Article
Medicine, Research & Experimental
Jiao Wang, Mingrui Xiong, Yu Fan, Chengyu Liu, Qing Wang, Dong Yang, Yangmian Yuan, Yixue Huang, Shun Wang, Yu Zhang, Shuxuan Niu, Junqiu Yue, Hua Su, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang
Summary: This study reveals a protective role of Mecp2 in acute kidney injury (AKI) induced by ischemia-reperfusion, suggesting that it inhibits renal tubular damage, inflammation, and fibrosis by suppressing the Il-6/STAT3 signaling pathway.
Article
Biochemistry & Molecular Biology
Krishna M. Chauhan, Yingxiao Chen, Yiyi Chen, Andrew T. Liu, Xiao-Xin Sun, Mu-Shui Dai
Summary: The study reveals that SENP1 is a critical p53 deSUMOylating enzyme, and its depletion induces p53 transactivation activity and synergizes with DNA damage-inducing agent etoposide to activate p53 and inhibit cancer cell growth.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo
Summary: The study found that Butea monosperma, a traditional Indian medicine, has potent anti-IL-6 activity and can be used for the treatment of ovarian cancer. It inhibits IL-6 signaling pathway, suppresses cell proliferation, migration, and invasion, induces cell cycle arrest and apoptosis, and significantly inhibits the growth of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marinela Krizanac, Paola Berenice Mass Sanchez, Sarah K. Schroeder, Ralf Weiskirchen, Anastasia Asimakopoulos
Summary: Perilipin 5 (PLIN5) is a lipid droplet coat protein highly expressed in oxidative tissues. It is regulated by peroxisome proliferator-activated receptors (PPARs) and cellular lipid status. Previous research focused on its role in non-alcoholic fatty liver disease (NAFLD) and lipid metabolism regulation. Limited studies connected PLIN5 to hepatocellular carcinoma (HCC), where its expression is upregulated. This study explores the regulation of PLIN5 by cytokines involved in HCC and NAFLD progression, revealing IL-6-induced upregulation mediated by the JAK/STAT3 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hejuan Hu, Bai Ling, Yuhan Shi, Haohao Wu, Bingying Zhu, Yiling Meng, Guo-Ming Zhang
Summary: Plasma exosome-derived SENP1 levels were significantly elevated in melanoma patients compared to healthy controls. Higher levels of plasma exosome-derived SENP1 were associated with worse disease-free survival and overall survival in melanoma patients, suggesting a potential prognostic value for predicting the 3-year outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Xiaodong Cheng
Summary: Protein SUMOylation is an essential post-translational modification for maintaining cellular homeostasis. Recent evidence suggests that liquid-liquid phase separation (LLPS)/ biomolecular condensates play a role in regulating cellular SUMOylation, providing insights into its cellular mechanism.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Oncology
Chunshui Ye, Wei Chong, Yuan Liu, Xingyu Zhu, Huicheng Ren, Kang Xu, Xiaozhou Xie, Fengying Du, Zihao Zhang, Mingfei Wang, Tianrong Ma, Liang Shang, Leping Li, Hao Chen
Summary: This study found that the expression of LRP1B was lower in LUAD tissues compared to normal tissues, and knockdown of LRP1B increased the malignancy of LUAD cells. Genomic analysis showed that low-level expression of LRP1B was associated with genomic instability and aneuploidy. Enrichment analysis of transcriptomic data revealed the activation of IL-6-JAK-STAT3, chemokine, cytokine, and other inflammation signaling pathways due to low expression of LRP1B. Furthermore, downregulation of LRP1B mRNA upregulated the activity of the IL-6-JAK-STAT3 pathway and promoted the secretion of IL-6 and IL-8. Overall, this study highlights LRP1B as a tumor suppressor gene and its role in promoting malignant progression in LUAD through the IL-6-JAK-STAT3 pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Lucy C. K. Bell, Cem Meydan, Jacob Kim, Jonathan Foox, Daniel Butler, Christopher E. Mason, Sagi D. Shapira, Mahdad Noursadeghi, Gabriele Pollara
Summary: The expression of IL-1 beta and IL-6 response modules can provide a dynamic readout of functional cytokine activity in vivo in COVID-19, without being associated with disease severity or mortality.
Article
Cell Biology
Yali Zhang, Yanni Ma, Guixian Wu, Mingling Xie, Chengxin Luo, Xiangtao Huang, Feng Tian, Jieping Chen, Xi Li
Summary: Mantle cell lymphoma (MCL) is a highly aggressive lymphoma, and the upregulation of SENP1 in MCL patients has been found to inhibit tumor cell proliferation and promote apoptosis. Additionally, the downregulation of SENP1 affects the JAK-STAT5 pathway and upregulates SOCS2, leading to suppressed MCL tumor growth in vivo, suggesting SENP1 as a potential therapeutic target for MCL.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Jihye Yoo, Darong Kim, Jiyoung Park, Young-Kook Kim, Hea-Young Park Choo, Hyun Ae Woo
Summary: Development of small molecule inhibitors for inflammatory cytokines is a promising strategy for treating inflammatory diseases like rheumatoid arthritis. The synthesized compounds demonstrated significant inhibitory activity on interleukins and their signaling pathways, showing potential for further development as small molecule inhibitors for RA.
Article
Cell Biology
Mengyuan Liu, Heming Li, Huijing Zhang, Huan Zhou, Taiwei Jiao, Mingliang Feng, Fangjian Na, Mingjun Sun, Mingfang Zhao, Lei Xue, Lu Xu
Summary: By analyzing high-throughput sequencing datasets, this study identified RBMS1 as a potential promoter gene for gastric cancer metastasis, which activates the JAK2/STAT3 signaling pathway and IL-6 transcriptional activation, promoting cell migration and invasion.
CELL DEATH & DISEASE
(2022)
Article
Microbiology
Julia Mai, Miona Stubbe, Samuel Hofmann, Sawinee Masser, Thomas Dobner, Christopher Boutell, Peter Groitl, Sabrina Schreiner
Summary: PML-NB-associated factors could have beneficial effects on viral processes. Different PML isoforms have diverging roles in HAdV infection, with PML-II supporting viral progeny production and PML-III and PML-IV suppressing viral replication. PML-track formation plays a crucial role in efficient viral replication.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Xiaoke Huang, Jing Fang, Weiqi Lai, Yu Hu, Liang Li, Yuanyou Zhong, Shiwei Yang, Dan He, Rui Liu, Qingfeng Tang
Summary: This study demonstrates that treatment with IL-6 activates fructose uptake and fructolysis in oral squamous cell carcinoma (OSCC) cells and prostate cancer cells. Mechanistically, the transcription factor STAT3 associates with the Glut5 promoter region and enhances Glut5 transcription in response to IL-6 treatment. Knockdown of Glut5 attenuates IL-6-induced tumor cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Jie Zhou, Jie Yang, Yu-Meng Wang, Hong Ding, Tu-Shuai Li, Zhi-Hong Liu, Li Chen, Rui-Qing Jiao, Dong-Mei Zhang, Ling-Dong Kong
Summary: High fructose can induce podocyte hypertrophy by down-regulating TTP, activating IL-6/STAT3 signaling, leading to abnormal podocyte proliferation and apoptosis. Inhibiting KHK-A to increase TTP may be a novel strategy for preventing high fructose-induced podocyte injury and proteinuria.
CELLULAR SIGNALLING
(2021)
Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ayano Kadota, Misato Moriguchi, Tadashi Watanabe, Yuichi Sekine, Shigeo Nakamura, Takumi Yasuno, Tomoyuki Ohe, Tadahiko Mashino, Masahiro Fujimuro
Summary: A pyridinium-type fullerene derivative (#5) was found to exhibit anti-tumor activity against PEL cells by suppressing Wnt/β-catenin signaling. This discovery may provide a novel therapeutic agent for the treatment of PEL.
Retraction
Cell & Tissue Engineering
Hiroki Ura, Sumihito Togi, Yumiko Iwata, Mamoru Ozaki, Yo Niida
Summary: This study reprogrammed peripheral blood mononuclear cells from a patient with hereditary hemorrhagic telangiectasia type 2, using episomal vectors, in order to establish an in vitro model for the disease.
STEM CELL RESEARCH
(2022)
Article
Neurosciences
Yuichi Sekine, Ramakrishnan Kannan, Xingxing Wang, Stephen M. Strittmatter
Summary: Neural repair after traumatic spinal cord injury relies on axonal sprouting and regeneration. Rab GTPases were found to inhibit successful sprouting and regeneration. This study identified Rabphilin3A as an effector within regenerating axons, and its loss enhanced axon extension by increasing integrin action in the growth cone.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sumihito Togi, Hiroki Ura, Hisayo Hatanaka, Yo Niida
Summary: This study analyzed genotype and phenotype of TSC in Japanese patients and found differences in lesions and symptoms between TSC1 and TSC2 patients. It also revealed that 20% of parents of a proband may have mild TSC and more mild neuropsychiatric phenotypes were diagnosed in Japan.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yuki Iwaisako, Tadashi Watanabe, Manami Futo, Rimiko Okabe, Yuichi Sekine, Youichi Suzuki, Takashi Nakano, Masahiro Fujimuro
Summary: In the process of KSHV capsid formation, ORF7 plays a role in capsid maturation and its zinc-finger motif is essential for TR cleavage and virus production in the KSHV genome.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Shohei Harabuchi, Omar Khan, Hamid Bassiri, Taku Yoshida, Yohei Okada, Masaomi Takizawa, Osamu Ikeda, Akihiro Katada, Taku Kambayashi
Summary: This study investigates the role of TCR signaling pathways in chronic viral infection, revealing the distinct effects of DAG and ERK on CD8+ T cell activation and survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jun-ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda
Summary: Adaptor molecules play a crucial role in signal transduction in immune cells and are potential therapeutic targets for T cell-mediated immune disorders. STAP-2, a member of the STAP family, is involved in T cell activation and autoimmune diseases. Understanding the impact of STAP-2 on T cell-mediated inflammation and immune diseases can aid in the development of novel therapeutic strategies.
Article
Biology
Takuro Kameda, Kotaro Shide, Ayako Kamiunten, Yasunori Kogure, Daisuke Morishita, Junji Koya, Yuki Tahira, Keiichi Akizuki, Takako Yokomizo-Nakano, Sho Kubota, Kosuke Marutsuka, Masaaki Sekine, Tomonori Hidaka, Yoko Kubuki, Yuichi Kitai, Tadashi Matsuda, Akinori Yoda, Takayuki Ohshima, Midori Sugiyama, Goro Sashida, Keisuke Kataoka, Seishi Ogawa, Kazuya Shimoda
Summary: The study investigates the oncogenic ability of mutant CARD11 (E626K), one of the most frequently mutated genes in adult T-cell leukemia, and its cooperative effect with HBZ expression. Using a mouse model, the researchers clarify the pathogenetic effects of these genes and find that they cooperatively activate multiple signaling pathways, promoting the development of ATL.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Terutsugu Koya, Kenichi Yoshida, Misa Togi, Yo Niida, Sumihito Togi, Hiroki Ura, Shuichi Mizuta, Tomohisa Kato Jr, Sohsuke Yamada, Takeo Shibata, Yi-Chang Liu, Shyng-Shiou Yuan, Deng-Chyang Wu, Hirohito Kobayashi, Taiju Utsugisawa, Hitoshi Kanno, Shigetaka Shimodaira
Summary: This study developed highly potent human platelet lysate-induced antigen-presenting cells (HPL-APCs) and aimed to verify the safety, tolerability, and immunoinducibility of HPL-APCs loaded with cancer candidate antigens. Interim analysis confirmed safety and tolerability in three patients and immune response in two completed cases. This study demonstrates the feasibility and immunoinducibility of personalized cancer vaccines using HPL-APCs and highlights the potential for further antitumor activity through optimized combination therapies.
Review
Pharmacology & Pharmacy
Tadashi Matsuda
Summary: The IL-6 family of cytokines uses the common beta-receptor signaling subunit gp130 to promote various signals. They have diverse effects on different cell types, including immune and inflammatory cells, and also have hormone-like features involved in homeostasis. The signaling molecule STAT3 is crucial in regulating IL-6/gp130 and is highly implicated in pathological conditions. This review focuses on IL-6-mediated signal transduction and introduces novel proteins that interact with STAT3, which can aid in developing strategies to clinically control IL-6/STAT3 functions.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Genetics & Heredity
Fumie Nomura, Akira Shimizu, Sumihito Togi, Hiroki Ura, Yo Niida
Summary: Advances in genetic technologies have made genetic testing more accessible. This study implemented integrated genetic diagnostic methods to rapidly diagnose a patient with xeroderma pigmentosum by detecting the mutation locus.
Review
Immunology
Ryuta Muromoto, Kenji Oritani, Tadashi Matsuda
Summary: Interleukin-17 (IL-17) is a proinflammatory cytokine that plays a crucial role in various inflammatory and autoimmune diseases. IL-17 has been found to regulate post-transcriptional modifications that affect the levels of inflammatory mRNA. Regnase-1 is an important regulator that downregulates IL-17-driven signaling pathways by degrading mRNA stability.
AIMS ALLERGY AND IMMUNOLOGY
(2022)
Article
Immunology
Kodai Saitoh, Jun-ichi Kashiwakura, Kota Kagohashi, Yuto Sasaki, Shoya Kawahara, Yuichi Sekine, Yuichi Kitai, Ryuta Muromoto, Michiko Ichii, Hiroko Nakatsukasa, Akihiko Yoshimura, Kenji Oritani, Tadashi Matsuda
Summary: This study identifies signal-transducing adaptor protein-2 (STAP-2) as a positive regulator of TCR signaling. STAP-2 deficiency leads to reduced TCR-mediated signaling and cytokine production, while STAP-2 overexpression enhances these responses. STAP-2 is associated with TCR signaling and is required for full activation of downstream TCR signaling. Manipulating STAP-2 may improve the treatment of patients with autoimmune diseases and chimeric Ag receptor T cell therapy.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Yuichi Sekine, Kazuna Kikkawa, Bruce A. Witthuhn, Jun-Ichi Kashiwakura, Ryuta Muromoto, Yuichi Kitai, Masahiro Fujimuro, Kenji Oritani, Tadashi Matsuda
Summary: This study identified a novel tyrosine phosphorylation site Y820 in Jak3, showing its role in negative regulation of IL-2-mediated STAT5 signaling cascade. We speculate that this may occur through direct interaction with STAT or through an interaction with molecules such as phosphatases via a SH2 interaction.
INTERNATIONAL IMMUNOLOGY
(2022)
Article
Food Science & Technology
Misa Nakasuji-Togi, Sumihito Togi, Keita Saeki, Yasuhiko Kojima, Keiko Ozato
Summary: The study found that the internatural (INT) mixture can induce type I interferons (IFNs) in murine bone marrow-derived macrophages (BMDMs) to enhance the body's immunity. This induction is mediated by the Toll-like receptor 4 (TLR4) pathway. The supernatants from INT-treated cells also displayed antiviral activity.
FOOD & NUTRITION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
