Article
Biochemistry & Molecular Biology
Anastasia Yu. Teterina, Igor V. Smirnov, Irina S. Fadeeva, Roman S. Fadeev, Polina V. Smirnova, Vladislav V. Minaychev, Margarita I. Kobyakova, Aleksandr Yu. Fedotov, Sergey M. Barinov, Vladimir S. Komlev
Summary: The study presented the synthesis of low-temperature calcium phosphate compounds with strontium substitution to improve bioactive properties, indicating the effectiveness of using strontium in OCP for enhancing biocompatibility in composite materials intended for bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Serife Buket Bozkurt, Sema Sezgin Hakki, Alpdogan Kantarci
Summary: This study evaluated the effects of RvD1 and RvE1 on cementoblasts and found that they promote cell proliferation and mineralization while regulating gene expression through different pathways, suggesting their potential therapeutic role in periodontal regeneration.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lia Hoz, Sonia Lopez, Margarita Zeichner-David, Higinio Arzate
Summary: This study demonstrated that CEMP1-p1 promotes periodontal regeneration in a rat fenestration model, including the formation of new cementum, periodontal ligament with Sharpey's fibers inserted, and new bone.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Chemistry, Physical
Lorenzo Degli Esposti, Marco Fosca, Aurelien Canizares, Leire Del Campo, Marco Ortenzi, Alessio Adamiano, Julietta Rau, Michele Iafisco
Summary: This study used in situ techniques to investigate the thermal crystallization of amorphous calcium phosphate (ACP) and observed transient structural changes before the crystallization process. The presence of carbonate and citrate ions significantly affected the thermal crystallization of ACP.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hsiang-Hsi Hong, Ting-An Chou, Adrienne Hong, Yi-Fang Huang, Tzung-Hai Yen, Chao-Hua Liang, Alex Hong, Hui-Yi Hsiao, Chung-Yi Nien
Summary: This study confirms the cemento-inductivity effect of calcitriol and the potential of enamel matrix derivative (EMD) on human periodontal ligament-derived cells (hPDLCs). Calcitriol enhances cementogenic gene expression and mineralization formation, while EMD stimulates protein expression but has weaker mineralization capacity. These findings suggest that calcitriol and EMD can provide differential enhancement of cemento-induction and mineralization at different differentiation stages.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Engineering, Biomedical
Zhuyun Cai, Xiaohao Liu, Miao Hu, Yichen Meng, Jianquan Zhao, Yixuan Tan, Xiong Luo, Ce Wang, Jun Ma, Zhongyi Sun, Yingying Jiang, Bingqiang Lu, Rui Gao, Feng Chen, Xuhui Zhou
Summary: A new biomineralization strategy is developed to prepare magnesium-based mineralized microspheres with controllable size and specific functions, showing great potential for bone regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Xiaodong Hou, Lei Zhang, Zifei Zhou, Xiong Luo, Tianlong Wang, Xinyu Zhao, Bingqiang Lu, Feng Chen, Longpo Zheng
Summary: This review discusses the role and properties of CaP-based biomaterials in bone regeneration, including synthesis strategies, structure control, biological behavior, and the mechanisms of CaP in promoting osteogenesis. It will be helpful for scientists and engineers to further understand CaP-based biomaterials and develop new high-performance biomaterials for bone repair.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Engineering, Biomedical
Shizu Saito, Ryo Hamai, Yukari Shiwaku, Tomoka Hasegawa, Susumu Sakai, Kaori Tsuchiya, Yuko Sai, Ryosuke Iwama, Norio Amizuka, Tetsu Takahashi, Osamu Suzuki
Summary: This study demonstrates that octacalcium phosphate (OCP) implanted in critical-sized rat calvaria bone defects can enhance the early differentiation of osteocytes embedded in newly formed bone matrices, even when the surface OCP is separated from the osteocytes. OCP stimulates osteocyte differentiation through ionic dissolution due to its metastable chemical properties.
ACTA BIOMATERIALIA
(2021)
Article
Biophysics
C. R. Akshata, G. Harichandran, E. Murugan
Summary: The plant polysaccharide pectin, which is chemically similar to bone extracellular matrix (ECM), has been found to promote the crystallization of strontium-substituted hydroxyapatite (HA). Pectin has a preferential affinity for strontium over calcium, resulting in the incorporation of strontium in apatite, reduced crystal size, and retention of more pectin residues.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Linghao Xiao, Yukari Shiwaku, Ryo Hamai, Kaori Tsuchiya, Keiichi Sasaki, Osamu Suzuki
Summary: This study found that the crystal phase of calcium phosphate (CaP) materials can affect the polarization of macrophages, with octacalcium phosphate (OCP) inhibiting excessive inflammatory responses and promoting anti-inflammatory M2 phenotype, while Ca-deficient hydroxyapatite stimulating excessive inflammation. Furthermore, an increase in ion concentration was found to be closely related to the expression of inflammatory-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Xiaoyan Ren, Qi Zhou, Meiwand Bedar, David Foulad, Kelly X. X. Huang, Dillon Dejam, Natalie J. J. Dahan, Vasiliki Kolliopoulos, Brendan A. C. Harley, Justine C. C. Lee
Summary: The study investigates the effects of phosphate content in nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) on the microenvironment and osteoprogenitor differentiation. It is found that MC-GAG exhibits a temporal relationship with soluble phosphate, eluting early in culture and then absorbing, regardless of the differentiation of primary human mesenchymal stem cells (hMSCs). The intrinsic phosphate content of MC-GAG is sufficient to stimulate osteogenic differentiation of hMSCs without the addition of exogenous phosphate, and this process can be reduced but not eliminated by knocking down the sodium phosphate transporters PiT-1 or PiT-2. The contributions of PiT-1 and PiT-2 to MC-GAG-mediated osteogenesis are nonredundant but nonadditive.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Ilijana Kovrlija, Janis Locs, Dagnija Loca
Summary: Octacalcium phosphate (OCP) has significant advantages as a precursor to biologically formed apatite and is utilized as a carrier for biologically active substances in bone regeneration. However, research on drug delivery systems with OCP is still in its pioneering stage, and comprehensive data is lacking to fully understand the benefits it can bring. Further studies are needed to explore the potential of OCP in drug delivery systems for bone tissue engineering.
ACTA BIOMATERIALIA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Isaac J. de Souza Araujo, Jessica A. Ferreira, Arwa Daghrery, Juliana S. Ribeiro, Miguel Castilho, Regina M. Puppin-Rontani, Marco C. Bottino
Summary: This study investigated the efficacy of using P11-4-functionalized electrospun scaffolds for bone regeneration. The results demonstrated that P11-4-laden scaffolds not only exhibited good cytocompatibility, but also stimulated cell-mediated mineral deposition and upregulated the expression of mineralization-related genes. Furthermore, P11-4-laden scaffolds enhanced bone regeneration in vivo.
Article
Multidisciplinary Sciences
Leoni Britz, Sonja Katrin Schickhardt, Timur Mert Yildirim, Gerd Uwe Auffarth, Ingo Lieberwirth, Ramin Khoramnia
Summary: The study develops a laboratory model to replicate the calcification of hydrophilic acrylic intraocular lenses (IOL). This model can identify IOLs at risk for calcification and assess the influence of associated risk factors, providing further understanding of this pathology.
SCIENTIFIC REPORTS
(2022)
Article
Materials Science, Multidisciplinary
C. Aubry, S. Camy, C. Combes, O. Marsan, T. Canceill, S. Cazalbou
Summary: The innovative low-temperature and high-pressure process used in this study successfully transformed HA and HA/TCP powders into bioactive ceramics composed of OCP and PCCA, showing great potential for bone mineral replacement.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Pediatrics
Luz Maria Torres-Espindola, Joel Demetrio-Rios, Liliana Carmona-Aparicio, Cesar Galvan-Diaz, Martin Perez-Garcia, Juan Luis Chavez-Pacheco, Julio Granados-Montiel, Israel Torres-Ramirez de Arellano, Arnoldo Aquino-Galvez, Manuel De Jesus Castillejos-Lopez
FRONTIERS IN PEDIATRICS
(2019)
Article
Biotechnology & Applied Microbiology
Luz Maria Torres Espindola, Daniela Rojo-Serrato, Antonio Alvaro-Heredia, Manuel de Jesus Castillejos Lopez, Armando de Una-Flores, Martin Perez-Garcia, Marta Zapata-Tarres, Rocio Cardenas-Cardos, Julio Granados, Juan Luis Chavez-Pacheco, Citlaltepetl Salinas-Lara, Israel Torres-Ramirez de Arellano, Arnoldo Aquino-Galve
Article
Pharmacology & Pharmacy
Carmen Flores-Perez, Manuel de Jesus Castillejos-Lopez, Juan Luis Chavez-Pacheco, Victor Manuel Davila-Borja, Janett Flores-Perez, Patricia Zarate-Castanon, Mario Acosta-Bastidas, Jonathan Cruz-Escobar, Luz Maria Torres-Espindola
Summary: This study aimed to investigate the frequency of allelic variants of CYP3A4 and CYP3A5 genes in critically ill Mexican pediatric patients and their effects on plasma levels and clearance of intravenous midazolam. The results showed that patients with the CYP3A5*3 allelic variant (rs776746) had higher plasma midazolam levels at 3 hours after infusion and greater drug clearance compared to carriers of the normal allele.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Article
Neurosciences
Itzel Jatziri Contreras-Garcia, Gisela Gomez-Lira, Bryan Victor Phillips-Farfan, Luz Adriana Pichardo-Macias, Mercedes Edna Garcia-Cruz, Juan Luis Chavez-Pacheco, Julieta G. Mendoza-Torreblanca
Summary: Research suggests that the effectiveness of levetiracetam in treating epilepsy is related to the expression levels of SV2A in glutamatergic terminals, where high SV2A-VGLUT co-expression may contribute to a positive response to the treatment.
Article
Medicine, General & Internal
Mario E. Baltazares-Lipp, Alberto Aguilera-Velasco, Arnoldo Aquino-Galvez, Rafael Velazquez-Cruz, Rafael J. Hernandez-Zenteno, Noe Alvarado-Vasquez, Angel Camarena, M. Patricia Sierra-Vargas, Juan L. Chavez-Pacheco, Victor Ruiz, Citlaltepetl Salinas-Lara, Martha L. Tena-Suck, Yair Romero, Luz M. Torres-Espindola, Manuel Castillejos-Lopez
Summary: The study identified factors such as age, gender, red blood cell distribution width, electrocardiographic ratios, and collagenopathies as important markers for assessing the prognosis of pulmonary hypertension in patients.
Review
Pharmacology & Pharmacy
Carmen Flores-Perez, Luis Alfonso Moreno-Rocha, Juan Luis Chavez-Pacheco, Norma Angelica Noguez-Mendez, Janett Flores-Perez, Maria Fernanda Alcantara-Morales, Luz Cortes-Vasquez, Lina Sarmiento-Argueello
Summary: Midazolam is commonly used for pediatric anesthesia. This study reviewed scientific articles and clinical assays on MDZ-induced sedation for pediatric surgery and identified important factors to consider when using MDZ in pediatric patients.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Carmen Flores-Perez, Janett Flores-Perez, Luis Alfonso Moreno-Rocha, Juan Luis Chavez-Pacheco, Norma Angelica Noguez-Mendez, Blanca Ramirez-Mendiola, Yolopsi Sanchez-Maza, Lina Sarmiento-Arguello
Summary: The influence of age and sex on the depth of sedation and pharmacokinetics of midazolam is still unknown. This study investigated these factors in 117 children aged 2 to 17 years who received intravenous sedation for minor surgery. Significant differences in volume of distribution (Vd) were found between different age groups and sexes. Patients younger than 6 years required lower doses of midazolam for deep sedation and dosage adjustments based on age group are suggested.
Article
Medicine, General & Internal
Carmen Flores-Perez, Janett Flores-Perez, Manuel de Jesus Castillejos Lopez, Juan Luis Chavez-Pacheco, Karla Miroslava Tejada-Gutierrez, Arnoldo Aquino-Galvez, Luz Maria Torres-Espindola
Summary: This study found that the rs776746 (T) allele in the CYP3A5 gene is associated with lower plasma midazolam levels in children, and age and sex also have a strong influence on midazolam metabolism.
Article
Pharmacology & Pharmacy
Carmen Flores-Perez, Luis Alfonso Moreno-Rocha, Juan Luis Chavez-Pacheco, Norma Angelica Noguez-Mendez, Janett Flores-Perez, Delfina Ortiz-Marmolejo, Lina Andrea Sarmiento-Arguello
Summary: This study proposes a pharmacokinetic-pharmacodynamic (PK-PD) population model for the use of midazolam in pediatric patients undergoing minor surgery. The results demonstrate that adequate sedation without adverse effects can be achieved at half the usual dose. Further research is needed to optimize dosing schedules and prevent potential adverse effects.
Article
Pediatrics
Ernestina Hernandez Garcia, Lizbeth Naranjo, Luz Adriana Pichardo-Macias, Maria Josefa Bernad Bernad, Lucila Isabel Castro-Pastrana, Matilde Ruiz Garcia, Tanya Alejandra Garcia Bernal, Jessica Lizbeth Mendoza Solis, David Calderon Guzman, Luisa Diaz-Garcia, Julieta Griselda Mendoza-Torreblanca, Juan Luis Chavez Pacheco
Summary: This study analyzed the adverse drug reactions (ADRs) produced by valproic acid (VPA), oxcarbazepine (OXC), phenytoin (PHT), and levetiracetam (LEV) among Mexican hospitalized pediatric epilepsy patients through intensive pharmacovigilance over a period of 112 months. The study found that there were a high incidence and severity of ADRs in these patients, with drowsiness, irritability, and thrombocytopenia being the most frequent ADRs. The risk analysis showed an association between younger age groups and polytherapy with ADR presence.
Review
Pharmacology & Pharmacy
Josefina Gomez-Garduno, Renato Leon-Rodriguez, Radames Alemon-Medina, Beatriz E. Perez-Guille, Rosa E. Soriano-Rosales, Ailema Gonzalez-Ortiz, Juan L. Chavez-Pacheco, Edelmira Solorio-Lopez, Paola Fernandez-Perez, Liliana Rivera-Espinosa
Summary: Phytochemicals found in fruits, vegetables, and other foods can modulate drug metabolism and transport, leading to alterations in therapeutic effects and pharmacokinetics. Compounds present in certain foods can affect the gene expression and enzymatic activity of CYP3A and P-gp transporter, thereby impacting the bioavailability of drugs.
Meeting Abstract
Pharmacology & Pharmacy
Ana Maria del Carmen Flores-Perez, Luis Alfonso Moreno-Rocha, Juan Luis Chavez-Pacheco, Norma Angelica Noguez-Mendez, Delfina Ortiz-Marmolejo, Lina Andrea Sarmiento-Arguello, Janett Flores-Perez, Blanca Ramirez-Mendiola, Karla Miroslava Tejada-Gutierrez
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Radames Alemon-Medina, Nelly Altamirano-Bustamante, Gustavo Lugo-Goytia, Raquel Garcia-Alvarez, Liliana Rivera-Espinosa, Luz Maria Torres-Espindola, Juan Luis Chavez-Pacheco, Hugo Juarez-Olguin, Josefina Gomez-Garduno, Carmen Flores-Perez, Paola Gabriela Fernandez-Perez
Summary: Metformin pharmacokinetics in liquid formulation and tablet were studied in pediatric patients, showing similar profiles. The liquid formulation offers advantages of more precise dose adjustment and ease of administration.
Article
Medicine, Legal
Ivet Gil-Chavarria, Corina Solis-Rosales, Maria Rodriguez-Ceja, Efrain Chavez-Lomeli, Miguel Angel Martinez-Carrillo, Maria Antonieta Mondragon Sosa, N. Sofia Huerta-Pacheco, Mirsha Quinto-Sanchez
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2020)
Article
Materials Science, Multidisciplinary
Osmar Alejandro Chanes-Cuevas, Ulises Arellano-Sanchez, Carlos Andres Alvarez-Gayosso, Fernando Suaste-Olmos, Eduardo Villarreal-Ramirez, Octavio Alvarez-Fregoso, Manuel Garcia-Hipolito, Patricia Gonzalez-Alva, Marco A. Alvarez-Perez
MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
