Article
Pharmacology & Pharmacy
Zhiyong Li, Zhilei Wang, Fang Dong, Wei Shi, Wenzhang Dai, Jing Zhao, Qiang Li, Zhi-E Fang, Lutong Ren, Tingting Liu, Ziying Wei, Wenqing Mou, Li Lin, Yan Yang, Xiaohe Xiao, Li Ma, Zhaofang Bai
Summary: Liver fibrosis is characterized by abnormal proliferation of connective tissue in the liver due to various pathogenic factors. The study demonstrates that germacrone (GER) can inhibit liver fibrosis by regulating multiple signaling pathways, including reducing ROS release to protect hepatocytes and inhibiting HSC activation through TGF-beta/Smad and apoptosis pathways. GER shows potential as a therapeutic drug for the treatment of liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yumei Hao, Kaichao Song, Xiaochuan Tan, Ling Ren, Xiuping Guo, Chuchu Zhou, He Li, Jin Wen, Ya Meng, Mingbao Lin, Yujia Zhang, Hongdong Huang, Lulu Wang, Wensheng Zheng
Summary: Hepatic fibrosis is a chronic liver disease that lacks effective pharmacotherapeutic treatments. Researchers have designed targeted and reactive oxygen species (ROS)-responsive micelles for the specific delivery of resveratrol (RES), a traditional Chinese medicine, to activated hepatic stellate cells (aHSCs) for the treatment of liver fibrosis. In vitro and in vivo experiments demonstrate that these micelles enhance the targeted delivery of RES to aHSCs, reduce collagen accumulation, and protect hepatocytes from damage.
Article
Medicine, Research & Experimental
Yan Guo, Anqi Zhou, Yuanyuan Zhang, Ying Chen, Yifei Chen, Yuan Gao, Xiulian Miao
Summary: Aberrant liver fibrosis is a hallmark event in end-stage liver diseases. Hepatic stellate cells (HSCs) are considered the major source of myofibroblasts in the liver that produce extracellular matrix proteins to promote liver fibrosis. We investigated the role of serum response factor (SRF) in this process.
Article
Biochemistry & Molecular Biology
Qi Chen, Jiabao Huang, Weizhao Tong, Xingang Gui, Jie Zheng, Guoxin Hu
Summary: This study investigated the geometric effect of GO nanomaterials on HSCs and found that GO nanosheets reduced cell viability and mobility of HSCs, while increasing the expression level of α-SMA. GO nanosheets disrupted mitochondria membrane and induced oxidative stress and HSCs activation. GO quantum dots decreased α-SMA expression level, and the correlation between GAPDH and α-SMA needs further exploration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Tong Wu, Yu Qi, Chen Xu, Dandan Sui, Fu-Jian Xu
Summary: This study constructed a targeting degradable nucleic acid delivery carrier specifically for hepatic stellate cells, which showed high gene transfection ability and specific targeting properties. It effectively silenced TGF beta 1 gene and exhibited good therapeutic effects on liver fibrosis.
Article
Biochemistry & Molecular Biology
Soonjae Hwang, Sangbin Park, Uzma Yaseen, Ho-Jae Lee, Ji-Young Cha
Summary: Liver fibrosis is a progressive and debilitating disease characterized by excessive deposition of extracellular matrix proteins. Our study reveals that KLF10 acts as a negative regulator of TGF-beta signaling pathway, suppressing hepatic stellate cell activation and fibrogenesis through modulation of ATF3 expression. Targeting the KLF10-ATF3 axis may have therapeutic implications for liver fibrosis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Minako Sakurai, Peter Weber, Gretchen Wolff, Annika Wieder, Julia Szendroedi, Stephan Herzig, Bilgen Ekim uestuenel
Summary: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and liver fibrosis are progressive liver diseases associated with metabolic syndrome. The elevated expression of TSC22D4 in patients with type 2 diabetes, NAFLD, and NASH suggests its involvement in the progression of these diseases. The study reveals that TSC22D4 contributes to the activation, proliferation, and migration of hepatic stellate cells (HSCs), implicating it as a key regulator in the development of liver fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Steffen K. Meurer, David A. Brenner, Ralf Weiskirchen
Summary: Misidentification, cross-contamination, and genetic drift of continuous animal cell lines are common problems in biomedical research, which can lead to erroneous results and inconsistent or invalidated studies. This study established a multi-loci short tandem repeat signature for the immortalized hepatic stellate cell line Col-GFP HSC, allowing for unique cell line authentication.
Article
Plant Sciences
Qian Zhang, Tao Song, Can Guan, Yingjie Gao, Jianchao Ma, Xiangyang Gu, Zhiguang Qi, Xiaoji Wang, Zhengge Zhu
Summary: This study revealed the crucial role of rice annexin OsANN4 in the ABA response, partially by modulating ROS production, mediating Ca2+ influx, or interacting with OsCDPK24.
Article
Cell Biology
Ye Tao, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Ningning Wang, Jintong Jiang, Xue Jia, Sen Wei, Jingyuan Zhang, Yuhan Zhu, Wenyue Tian, Guang Yang, Xiaofang Liu, Shuang Liu, Yang Ding, Xiance Sun
Summary: Liver fibrosis is a significant global health issue characterized by HSCs activation and collagen deposition, which can be induced by arsenic exposure leading to ROS generation and IRE1α/NOX4 pathway activation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ji Hye Yang, Sae Kwang Ku, Il Je Cho, Je Hyeon Lee, Chang-Su Na, Sung Hwan Ki
Summary: Neoagarooligosaccharides (NAOs) have protective effects against hepatic fibrosis and inhibit the TGF-beta/Smad signaling pathway. This was validated in in vitro experiments and mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ting-Ting Li, Xiao-Wei Su, Lin-Lin Chen, Wan-Nian Zhang, Jun-Ping Zhang, Yan Wang, Wei-Heng Xu
Summary: Hepatic fibrosis is a stage of chronic liver disease that can lead to cirrhosis or liver cancer. The activation of hepatic stellate cells (HSCs) is a crucial event in fibrosis development and inhibiting this activation has been shown to alleviate fibrosis. Roxarsone, an organoarsenic additive used in livestock production, has been found to inhibit HSC activation and improve liver function in a mouse model of fibrosis. These findings suggest that Roxarsone could be a potential treatment for liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hanglu Ying, Long Li, Yufen Zhao, Feng Ni
Summary: This study evaluated the function of ivermectin in regulating liver fibrosis. The results showed that ivermectin alleviated histopathological changes, improved liver function, reduced collagen deposition, and downregulated the expression of profibrotic genes. Mechanistically, it inhibited intrahepatic macrophage accumulation and suppressed the production of proinflammatory factors. Importantly, it also promoted HSC deactivation by reducing the protein levels of alpha-smooth muscle actin (alpha-SMA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Sha Huang, Yuhua Wang, Shuwen Xie, Yuqi Lai, Chan Mo, Ting Zeng, Shanshan Kuang, Chuying Zhou, Zhiyun Zeng, Yuyao Chen, Shaohui Huang, Lei Gao, Zhiping Lv
Summary: The study aimed to explore the regulatory mechanism of ISL in the process of liver fibrosis and the relationship between Cav-1 and ferroptosis. The results showed that ISL relieved liver fibrosis by inducing HSCs ferroptosis, while Cav-1 exerted its anti-hepatic fibrosis effect by promoting HSCs ferroptosis.
Article
Environmental Sciences
Siwen Li, Yang Cao, Qiangwen Pan, Yewei Xiao, Yanling Wang, Xiali Wang, Xinlian Li, Qiuyue Li, Xiaoqing Tang, Bing Ran
Summary: The study suggests that neonicotinoids may induce liver damage through Ca2+ overload and S-phase arrest, with NAC alleviating the damage caused by DIN. Additionally, DIN treatment may lead to mitochondrial dysfunction, which can be reversed by specific activators.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Yanyi He, Kun Yang, Martin Wild, Kaicun Wang, Dan Tong, Changkun Shao, Tianjun Zhou
Summary: We reduced the uncertainties in projecting surface downward solar radiation by approximately 56% using emergent constraints. Our findings reveal significant brightening in North and Southeast China, regions with high energy demand. Surface downward solar radiation is crucial for renewable solar energy and climate change mitigation, however, future projections based on climate models are highly uncertain, hindering efficient deployment. By using emergent constraints, we obtained credible and narrowed projections for future solar radiation, emphasizing the need to consider spatial changes in order to optimize solar energy infrastructure placement.
NATIONAL SCIENCE REVIEW
(2023)
Article
Engineering, Environmental
Xu Li, Huijie Lu, Kun Yang, Lizhong Zhu
Summary: The use of nanoscale zero-valent iron (NZVI) can effectively degrade tetracyclines (TCs) and reduce the potential risks of antibiotic resistance genes (ARGs) by decreasing horizontal gene transfer. NZVI's biotic degradation contributes significantly to the removal of TCs and is attributed to reduced toxicity and increased microbial biomass and enzyme activities.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Civil
Mijun Zou, Kun Yang, Hui Lu, Yanghang Ren, Jing Sun, Han Wang, Shen Tan, Long Zhao
Summary: A new evapotranspiration model (EEOET) was developed in this study based on eco-evolutionary optimality principles, which reduced the number of plant functional type-specific parameters and improved the robustness of the model. The EEOET model requires inputs of daily land surface temperature, vegetation-related data, soil information, and routine meteorological data, and provides daily estimates of evapotranspiration. Global evaluation across 74 FLUXNET sites showed that the model performed well for all plant functional types and was comparable to existing models.
JOURNAL OF HYDROLOGY
(2023)
Article
Meteorology & Atmospheric Sciences
Peng Ji, Xing Yuan, Chunxiang Shi, Lipeng Jiang, Guoqing Wang, Kun Yang
Summary: By conducting simulations with a resolution of 6 kilometers over China, it is found that high-resolution land surface modeling has lower simulation errors for snow depth, evapotranspiration, and soil moisture compared to global products. It can also accurately simulate urban heat islands and long-term trends. This highlights the significant added value of high-resolution land surface modeling at continental scales.
JOURNAL OF HYDROMETEOROLOGY
(2023)
Article
Meteorology & Atmospheric Sciences
Jing Sun, Kun Yang, Hui Lu, Xu Zhou, Xin Li, Yingying Chen, Weidong Guo, Jonathon S. Wright
Summary: This study comprehensively explores the effects of soil organic matter (SOM) on the hydrothermal state of the land-atmosphere system on the eastern Tibetan Plateau. The results show that SOM can improve the simulations by reducing cold and wet biases, increasing air temperature, decreasing humidity, and reducing precipitation. Including SOM in climate models not only improves the representation of atmospheric energy and water cycles, but also enhances the simulation of frozen soil evolution with increased confidence and reliability.
JOURNAL OF HYDROMETEOROLOGY
(2023)
Article
Environmental Sciences
Jun Qin, Min He, Wei Yang, Ning Lu, Ling Yao, Hou Jiang, Jin Wu, Kun Yang, Chenghu Zhou
Summary: The Tibetan Plateau is experiencing rapid warming, leading to increased glacial melting and natural hazards. However, due to a lack of high-quality, long-term observations, there is no complete understanding of its temperature status in the past few decades. This study uses satellite and weather station data to derive long-term surface air temperatures, revealing widespread warming across the plateau, particularly in the western region. The derived warming rate is higher than other datasets, implying a severe threat to the cryosphere.
REMOTE SENSING OF ENVIRONMENT
(2023)
Article
Meteorology & Atmospheric Sciences
Yanyi He, Kun Yang, Yanghang Ren, Mijun Zou, Xu Yuan, Wenjun Tang
BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY
(2023)
Article
Engineering, Electrical & Electronic
Da Lu, Rui Duan, Kunde Yang
Summary: This paper presents a constrained CPD-based algorithm for DOA estimation using a highly structured uniform linear AVSA. The algorithm incorporates prior structured information to improve the accuracy of DOA estimation. Numerical simulations verify the effectiveness and superior performance of the algorithm.
CIRCUITS SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Engineering, Electrical & Electronic
Qi Zhang, Shuwen Wang, Yang Shi, Kunde Yang
Summary: This article presents the measurement results of maritime wireless propagation channel at 8 GHz in the South China Sea (SCS) region. The study investigates the large-scale path loss and small-scale fading between a marine observation platform and a moving vessel. Different models and distributions are compared to analyze their suitability for the scenario. The research provides guidance for efficient design and future deployments of distributed buoy networks in the SCS region.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Computer Science, Artificial Intelligence
Fan Meng, Kunlin Yang, Yichen Yao, Zhibin Wang, Tao Song
Summary: Tropical cyclones are extreme disasters with significant impact on human beings, and forecasting their intensity has been a challenging task. Deep learning-based intensity forecasting has shown potential to outperform traditional methods, but inherent uncertainty in weather forecasting needs to be quantified for decision-making and risk assessment. This study proposes an intelligent system, PTCIF, based on deep learning to quantify uncertainty using multimodal meteorological data, the first study to assess uncertainty of tropical cyclones using a deep learning approach. Probabilistic forecasts are made for the intensity of 6-24 hours, showing comparable performance to weather forecast centers in terms of deterministic forecasts. Reliable prediction intervals and probabilistic forecasts are obtained, which are crucial for disaster warning and expected to complement operational models.
INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS
(2023)
Article
Engineering, Environmental
Hongyuan Zheng, Zhiyi Chen, Kunde Yang, Kaiyan Xiao, Jincai Zhu, Zhiwei Gao, Zheyi Han, Yanguang Liu, Minghong Cai
Summary: Current-use Organoamine Pesticides (CUOAPs) are emerging pesticide pollutants found in Chinese Marginal Seas (CMSs), with the highest levels detected in the East China Sea. The Yangtze and Yellow rivers play a crucial role as significant terrestrial sources, leading to variations in the source, distribution, and seasonal patterns of CUOAPs. Spatial redistribution occurs through ocean current transport, resulting in significant regional disparities. CMSs may become a secondary source region for the surrounding seas.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Limin Duan, Huihao Jiang, Wenhao Wu, Daohui Lin, Kun Yang
Summary: Introducing crystal defects into iron-based metal-organic frameworks (Fe-MOFs) is a promising strategy to enhance Fenton-like performance. However, developing a facile and effective strategy to construct defective Fe-MOFs as highly efficient Fenton-like catalysts is still challenging. In this study, MIL-100(Fe) (Def-MIL-100 (Fe)) with missing ligand defects was synthesized by a simple heterogeneous reaction, and it exhibited significantly higher Fenton-like activity compared to the perfect MIL-100(Fe). The missing ligand defects played a key role in promoting fast H2O2 adsorption, accelerating electron transfer, and improving OH generation and utilization efficiency.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Civil
Yanbin Lei, Tandong Yao, Yongwei Sheng, Kun Yang, Wei Yang, Shenghai Li, Jing Zhou, Yaozhi Jiang, Yifan Yu
Summary: Extreme events on the Tibetan Plateau, such as unprecedented lake expansion, have become more frequent and severe due to climate warming and moistening. This expansion, attributed to abnormally high precipitation, poses a substantial threat to regional ecosystems, infrastructure, and habitats. Therefore, it is necessary to identify threatened areas using satellite images and conduct real-time observations of lake level changes.
JOURNAL OF HYDROLOGY
(2023)
Article
Oncology
Qi Zhang, Jinglei Li, Zihan Chen, Ke Jiang, Kunyu Yang, Fang Huang, Ai Huang, Xiaodong Zhang, Jinxiang Zhang, Hui Wang
Summary: In this study, it was found that the deubiquitinase OTUD1 is downregulated in lung adenocarcinoma (LUAD) and inhibits the progression of LUAD by deubiquitinating and stabilizing FHL1. Furthermore, the drug VE-822 was identified as a candidate agonist for OTUD1 and showed inhibitory effects on the proliferation of LUAD both in vitro and in vivo.
Article
Multidisciplinary Sciences
Vagner Ferreira, Bin Yong, Henry Montecino, Christopher E. E. Ndehedehe, Kurt Seitz, Hansjoerg Kutterer, Kun Yang
Summary: The availability and use of terrestrial water storage anomaly (TWSA) data from Gravity Recovery and Climate Experiment (GRACE) supports various hydrological applications. There are currently five operational TWSA products, three based on mass concentration (mascon) solutions and two based on spherical harmonic coefficients (SHCs) synthesis. This study presents a new TWSA data set based on novel processing protocols, with a spatial re-sampling of 0.25 arc-degrees from 2002 to 2022, which reliably agrees with mascon solutions. The proposed data set would be valuable for regional hydrological applications, particularly for improved assessment of regional water budgets.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
