Article
Cell Biology
Qun Zhang, Ping Feng, Xun-Hua Zhu, Shi-Qing Zhou, Ming-Liang Ye, Xiao-Jing Yang, Sha Gong, Sheng-Yan Huang, Xi-Rong Tan, Shi-Wei He, Ying-Qing Li
Summary: DNAJA4 is hypermethylated and downregulated in nasopharyngeal carcinoma (NPC). Overexpression of DNAJA4 inhibits NPC cell migration, invasion, and EMT by promoting MYH9 protein degradation. Low level of DNAJA4 is associated with poor prognosis and increased probability of distant metastasis in NPC patients.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Yijie Hao, Qingxia Yang, Qiye He, Huanjing Hu, Zongpeng Weng, Zhixi Su, Shuling Chen, Sui Peng, Ming Kuang, Zhihang Chen, Lixia Xu
Summary: In this study, we developed and established a preoperative predictive model for microvascular invasion (MVI) status in patients with hepatocellular carcinoma (HCC) based on DNA methylation markers. The model showed high accuracy and is important for surgical strategy determination in HCC patients.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Oncology
Ganji Purnachandra Nagaraju, Begum Dariya, Prameswari Kasa, Sujatha Peela, Sujatha Peela Bassel F. El-Rayes
Summary: HCC is the most common primary malignancy of the liver, with a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC, including chromatin remodeling, histone alterations, DNA methylation, and ncRNA expression. In-depth understanding of the epigenetics of HCC is critical for developing rational clinical strategies, improving overall survival, and predicting therapeutic outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Surgery
Incheon Kang, Mi Jang, Jae Geun Lee, Dai Hoon Han, Dong Jin Joo, Kyung Sik Kim, Myoung Soo Kim, Jin Sub Choi, Soon Il Kim, Young Nyun Park, Gi Hong Choi
Summary: Subclassification of MiVI in HCC showed that MPVI was associated with more aggressive tumor characteristics and poorer survival compared to MI only. The original MiVI classification should be divided into MI and MPVI for better prognostic assessment.
Review
Oncology
Yan Li, Yuanyuan Zheng, Liwei Wu, Jingjing Li, Jie Ji, Qiang Yu, Weiqi Dai, Jiao Feng, Jianye Wu, Chuanyong Guo
Summary: The traditional method of tumor biopsy for hepatocellular carcinoma is limited and there is a need for a novel non-invasive diagnostic technique; circulating tumor DNA technology provides an important method for cancer screening, diagnosis, treatment selection, and prognosis prediction in hepatocellular carcinoma.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Wu Xing, Peng-Cheng Zhou, Hao-Ye Zhang, Li-Min Chen, Yang-Mei Zhou, Xue-Fei Cui, Zhen-Guo Liu
Summary: The study revealed that circ_GLIS2 suppresses the growth and metastasis of HCC by inhibiting cell proliferation, migration, and invasion, while promoting cell apoptosis. This suggests that circ_GLIS2 could potentially serve as a diagnostic marker or therapeutic target for HCC.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Ting-juan Zhang, Zi-jun Xu, Xiang-mei Wen, Yu Gu, Ji-chun Ma, Qian Yuan, Jiang Lin, Jing-dong Zhou, Jun Qian
Summary: The hypermethylation of SLIT2 promoter is associated with disease evolution in MDS and predicts poor prognosis in both MDS and AML. The inactivation of SLIT2-IT1/miR-218 through SLIT2 promoter hypermethylation could be a promising therapeutic target in MDS.
Article
Biotechnology & Applied Microbiology
Zhijun Liu, Yuyu You, Qiyi Chen, Guobang Li, Wenfeng Pan, Qing Yang, Jiajun Dong, Yi Wu, Jin-Xin Bei, Chaoyun Pan, Fuming Li, Bo Li
Summary: Hepatocellular carcinoma (HCC) is characterized by metabolic and immune remodeling in the tumor microenvironment. Liver-specific deletion of fructose-1, 6-bisphosphatase 1 (FBP1) promotes liver tumorigenesis, partly due to the suppression of natural killer (NK) cells. Mechanistically, FBP1 attenuation in hepatocytes inhibits PKLR expression and reduces the activity of NK cells by transferring PKLR-attenuated extracellular vesicles (EVs) from hepatocytes.
Article
Biochemical Research Methods
Yang Ma, Wan-liang Sun, Shuo Shuo Ma, Guanru Zhao, Zhong Liu, Zheng Lu, Dengyong Zhang
Summary: This study investigated the expression and function of ZNF529-AS1 in hepatocellular carcinoma (HCC) and explored its prognostic significance. The results showed that ZNF529-AS1 was highly expressed in HCC and correlated with clinicopathological characteristics of HCC patients. Immunological analysis revealed its association with immune cell abundance and function. Knockdown of ZNF529-AS1 inhibited HCC cell invasion and migration.
BMC BIOINFORMATICS
(2023)
Article
Oncology
Qizhen Huang, Kongying Lin, Zhipeng Lin, Hongbin Ji, Xiaoyu Zhou, Bin Wang, Yufeng Chen, Chuandong Sun, Shuguo Zheng, Jinhong Chen, Yifan Wang, Yanming Zhou, Weiping Zhou, Yongyi Zeng
Summary: This study evaluated the prognostic significance of microscopic bile duct invasion (MiBDI) in hepatocellular carcinoma (HCC) after R0 resection. The results showed that isolated MiBDI did not influence overall survival (OS), while the presence of both bile duct and vascular invasion (MiBDI+MVI+), microscopic vascular invasion alone (MiBDI-MVI+), and macroscopic bile duct invasion (MaBDI) were associated with worse OS.
Article
Multidisciplinary Sciences
Jianping Wang, Peipei Cong, Zhipeng Jin, Lingli Liu, Dongxu Sun, Wenjing Zhu, Guangjun Shi
Summary: SUMOylation has a significant role in the progression of malignancies. This study aims to construct a signature for hepatocellular carcinoma (HCC) using SUMOylation-related genes (SRGs). Differentially expressed SRGs were identified through RNA sequencing and used to build a signature using Univariate Cox regression and LASSO analysis. The accuracy of the model was validated using ICGC and GEO datasets, and the risk score was found to be associated with cancer-related pathways.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Ewa Wolinska, Maciej Skrzypczak
Summary: Hepatocellular carcinoma (HCC) is a life-threatening disease with unsatisfactory treatment outcomes. Epigenetic studies have revealed modified methylation patterns in HCC, dysfunction of enzymes engaged in DNA methylation process, aberrant function of non-coding RNAs, and histone modifications affecting gene expression.
Review
Immunology
Zunyi Zhang, Erlei Zhang
Summary: Hepatocellular carcinoma (HCC) is a common type of liver cancer with high mortality rate. A significant percentage of HCC patients have vascular invasion at initial diagnosis. Traditional guidelines classify HCC with vascular invasion as advanced stage, limiting surgical options. However, recent advancements in systemic and locoregional treatments have shown promising responses, leading to the proposal of a conversion therapy strategy to eventually enable surgical resection. This review summarizes the clinical experience and evidence of conversion treatment in HCC patients with vascular invasion.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yao Huang, Xiaoyu Huang, Jianxing Zeng, Jun Lin
Summary: This study investigated the role of MUC16 in the inhibition of migration and invasion of HepG2 and Huh7 cells, demonstrating the significance of MUC16 in this process. Knockdown of MUC16 resulted in enhanced migration and invasion of the cells, indicating its potential as a tumor biomarker for hepatocellular carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Yijie Tang, Yingda Wang, Xiaodong Xu, Hongxia Sun, Weidong Tang
Summary: This study identified STEAP4 as a tumor suppressor gene in hepatocellular carcinoma (HCC), with its expression regulated by promoter methylation. STEAP4 inhibited the proliferation and metastasis of HCC cells by inhibiting the PI3K/AKT/mTOR pathway. These findings reveal the important role of STEAP4 and methylation regulation in HCC progression.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)