Article
Pharmacology & Pharmacy
Daniel Sandin, Javier Valle, Jordi Morata, David Andreu, Marc Torrent
Summary: Research has shown that antimicrobial peptides can induce tolerance in bacteria, which may be an important step in the development of antibiotic resistance. The tolerance is dependent on the type of antimicrobial peptide the bacteria are exposed to and can also affect antibiotic treatment.
Article
Chemistry, Physical
Jing Zhang, Haoning Gong, Mingrui Liao, Zongyi Li, Ralf Schweins, Jeffrey Penny, Jian R. Lu
Summary: The research designed a group of short AMPs with high antifungal activities against Candida species and Cryptococcus neoformans, some of which showed effectiveness against fungal biofilms with low cytotoxicity to host cells. The fast action and high selectivity of these AMPs were found to be correlated to their fast membrane lysis, evidenced by various measurements and simulations.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Tania Vanzolini, Michela Bruschi, Andrea C. Rinaldi, Mauro Magnani, Alessandra Fraternale
Summary: This review focuses on synthetic peptides and their multifaceted mechanisms of action as antiviral, antibacterial, and antifungal agents. Synthetic peptides have been shown to affect pathogen structures, disrupt microbial communities, and influence viral life cycles, making them promising tools against emerging infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mayra Queme-Pena, Tunde Juhasz, Gergely Kohut, Maria Ricci, Priyanka Singh, Imola Cs Szigyarto, Zita Papp, Livia Fulop, Tamas Beke-Somfai
Summary: Anticancer peptides have advantages targeting cell membranes, with three distinct binding modes identified: surface helical structure, partially helical structure with disordered regions, and non-inserted helical monomeric form.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Agustina Fernandez, Maria Laura Colombo, Lucrecia M. Curto, Gabriela E. Gomez, Jose M. Delfino, Fanny Guzman, Laura Bakas, Ismael Malbran, Sandra E. Vairo-Cavalli
Summary: Fusarium graminearum is the causative agent of Fusarium head blight (FHB), a disease that leads to significant reduction in wheat yield and poses health risks due to mycotoxins in infected grains. Plant defensins are small basic peptides with conserved structures that play a role in host defense, and novel antifungal peptides designed from DefSm2 exhibit promising activity against F. graminearum, suggesting potential for development as fungicidal agents.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Chemistry, Medicinal
Katelyn A. M. McMillan, Melanie R. Power Coombs
Summary: Pleurocidin, an anti-microbial peptide found in winter flounder, shows promising potential for clinical, aquaculture, and veterinary applications. Research indicates its effectiveness against various Gram-positive and Gram-negative bacteria, as well as its potential as a novel anti-cancer therapy. More studies are needed to explore pleurocidin's suitability as a treatment for antibiotic-resistant pathogens and its therapeutic use for fish species.
Article
Infectious Diseases
Agustina Fernandez, Mariano Gonzalez, Ismael Malbran, Romina F. Vazquez, Sabina M. Mate, Fanny Guzman, Laura S. Bakas, Sandra Vairo Cavalli
Summary: This study investigates the mode of action and structure-activity relationship of the antifungal peptide SmAP(alpha 1-21). It is found that SmAP(alpha 1-21) alters fungal cell wall and membrane permeability through a multistep mechanism, inducing peroxisome biogenesis and oxidative stress. The replacement of His19 has an impact on the peptide's activity and cellular localization.
Article
Biotechnology & Applied Microbiology
Eliana Dell'Olmo, Rosa Gaglione, Angela Cesaro, Valeria Cafaro, Wieke R. Teertstra, Hans de Cock, Eugenio Notomista, Henk P. Haagsman, Edwin J. A. Veldhuizen, Angela Arciello
Summary: Therapeutic options for invasive fungal infections are limited, highlighting the need for novel antifungal agents. ApoB-derived peptides show promising antifungal properties, interacting with fungal cells and causing membrane damage, making them potential candidates for effective antifungal agents.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Naiem Ahmad Wani, Elad Stolovicki, Daniel Ben Hur, Yechiel Shai
Summary: In this study, a site-specific approach was used to modify antimicrobial peptides (AMPs), resulting in improved antimicrobial activity, resistance to proteolytic degradation, and reduced toxicity and hemolytic activity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Vanessa Duncan, Daniel Smith, Laura Simpson, Emma Lovie, Laura Katvars, Leon Berge, Jennifer Robertson, Shane Smith, Carol Munro, Derry Mercer, Deborah O'Neil
Summary: Fungi cause disease in nearly one billion individuals worldwide, and current antifungal agents face challenges such as emerging and drug-resistant fungi, toxicity, and drug-drug interactions. The development of NP339, a polyarginine peptide with potent antifungal activity against various pathogenic fungi, presents a promising solution to these challenges. NP339 targets fungal cell membranes specifically, demonstrating rapid fungicidal activity without inducing resistance, suggesting its potential as a differentiated antifungal candidate for serious fungal diseases.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Organic
Md Rokon Ul Karim, Yasuko In, Tao Zhou, Enjuro Harunari, Naoya Oku, Yasuhiro Igarashi
Summary: Two bicyclic peptides, nyuzenamides A and B, isolated from Streptomyces in deep sea water collected in the Sea of Japan, exhibited antifungal activity against pathogenic fungi and cytotoxicity against P388 murine leukemia cells. The structures of these compounds, comprising ten amino acid residues with four unusual amino acids and aromatic acyl units, were determined through various analytical methods.
Article
Infectious Diseases
Rosa Bellavita, Elisabetta Buommino, Bruno Casciaro, Francesco Merlino, Floriana Cappiello, Noemi Marigliano, Anella Saviano, Francesco Maione, Rosaria Santangelo, Maria Luisa Mangoni, Stefania Galdiero, Paolo Grieco, Annarita Falanga
Summary: In this study, a Temporin L analogue, [Nle(1), dLeu(9), dLys(10)]TL, was developed, which exhibited more efficient antimicrobial activity and induced membrane destabilization and deformation in bacterial membranes. The modification increased the peptide's hydrophobicity without affecting its anti-inflammatory activity compared to the lead peptide.
Article
Biochemistry & Molecular Biology
Emerenziana Ottaviano, Elisa Borghi, Laura Giovati, Monica Falleni, Delfina Tosi, Walter Magliani, Giulia Morace, Stefania Conti, Tecla Ciociola
Summary: The synthetic peptide F11A showed significant candidacidal activity in vitro and improved survival in Galleria mellonella larvae infected with Candida albicans by modulating the host immune system and enhancing antifungal capabilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ning Shao, Ling Yuan, Pengcheng Ma, Min Zhou, Ximian Xiao, Zihao Cong, Yueming Wu, Guohui Xiao, Jian Fei, Runhui Liu
Summary: The study presents a rational design of heterochiral beta-peptide polymers as anticancer agents for combating multidrug-resistant cancers. The optimal polymer shows potent and broad-spectrum anticancer activities against multidrug-resistant cancer cells by damaging cell membranes. In vivo experiments demonstrate that the polymer efficiently inhibits the growth and transfer of solid tumors and the metastasis and seeding of circulating tumor cells. Additionally, the beta-peptide polymers have excellent biocompatibility, superior stability against proteolysis, easy large-scale synthesis, and low cost compared to anticancer peptides.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Fernando Lobo, Maily Selena Gonzalez, Alicia Boto, Jose Manuel Perez de la Lastra
Summary: In this study, pretrained protein models were used as feature extractors to develop predictive models for antifungal peptide activity. Various machine learning classifiers were trained and evaluated, with the AFP predictor achieving comparable performance to state-of-the-art methods. Overall, this study demonstrates the effectiveness of pretrained models for peptide analysis and provides a valuable tool for predicting antifungal peptide activity and potentially other peptide properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Acoustics
Daechul Kim, Sungryul Shin, Wookeen Chung, Jong-Se Lim, Dong-Gun Lee, Dae-Mo Lee, Jiho Ha
Summary: The phenomenon of wax deposition in crude oil transportation pipelines can cause extensive damage. Therefore, it is essential to monitor flow assurance by estimating the wax appearance temperature (WAT) of the produced crude oil. This study proposes a method for determining WAT through ultrasonic characteristics analysis and confirms its high reliability through experiments.
Article
Thermodynamics
Dong-Gun Lee, Padmini Pandey, Bhaskar Parida, Jun Ryu, SungWon Cho, Jae-Kwang Kim, Dong-Won Kang
Summary: Organic cations, particularly phenylethylammonium (PEA(+)), are found to improve the quality and crystallinity of all-inorganic cesium lead halide perovskite films. PEA(+) acts as an additive to control intermediate perovskite phase and promote pure phase perovskite crystal growth, leading to reduced pinholes and enhanced film quality. The presence of PEA(+) also helps in the uniform distribution of bromide ions, resulting in improved stability and performance of perovskite solar cells.
Article
Infectious Diseases
Ji-Yoon Jung, Dukhee Nho, Sung-Yeon Cho, Dong-Gun Lee, Su-Mi Choi, Hee-Je Kim, Myungshin Kim, Eun-Jee Oh
Summary: This article reports a case of a patient with acute myeloid leukemia and drug-resistant CMV infection, highlighting the challenges posed by drug-resistant mutations and intra-host diversity of CMV in treatment outcomes.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Giyeol Han, Dong Gun Lee
Summary: This study provides an initial investigation into the antibacterial mode of action of naringin in Escherichia coli. It was found that naringin can induce ROS accumulation, leading to cellular dysfunction and apoptosis-like death. Different ROS have varying degrees of damage to E. coli and contribute differently to cell death.
Article
Multidisciplinary Sciences
Jaeeun Yoo, Hyung Suk Cho, Jae-Ho Yoon, Byung Sik Cho, Hee-Je Kim, Dong-Gun Lee, Dong Wook Jekarl, Myungshin Kim, Eun-Jee Oh, Yeon-Joon Park, Yonggoo Kim
Summary: This study analyzed clinical and laboratory data from 219 patients with AML who underwent granulocyte transfusions (GT) and identified 8 score markers that reflect the response to GT. The study found that GT was significantly effective in the low-risk group of patients.
Article
Biology
Issam I. Raad, Ray Hachem, Nigo Masayuki, Tarcila Datoguia, Hiba Dagher, Ying Jiang, Vivek Subbiah, Bilal Siddiqui, Arnaud Bayle, Robert Somer, Ana Fernandez Cruz, Edward Gorak, Arvinder Bhinder, Nobuyoshi Mori, Nelson Hamerschlak, Samuel Shelanski, Tomislav Dragovich, Yee Elise Vong Kiat, Suha Fakhreddine, Abi Hanna Pierre, Roy F. Chemaly, Victor Mulanovich, Javier Adachi, Jovan Borjan, Fareed Khawaja, Bruno Granwehr, Teny John, Eduardo Yepez Yepez, Harrys A. Torres, Natraj Reddy Ammakkanavar, Marcel Yibirin, Cielito C. Reyes-Gibby, Mala Pande, Noman Ali, Raniv Dawey Rojo, Shahnoor M. Ali, Rita E. Deeba, Patrick Chaftari, Takahiro Matsuo, Kazuhiro Ishikawa, Ryo Hasegawa, Ramon Aguado-Noya, Alvaro Garcia Garcia, Cristina Traseira Puchol, Dong Gun Lee, Monica Slavin, Benjamin Teh, Cesar A. Arias, Dimitrios P. Kontoyiannis, Alexandre E. Malek, Anne-Marie Chaftari
Summary: This international multicenter study aimed to identify independent risk factors for increased 30-day mortality in COVID-19 patients with and without cancer. The study analyzed data from 16 international centers and found that cancer itself was not an independent risk factor for increased mortality. Older age and lymphopenia were the main predictors of 30-day mortality in all patients, and remdesivir was the only therapeutic agent associated with decreased mortality.
Article
Chemistry, Physical
Jitendra Bahadur, Jun Ryu, Dong-Gun Lee, Jongin Hong, Shuzi Hayase, Jung Sang Cho, Sang Mun Jeong, Dong-Won Kang
Summary: In this study, small carbon chain molecules were introduced as liquid additives to improve the crystal growth and surface processing of CsPbI2Br perovskite. The additives could passivate surface defects by conducting with halide ions, leading to improved performance and stability of the photovoltaic devices. The addition of diiodo-methane was found to significantly enhance the power conversion efficiency of perovskite solar cells, reaching a record high of 16.42%.
APPLIED SURFACE SCIENCE
(2023)
Article
Medicine, General & Internal
Alberto Papi, Michael G. Ison, Joanne M. Langley, Dong-Gun Lee, Isabel Leroux-Roels, Federico Martinon-Torres, Tino F. Schwarz, Richard N. van Zyl-Smit, Laura Campora, Nancy Dezutter, Nathalie de Schrevel, Laurence Fissette, Marie-Pierre David, Marie Van der Wielen, Lusine Kostanyan, Veronica Hulstrom
Summary: A phase 3 clinical trial showed that a candidate vaccine for respiratory syncytial virus (RSV) infection has a high efficacy in preventing RSV-related respiratory infection and lower respiratory tract disease in older adults. The vaccine was effective against both RSV subtypes and in individuals with underlying conditions.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Chemistry, Analytical
Ae Sol Lee, Su Min Kim, Kyeong Rok Kim, Chulmin Park, Dong-Gun Lee, Hyung Joon Cha, Hye Ryoung Heo, Chang Sup Kim
Summary: To control SARS-CoV-2, early diagnosis of infected individuals is crucial. A colorimetric lateral flow immunoassay (LFIA) was developed in this study, enabling sensitive detection of cultured SARS-CoV-2 in 15 minutes with a detection limit of 5 x 10^4 copies/mL. Clinical evaluation showed that the LFIA accurately detected all positive and negative samples, achieving 100% accuracy.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Virology
Seungwan Chae, Hoon Seok Kim, Sung-Yeon Cho, Dukhee Nho, Raeseok Lee, Dong-Gun Lee, Myungshin Kim, Yonggoo Kim
Summary: This study aimed to identify variants associated with CMV drug resistance in HCT recipients and assess their clinical significance. The study found that 8.1% of patients had resistance variants, and 39.0% of patients had variants of uncertain significance. Patients with resistance variants had higher CMV viral load and higher risks of severe graft-versus-host disease and lower one-year survival rates.
Article
Biophysics
Juhwan Park, Minjun Park, Junbeom Kim, Youhee Heo, Bo Hoon Han, Nakwon Choi, Chulmin Park, Raeseok Lee, Dong-Gun Lee, Seok Chung, Ji Yoon Kang
Summary: Digital enzyme linked immunosorbent assays (ELISA) can detect SARS-CoV-2 antigens with higher sensitivity compared to conventional antigen tests. To improve detection sensitivity, researchers developed an oil-and bead-free single molecule counting assay with rolling circle amplification (RCA) on a substrate. This method showed more than 100-fold improvement in detecting the N protein of SARS-CoV-2 compared to conventional ELISA.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Immunology
Geon Young Ko, Jihyun Lee, Hyunjoo Bae, Ji Hyeong Ryu, Hye-Sun Park, Hyunhye Kang, Jin Jung, Ae-Ran Choi, Raeseok Lee, Dong-Gun Lee, Eun-Jee Oh
Summary: This prospective study evaluated immune responses and breakthrough infections in 235 infection-naive healthcare workers. The study found that both vaccine groups exhibited peak responses one to two months after the second or third dose, followed by gradual declines. The ChAd group showed a gradual increase in ELISPOT results, but their antibody levels declined more rapidly than the BNT group. Six months after the third dose, both groups had substantial cellular responses, with superior humoral responses in the BNT group.
Article
Pediatrics
Jeong Min Kim, Hyun Mi Kang, In Hyuk Yoo, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho
Summary: Gastrointestinal bleeding is a rare adverse event of dasatinib, which can be caused by dasatinib-induced colitis, severe thrombocytopenia, and platelet dysfunction. We report two cases of pediatric patients who developed hematochezia during treatment with dasatinib after hematopoietic stem cell transplantation (HSCT). A colonic tissue biopsy was performed to differentiate the cause of GI bleeding. Both patients were diagnosed with proven cytomegalovirus (CMV) colitis, but only one received ganciclovir treatment. The patient who did not receive antiviral therapy experienced recurrent GI bleeding during dasatinib administration, leading to multiple treatment interruptions. Patients with GI bleeding and confirmed CMV colitis during dasatinib therapy after HSCT may benefit from antiviral therapy to reduce interruptions in dasatinib therapy.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jongmin Lee, Raeseok Lee, Kyongmin Sarah Beck, Dae Hee Han, Gi June Min, Suyon Chang, Jung Im Jung, Dong-Gun Lee
Summary: This study reported the clinical and radiological characteristics of patients with B-cell lymphoma and COVID-19, showing migratory airspace opacities on serial chest CT. The results showed that these patients exhibited multifocal patchy peripheral ground glass opacities (GGOs) with basal predominance in the baseline CTs, and clearance of previous opacities with the development of new peripheral and peribronchial GGO and consolidation in different locations. All patients demonstrated prolonged COVID-19 symptoms accompanied by positive polymerase chain reaction results throughout the follow-up period.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Infectious Diseases
Jing Chen, Ju-Young Shin, Sumitra Shantakumar, Sungho Bea, Byong Duk Ye, Dong-Gun Lee, Hyungwoo Kim, Won Suk Choi, Iain Kaan
Summary: The incidence rate of herpes zoster (HZ) is higher in individuals with immunocompromised conditions and autoimmune diseases (IC/AID) in the Republic of Korea (ROK), especially in women, those aged 50 years and above, and those who have undergone transplants and hemato-oncology treatment. HZ in IC/AID patients leads to higher medical costs.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)