Article
Materials Science, Multidisciplinary
Xinmei Liu, Farsad Imtiaz Chowdhury, Lingju Meng, Qiwei Xu, Xihua Wang
Summary: This study introduces a method for preparing high-quality luminescent films using QD-CNC hybrid materials, which involves replacing the organic ligands on the QD surface and acetylating the CNC surface to overcome the challenge of dissolving QD and environmentally friendly material CNC simultaneously. The fabricated film maintains similar photoluminescence quantum yield and lifetime to QDs synthesized in non-polar organic solvents.
Article
Chemistry, Physical
Jinhyeon Kang, Jae Taek Oh, Hyeokjun Kim, Hanjae Kim, Hyosung Choi, In Hwan Jung
Summary: This study reports the development of high-performance AgBiS2 nanocrystal-based quantum-dot photodetectors (QPDs) with improved photodetection ability. A novel conjugated polyelectrolyte (CPE) was incorporated as a cathode buffer layer (CBL) to enhance the photocurrent density and reduce the dark current density.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Applied
Umphan Ngoensawat, Attasith Parnsubsakul, Supakpong Kaitphaiboonwet, Tuksadon Wutikhun, Chaweewan Sapcharoenkun, Prompong Pienpinijtham, Sanong Ekgasit
Summary: The study developed a nanohybrid ink with improved solvent resistance and message encryption capability through electrostatic self-assembly, providing enhanced print permanence under wet conditions. The ink's high water resistance allows for higher security levels and reveals hidden messages in specific solutions.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Jae-Hwan Choi, Min -Jae Si, Sol -Hee Kim, Nipuni Maniyamgama, Dongeon Kim, Seungin Jee, Yun Hoo Kim, Hoon-Seok Jeong, Beomkwan Kim, Changjo Kim, Jung -Yong Lee, Se-Woong Baek
Summary: This study demonstrates the successful preparation of a stable hybrid ink by modifying the synthesis route of nanoparticles, which enables the formation of efficient heterostructured thin films and improves the power conversion efficiency of solar cells.
APPLIED SURFACE SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Weyde M. M. Lin, Nuri Yazdani, Olesya Yarema, Maksym Yarema, Mengxia Liu, Edward H. Sargent, Thomas Kirchartz, Vanessa Wood
Summary: Significant performance improvements have been achieved in nanocrystal-based solar cells in the past decade, but challenges such as surface recombination, dopants, and electronic defects still limit their potential. Strategies for enhancing device performance include reducing dopants, controlling doping and electronic structure, and optimizing interfaces.
ACS APPLIED ELECTRONIC MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Danting Xu, Xia Zhu, Jiakun An, Gaoyu Chen, Jianchun Bao, Xiangxing Xu
Summary: Photodetectors based on VO2-ZnO nanocrystal composite films were prepared using nanocrystal-mist deposition, resulting in an enhanced photodetection switching ratio covering the ultraviolet to infrared wavelength. The transfer and transport of photogenerated carriers, modulated by the nanosize, surface, phase transition, percolation threshold, and band structure of the heterojunction, play a crucial role in determining the device performance.
Article
Computer Science, Information Systems
Ching-Ho Tien, Ni-Pin Yeh, Kuan-Lin Lee, Lung-Chien Chen
Summary: In this study, a display consisting of a 64-cell quantum dot light-emitting diodes (QDLEDs) array was presented, with high operating rate and maximum brightness achieved. The surface modification of perovskite nanocrystal composite using aloe-vera gel as the organic precursor enabled high-quality narrow band photoluminescence emission. The use of an Arduino microcontroller unit for dynamic micro-control terminal and motor drive modules for the display driver circuit demonstrates the potential of perovskite devices for next-generation displays.
Article
Chemistry, Multidisciplinary
Hao Ren, Ao Xu, Yiyang Pan, Donghuan Qin, Lintao Hou, Dan Wang
Summary: In this study, a Mg-doped ZnO thin film was prepared as the window layer for PbS solar cells, with ZnO nanocrystals deposited on top to improve performance. The addition of ZnO NCs greatly enhanced the power conversion efficiency of the solar cells by reducing carrier recombination at the interface. The use of MZO buffer layer along with ZnO NC interface passivation technique is expected to further enhance the performance of quantum dot solar cells.
Article
Nanoscience & Nanotechnology
Jian Gan, Yan Wu, Feng Yang, Xinyu Wu, Yajing Wang, Jing Wang
Summary: The study reported an effective UV-filtered film composed of carbon quantum dots and cellulose nanocrystals, which had high transparency and light absorption capabilities, providing a new indoor lighting experience.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Physical
Maximilian Jansen, William A. Tisdale, Vanessa Wood
Summary: Colloidal nanocrystals are used as building blocks to create hierarchical solids with various structures, and recent studies have shown that these structures exhibit collective vibrations. This Perspective discusses the potential applications of these collective vibrations in phononic crystals, acoustic metamaterials, and optomechanical systems.
Article
Nanoscience & Nanotechnology
Claudius Kocher, John C. Jarman, Tongtong Zhu, Gunnar Kusch, Rachel A. Oliver, Robert A. Taylor
Summary: The study found that InGaN quantum dots grown on a nonpolar plane exhibit a lower spectral diffusion rate and longer spectral diffusion time. The lifetime of nonpolar dots is shorter than that of polar dots, but the ratio of spectral diffusion time to lifetime is more favorable for nonpolar quantum dots, increasing the chances of generating indistinguishable photons.
Article
Optics
Michal Lipka, Michal Parniak
Summary: Hyperentangled photonic states, which exhibit nonclassical correlations in multiple degrees of freedom, offer enhanced performance for quantum optical communication and computation schemes. Experimental characterization of such states remains challenging, requiring high spatial resolution single-photon detection and a suitable mode converter to observe the spectral-temporal degree of freedom. Researchers have successfully demonstrated the measurement of full four-dimensional transverse-wave-vector-spectral correlations between pairs of photons generated in noncollinear spontaneous parametric downconversion.
Article
Multidisciplinary Sciences
Kaoru Okura, Hitoshi Tatsumi
Summary: The spectral changes in a single quantum dot emission have been studied in detail when interacting with the glass surface. Low-temperature plasma treatment of glass surfaces reduces the intensity of a specific emission peak, while silanization of the glass surface increases it. The local interaction between quantum dots and the glass surface improves the spatial and temporal resolution of optical measurements of biomolecules labeled with quantum dots.
SCIENTIFIC REPORTS
(2023)
Article
Thermodynamics
Yang Xiao, Yanqiong Bao, Linfeng Yu, Xiong Zheng, Guangzhao Qin, Meijie Chen, Maogang He
Summary: This study demonstrates the potential application of carbon quantum dot nanofluids as spectral beam splitters in photovoltaic/thermal systems. The optical properties of the nanofluids can be fine-tuned by adjusting the heating time and PEG concentration, resulting in a highly stable and efficient nanofluid filter.
Article
Optics
Yingwen Zhang, Duncan England, Andrei Nomerotski, Benjamin Sussman
Summary: In this work, spectral-temporal correlation measurements of the Hong-Ou-Mandel interference effect were demonstrated using a spectrometer based on a photon-counting camera. The setup offers high resolution and flexibility, allowing for efficient gathering of spectral and temporal information from a HOM interferometer.
Review
Oncology
Alexander D. Murphy, Robert D. Morgan, Andrew R. Clamp, Gordon C. Jayson
Summary: Advanced epithelial ovarian, fallopian tube, and primary peritoneal cancers are a leading cause of gynecological cancer-related mortality, with angiogenesis playing a key role in their growth. Vascular endothelial growth factor inhibitors can improve response rate, progression-free survival, and overall survival, regardless of platinum sensitivity in EOC.
BRITISH JOURNAL OF CANCER
(2022)
Article
Endocrinology & Metabolism
Anie Naqvi, Michelle L. MacKintosh, Abigail E. Derbyshire, Anna-Maria Tsakiroglou, Thomas D. J. Walker, Rhona J. McVey, James Bolton, Martin Fergie, Steven Bagley, Garry Ashton, Philip W. Pemberton, Akheel A. Syed, Basil J. Ammori, Richard Byers, Emma J. Crosbie
Summary: This study suggests a correlation between endometrial cancer incidence and obesity, with weight loss leading to reduced inflammation and increased protective immune cell recruitment in the endometrium, supporting the concept that immune surveillance may play a role in endometrial cancer prevention.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Medicine, General & Internal
Chloe A. Logue, Julia Pugh, Philip Foden, Reem D. Mahmood, Robert D. Morgan, Claire Mitchell, Jurjees Hasan, Andrew R. Clamp, Gordon C. Jayson
Summary: This study aims to assess whether women with gBRCAm ovarian cancer experience distinct psychosexual morbidity. The results showed that women with gBRCAm ovarian cancer were younger and expressed more interest for specialist psychosexual support, and they may have different psychosexual problems compared to women with gBRCAwt ovarian cancer.
Article
Oncology
Aya El Helali, Ruth Plummer, Gordon C. Jayson, Vicky M. Coyle, Yvette Drew, Nerissa Mescallado, Noor Harris, Andrew R. Clamp, Janine McCann, Helen Swaisland, Richard D. Kennedy, Aaron N. Cranston, Richard H. Wilson
Summary: This study evaluated the safety and tolerability of a novel anti-angiogenic peptide, ALM201. The results showed that ALM201 subcutaneous doses up to 300 mg were feasible and well-tolerated. Further investigation of this agent would benefit from patient selection biomarkers in specific tumor types/settings.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Emma J. Crosbie, Richard J. Edmondson, Andrew J. Wallace, Gordon C. Jayson, D. Gareth R. Evans
Summary: This study validates the recommendation of testing for BRCA1/2 pathogenic variants in both blood and tumor samples in cases of non-mucinous epithelial ovarian cancer. The findings suggest that reflex tumor BRCA1/2 testing should be performed in all NMEOC cases, and germline BRCA testing may not be necessary for older women without identified tumor BRCA1/2 variants or a family history of specific cancers.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
C. Zhou, J. O'Connor, A. Backen, J. W. Valle, J. Bridgewater, C. Dive, G. C. Jayson
Summary: In this study, it was found that plasma Tie2 (pTie2) can serve as a response biomarker for vascular endothelial growth factor inhibitors (VEGFi) treatment, predicting treatment response and disease progression. By integrating data from different types of cancer, it was demonstrated that pTie2 can guide the optimal use of VEGFi in clinical practice.
Article
Pathology
Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Joseph Shaw, Sudha Desai, Emma J. Crosbie, Richard J. Edmondson, Helene Schlecht, Andrew J. Wallace, Gordon C. Jayson, D. Gareth R. Evans
Summary: According to this study, some mutations in the tumor BRCA1/2 genes may be somatic mutations, and it may not be necessary to test all non-mucinous high-grade epithelial ovarian cancer cases for germline BRCA1/2 mutations.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Lois Gardner, Kostas Kostarelo, Parag Mallick, Caroline Dive, Marilena Hadjidemetriou
Summary: Liquid biopsy assays offer opportunities for early detection of cancer and improved management of the disease by detecting cancer-associated molecular alterations in blood. This Perspective reviews key advances in liquid biopsy-based multi-omics approaches for biomarker discovery and introduces the 'nano-omics' paradigm, which utilizes nanotechnology tools for the analysis of blood-circulating cancerome.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Review
Oncology
Ann Tivey, Matt Church, Dominic Rothwell, Caroline Dive, Natalie Cook
Summary: Over the past decade, liquid biopsy techniques have emerged as alternatives to traditional tissue biopsy samples. Majority of research in this field has focused on blood-based biomarkers, especially circulating tumor DNA (ctDNA) derived from plasma. However, ctDNA can also be obtained from non-blood sources such as urine, cerebrospinal fluid, and pleural or peritoneal fluid. In this review, the authors discuss the advances in analyzing ctDNA from non-blood sources, exploring the distinct advantages and technical aspects of non-blood ctDNA assay development. They also reflect on when non-blood ctDNA can have advantages over plasma ctDNA and the challenges of translating these assays into clinical use.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Oncology
Oskar Wysocki, Cong Zhou, Jacobo Rogado, Prerana Huddar, Rohan Shotton, Ann Tivey, Laurence Albiges, Angelos Angelakas, Dirk Arnold, Theingi Aung, Kathryn Banfill, Mark Baxter, Fabrice Barlesi, Arnaud Bayle, Benjamin Besse, Talvinder Bhogal, Hayley Boyce, Fiona Britton, Antonio Calles, Luis Castelo-Branco, Ellen Copson, Adina Croitoru, Sourbha S. Dani, Elena Dickens, Leonie Eastlake, Paul Fitzpatrick, Stephanie Foulon, Henrik Frederiksen, Sarju Ganatra, Spyridon Gennatas, Andreas Glenthoj, Fabio Gomes, Donna M. Graham, Christina Hague, Kevin Harrington, Michelle Harrison, Laura Horsley, Richard Hoskins, Zoe Hudson, Lasse H. Jakobsen, Nalinie Joharatnam-Hogan, Sam Khan, Umair T. Khan, Khurum Khan, Alexandra Lewis, Christophe Massard, Alec Maynard, Hayley McKenzie, Olivier Michielin, Anne C. Mosenthal, Berta Obispo, Carlo Palmieri, Rushin Patel, George Pentheroudakis, Solange Peters, Kimberly Rieger-Christ, Timothy Robinson, Emanuela Romano, Michael Rowe, Marina Sekacheva, Roseleen Sheehan, Alexander Stockdale, Anne Thomas, Lance Turtle, David Vinal, Jamie Weaver, Sophie Williams, Caroline Wilson, Caroline Dive, Donal Landers, Timothy Cooksley, Andre Freitas, Anne C. Armstrong, Rebecca J. Lee
Summary: Indicators of COVID-19 severity in cancer patients remain predictive across different waves of the pandemic. Vaccination and steroid use have contributed to improved outcomes. The CORONET model performs well regardless of SARS-CoV-2 variants.
Meeting Abstract
Oncology
R. D. Morgan, A. R. Clamp, B. Barnes, H. Schlecht, L. Yarram-Smith, Y. Wallis, S. Morgan, M. Valganon, E. Hudson, S. McKenna, S. Sundar, S. Nicum, J. D. Brenton, R. Kristeleit, S. Banerjee, I. McNeish, J. A. Ledermann, S. Taylor, G. Evans, G. C. Jayson
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
N. C. Ramchander, N. Billy Graham Mariam, S. Rack, K. Shohdy, A. Ortega Franco, F. Thistlethwaite, D. M. Graham, L. Carter, S. Dransfield, A. Henshaw, E. Darlington, D. Rothwell, G. J. Burghel, C. Dive, M. G. Krebs, N. Cook
ANNALS OF ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Maja Kopczynska, Antje Teubner, Arun Abraham, Michael Taylor, Ashley Bond, Andrew Clamp, Rebecca Wight, Zena Salih, Jurjees Hasan, Claire Mitchell, Gordon C. Jayson, Simon Lal
Summary: This study demonstrates that a centralized approach to home parenteral nutrition (HPN) management can effectively provide care for patients with advanced cancer over a wide geographic area, while maintaining low rates of HPN-related complications and hospital readmissions.
Article
Oncology
Robert D. D. Morgan, George J. J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. R. Clamp, Jurjees Hasan, Claire L. L. Mitchell, Zena Salih, Emma R. R. Woodward, Fiona Lalloo, Emma J. J. Crosbie, Richard J. J. Edmondson, Helene Schlecht, Gordon C. C. Jayson, D. Gareth R. Evans
Summary: Approximately 15% of patients diagnosed with high-grade non-mucinous epithelial ovarian cancer (EOC) have a germline BRCA1/2 mutation, with somatic mutations occurring more frequently in patients aged >= 80. Germline BRCA1/2 testing in this age group can be reserved for those with a detectable tumour BRCA1/2 mutation. Testing for tumour BRCA1/2 and homologous recombination deficiency is sufficient for patients aged >= 80 with non-mucinous high-grade EOC.
Article
Oncology
Robert D. Morgan, Andrew R. Clamp, Bethany M. Barnes, Kirsten Timms, Helene Schlecht, Laura Yarram-Smith, Yvonne Wallis, Mikel Valganon-Petrizan, Suzanne MacMahon, Rhian White, Sian Morgan, Sarah McKenna, Emma Hudson, Laura Tookman, Angela George, Ranjit Manchanda, Sudha S. Sundar, Shibani Nicum, James D. Brenton, Rebecca S. Kristeleit, Susana Banerjee, Iain A. McNeish, Jonathan A. Ledermann, Stephen S. Taylor, D. Gareth R. Evans, Gordon C. Jayson
Summary: This study reports data from the first year of routine homologous recombination deficiency testing in the NHS in England, Wales, and Northern Ireland, demonstrating the significant survival benefits of olaparib plus bevacizumab maintenance therapy in women with newly diagnosed, advanced, high-grade ovarian cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
