Review
Cardiac & Cardiovascular Systems
Harsh Bahrar, Siroon Bekkering, Rinke Stienstra, Mihai G. Netea, Niels P. Riksen
Summary: Low-grade systemic inflammation is an important component of atherosclerotic cardiovascular disease, and long-term activation of myeloid cells plays a crucial role in this process. Obesity and metabolic complications induce long-lasting inflammatory reprogramming of innate immune cells, leading to atherosclerosis. This review discusses the mechanisms through which innate immune cells undergo long-term changes upon exposure to endogenous ligands, termed "trained immunity". Inappropriate induction of trained immunity contributes to hyperinflammation and proatherogenic changes, highlighting the importance of identifying novel pharmacological targets for preventing or treating cardiovascular diseases.
CARDIOVASCULAR RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Eugenia Gkaliagkousi, Antonios Lazaridis, Soner Dogan, Emil Fraenkel, Bilge Guvenc Tuna, Ioana Mozos, Milica Vukicevic, Ozlem Yalcin, Kristina Gopcevic
Summary: Vascular aging, characterized by structural and functional changes in the vascular wall, is a significant marker of aging and is closely associated with cardiovascular mortality and age-related vascular pathologies. Understanding the molecular mechanisms involved in vascular aging could provide new insights into the complex biology of this irreversible process and guide future interventions to improve longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Danielle N. Huggins, Rebecca S. LaRue, Ying Wang, Todd P. Knutson, Yingzheng Xu, Jesse W. Williams, Kathryn L. Schwertfeger
Summary: This study used single-cell RNA sequencing to analyze macrophages isolated from the lungs of mice with orthotopic mammary tumors, revealing seven distinct macrophage clusters. The findings highlight the diversity of macrophages present within metastatic lesions, including a novel subset of lipid-associated macrophages previously unidentified in lung metastases. Gene enrichment analysis revealed involvement in pathways related to lipid metabolism, extracellular matrix remodeling, and immunosuppression.
Article
Biochemistry & Molecular Biology
Rie Ohara, Felipe Lima Dario, Maycon Tavares Emilio-Silva, Renata Assuncao, Vinicius Peixoto Rodrigues, Gabriela Bueno, Priscila Romano Raimundo, Lucia Regina Machado da Rocha, Clelia Akiko Hiruma-Lima
Summary: Obesity leads to low-grade inflammation and worsens gastric mucosal lesions. This study investigated the effects of citral on gastric lesion healing in normal and obese animals. The results showed that HFD 100 and 300 mg/kg citral treatment significantly reduced the ulcer base area. Furthermore, 100 mg/kg citral treatment led to reduced MMP-9 activity and improved scar tissue progression in obese animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Helena Laronha, Ines Carpinteiro, Jaime Portugal, Ana Azul, Mario Polido, Krasimira T. Petrova, Madalena Salema-Oom, Isabel Barahona, Jorge Caldeira
Summary: A new class of MMP inhibitors has been discovered, which can be co-polymerized with other vinyl compounds in commercial dental resins, limiting release and potential toxicity, and increasing safety. These inhibitors show unique properties towards various MMPs and did not significantly decrease cell viability at high concentrations.
Article
Medicine, General & Internal
Jaromir Jarecki, Teresa Malecka-Massalska, Izabela Polkowska, Bartosz Potoczniak, Ewa Kosior-Jarecka, Imre Szerb, Ewa Tomaszewska, Martina Gutbier, Maciej Dobrzynski, Tomasz Blicharski
Summary: This study found correlations between concentrations of leptin and ACRP-30 in serum and SF in overweight females. Leptin levels increase with BMI, while ACRP-30 serum level increases in more advanced stages of GOA. Additionally, leptin levels were correlated with TIMP-1 serum concentration, a biochemical marker of GOA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Bruna Natalia Alves da Silva Pimentel, Sarah Raquel De Annunzio, Marcelo Assis, Paula Aboud Barbugli, Elson Longo, Carlos Eduardo Vergani
Summary: Silver tungstate (alpha-Ag2WO4), silver molybdate (beta-Ag2MoO4), and silver vanadate (alpha-AgVO3) microcrystals exhibit interesting antimicrobial properties, but their biocompatibility is not fully understood. This study analyzed the cytotoxicity and inflammatory response of silver-containing microcrystals in different cell models and evaluated the production of cytokines and matrix metalloproteinases. The results showed promising biocompatibility profiles for alpha-Ag2WO4, beta-Ag2MoO4, and alpha-AgVO3 microcrystals.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Hematology
P. Gresele, E. Falcinelli, S. Momi, E. Petito, M. Sebastiano
Summary: Platelets contain and release matrix metalloproteinases (MMPs), which play important roles in organism defense and repair, as well as modulating platelet function in health and disease. Understanding the role of MMPs in platelet function may lead to novel therapeutic approaches for cardiovascular, inflammatory, and neoplastic disorders.
Article
Biochemistry & Molecular Biology
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Eirini Christodoulou, Georgia Valsami, Nikolaos Kostomitsopoulos
Summary: This study evaluated the effects of exercise training on the progression of atherosclerotic lesions in hypercholesterolemic mice. It was found that exercise training reduced aortic stenosis, increased fibrous cap thickness and collagen/elastin content within plaques. Furthermore, exercise training decreased the concentrations of VE-cadherin, MMP-8 and MMP-9, while increasing the concentrations of TIMP-1 and TIMP-2 within the plaques.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Hematology
Michele Silvestro, Cristobal F. Rivera, Dornazsadat Alebrahim, John Vlahos, Muhammad Yogi Pratama, Cuijie Lu, Claudia Tang, Zander Harpel, Rayan Sleiman Tellaoui, Ariadne L. Zias, Delphina J. Maldonado, Devon Byrd, Mukundan Attur, Paolo Mignatti, Bhama Ramkhelawon
Summary: The cytoplasmic domain of MT1-MMP protects against the development of AAA and atherosclerotic plaques through a nonproteolytic signaling mechanism. This finding reveals a novel mechanism of synchronous onset of AAA and atherogenesis and highlights the importance of MT1-MMP in the control of vascular wall homeostasis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Chemistry, Medicinal
Nikolaos P. E. Kadoglou, Marianna Stasinopoulou, Evangelia Gkougkoudi, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Georgia Valsami
Summary: Dabigatran etexilate and exercise training have complementary effects on the development and stability of atherosclerotic lesions in diabetic mice, mediated by anti-inflammatory modulation.
Article
Materials Science, Multidisciplinary
Richard J. R. Kelwick, Alexander J. Webb, Yizhou Wang, Amelie Heliot, Fiona Allan, Aidan M. Emery, Michael R. Templeton, Paul S. Freemont
Summary: The ALPHA beads, containing a library of low-cost, biodegradable protease biosensors utilizing PhaC-reporter fusion proteins, can detect specific proteases in various samples and have the potential for use in resource-limited settings.
Review
Biochemistry & Molecular Biology
Milosz Caban, Katarzyna Owczarek, Urszula Lewandowska
Summary: Eye diseases are linked to visual impairment and reduced quality of life. Current treatments for these diseases are not satisfactory, highlighting the need for new therapeutic approaches. Matrix metalloproteinases and tissue inhibitors of metalloproteinases play crucial roles in eye diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
M. S. Magalhaes, P. Smith, J. R. Portman, L. H. Jackson-Jones, C. C. Bain, P. Ramachandran, Z. Michalidou, R. H. Stimson, M. R. Dweck, L. Denby, N. C. Henderson, S. J. Jenkins, C. Benezech
Summary: The research suggests that Tim4 plays a key regulatory role in resident adipose tissue macrophages, leading to specific transcriptional activation and affecting cholesterol transport after lipid ingestion. This provides a new pathway for treating dyslipidemia.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Nadia Di Pietrantonio, Carola Palmerini, Caterina Pipino, Maria Pompea Antonia Baldassarre, Giuseppina Bologna, Angelika Mohn, Cosimo Giannini, Paola Lanuti, Francesco Chiarelli, Assunta Pandolfi, Natalia Di Pietro
Summary: Childhood obesity is associated with impaired vascular insulin sensitivity, altered oxidant-antioxidant state, and chronic inflammation leading to endothelial dysfunction. In vitro study shows that inhibiting the mTORC1-S6K1 pathway can restore insulin receptor signaling and provide insights into the mechanisms underlying endothelial dysfunction in childhood obesity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Arne Thiele, Katja Luettges, Daniel Ritter, Niklas Beyhoff, Elia Smeir, Jana Grune, Julia S. Steinhoff, Michael Schupp, Robert Klopfleisch, Michael Rothe, Nicola Wilck, Hendrik Bartolomaeus, Anna K. Migglautsch, Rolf Breinbauer, Erin E. Kershaw, Gernot F. Grabner, Rudolf Zechner, Ulrich Kintscher, Anna Foryst-Ludwig
Summary: The specific inhibitor of ATGL, Atglistatin, can alleviate catecholamine-induced cardiac damage by exerting anti-fibrotic and anti-apoptotic effects. These effects are likely mediated by non-cardiac tissues.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jana Goerg, Manuela Sommerfeld, Bettina Greiner, Dilyara Lauer, Yasemin Seckin, Alexander Kulikov, Dmitry Ivkin, Ulrich Kintscher, Sergey Okovityi, Elena Kaschina
Summary: The study found that low-dose empagliflozin can increase cardiac contractility in normoglycemic rats and improve heart function early after myocardial infarction. These effects are achieved through the down-regulation of MMP9 and NHE1, as well as the up-regulation of SERCA2a, indicating a potential treatment option to improve cardiovascular outcomes post-MI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Christoph Hoermandinger, Felix Schoenrath, Philipp Stawowy, David Winkler, Volkmar Falk, Evgenij Potapov, Isabell Anna Just
Summary: A patient was admitted in cardiogenic shock with a suspected LVAD outflow obstruction, which was not confirmed by standard imaging but only revealed during a post-mortem examination. Despite the lack of confirmation from CT scan and angiography, a fungal thrombus formation was discovered as the cause of the outflow obstruction in the LVAD.
Article
Engineering, Biomedical
Pia Lanmueller, Jaime-Juergen Eulert-Grehn, Axel Unbehaun, Christoph Klein, Matthias Hommel, Markus Kofler, Joerg Kempfert, Christoph Hoermandinger, Friedrich Kaufmann, Philipp Stawowy, Stephan Dreysse, Johanna Mulzer, Marcus Mueller, Volkmar Falk, Felix Schoenrath, Evgenij Potapov, Isabell A. Just
Summary: Interventional treatment approaches have become increasingly important in patients on long-term left ventricular assist device (LVAD), with promising outcomes in improving symptoms and complication management. However, there are also potential risks and complications associated with these procedures, including exacerbation of existing heart failure and procedural-related adverse events.
Review
Pharmacology & Pharmacy
Ulrich Kintscher, George L. Bakris, Peter Kolkhof
Summary: This review provides information on the molecular pharmacology and relevant clinical data of a new class of non-steroidal MRAs, discussing their cardiorenal outcomes. These compounds have an improved benefit-risk profile in treating cardiovascular diseases, and finerenone has a novel indication.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Karin M. Kirschner, Anna Foryst-Ludwig, Sabrina Gohlke, Chen Li, Roberto E. Flores, Ulrich Kintscher, Michael Schupp, Tim J. Schulz, Holger Scholz
Summary: The study shows that WT1 has a role as a white adipocyte determination factor in intra-abdominal WAT by suppressing thermogenic genes. Reducing the expression of WT1 in these fat depots may represent a novel treatment strategy for metabolic diseases.
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Marita Kieble, Salka Enners, Ulrich Kintscher, Ulrich Laufs, Michael Bohm, Martin Schulz
Summary: The study found that the recommendations for hypertension treatment in the 2018 ESC/ESH guidelines were underutilized in clinical practice, with a decreasing trend in the prescription of FDC products over the years.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
David Lohr, Arne Thiele, Max Stahnke, Vera Braun, Elia Smeir, Joachim Spranger, Sebastian Brachs, Robert Klopfleisch, Anna Foryst-Ludwig, Laura M. Schreiber, Ulrich Kintscher, Niklas Beyhoff
Summary: This study aimed to characterize myocardial microstructure and function in an experimental model of obesity-related cardiac dysfunction. The results showed that a high-fat diet induced alterations in myocardial diffusion properties, but did not lead to remodeling of the three-dimensional myofiber arrangement of the left ventricle. Obese mice exhibited reduced diastolic function and longitudinal strain, emphasizing the need for further investigation into the significance of regional patterns in obesity-related cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Urology & Nephrology
Katja Luettges, Marlies Bode, Jan Niklas Diemer, Juliane Schwanbeck, Eva K. Wirth, Robert Klopfleisch, Kai Kappert, Arne Thiele, Daniel Ritter, Anna Foryst-Ludwig, Peter Kolkhof, Ulrich Otto Wenzel, Ulrich Kintscher
Summary: This study investigated the anti-inflammatory/fibrotic and immunological effects of the nonsteroidal MR antagonist finerenone in a cardiorenal disease model. The results showed that finerenone could alleviate cardiorenal damage, reduce blood pressure, decrease renal inflammatory cell content, and improve cardiac function.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Luisa Barcena, Misael Estepa, Louis Marx, Anne Breiter, Natalie Haritonow, Philipp Stawowy
Summary: This study investigated the effect of the VLDL/VLDL receptor axis on mononuclear cell polarization and the role of PCSK9 and PCSK9 inhibitors within this network. The results showed that VLDL promotes the differentiation of mononuclear cells towards an anti-inflammatory phenotype, and PCSK9 reverses the VLDL-mediated anti-inflammatory action by inhibiting VLDL receptor expression, promoting a pro-inflammatory phenotype.
Article
Multidisciplinary Sciences
Wonyul Jang, Dmytro Puchkov, Paula Samso, YongTian Liang, Michal Nadler-Holly, Stephan J. Sigrist, Ulrich Kintscher, Fan Liu, Kamel Mamchaoui, Vincent Mouly, Volker Haucke
Summary: Cells respond to fluctuating nutrient supply by changing organelle dynamics and metabolism. This study reveals that lipid signaling on the endoplasmic reticulum can control mitochondrial morphology and function, enabling cells to adapt to changing nutrient environments.
Article
Biochemistry & Molecular Biology
Bettina Greiner, Manuela Sommerfeld, Ulrich Kintscher, Thomas Unger, Kai Kappert, Elena Kaschina
Summary: Cannabinoids regulate cell glucose uptake, proteolysis, and apoptosis through CB1R and CB2R receptors. The CB2R agonist JWH133 shows the highest protective properties.
Article
Engineering, Biomedical
Christoph Hoermandinger, Nadine Riedler, Julia Stein, Philipp Stawowy, Evgenij Potapov, Felix Schoenrath, Isabell A. Just
Summary: This study investigated the occurrence of acute outflow graft occlusions (OGO) following lysis therapy in left ventricular assist device (LVAD) patients. The results showed that subclinical OGO was a major risk factor for acute OGO after rtPA lysis therapy. An algorithm for risk stratification and management of this complication is proposed.
Article
Cardiac & Cardiovascular Systems
Emanuel Heil, Jin-Hong Gerds-Li, Julian Keznickl-Pulst, Vesna Furundzija-Cabraja, Felix Hohendanner, Leif-Hendrik Boldt, Philipp Stawowy, Doreen Schoeppenthau
Summary: This study examined the conduction characteristics in patients with persistent atrial fibrillation. It found that the severity of fibrotic atrial cardiomyopathy and the extension of low voltage areas were associated with prolongation of left atrial conduction time. Furthermore, the conduction velocity was slower in low voltage areas compared to normal voltage areas.
Review
Peripheral Vascular Disease
Ulrich O. Wenzel, Ulrich Kintscher
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)