Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice

Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells

(2014) José L. Areta et al.   NUTRITION RESEARCH

Metabolite Regulation of Nucleo-cytosolic Trafficking of Carbohydrate Response Element-binding Protein (ChREBP)

(2013) Tsutomu Nakagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RETRACTED: Mitochondrial Dynamics, Biogenesis, and Function Are Coordinated with the Cell Cycle by APC/CCDH1

(2012) Assegid Garedew et al.   Cell Metabolism

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription

(2012) F. Riuzzi et al.   JOURNAL OF CELL SCIENCE

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

(2012) Masato Sasaki et al.   NATURE

Alterations of metabolic genes and metabolites in cancer

(2012) Eric K. Oermann et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Signaling in Control of Cell Growth and Metabolism

(2012) P. S. Ward et al.   Cold Spring Harbor Perspectives in Biology

Inhibition of GSK3 by lithium, from single molecules to signaling networks

(2012) Laure Freland et al.   Frontiers in Molecular Neuroscience

The emerging role of fumarate as an oncometabolite

(2012) Ming Yang et al.   Frontiers in Oncology

Metabolites as global regulators: A new view of protein regulation

(2011) Xiyan Li et al.   BIOESSAYS

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Leucine limitation regulates myf5 and myoD expression and inhibits myoblast differentiation

(2011) J. Averous et al.   EXPERIMENTAL CELL RESEARCH

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

(2011) Chiara Bardella et al.   JOURNAL OF PATHOLOGY

Satellite cells, the engines of muscle repair

(2011) Yu Xin Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis

(2011) Thomas Braun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G i2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration

(2011) G. C. Minetti et al.   Science Signaling

Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transfer-associated production of reactive oxygen species

(2010) Peter Schönfeld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Extensive In Vivo Metabolite-Protein Interactions Revealed by Large-Scale Systematic Analyses

(2010) Xiyan Li et al.   CELL

Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells

(2010) Yuewen Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor

(2010) Ling Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

(2010) Stefan Gross et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

(2010) Jean-Pierre Bayley et al.   LANCET ONCOLOGY

The engine driving the ship: metabolic steering of cell proliferation and death

(2010) Marisa R. Buchakjian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signal transduction and adaptive regulation through bacterial two-component systems: the Escherichia coli AtoSC paradigm

(2009) Dimitrios A. Kyriakidis et al.   AMINO ACIDS

β-hydroxy-β-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways

(2009) Reut Kornasio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SDH5 Mutations and Familial Paraganglioma: Somewhere Warburg is Smiling

(2009) William G. Kaelin   CANCER CELL

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

CANCER: Puzzling Patterns of Predisposition

(2009) P. J. Pollard et al.   SCIENCE

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Studies with leucine, β-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion

(2008) M MACDONALD et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation

(2008) Shihuan Kuang et al.   Cell Stem Cell

All muscle satellite cells are equal, but are some more equal than others?

(2008) P. S. Zammit   JOURNAL OF CELL SCIENCE

Liver-Specific Silencing of the Human Gene Encoding Succinyl-CoA: 3-Ketoacid CoA Transferase

(2008) Kenji E. Orii et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Stem Cell Based Therapy for Skeletal Muscle Diseases

(2008) Satyakam Bhagavati   Current Stem Cell Research & Therapy