期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 377, 期 3, 页码 792-796出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2008.10.061
关键词
Fucosylation; Haptoglobin; Interleukin 6; Pancreatic cancer; Oligosaccharide
资金
- Japan Science and Technology Agency (JST)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japan Society for the Promotion of Science [20014011]
- New Energy and Industrial Technology Development Organization
- Grants-in-Aid for Scientific Research [20014011] Funding Source: KAKEN
Fucosylation is one of the most important oligosaccharide modifications and is involved in cancer and inflammation. Recently, fucosylated haptoglobin was identified as a possible tumor market for pancreatic cancer. The molecular mechanism underlying increases in fucosylated haptoglobin in sera of patients with pancreatic cancer seems to be complicated. Our previous study IN. Okuyama, Y. Ide, M. Nakano, T. Nakagawa, K. Yamanaka. K. Moriwaki, K. Murata, H. Ohigashi, S. Yokoyama, H. Eguchi. O. Ishikawa, T Ito, M. Kato, A. Kasahara, S. Kawano, J. Gu, N. Taniguchi, E. Miyoshi, Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation, Int.J. Cancer 118 (I I) (2006) 2803-2808] demonstrated that pancreatic cancer cells secrete a factor, which induces the production of haptoglobin in hepatoma cells. In the present study, we found that interleukin 6 (11,6) expressed in pancreatic cancer is a factor that induces the haptoglobin production, using a neutralizing antibody for IL6. Real-time PCR analyses revealed the up-regulation of fucosylation regulatory genes after IL6 treatment, resulting increases in fucosylated haptoglobin being revealed by a lectin ELISA. This pathway could be one of the possible mechanisms underlying increases in haptoglobin in sera of patients with pancreatic cancer. (C) 2008 Elsevier Inc. All rights reserved.
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