Article
Oncology
Feng Li, Syeda Qasim, Dapeng Li, Q. Ping Dou
Summary: In-depth insights on cancer biology have highlighted the important roles of epigenetic mechanisms in tumorigenesis. Targeting the cancer epigenome with epi-drugs, including phytochemicals like EGCG, offers promising strategies for cancer chemoprevention and therapy. However, there are limitations to using EGCG as an epigenetic modulator in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Daniela Mokra, Jana Adamcakova, Juraj Mokry
Summary: This article reviews the biological effects of (-)-Epigallocatechin-3-gallate (EGCG) in respiratory diseases, including antioxidant, anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects. EGCG may be beneficial in respiratory diseases through modulation of various intracellular signaling cascades.
Review
Food Science & Technology
Chunpeng Wan, Jian Ouyang, Mingxi Li, Kannan R. R. Rengasamy, Zhonghua Liu
Summary: Diabetes mellitus is a major non-communicable disease with high mortality rates and economic burden. Green tea extract (GTE) and epigallocatechin-3-O-gallate (EGCG) found in green tea have shown promising results in managing diabetes by acting as potent antioxidants. The beneficial effects of green tea and its catechins, particularly EGCG, make it an attractive pharmacological agent for treating diabetes and its complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Food Science & Technology
Sarah Auguste, Bing Yan, Maolin Guo
Summary: Polyphenols found in tea can induce mitophagy in human fibroblast cells, and the induction of mitophagy may play an important role in the anti-aging mechanism of tea.
Article
Nutrition & Dietetics
Chen Liu, Sjef Boeren, Ignacio Miro Estruch, Ivonne M. C. M. Rietjens
Summary: This study found that the gut microbiota-derived metabolite PG is a more potent inducer of Nrf2-related gene expression than its parent compound EGCG.
Article
Cell Biology
Jing Tian, Caroline Geiss, Kim Zarse, Corina T. Madreiter-Sokolowski, Michael Ristow
Summary: Green tea catechins such as EGCG and ECG have been found to extend healthspan and lifespan in Caenorhabditis elegans by inhibiting mitochondrial complex I and temporarily lowering ATP levels, leading to activation of SKN-1 and DAF-16. These catechins also reduce fat content, enhance ROS defense, and ultimately improve overall healthspan through adaptive responses.
Article
Biochemistry & Molecular Biology
Jia-Ping Ke, Jing-Ya Yu, Biao Gao, Feng-Lin Hu, Feng-Qing Xu, Guangmin Yao, Guan-Hu Bao
Summary: Two new catechins, zijuanins E and F, were isolated and identified from Zijuan green tea. These compounds were found to prolong the lifespan of Caenorhabditis elegans, enhance stress resistance, and reduce oxidative stress. They also exhibited strong antioxidant activity and binding ability to human serum albumin.
Article
Biophysics
Xu Ding, Fengxia Wang, Hui Hu, Sarah Imhanria, Wei Wang, Ji Zhang
Summary: This study reports a facile and green strategy of fabricating catkin-like CuAg nanocomposites using tea-polyphenols as the reduction agent. The nanocomposites exhibit a catkin-like special morphology as characterized by physical characterizations. The electrochemical detection hydrogen peroxide (H2O2) results demonstrate the good sensitivity, stability, and anti-interference of the catkin-like CuAg nanocomposites, which can detect H2O2 without any additional mediator or enzyme.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Chang Xu, Su Zhou, Hao Hu, Haizhao Song, Xiangchun Zhang, Xinyu Feng, Yunyun Yang, Yani Pan, Shuying Gong, Fangyuan Fan, Ping Chen, Qiang Chu
Summary: Tea polyphenols, as active ingredients in tea, have excellent physicochemical properties and bioactivities, making them versatile in material synthesis. Tea polyphenol-derived materials are environmentally friendly, biocompatible and retain potent bioactivities such as antioxidant, antibacterial and anti-cancer properties.
Article
Food Science & Technology
Sirui Qin, Ruyi Li, Mianhong Chen, Fanke Zeng, Yaping Dai, Guang Wu, Wei Zhou, Jihua Li
Summary: Oat milk tea can curdle when mixed with tea, affecting consumer acceptability. This study investigated the stability and polyphenol bioaccessibility of oat milk tea model systems. The addition of green tea extract influenced stability, with higher fat content resulting in greater stability. Tea polyphenols were stable in oral and stomach digestion stages but degraded in the small intestine stage. The bioaccessibility of tea polyphenols was higher in high-fat oat milk tea models, especially at low green tea extract concentrations.
Review
Neurosciences
Luiza Fernandes, Thyago R. Cardim-Pires, Debora Foguel, Fernando L. Palhano
Summary: The accumulation of protein aggregates in human tissues is a hallmark of more than 40 diseases called amyloidoses, with seven of them being associated with neurodegenerative processes. EGCG, a natural compound found in green tea, has shown potential in inhibiting protein aggregation, reducing toxicity, and remodeling fibril structures in neurodegenerative diseases such as AD, PD, and HD.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Suchisnigdha Datta, Sukanya Ghosh, Anupam Bishayee, Dona Sinha
Summary: Nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key role in stress-defense and detoxification. Tea, with its bioactive compounds, has the potential to modulate the Nrf2 signaling and may be used as a preventive and therapeutic strategy for cancer. However, the rapid biotransformation and low bioavailability of tea compounds need further investigation.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Chemistry, Medicinal
Pawel Bakun, Dariusz T. Mlynarczyk, Tomasz Koczorowski, Magdalena Cerbin-Koczorowska, Ludwika Piwowarczyk, Emil Kolasinski, Maciej Stawny, Joanna Kuzminska, Anna Jelinska, Tomasz Goslinski
Summary: Epigallocatechin gallate (EGCG), a polyphenol found in green tea, has potential anticancer and neurodegenerative disease protective effects. However, its bioavailability is limited due to chemical instability and poor absorption, resulting in its current use as a dietary supplement rather than medication.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Richard J. Steel, Maria A. O'Connell, Mark Searcey
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Chemistry, Multidisciplinary
Benoit Bertrand, Maria A. O'Connell, Zoe A. E. Waller, Manfred Bochmann
CHEMISTRY-A EUROPEAN JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Emily F. Warner, Ildefonso Rodriguez-Ramiro, Maria A. O'Connell, Colin D. Kay
Article
Chemistry, Inorganic & Nuclear
Morwen R. M. Williams, Benoit Bertrand, Julio Fernandez-Cestau, Zoe A. E. Waller, Maria A. O'Connell, Mark Searcey, Manfred Bochmann
DALTON TRANSACTIONS
(2018)
Article
Biochemistry & Molecular Biology
Morwen R. M. Williams, Benoit Bertrand, David L. Hughes, Zoe A. E. Waller, Claudia Schmidt, Ingo Ott, Maria O'Connell, Mark Searcey, Manfred Bochmann
Article
Chemistry, Inorganic & Nuclear
Mark A. Wright, Maria A. O'Connell, Joseph A. Wright
Summary: The reaction of Ru(CO)4Br2 with various heterocyclic amines leads to the formation of ruthenium carbamoyl complexes, which are similar to the ferracyclic systems reported by the researchers. Unlike the iron compounds, the ruthenium carbamoyls only release CO when irradiated with UV light, and they do not exhibit anti-inflammatory activity.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Organic
Marco M. M. D. Cominetti, Zoe R. Goddard, Chloe E. Howman, Maria A. O'Connell, Mark Searcey
Summary: Duocarmycins are highly potent anticancer payloads with the potential for combinatorial design of payload analogues and linkers through solid phase synthesis. The synthesis of an alkylating unit suitable for solid phase synthesis has been reported, as well as its applicability to the synthesis of duocarmycin SA analogues and a side reaction for stereoselective synthesis.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Mohammed Aldholmi, Rizwan Ahmad, Daniel Carretero-Molina, Ignacio Perez-Victoria, Jesus Martin, Fernando Reyes, Olga Genilloud, Lea Gourbeyre, Thierry Gefflaut, Hanne Carlsson, Alexei Maklakov, Ellis O'Neill, Robert A. Field, Barrie Wilkinson, Maria O'Connell, A. Ganesan
Summary: The study discovered that euglenatides from Euglena gracilis can inhibit pathogenic fungi and cancer cells, and bear resemblance to nemamides in Caenorhabditis elegans. Molecular network analysis also revealed the presence of multiple euglenatide-like metabolites in Euglena species.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Zoe Rachael Goddard, Andrew Michael Beekman, Marco M. D. Cominetti, Maria A. O'Connell, Isabelle Chambrier, Michael J. Cook, Maria J. Marin, David A. Russell, Mark Searcey
Summary: The study utilized functionalized gold nanoparticles to target cancer cells overexpressing epidermal growth factor receptor, achieving selective phototoxicity through the photosensitizer with minimal impact on normal cells.
RSC MEDICINAL CHEMISTRY
(2021)
Meeting Abstract
Pharmacology & Pharmacy
Nursabah Atli, James Harvey, Colin Kay, Richard Draijer, Mark Searcey, Maria O'Connell
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Mark A. Wright, Tyler Wooldridge, Maria A. O'Connell, Joseph A. Wright
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Andrew M. Beekman, Marco M. D. Cominetti, Samuel J. Walpole, Saurabh Prabhu, Maria A. O'Connell, Jesus Angulo, Mark Searcey
Article
Chemistry, Multidisciplinary
Andrew Michael Beekman, Maria Anne O'Connell, Lesley Ann Howell
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Inorganic & Nuclear
Benoit Bertrand, Alexander S. Romanov, Mark Brooks, Josh Davis, Claudia Schmidt, Ingo Ott, Maria O'Connell, Manfred Bochmann
DALTON TRANSACTIONS
(2017)
Article
Chemistry, Inorganic & Nuclear
Morwen Williams, Adam I. Green, Julio Fernandez-Cestau, David L. Hughes, Maria A. O'Connell, Mark Searcey, Benoit Bertrand, Manfred Bochmann
DALTON TRANSACTIONS
(2017)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)