Article
Cell Biology
Irene Gimeno-LLuch, Maria Benito-Jardon, Gemma Guerrero-Barbera, Natalia Burday, Mercedes Costell
Summary: Skin injuries can lead to either regeneration or scarring, and the process is influenced by physical forces transmitted by integrins. Fibronectin (FN) plays a crucial role in repairing skin wounds and its synergy site is essential for cell adhesion and resistance to physical forces. In the absence of the FN synergy site, there are defects in keratinocyte migration and reduced fibrotic responses in skin.
Article
Biochemistry & Molecular Biology
Yun-Lung Chung, Pei-Yu Chou, Ming-Jyh Sheu
Summary: This study evaluated the wound-healing activity of PEDOT: PSS and found that it significantly improved wound healing in SD rats. The treatment increased angiogenic behavior and VEGF expression, indicating its angiogenic effects. The results suggest that PEDOT: PSS can be potentially used as a dressing for medical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Shaolong Zhou, Lingling Wan, Xu Liu, Delin Hu, Feng Lu, Xihang Chen, Fangguo Liang
Summary: Diabetes delays wound healing and impairs function of Schwann cells (SCs) in the peripheral nervous system. SCs in diabetic mice are dysfunctional and fail to rapidly activate a repair program after skin wound injury. Additionally, high glucose conditions impair SC function and affect the paracrine effects of SCs on myofibroblast formation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Chemistry, Medicinal
Shasha Jia, Xueya Wang, Guowei Wang, Xiaojing Wang
Summary: Soft tissue damage stimulates the release of catecholamine hormones which bind to beta-adrenergic receptors on the cell membrane surface, impairing soft tissue wound healing. Beta-blockers inhibit this activation and accelerate wound healing by reducing inflammation, promoting cell migration, and inhibiting bacterial effects. They are being studied for their efficacy in various soft tissue wound repair applications, but further investigation into their mechanisms of action is necessary.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Endocrinology & Metabolism
Keyan Hu, Xueying Liu, Hongfeng Chang, Yi Zhang, Hui Zhou, Lei Liu, Xin Zhang, Ziying Jiao, Bing Shen, Qiu Zhang
Summary: The study found that miR-221-3p can promote wound healing in diabetes by targeting THBS1. Lack of miR-221-3p may result in impaired healing in chronic wounds of type 2 diabetes.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Cell Biology
Xiao Feng, Wei Feng, Yu Ji, Tingting Jin, Jingyu Li, Jincai Guo
Summary: This study investigates the relationship between TGF-beta 1 and SOCS7 in the re-epithelialization of keratinocytes during skin wound healing. The results show that TGF-beta 1 downregulates SOCS7 expression and overexpression of SOCS7 suppresses TGF-beta 1-induced keratinocyte migration. TGF-beta 1 negatively regulates SOCS7 through the binding of EGR1 to the SOCS7 promoter. This study identifies the TGF-beta 1/EGR1/SOCS7 pathway as a potential therapeutic target for promoting wound healing.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Abdulrahman E. Koshak, Mardi M. Algandaby, Mohammad Mujallid, Ashraf B. Abdel-Naim, Nabil A. Alhakamy, Usama A. Fahmy, Anas Alfarsi, Shaimaa M. Badr-Eldin, Thikryat Neamatallah, Mohammed Z. Nasrullah, Hossam M. Abdallah, Ahmed Esmat
Summary: OFI and OFI-SNEDDS demonstrated superior wound healing activity in a rat model of full-thickness skin excision, with enhanced antioxidant and anti-inflammatory properties. OFI-SNEDDS showed higher activity compared to OFI seed oil, improving collagen and angiogenesis expression.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Basma G. Eid, Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Shadab Md, Ashraf B. Abdel-Naim, Giuseppe Caruso, Filippo Caraci
Summary: The study aimed to evaluate the synergistic effect of melittin and diclofenac in a nano-complex, which showed significantly better wound healing activity compared to individual drugs. The nano-complex promoted regenerated epithelium and granulation tissue formation, as well as exhibited enhanced antioxidant activity.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Dharshan Sivaraj, Chikage Noishiki, Nina Kosaric, Harriet Kiwanuka, Hudson C. Kussie, Dominic Henn, Katharina S. Fischer, Artem A. Trotsyuk, Autumn H. Greco, Britta A. Kuehlmann, Filiberto Quintero, Melissa C. Leeolou, Maia B. Granoski, Andrew C. Hostler, William W. Hahn, Michael Januszyk, Ferid Murad, Kellen Chen, Geoffrey C. Gurtner
Summary: According to the American Diabetes Association, there is a significant unmet need for new therapies to accelerate the closure of non-healing wounds. In this study, the effects of NO-releasing gel on diabetic wound healing in mice were investigated. The results showed that topical administration of NO-gel significantly accelerated the rate of wound healing and promoted a more regenerative ECM architecture.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hong-Lian Wang, Li Wang, Chang-Ying Zhao, Hui-Yao Lan
Summary: Research has shown that TGF-beta signaling plays diverse roles in beta cell development, function, proliferation, and apoptosis, with Smad3 identified as a key mediator and ideal therapeutic target for type-2 diabetes. However, the effects of Smad7 on beta cell proliferation and glucose homeostasis remain controversial. Overexpression of Tgfb1 has been found to prevent beta cells from autoimmune destruction without affecting beta cell function. These findings highlight the complex regulatory roles of TGF-beta signaling in beta cell biology.
Article
Biochemistry & Molecular Biology
Tarfah Al-Warhi, Eman Maher Zahran, Samy Selim, Mohammad M. Al-Sanea, Mohammed M. Ghoneim, Sherif A. Maher, Yaser A. Mostafa, Faisal Alsenani, Mahmoud A. Elrehany, Mohammed S. Almuhayawi, Soad K. Al Jaouni, Usama Ramadan Abdelmohsen, Abeer H. Elmaidomy
Summary: This study demonstrates the potential of Vitis vinifera seed extract in promoting wound healing by accelerating wound closure rates, increasing TGF-beta and VEGF levels, and reducing TNF-alpha and IL-1 beta levels. Phytochemical analysis identified multiple compounds, and molecular docking experiments were performed to investigate the mechanisms of action.
Article
Biochemistry & Molecular Biology
Zhang Feng, Chengyu Zang, Linfeng Zhang, Siyuan Yin, Qianqian Zhuang, Xiaojie Wang
Summary: The activation of STING is associated with delayed wound repair in diabetic skin, and enhanced STING expression may contribute to sustained inflammatory responses. In addition, the dysfunction of autophagy is correlated with STING expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Wang Xiaojie, Joshua Banda, Hui Qi, Alan K. Chang, Canol Bwalya, Lu Chao, Xiaokun Li
Summary: The process of wound healing involves the interaction of growth factors and cytokines, including inflammation, proliferation, and remodeling. Abnormal regulation of these events can lead to excessive scarring or non-healing wounds. Early events in wound healing play a crucial role in the outcome, and high levels of inflammation can result in scarring. Inhibiting TGF-β3 and administering KGFs have shown positive results in wound closure and reduced scarring, hinting at the potential for scarless wound healing.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Minguen Yoon, Eunhwan Kim, Seol Hwa Seo, Geon-Uk Kim, Kang-Yell Choi
Summary: The Wnt/beta-catenin signaling pathway plays important roles in wound healing, and a study tested the effect of a small molecule called KY19382 on cutaneous wound healing by activating this pathway. KY19382 significantly enhanced cell migration and increased levels of key proteins involved in wound healing without causing significant cytotoxicity. In a murine wound healing model, KY19382 accelerated re-epithelialization, collagen deposition, and stem cell activation. Overall, KY19382 may have the potential to be used as a new wound healing agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)