Article
Cell Biology
Jing Bai, Qiang Ma, Yunfeng Lan, Yating Chen, Shanshan Ma, Jiaxin Li, Chuanbin Liu, Zihao Fu, Xu Lu, Yun Huang, Yang Li
Summary: This study explores how the mitochondrial tRNA 15910 C>T mutation leads to maternally inherited essential hypertension (EH), revealing its significant role in the pathogenesis of the disease. Family members carrying this mutation have a significantly higher incidence of hypertension and mutation-carrying cells exhibit increased viability and proliferative capacity, contributing to the occurrence of EH.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yu Ding, Jinfang Yu, Qinxian Guo, Beibei Gao, Jinyu Huang
Summary: The mutations m.T10410C and m.T10454C affect the structure and function of tRNA(Arg), leading to altered mitochondrial function, oxidative stress, and the pathogenesis of maternally inherited hypertension.
JOURNAL OF GENE MEDICINE
(2021)
Article
Genetics & Heredity
Sarah J. J. Brockmann, Eva Buck, Tiziana Casoli, Joao L. Meirelles, Wolfgang P. P. Ruf, Paolo Fabbietti, Karlheinz Holzmann, Jochen H. H. Weishaupt, Albert C. C. Ludolph, Fiorenzo Conti, Karin M. M. Danzer
Summary: This study investigates the role of homoplasmic and heteroplasmic mutations in familial ALS. The analysis of blood samples from ALS patients with maternal inheritance patterns reveals an increase in homoplasmic ND5 mutations and heteroplasmic mutations in mitochondrial genes in platelets. This suggests that specific maternally transmitted mitochondrial DNA mutations might contribute to the disease process in ALS with a maternal pattern of inheritance, in contrast to other neurodegenerative diseases.
Article
Cell Biology
Liyun Guo, Yajuan Chen, Huiqin Li, Fanqian Yin, Mingxia Ge, Li Hu, Meiting Zi, Zhenghong Qin, Yonghan He
Summary: This study found that telomere length shortens with age in humans, with females maintaining their telomeres better than males. There is a strong association of telomere length between mothers and their offspring, but not between fathers and their offspring. Telomere length is inversely associated with visceral fat index in females and positively associated with apolipoprotein A levels. Impairment of lipid metabolism may contribute to telomere length shortening in the Chinese population.
Article
Medicine, General & Internal
Ting Zhang, Renjie Su, Wen Xiang, Wenbin Wang
Summary: This study investigates a Chinese pedigree with maternally inherited non-syndromic hearing loss. Biochemical characterizations of cybrid cell lines derived from an affected matrilineal subject and control subject reveal that the m.14502 T>C mutation decreases ND6 protein synthesis, mitochondrial membrane potential, and ATP synthesis. These mitochondrial dysregulations enhance the generation of ROS in the mutant cells.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Cell Biology
Yuqi Liu, Yundai Chen
Summary: Essential hypertension is a common cardiovascular disease influenced by genetic and environmental factors, including mitochondrial DNA mutations. These mutations alter tRNA structure and lead to metabolic disorders, affecting protein synthesis and oxidative phosphorylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna, Leo Hanke, Monika Adori, Daniel J. Sheward, Sina Teifel, Shreekara Gopalakrishna, Qiuya Shao, Yong Liu, Keying Zhu, Robert A. Harris, Gerald Mcinerney, Ben Murrell, Mike Aoun, Liselotte Baeckdahl, Rikard Holmdahl, Marcin Pekalski, Anna Wedell, Martin Engvall, Anna Wredenberg, Gunilla B. Karlsson Hedestam, Xaquin Castro Dopico, Joanna Rorbach
Summary: This study investigates the impact of pathogenic mutations in mitochondrial tRNA genes on the immune system. The results show that memory T and B cells have lower mutation burdens compared to their antigen-inexperienced naïve counterparts, and this reduction is less pronounced in myeloid lineages. The rapid dilution of the mutations in T and B cells can be induced by antigen receptor-triggered proliferation and is accelerated under metabolic stress conditions. In addition, the pathogenic mutations affect the metabolic remodeling and IFN-gamma production in CD8(+) T cells.
Article
Multidisciplinary Sciences
Tomohiko Sato, Naoko Goto-Inoue, Masaya Kimishima, Jike Toyoharu, Ryuhei Minei, Atsushi Ogura, Hiroyuki Nagoya, Tsukasa Mori
Summary: This study found that growth hormone transgenic salmon exhibit hypoglycemia and reduced ROS levels. Proteomic and signal network analyses revealed decreased mitochondrial ND1 function and the presence of deletion mutations in the transgenic fish.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yicheng Luo, Peng He, Nivedita Kanrar, Katalin Fejes Toth, Alexei A. Aravin
Summary: piRNA clusters can be spontaneously formed from repetitive transgenic sequences, with continuous trans-generational maternal transmission of small RNAs triggering de novo cluster activation in progeny.
Article
Cell Biology
Yanchun Ji, Juanjuan Zhang, Min Liang, Feilong Meng, Minglian Zhang, Jun Q. Mo, Meng Wang, Min-Xin Guan
Summary: This study found that mitochondrial tRNA variants play an important role in the development of LHON, accounting for 8.75% of cases in the Han Chinese population. These new findings may have beneficial applications in the pathophysiology, disease management, and genetic counseling of LHON.
Article
Biochemistry & Molecular Biology
Xiaofen Jin, Zengming Zhang, Zhipeng Nie, Chenghui Wang, Feilong Meng, Qiuzi Yi, Mengquan Chen, Jiji Sun, Jian Zou, Pingping Jiang, Min-Xin Guan
Summary: YARS2 deficiency can lead to impaired mitochondrial protein synthesis, affecting the stability and activity of the oxidative phosphorylation system, ultimately causing vision impairments. Utilizing CRISPR/Cas9 technology, YARS2 knockout was successfully generated in HeLa cells and zebrafish, revealing the underlying pathophysiology and highlighting the critical role of YARS2 in mitochondrial function and vision disorders.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Gui-Xin Peng, Xue-Ling Mao, Yating Cao, Shi-Ying Yao, Qing-Run Li, Xin Chen, En-Duo Wang, Xiao-Long Zhou
Summary: The study found that mitochondrial aminoacyl-tRNA synthetases (mito aaRSs) partially colocalize with mitochondrial RNA granules (MRGs), possibly facilitated by their tRNA-binding capacity. Additionally, several mito aaRS-containing complexes were discovered, and their activities were influenced by interactions. These findings deepen our understanding of the functional and regulatory mechanisms of mito aaRSs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Li Mi, Ming Shi, Yu-Xuan Li, Gang Xie, Xichen Rao, Damu Wu, Aimin Cheng, Mengxiao Niu, Fengli Xu, Ying Yu, Ning Gao, Wensheng Wei, Xianhua Wang, Yangming Wang
Summary: There is a need for improving and expanding mitochondrial base editing tools. In this study, researchers identified a DddA homolog from Simiaoa sunii (Ddd_Ss) that efficiently deaminates cytosine in double-stranded DNA. They successfully developed cytosine base editors based on Ddd_Ss and introduced mutations at previously inaccessible mitochondrial DNA loci. This study expands the toolbox for mitochondrial DNA editing and provides resources for further development of double-stranded DNA base editors.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Julie Perreau, Bo Zhang, Gerald P. Maeda, Mark Kirkpatrick, Nancy A. Moran
Summary: Many animal lineages have maternally inherited symbionts, but they also pose risks to hosts due to genetic drift or selfish mutations. Research has shown that closely related haplotypes are subject to strong within-host selection, resulting in rapid mutation fixation with little impact on host fitness.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Christina Del Greco, Anthony Antonellis
Summary: Aminoacyl-tRNA synthetases are essential enzymes involved in protein synthesis and mutations in these genes can cause a range of clinical phenotypes. Although there is significant clinical heterogeneity, the underlying mechanisms are not fully understood.
Review
Cell Biology
Yuqi Liu, Yundai Chen
Summary: Essential hypertension is a common cardiovascular disease influenced by genetic and environmental factors, including mitochondrial DNA mutations. These mutations alter tRNA structure and lead to metabolic disorders, affecting protein synthesis and oxidative phosphorylation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiufen He, Xiao He, Yun Xiao, Qiong Zhao, Zhenzhen Ye, Limei Cui, Ye Chen, Min-Xin Guan
Summary: The study showed significant tissue-specific differences in mammalian mitochondrial tRNA expression, correlating with mtDNA contents but not with 2-thiouridylation levels of specific tRNAs. Aminoacylation levels of mt-tRNAs varied among tissues, with a negative correlation observed between levels and mitochondrial tRNA synthetases expression. Differential levels of OXPHOS subunits encoded by mtDNA or nuclear genes may reflect functional emphasis for mitochondria in each tissue.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Liuyang Tian, Chao Zhu, Huanwan Yang, Yang Li, Yuqi Liu
Summary: The MT-ND2 m. 5178C>A mutation is a protective mutation that may be related to improvement of mitochondrial functions and decrease in apoptosis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Shihao Yao, Boyuan Ma, Qiuzi Yi, Min-Xin Guan, Xiaohui Cang
Summary: The study focuses on the conserved m-gate network in the mitochondrial ADP/ATP carrier, revealing interactions between residues and the promoting effect of CATR on symmetry. These findings provide new insights into the highly conserved yet variable networks within the mitochondrial carrier family.
Article
Biochemistry & Molecular Biology
Wenlu Fan, Xiaoye Jin, Man Xu, Yongmei Xi, Weiguo Lu, Xiaohang Yang, Min-Xin Guan, Wanzhong Ge
Summary: Mutations in genes encoding mitochondrial aminoacyl-tRNA synthetases are associated with various diseases, but the precise mechanisms remain unclear. Using a Drosophila model, researchers found that inactivation of dFARS2 leads to developmental delay and seizure, and modeling human disease-associated FARS2 variants in Drosophila demonstrated their role in inducing neurological disorders. This study highlights the importance of mitochondrial aminoacylation system dysfunction in pathologies and the potential of Drosophila model for functional analysis of human disease-causing variants.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yaling Han, Bimmer E. Claessen, Shao-Liang Chen, Qiu Chunguang, Yujie Zhou, Yawei Xu, Lin Hailong, Jiyan Chen, Wu Qiang, Ruiyan Zhang, Suxin Luo, Yongjun Li, Jianhua Zhu, Xianxian Zhao, Xiang Cheng, Jian'an Wang, Xi Su, Jianhong Tao, Yingxian Sun, Geng Wang, Yi Li, Liya Bian, Ridhima Goel, Samantha Sartori, Zhongjie Zhang, Dominick J. Angiolillo, David J. Cohen, C. Michael Gibson, Adnan Kastrati, Mitchell Krucoff, Shamir R. Mehta, E. Magnus Ohman, Philippe Gabriel Steg, Yuqi Liu, George Dangas, Samin Sharma, Usman Baber, Roxana Mehran
Summary: The TWILIGHT trial enrolled 1169 patients from China, showing that ticagrelor monotherapy significantly reduced clinically relevant bleeding without increasing ischemic events compared to ticagrelor plus aspirin in Chinese patients undergoing high-risk percutaneous coronary intervention.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Biochemistry & Molecular Biology
Chao Chen, Min-Xin Guan
Summary: This study reports the generation of induced pluripotent stem cells (iPSCs) from lymphoblastoid cell lines of individuals from an Arab-Israeli family with different mutations related to hearing loss. The researchers corrected a mutation using CRISPR/Cas9 in iPSCs derived from a hearing-impaired individual. Differentiation of these iPSCs into ear epithelial progenitor cells and inner ear hair cell-like cells revealed defects in morphology and function, with greater defects observed in cells carrying multiple mutations. Transcriptome analysis of patient-derived cells showed altered gene expression related to hair cell mechanotransduction. Genetic correction of specific mutations led to recovery in morphology and function. These findings provide insights into the underlying mechanisms of inherited hearing loss and offer potential for therapeutic interventions.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Min Liang, Yanchun Ji, Liyao Zhang, Xuan Wang, Cuifang Hu, Juanjuan Zhang, Yiwei Zhu, Jun Q. Mo, Min-Xin Guan
Summary: LHON is a maternally inherited eye disease caused by mitochondrial DNA mutations. A specific mutation has been found to affect the structure and function of complex I, leading to mitochondrial dysfunction and cell apoptosis.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Zhipeng Nie, Chenhui Wang, Jiarong Chen, Yanchun Ji, Hongxing Zhang, Fuxin Zhao, Xiangtian Zhou, Min-Xin Guan
Summary: This study provides new insights into the pathophysiology of LHON by analyzing retinal ganglion cell-like cells derived from induced pluripotent stem cells (iPSCs) from a Chinese family. The mitochondrial dysfunctions caused by specific mutations affect the development, morphology, and functions of the cells. Individuals carrying both mutations exhibit more severe defects compared to those carrying a single mutation.
HUMAN MOLECULAR GENETICS
(2023)
Article
Cell Biology
Yanchun Ji, Juanjuan Zhang, Min Liang, Feilong Meng, Minglian Zhang, Jun Q. Mo, Meng Wang, Min-Xin Guan
Summary: This study found that mitochondrial tRNA variants play an important role in the development of LHON, accounting for 8.75% of cases in the Han Chinese population. These new findings may have beneficial applications in the pathophysiology, disease management, and genetic counseling of LHON.
Article
Biochemistry & Molecular Biology
Feilong Meng, Zidong Jia, Jing Zheng, Yanchun Ji, Jing Wang, Yun Xiao, Yong Fu, Meng Wang, Feng Ling, Min-Xin Guan
Summary: In this study, we investigated the molecular mechanism of the m.5783C > T mutation associated with deafness. We found that this mutation significantly affects mitochondrial DNA replication and tRNA metabolism, leading to mitochondrial dysfunction and the occurrence of deafness.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Qi Shen, Honghong Zhang, Yiming Huang, Mingyu Li, Hao Zhao, Zhiwen Yang, Haijing Zhao, Qi Liu, Zihao Fu, Yufei Di, Libing Liu, Haotian Bai, Fengting Lv, Yundai Chen, Yuqi Liu, Shu Wang
Summary: Genetic variants are associated with ineffective control of hypertension. This study used a technique called MS-FRET to analyze DNA genotypes associated with hypertension in the Chinese population. The personalized treatment based on the MS-FRET technique improved blood pressure control rate and shortened the duration to controlling blood pressure compared to conventional treatment. The CCP-based MS-FRET genetic variant detection can assist clinicians in rapid and accurate risk classification of patients with hypertension and improve treatment outcomes.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Jing Wang, Yanchun Ji, Cheng Ai, Jia-Rong Chen, Dingyi Gan, Juanjuan Zhang, Jun Q. Mo, Min-Xin Guan
Summary: In this study, it was shown that allotopic expression of the nucleus-versions of ND6 can restore complex I, apoptosis, and mitophagy deficiencies caused by the m.14484T > C mutation. Restoring mitochondrial dysfunctions caused by the m.14484T > C mutation through overexpression of ND6 is a step towards therapeutic interventions for LHON and mitochondrial diseases.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Review
Cell Biology
Chao Chen, Min-Xin Guan
Summary: Mitochondria are essential organelles for cellular metabolism and physiology, and mtDNA mutations are associated with a wide range of degenerative and neuromuscular diseases. However, the pathophysiology of mitochondrial diseases, especially threshold effect and tissue specificity, is not well understood and effective treatment is lacking. Using patients-derived iPSCs as ex vivo models has advanced our understanding of the pathophysiology of maternally inherited diseases and has potential for therapeutic interventions.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Yu-Qi Liu, Dan-Dan Li, Meng Chai, Hong-Liang Cong, Xiao-Qiang Cong, Jun Dai, Rong-Pin Du, Ming Gao, Jin-Cheng Guo, Yan-Qing Guo, Xiao-Jian Hong, Rong-Chong Huang, Feng-Shun Jia, Jia-Yu Li, Qing Li, Jia-Mei Liu, Xin-Ping Liu, Yu-Guo Liu, Hong-Gang Nie, Bing Shao, Xiao-Yu Shen, Hai-Qing Song, Yi-Jun Song, Li-Jun Wang, Shuo Wang, Dong-Mei Wu, Jing Xia, Zhi-Yong Yang, Hong-Ying Yu, Hui Zhang, Tie-Mei Zhang, Ji-Yi Zhao, Liang-Chen Zhao, Ming-Qi Zheng, Yun-Dai Chen
Summary: In China, PCSK-9 inhibitors combined with statins significantly reduce LDL-C levels among patients at very high risk of ASCVD, but the long-term clinical benefits in reducing the risk of MACE for patients receiving PCSK-9 inhibitors are still unclear and require further study.
JOURNAL OF GERIATRIC CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)