Review
Biology
Mara Fiorani, Andrea Guidarelli, Orazio Cantoni
Summary: This article discusses the antioxidant effects in mitochondria and their regulation of physiological and pathological processes. Mitochondria-targeted antioxidants are more effective but may interfere with normal signaling. The complex regulation of vitamin C uptake and distribution in cells plays a crucial role in controlling mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Chemistry, Analytical
Wei Wang, Jingkang Li, Yibing Liu, Wei Zhang, Ying Sun, Pinyi Ma, Daqian Song
Summary: Alkaline phosphatase (ALP) is a widely present and important biomarker in the human body. Researchers synthesized a core-shell metal-organic framework sensor that can be used for sensitive and accurate ALP detection. By self-triggered control of phosphate ions (Pi), the sensor avoids the potential inaccuracy caused by using ascorbic acid (AA) as the reducing component. The developed strategy has shown linear response to ALP concentrations ranging from 0.1 to 150 mU/mL with a detection limit of 0.03 mU/mL.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Abhishek Kumar, Mathieu F. Bettinger, Vaibhav Vibhu, Marcel Bouvet, Rita Meunier-Prest
Summary: Optimization of mass transfer within nanoporous gold-modified gold electrode greatly influences the voltammetric profile of ascorbic acid oxidation reaction. The surface porosity of nanoporous gold depends on electrodeposition parameters and affects the mass transport behavior of ascorbic acid. The combination of diffusion and thin layer EC1 mechanism determines the predominance of mass transport and can be controlled by electrodeposition parameters and substrate size.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Keke Ning, Yao Fu, Jianghong Wu, Yujie Sun, Ke Liu, Kang Ye, Jiaxin Liu, Yuan Wu, Jiangong Liang
Summary: In this study, sulfur quantum dots (SQDs) were synthesized using a simple H2O2 assisted top-down method and applied in alkaline phosphatase (ALP) detection. By measuring the red shift in emission wavelength and fluorescence intensity quenching, a dual-sensor platform based on red shift of emission wavelength (RSEW) and fluorescence quenching of SQDs was successfully constructed. The platform exhibited high sensitivity and selectivity towards ALP and was able to detect ALP in serum samples and cells.
ANALYTICAL METHODS
(2022)
Article
Multidisciplinary Sciences
Zheng-Jie Chen, Jiuyi Dong, Jiajing Wu, Qiting Shao, Na Luo, Minwei Xu, Yuanmiao Sun, Yongbing Tang, Jing Peng, Hui-Ming Cheng
Summary: This study reports an acidic hydrogen production system that combines anodic ascorbic acid electrooxidation with cathodic hydrogen evolution. Using Fe single-atom catalysts, the highly active enol structure in ascorbic acid allows for ultralow overpotential and high Faraday efficiency for hydrogen production. The fabricated two-electrode membrane-free electrolyser achieves industrial-scale hydrogen production from biomass with reduced electricity consumption.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Jing Guo, Lihua Wu, Yu-Xin Ye, Fang Zhu, Jianqiao Xu, Gangfeng Ouyang
Summary: Two-dimensional (2D) conductive metal-organic frameworks (cMOFs) have been used as transducers for electrochemical sensing, but its application in aqueous solutions is in the early stage. This study utilizes the interfacial capacitances of a 2D cMOF for the first time in electrochemical sensing. Various compounds, including redox-innocent and redox-active compounds, are successfully detected based on the responses of capacitance peaks at low voltages. The insights into the response mechanisms represent an important step in promoting the application of 2D cMOFs in chemical sensing.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Jing Guo, Lihua Wu, Yu-Xin Ye, Fang Zhu, Jianqiao Xu, Gangfeng Ouyang
Summary: Two-dimensional conductive metal-organic frameworks (cMOFs) have been used for electrochemical sensing, but their application in aqueous solutions is still in the early stage. In this study, the interfacial capacitances of a 2D cMOF are utilized for electrochemical sensing for the first time and successfully detect various compounds in aqueous solutions. The responses are rooted in the pseudocapacitances of the 2D cMOF, revealing deep insights into the response mechanisms and promoting the application of 2D cMOFs in chemical sensing.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xinlei Zhang, Peng Liu, Bohan Li, Xianliang Li, Yan Xu
Summary: By utilizing hydrogen bond interactions, carbon dots were successfully confined into a zirconium-based MOF material, forming the composite CDs@UiO-66(COOH)(2). This composite exhibited excellent detection performance for chlortetracycline and showed stimuli-response towards pH and temperature changes. This work opens a new avenue for multifunctional fluorescent sensing applications.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Guiqun Zhang, Chao Yao, Yulong Li, Yan Guan, Rong Hu, Yunhui Yang
Summary: A ratiometric fluorescent sensing platform with smartphones was developed for the highly sensitive detection of GSH, AA, and ALP activity. The platform utilized the inner filter effect between persistent luminescent nanoparticles and 2,3-diaminophenazine to modulate the fluorescence signals. By measuring the ratio of the fluorescence intensity of DAP and PLNPs, a simple and highly sensitive detection method was achieved.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Ye Yuan, Changyong Gao, Zhexu Wang, Jianming Fan, Haofei Zhou, Daolin Wang, Chang Zhou, Baohua Zhu, Qiang He
Summary: Janus micromotors powered by enzymes and functionalized with upconversion nanoparticles can efficiently move and detect uric acid in urine, showing promise for multifunctional micro/nanomotors in bioassay and biomedical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Inorganic & Nuclear
Yudong Wu, Wujun Chen, Chao Wang, Dongming Xing
Summary: Alkaline phosphatase (ALP) is a zinc-containing metalloprotein widely distributed in mammalian tissues that plays a vital role in clinical diagnosis. It is widely used for signal amplification in enzyme-linked assays and is a promising biomarker for disease diagnosis. Assays using L-ascorbic acid 2-phosphate (AAP) as a substrate have been developed to detect ALP activity, providing new insights into the construction of advanced sensing platforms for clinical diagnosis.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Electrochemistry
Bethany Kersten, Nora Shaheen, Rohan Akolkar
Summary: This article presents an electrochemical technique that uses an electroactive tracer species to probe the rate-limiting factors of redox reactions at an electrode surface. A theoretical model is developed for the transient response in step 2, considering diffusion-limited and desorption-limited recovery of the electrode potential. The mathematical modeling shows that in a desorption-limited system, the electrode potential drifts to open circuit slowly compared to a diffusion-limited system. This technique can be used to study adsorption-desorption processes during electrochemistry.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Oncology
Jun Liu, Suji Min, Dongchan Kim, Jihyun Park, Eunchae Park, Shanshan Pei, Youngil Koh, Dong-Yeop Shin, Ja Min Byun, Myunggon Ko, Sung-Soo Yoon, Junshik Hong
Summary: Vitamin C is known to regulate hematopoietic stem cells and leukemogenesis. However, glucose transporter 3 (GLUT3) deficiency in acute myeloid leukemia (AML) blocks the uptake of vitamin C and diminishes its clinical benefits. This study aimed to investigate the therapeutic potential of restoring GLUT3 in AML. Restoring GLUT3 expression in AML cells enhanced TET2 activity and improved the anti-leukemic effect of vitamin C treatments. Pharmacological salvage of GLUT3 deficiency has the potential to improve the effectiveness of vitamin C in AML treatment.
Article
Chemistry, Analytical
Ayesha Kousar, Ishan Pande, Laura F. Pascual, Emilia Peltola, Jani Sainio, Tomi Laurila
Summary: One of the major challenges in measuring dopamine (DA) using electro-chemical methods in living organisms is to achieve selectivity in the presence of interfering substances like ascorbic acid (AA) and uric acid (UA). Researchers have used complicated multimaterial structures and ill-defined pretreatments to enhance selectivity. However, the lack of control over the electrode structures has made it difficult to establish a relationship between selectivity and structure. Carbon nanofiber (CNF) electrodes have shown promise in neurobiological applications due to their easily customizable structure. In this study, the sensitivity and selectivity of CNF electrodes towards DA were controlled by adjusting the lengths of the CNF during the fabrication process while maintaining similar surface chemistries. It was found that increasing the fiber length enhanced the sensitivity towards DA while also causing a shift in the oxidation peaks of AA and DA, leading to excellent selectivity.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
X. Liu, J. Song, B. Yin, T. Jiang, H. Pang, L. Yang, S. Wu
Summary: In this study, a powerless, gas-permeable, flexible and transparent ascorbic acid biosensor based on carbon micromesh electrode was developed. The biosensor showed excellent performances including high transmittance, wide detection range, low limit of detection, good selectivity, and long-term storage stability. By integrating a pH-sensing electrode, the analysis of ascorbic acid can be corrected. The biosensor demonstrated good sensitivity and practicability towards wearable electronics in the detection of artificial tears.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Christopher W. Heskett, Trevor Teafatiller, Carly Hennessey, Melanie G. Gareau, Jonathan S. Marchant, Hamid M. Said, Veedamali S. Subramanian
Summary: EPEC infection inhibits intestinal absorption of ascorbic acid (AA) through a multifactorial dysregulation of SVCT1 and SVCT2 expression in intestinal epithelial cells. This study also found that microRNA regulators miR103a, miR141, and miR200a were upregulated significantly upon EPEC infection, and EPEC infection significantly decreased the expression of the accessory protein GRHPR which regulates SVCT1 function.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Peiling Su, James D. Bretz, Gihan S. Gunaratne, Jonathan S. Marchant, Timothy F. Walseth, James T. Slama
Summary: Researchers in this study utilized recombinant human NAD kinase to convert synthetic NAD derivatives into NADP analogs, and subsequently transformed them into NAADP derivatives using enzyme catalysis. Multiple NAADP analogs were synthesized through a combination of chemical and enzymatic steps, and successfully demonstrated to be recognized by sea urchin NAADP receptors at low concentrations.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Trevor Teafatiller, Christopher W. Heskett, Anshu Agrawal, Jonathan S. Marchant, Janet E. Baulch, Munjal M. Acharya, Veedamali S. Subramanian
Summary: The study reveals an adaptive up-regulation of intestinal ascorbic acid uptake in the 5xFAD mouse model of Alzheimer's disease, shedding light on the molecular mechanisms involved in this process.
Article
Cell Biology
Winka Le Clec'h, Frederic D. Chevalier, Ana Carolina A. Mattos, Amanda Strickland, Robbie Diaz, Marina McDew-White, Claudia M. Rohr, Safari Kinung'hi, Fiona Allan, Bonnie L. Webster, Joanne P. Webster, Aidan M. Emery, David Rollinson, Amadou Garba Djirmay, Khalid M. Al Mashikhi, Salem Al Yafae, Mohamed A. Idris, Helene Mone, Gabriel Mouahid, Philip LoVerde, Jonathan S. Marchant, Timothy J. C. Anderson
Summary: Mass drug administration with praziquantel is a key strategy for controlling and eliminating schistosomiasis, but there is variability in parasite response to the drug. A study identified a transient receptor potential channel, Sm.TRPMPZQ, that influences the response of Schistosoma mansoni to praziquantel, providing a potential method for monitoring emerging PZQ-resistant alleles in schistosome elimination programs.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Sang-Kyu Park, Lukas Friedrich, Nawal A. Yahya, Claudia M. Rohr, Evgeny G. Chulkov, David Maillard, Friedrich Rippmann, Thomas Spangenberg, Jonathan S. Marchant
Summary: This study reveals the mechanism of action of PZQ on schistosomes, activating the TRPMPZQ channel to cause calcium entry and worm paralysis. PZQ activates TRPMPZQ homologs in schistosomes, but is ineffective against Fasciola hepatica.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Obinna C. Ubah, Eric W. Lake, Gihan S. Gunaratne, Joseph P. Gallant, Marie Fernie, Austin J. Robertson, Jonathan S. Marchant, Tyler D. Bold, Ryan A. Langlois, William E. Matchett, Joshua M. Thiede, Ke Shi, Lulu Yin, Nicholas H. Moeller, Surajit Banerjee, Laura Ferguson, Marina Kovaleva, Andrew J. Porter, Hideki Aihara, Aaron M. LeBeau, Caroline J. Barelle
Summary: Scientists have identified the smallest antibody fragments from sharks, called VNARs, which have the ability to neutralize the SARS-CoV-2 virus and may be used as therapeutic agents. VNARs possess flexible paratopes that can recognize protein motifs inaccessible to classical antibodies, suggesting their potential in fighting against emerging coronaviruses.
NATURE COMMUNICATIONS
(2021)
Article
Infectious Diseases
Evgeny G. Chulkov, Emery Smith, Claudia M. Rohr, Nawal A. Yahya, Sang-Kyu Park, Louis Scampavia, Timothy P. Spicer, Jonathan S. Marchant
Summary: This study optimized a high-throughput screening method for Schistosoma mansoni TRPMPZQ activity, leading to the discovery of a novel activator of Sm.TRPMPZQ and numerous potential blockers. The new activator, though distinct from PZQ, was similar to a known chemical entity identified through phenotypic screening.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Jonathan S. Marchant, Gihan S. Gunaratne, Xinjiang Cai, James T. Slama, Sandip Patel
Summary: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca2+ from endosomes and lysosomes by activating two-pore channels (TPCs). Two different NAADP-binding proteins (NAADP-BPs), JPT2 and LSM12, have recently been identified, bridging the gap between NAADP generation and NAADP activation of TPCs. The discovery of these NAADP-BPs will facilitate future studies on the molecular mechanism of NAADP action.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Article
Cell Biology
Nawal A. Yahya, Janelle K. Lanham, Daniel J. Sprague, Oleg Palygin, John D. McCorvy, Jonathan S. Marchant
Summary: The anthelmintic drug praziquantel (PZQ) causes contraction of parasitic schistosomes and blood vessels. PZQ's action on the vasculature is mediated by the activation of host serotonergic 5-HT2B receptors. The molecular basis for PZQ interaction with these receptors and their location in the vessel wall have not been experimentally defined.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Parasitology
Evgeny G. Chulkov, Elena Isaeva, Cheryl L. Stucky, Jonathan S. Marchant
Summary: The parasitic flatworm ion channel, TRPMPZQ, is activated by praziquantel (PZQ) and membrane stretch, making it a multimodal ion channel. Conservation of TRPMPZQ suggests its importance in flatworm physiology. The mechanosensitivity of TRPMPZQ is significant for schistosome physiology due to recurring pressures and mechanical cues.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2023)
Article
Multidisciplinary Sciences
Claudia M. Rohr, Daniel J. Sprague, Sang-Kyu Park, Nicholas J. Malcolm, Jonathan S. Marchant
Summary: The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other infections caused by parasitic flatworms. A recent study identified a target for PZQ in parasitic flatworms, but little is known about its properties in other flatworms. This study found that the PZQ target is present in all parasitic flatworms and showed different sensitivities to PZQ among different flatworms. The study also identified variations in the binding pocket of the PZQ target, which explains why PZQ is effective against specific infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Biochemistry & Molecular Biology
Sandip Patel, Martin D. Bootman, Ana Rossi, Taufiq Rahman, Jonathan S. Marchant
Article
Chemistry, Medicinal
Lukas Friedrich, Sang-Kyu Park, Peter Ballard, Tobias Hyun Ho Baeurle, David Maillard, Matthias Boedding, Jennifer Keiser, Jonathan S. Marchant, Thomas Spangenberg
Summary: Praziquantel (PZQ) is an important anthelmintic drug that activates the TRPMPZQ ion channel in trematode worms. Recent findings suggest that the cyclohexyl ring of PZQ is crucial for its activity, as well as its metabolism. In this study, the in vitro and in vivo activities of PZQ analogues with improved metabolic stability were evaluated, along with the contribution of the parent drug and its main metabolite to overall activity in humans.
Article
Biochemistry & Molecular Biology
Gihan S. Gunaratne, Eugen Brailoiu, Sushil Kumar, Yu Yuan, James T. Slama, Timothy F. Walseth, Sandip Patel, Jonathan S. Marchant
Summary: The NAADP-binding proteins JPT2 and LSM12 regulate Ca2+ release and endolysosomal trafficking through TPCs.
Article
Chemistry, Medicinal
Daniel J. Sprague, Marc Kaethner, Sang-Kyu Park, Claudia M. Rohr, Jade L. Harris, David Maillard, Thomas Spangenberg, Britta Lundstrom-Stadelmann, Jonathan S. Marchant
Summary: The anthelmintic drug praziquantel is highly effective against parasitic flatworms, but its target has remained undefined. This study demonstrates that praziquantel analogs show different activities against different parasites, which is reflected by unique structure-activity relationships at the TRPMPZQ channels found in these organisms. These findings provide further support for TRPMPZQ as the therapeutically relevant target of praziquantel.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
