期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 372, 期 2, 页码 326-330出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2008.05.067
关键词
TonEBP; osmotic stress; tonicity; gene regulation; aldose reductase; cardiomyocytes; heart
资金
- NIDDK NIH HHS [DK42479, R01 DK042479-18, R01 DK042479] Funding Source: Medline
Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanism may, therefore, play a Crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key transcription factor participating in the adaptation of cells to increases in tonicity. However, it is unknown whether cardiac TonEBP is activated by tonicity. Hypertonicity activated transcriptional activity of TonEBP, increased the amounts of both TonEBP mRNA and protein, and induced both the mRNA and protein of TonEBP target genes (aldose reductase and heat shock protein-70). Hypotonicity decreased the amount of TonEBP protein indicating bidirectional osmoregulation of this transcription factor. Adenoviral expression of a dominant negative TonEBP suppressed the hypertonicity-dependent increase of aldose reductase protein. These results indicated that TonEBP controls osmoregulatory mechanisms in cardiomyocytes. (C) 2008 Elsevier Inc. All rights reserved.
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