The results highlight the relevance of isoforms such as ENST00000464835, ENST00000622663, and ENST00000284311, as well as pathways related to smoking response.
BIOMED RESEARCH INTERNATIONAL
(2023)
Article
Andrology
Xin Qi, Zhuo-Fei Zhang, Xian-Shu Gao, Shang-Bin Qin, Yun Bai, Wei Yu, Qun He, Yu Fan, Jian-Hua Zhang, Yuan Jiang, Zhi-Song He, Hong -Zhen Li
Summary: In this case series, we discussed 4 t-NEPC cases who were treated with partial stereotactic ablative radiotherapy (P-SABR) for bulky tumors. The results indicated that P-SABR is safe and effective in the treatment of a large prostate mass and may prolong the survival of these patients.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)
Article
Respiratory System
Chuan-cai Xu, Zhi-song He, Wei Lei, Jin-zhou Zhu, Da-guo Zhao, Jin-dan Kong, Yao Wei, Ying Xu, Jian-An Huang
Summary: This study found that patients with breakthrough infections after receiving the COVID-19 vaccine had higher lymphocyte counts, anti-SARS-CoV-2 spike IgG and IgM antibody titers within 60 days of receiving the second dose compared to those with a 60-day or longer interval. Additionally, the IL-6 level was significantly lower in the group with a shorter interval.
CLINICAL RESPIRATORY JOURNAL
(2023)
Article
Biology
Jingxin Ren, Yuhang Zhang, Wei Guo, Kaiyan Feng, Ye Yuan, Tao Huang, Yu-Dong Cai
Summary: COVID-19 can cause impairment of smell and taste, and this study used machine learning to analyze gene expression levels in COVID-19 patient samples to identify important biomarkers associated with this loss of sensory ability. The study suggests potential mechanisms for COVID-19 complications and provides biomarkers for predicting olfactory and gustatory impairment.
Article
Biology
Yaochen Xu, Qinglan Ma, Jingxin Ren, Lei Chen, Wei Guo, Kaiyan Feng, Zhenbing Zeng, Tao Huang, Yudong Cai
Summary: COVID-19 not only damages the respiratory system, but also puts strain on the cardiovascular system. This study analyzed the gene expression levels of vascular endothelial cells and cardiomyocytes in COVID-19 patients and healthy controls using a machine learning-based workflow. The findings suggest that COVID-19 affects the gene expression levels in cardiac cells, providing insights into the pathogenesis of COVID-19 and potential therapeutic targets.
Article
Biology
Qinglan Ma, FeiMing Huang, Wei Guo, KaiYan Feng, Tao Huang, Yudong Cai
Summary: Phase-separation proteins (PSPs) play a role in liquid-liquid phase separation and have implications for cellular biology and disease development. Identifying PSPs and their functions can provide valuable insights.
Article
Biology
Qing-Lan Ma, Fei-Ming Huang, Wei Guo, Kai-Yan Feng, Tao Huang, Yu-Dong Cai
Summary: Vaccines elicit an immune response involving B and T cells, with B cells producing antibodies. The immunity to SARS-CoV-2 diminishes over time after vaccination. This study aimed to identify important changes in antigen-reactive antibodies post-vaccination to enhance vaccine efficacy.
Article
Biology
Jing-Xin Ren, Qian Gao, Xiao-Chao Zhou, Lei Chen, Wei Guo, Kai-Yan Feng, Lin Lu, Tao Huang, Yu-Dong Cai
Summary: A machine-learning-based method was used to analyze the scRNA-seq data of B cells, T cells, and myeloid cells from patients with COVID-19. Key genes related to SARS-CoV-2 infection were identified. The study revealed the dynamic changes in the immune system of COVID-19 patients at different stages, providing valuable insights into the ongoing effect of COVID-19 development on the immune system.
Article
Biology
Yong Yang, Yuhang Zhang, Jingxin Ren, Kaiyan Feng, Zhandong Li, Tao Huang, Yudong Cai
Summary: This study analyzed single-cell RNA sequencing data from a normal colon to identify genetic markers of 25 immune cell types and reveal quantitative differences between them. Machine learning-based methods were used to analyze the importance of gene features and classify the most important genetic markers. The results provide a reference for exploring the cell composition of the colon cancer microenvironment and clinical immunotherapy.
Article
Cell & Tissue Engineering
Lvzhong Hu, Jinhua Zhou, Zhisong He, Lin Zhang, Fangzhou Du, Mengting Nie, Yao Zhou, Hang Hao, Lixing Zhang, Shuang Yu, Jingzhong Zhang, Youguo Chen
Summary: The study found that implanting human umbilical cord mesenchymal stem cells (hUC-MSCs) in a fibrin hydrogel scaffold can promote skin repair, prolong cell survival, and accelerate wound healing. The hydrogel scaffold provides a stable environment for cell adhesion, proliferation, and migration, while the combination therapy with hUC-MSCs promotes epithelial regeneration and angiogenesis. It exhibits a remarkable therapeutic effect, more effective than monotherapy with hUC-MSCs or hydrogel.
CELL TRANSPLANTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Wang, Pei Dong, Yuanyuan Qu, Wenhao Xu, Zhaohui Zhou, Kang Ning, Yulu Peng, Longbin Xiong, Zhen Li, Xiangpeng Zou, Zhenhua Liu, Mingzhao Li, Zhisong He, Junhang Luo, Xi Tian, Hailiang Zhang, Shengjie Guo, Hui Han, Fangjian Zhou, Shaohan Yin, Dingwei Ye, Chunping Yu, Zhiling Zhang
Summary: This study investigated the association between computed tomography-assessed body composition and survival outcomes in patients with metastatic renal cell carcinoma (mRCC) receiving immunotherapy. The results showed that high subcutaneous adipose tissue percentage (SAT%) predicts better survival outcomes and this association is consistent in different subgroups.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
