Article
Microbiology
Seul Kim, Eunsuk Kim, Hyunjin Yoon
Summary: Salmonella alters cellular processes to improve intracellular fitness during host infection by rewiring cellular transcriptional regulation through alternative sigma factors such as rpoS. Deprivation of outer membrane protein YcfR in Salmonella Typhimurium leads to decreased intracellular survival and downregulation of SPI-2 genes, which is abolished in the absence of rpoS. RpoS-associated stress responses in Salmonella due to impaired envelope integrity may reciprocally downregulate the expression of SPI-2 genes to reduce its virulence.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Rui Dong, Xiaojie Qin, Shoukui He, Xiujuan Zhou, Yan Cui, Chunlei Shi, Yiping He, Xianming Shi
Summary: The study revealed that DsrA plays a crucial role in promoting oxidative stress resistance in S. Typhimurium by regulating the expression of antioxidant enzymes and maintaining intracellular redox balance.
Article
Microbiology
Yu Han, Yu Li, Zhiwei Zeng, Wenjing Li, Saixiang Feng, Weisheng Cao
Summary: This study explores the resistance mechanism and activity of the antimicrobial peptide MccY against Salmonella strains. The deletion of Ton system genes resulted in resistance to MccY and mutants showed increased susceptibility to MccY under a low-iron condition. MccY may decrease the virulence of S. Typhimurium by altering multiple physiological properties.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Analytical
Han Du, Xu Zhang, Mingru Yao, Qingli Yang, Wei Wu
Summary: This study successfully constructed aptamer-guided luminous microspheres using carbon dots fluorescence, which can efficiently recognize and detect Salmonella enterica serovar Typhimurium. The method shows high sensitivity and has broad application prospects.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Microbiology
Stephanie Paulini, Florian D. Fabiani, Anna S. Weiss, Ana Laura Moldoveanu, Sophie Helaine, Baerbel Stecher, Kirsten Jung
Summary: Pyruvate, the simplest of the alpha-keto acids, plays a crucial role in the metabolic pathways of bacteria and eukaryotes. This study identified two specific transporters, BtsT and CstA, in Salmonella enterica serovar Typhimurium, which are important for pyruvate uptake and have significant effects on bacterial survival, infection, and persistence.
Article
Microbiology
Jiwon Baek, Hyunjin Yoon
Summary: Cyclic di-GMP is a signaling molecule that controls the transition between motile and nonmotile lifestyles in bacteria. It regulates biofilm formation and dispersal, and it can alter carbon metabolic pathways in Salmonella enterica serovar Typhimurium.
MICROBIOLOGY SPECTRUM
(2023)
Article
Marine & Freshwater Biology
Jiaying Cheng, Mengshi Xiao, Xinmiao Ren, Francesco Secundo, Ying Yu, Shihao Nan, Weimiao Chen, Changliang Zhu, Qing Kong, Youtao Huang, Xiaodan Fu, Haijin Mou
Summary: This study investigated the response of Salmonella enterica serovar Typhimurium to fermented alginate oligosaccharides (AOS) using metabolomic and transcriptomic analyses. The results showed that fermented AOS exhibited significant antibacterial activity against S. Typhimurium and could influence its growth and metabolism. This study provides a new perspective for the application of AOS as a feed additive against pathogenic intestinal bacteria.
MARINE LIFE SCIENCE & TECHNOLOGY
(2023)
Article
Microbiology
R. Kavi Bharathi, C. S. Srinandan, N. Sai Subramanian
Summary: This study investigates the cooperative ability and matrix sharing between specialist and generalist strains during biofilm formation. The results show that the matrix aids in survival during antibiotic, chlorine, and predatory stress, and possible sharing of the matrix occurs in co-culture.
Article
Microbiology
Yuan Yuan, Yara Seif, Kevin Rychel, Reo Yoo, Siddharth Chauhan, Saugat Poudel, Tahani Al-bulushi, Bernhard O. Palsson, Anand Sastry
Summary: By combining pan-genome and transcriptomic analytics, variations in transcriptional regulatory networks across six strains of Salmonella enterica serovar Typhimurium were revealed.
Article
Food Science & Technology
Hui Li, Keren Agyekumwaa Addo, Yi-gang Yu, Xing-long Xiao
Summary: The study investigated the influence of cuminaldehyde (CUM) on cell membrane and genomic DNA of Salmonella enterica serovar Typhimurium (S. Typhimurium), and revealed its antibacterial mechanism. CUM could bind to bacterial membrane proteins and change its structure and conformation, leading to the leakage of intracellular substances and the destruction of cell integrity. DNA interaction analysis showed that CUM bound to genomic DNA through groove mode, affecting the normal functioning of S. Typhimurium.
Article
Nutrition & Dietetics
Weihua Tan, Yuanyuan Tian, Qingya Zhang, Siwei Miao, Wenrong Wu, Xiaoqing Miao, Haiou Kuang, Wenchao Yang
Summary: In this study, it was found that Apis laboriosa honey (ALH) harvested in China has antibacterial activity against Salmonella enterica serovar Typhimurium (S. Typhimurium). The physicochemical parameters and antioxidant activity of ALH were influenced by the time and region of harvest. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ALH against S. Typhimurium were similar to UMF5+ manuka honey. Proteomic experiment revealed the antibacterial mechanism of ALH.
FRONTIERS IN NUTRITION
(2023)
Article
Food Science & Technology
Ji-Yeon Kim, Hana Song, Danbi Kim, Sun-Young Lee
Summary: Mild heat treatment can enhance the thermal resistance of S. Typhimurium and reduce membrane damage and heat-induced injury, leading to increased tolerance against heat, alcohol, and salt stress. Further research into the heat shock response mechanism of S. Typhimurium may provide insights for developing microbial control measures in food processing.
Article
Multidisciplinary Sciences
Hussein A. Almehdar, Nawal Abd El-Baky, Ehab H. Mattar, Raed Albiheyri, Atif Bamagoos, Abdullah Aljaddawi, Vladimir N. Uversky, Elrashdy M. Redwan
Summary: Camel lactoferrin obtained from different clans of camels in Saudi Arabia exhibits antimicrobial action against S. typhimurium and S. sonnei, and is more effective than bovine and human lactoferrin. It can kill the bacterial strains by iron chelation, affecting bacterial proteins, binding to bacterial LPS and membrane proteins, and disrupting the integrity of bacterial cells and membranes when used alone or in combination with antibiotics.
Article
Immunology
Zecai Zhang, Siyu Liu, Jiang Huang, Yueqi Cui, Yu Liu, Yulong Zhou, Zhanbo Zhu
Summary: The study found that phloretin can alleviate intestinal damage caused by Salmonella and inhibit its translocation to other organs. Phloretin protects colonic tissue by reducing inflammation and oxidative stress levels, and prevents Salmonella from damaging the colonic epithelium barrier by regulating ZO-1 and occludin levels. Additionally, phloretin does not inhibit Salmonella growth but reduces its internalization into Caco-2 cells.
MICROBIAL PATHOGENESIS
(2021)
Article
Virology
Cedric Woudstra, Sophie A. Granier
Summary: This study investigates the anti-phage defenses in Salmonella Typhimurium using bioinformatics and identifies nucleic acid degradation and abortive infection mechanisms. Mobile genetic elements containing anti-phage systems were also found in Salmonella and the Enterobacteriaceae family. This research provides insights for designing preventive measures against the spread of phage resistance.
Article
Genetics & Heredity
Anais C. Bourges, Oscar E. Torres Montaguth, Wubishet Tadesse, Gilles Labesse, Abram Aertsen, Catherine A. Royer, Nathalie Declerck
Summary: The study showed that Escherichia coli K12's Mrr can recognize and cleave foreign methylated DNA, but may also become activated and cause DNA damage in the host cell under certain perturbations. Through experiments and the construction of a structural model, the mechanism of Mrr and its mutants' activity was investigated.
Article
Food Science & Technology
Tom Dongmin Kim, Katrien Begyn, Sadhana Khanal, Fatima Taghlaoui, Marc Heyndrickx, Andreja Rajkovic, Frank Devlieghere, Chris Michiels, Abram Aertsen
Summary: Eliminating bacterial endospores in foods and food processing environment can be challenging due to their extreme resistance. Specific strains, such as non-emetic Bacillus weihenstephanensis, have the ability to evolve enhanced heat resistance in their endospores without compromising their growth capacities at different temperatures.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jeroen De Smet, Jeroen Wagemans, Hanne Hendrix, Ines Staes, Annegrete Visnapuu, Benjamin Horemans, Abram Aertsen, Rob Lavigne
Summary: The phage proteins known as YIPs interfere with c-di-GMP signaling by directly targeting Pseudomonas diguanylate cyclase YfiN. This results in increased c-di-GMP production, reduced motility, and increased biofilm mass in P. aeruginosa. The phage-based mechanism of metabolic regulation through intracellular signaling interference could inspire the development of new molecules to disrupt biofilm formation in various pathogens.
MICROBIAL BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Lei Sun, Gil Rogiers, Chris W. Michiels
Summary: This study investigated the antimicrobial mechanisms of trans-cinnamaldehyde (t-CIN) in Listeria monocytogenes, revealing that the YvcK protein plays a crucial role in diverting substrates to UDP-GlcNAc biosynthesis, and t-CIN interferes with this pathway, leading to a peptidoglycan synthesis defect. Complementation with wild-type yvcK gene restored tolerance to t-CIN, and evolutionary experiments identified suppression mutations related to UDP-GlcNAc biosynthesis that partially reversed t-CIN sensitivity. Feeding N-acetylglucosamine or increasing UDP-GlcNAc synthetic enzymes restored t-CIN tolerance in the yvcK mutant.
Article
Biotechnology & Applied Microbiology
David Van der Veken, Charlie Hollanders, Marko Verce, Chris Michiels, Steven Ballet, Stefan Weckx, Frederic Leroy
Summary: The analysis of the genome of Mammaliicoccus sciuri IMDO-S72 has revealed the genetic mechanisms behind its antibacterial phenotype and provided insights into the potential virulence factors of this species. The presence of a plasmid-encoded gene cluster responsible for antimicrobial activity, as well as the identification of micrococcin P1 as the compound produced, were significant findings. The genome also showed the presence of innate virulence factors and antibiotic resistance genes, although their consistent link to a resistance phenotype was not observed. Importantly, this study highlights the commensal lifestyle of M. sciuri and the role of mobile genetic elements in conferring antibiotic resistance.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Cell Biology
Hanne Hendrix, Maria Zimmermann-Kogadeeva, Michael Zimmermann, Uwe Sauer, Jeroen De Smet, Laurens Muchez, Maries Lissens, Ines Staes, Marleen Voet, Jeroen Wagemans, Pieter-Jan Ceyssens, Jean-Paul Noben, Abram Aertsen, Rob Lavigne
Summary: This study reveals the role of the Pseudomonas quinolone signal (PQS) in bacterial virus infection. The virus LUZ19 targets the PQS system by expressing the quorum sensing targeting protein (Qst), which interacts with key enzymes in the PQS biosynthesis pathway. This interaction leads to a decrease in PQS levels and impairs the virus infection, but can be restored by external supplementation of a PQS precursor. Qst represents a potential tool for combating antibiotic resistance in bacterial pathogens.
Article
Microbiology
Lei Sun, Gil Rogiers, Pascal Courtin, Marie-Pierre Chapot-Chartier, Helene Bierne, Chris W. Michiels
Summary: AsnB of L. monocytogenes plays a role in mediating the amidation of mDAP residues in peptidoglycan, affecting various cell wall and cell surface-related properties as well as bacterial virulence. This study highlights the importance of amidation of peptidoglycan mDAP residues in cell wall anchoring of invasion proteins and its implications for virulence.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Dominique Holtappels, Kiandro J. Fortuna, Lauren Moons, Nand Broeckaert, Leon E. Backer, Sofie Venneman, Sofie Rombouts, Louis Lippens, Steve Baeyen, Sabien Pollet, Jean-Paul Noben, Frank Oechslin, Marta Vallino, Abram Aertsen, Martine Maes, Johan Van Vaerenbergh, Rob Lavigne, Jeroen Wagemans
Summary: Specific bacteriophages were found to effectively recognize polysaccharides that affect bacterial cell walls, potentially providing a solution for controlling black rot disease in Brassica crops. An irrigation-based application showed promising results in a series of experiments. A phage cocktail formulated with calcium chloride successfully controlled the outbreak of the pathogen in open fields.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Cell Biology
Ines Staes, Leonard E. Backer, Kenneth Simoens, Kjerstin De Winter, Gasper Marolt, William Cenens, Sanne Wolput, Alan R. Vazquez, Peter Goos, Rob Lavigne, Kristel Bernaerts, Abram Aertsen
Summary: This study reveals the impact of phage-borne superinfection exclusion factors (SEFs) in P22-infected Salmonella populations, leading to a switch from vertical to horizontal transmission in the face of host-cell scarcity.
Article
Biochemistry & Molecular Biology
Malgorzata Sobota, Pilar Natalia Rodilla Ramirez, Alexander Cambre, Andrea Rocker, Julien Mortier, Theo Gervais, Tiphaine Haas, Delphine Cornillet, Dany Chauvin, Isabelle Hug, Thomas Julou, Abram Aertsen, Mederic Diard
Summary: Virulence gene expression can incur fitness costs to pathogenic bacteria, causing instability in membrane stability and leading to repression of their expression in harsh environments. The trade-off between virulence and stress resistance plays a role in the instability of pathogenic bacterial virulence.
Article
Food Science & Technology
Marijke Poortmans, Kristof Vanoirbeek, Martin B. Dorner, Chris W. Michiels
Summary: Challenge studies with Clostridium botulinum are important for ensuring food safety, but are complicated by a lack of effective counting medium. This study developed selectable nontoxic surrogate strains for C. botulinum to facilitate food challenge studies and provide a safe alternative for research. The strains were successfully equipped with an erythromycin resistance marker and a selective medium was developed to inhibit background microbiota but support growth of the surrogate strains.
Article
Ecology
Jose R. Morales-Poole, Clara de Vega, Kaoru Tsuji, Hans Jacquemyn, Robert R. Junker, Carlos M. Herrera, Chris Michiels, Bart Lievens, Sergio Alvarez-Perez
Summary: The growth performance of Acinetobacter spp. and Rosenbergiella spp. in floral nectar is largely influenced by the nectar chemistry and bacterial phylogeny.
Article
Food Science & Technology
Lowieze Lenaerts, Tathiane Ferroni Passos, Elisa Gayan, Chris W. Michiels, Marcia Nitschke
Summary: This study evaluates the combination of mild heat with a natural surfactant for the inactivation of L. monocytogenes Scott A in low-water-activity model systems. The results show that the combination of both hurdles reached around 5.0 log reduction in glycerol medium and >6.0 log reduction in NaCl medium. The growth inhibition activity of RL was enhanced by the presence of monovalent salts, reducing MIC values significantly.
Article
Biochemistry & Molecular Biology
Lise Vanderkelen, Joris M. Van Herreweghe, Chris W. Michiels
Summary: This study developed a novel tool for detecting and differentiating lysozymes in animal fluids using affinity chromatography with inhibitors. Validation on blue mussels revealed the important role of g-type lysozyme in innate immunity, while the i-type lysozyme showed no contribution.
Article
Microbiology
Julien Mortier, Stefanie Van Riet, Diana Senovilla Herrero, Kristof Vanoirbeek, Abram Aertsen
Summary: Elucidating phenotypic heterogeneity is important for understanding bacterial behavior and engineering bacteria in biotechnology. This study presents a high-throughput and high-resolution time-lapse fluorescence microscopy-based strategy for screening heterogeneously expressed genes in Bacillus subtilis. The proof-of-concept screening validates this approach.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)