Article
Chemistry, Multidisciplinary
Xiaogang An, Renfeng Wang, Erfang Chen, Yang Yang, Bei Fan, Yao Li, Bang Han, Qiong Li, Zhenzhen Liu, Yu Han, Jun Chen, Dingjun Zha
Summary: This study developed a nanoparticle system that effectively delivered forskolin (FSK) to the inner ear through the targeting peptide LS19, providing significant protection against noise-induced hearing damage.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Peripheral Vascular Disease
Jang-Hyuk Yun
Summary: The study showed that HGF could prevent diabetic retinopathy-induced vascular leakage by reducing pericyte apoptosis and enhancing endothelial cell tight junctions.
MICROVASCULAR RESEARCH
(2021)
Review
Physiology
Sera Nakisli, Alfonso Lagares, Corinne M. M. Nielsen, Henar Cuervo
Summary: Previously considered passive support cells, mural cells-pericytes and vascular smooth muscle cells-have started to garner more attention in disease research, as more subclassifications, based on morphology, gene expression, and function, have been discovered. Central nervous system (CNS) arteriovenous malformations (AVMs) represent a neurovascular disorder in which mural cells have been shown to be affected, both in animal models and in human patients. In this review, we summarize the observed perturbations to mural cells in human CNS AVM samples and CNS AVM animal models, and we discuss various potential mechanisms relating mural cell pathologies to AVMs.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Clinical Neurology
Bardia Nourbakhsh, Christian Cordano, Carlo Asteggiano, Klemens Ruprecht, Carolin Otto, Alice Rutatangwa, Allysa Lui, Janace Hart, Eoin P. Flanagan, Judith A. James, Emmanuelle Waubant
Summary: In children with EBV seronegativity, a higher percentage have MOG antibodies, leading to a reconsideration of the diagnosis of MS. Clinicians should consider MOG-antibody disease as an alternative diagnosis to MS in children presenting with MS-like symptoms.
ANNALS OF NEUROLOGY
(2021)
Review
Neurosciences
Yuyao Li, Dongqiong Xiao, Xiaodong Wang
Summary: Ferroptosis plays an important role in glial cells, neurons, and pericytes in the central nervous system (CNS), and may contribute to CNS diseases. Certain drugs are potential therapeutic strategies for neurological diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Adriana Mannino, Alison Daly, Eleanor Dunlop, Yasmine Probst, Anne-Louise Ponsonby, Ingrid A. F. van der Mei, Lucinda J. Ausimmune Investigator Grp, Lucinda Black
Summary: Consumption of ultra-processed foods is associated with a higher likelihood of central nervous system demyelination. Higher intakes of ultra-processed foods are linked to an increased risk of FCD in this Australian cohort.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Neurosciences
Hannah C. Bennett, Yongsoo Kim
Summary: Pericytes are a specialized cell type that surrounds the microvasculature of the brain and spinal cord, playing a crucial role in the development and maintenance of the blood-brain barrier. Recent evidence suggests that pericyte dysfunction is associated with various diseases such as diabetes mellitus, Alzheimer's disease, and stroke. Understanding of pericyte distribution and function in the entire brain is limited and requires further research to delineate their role in both the normal brain and pathological conditions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Gary P. P. Morris, Catherine G. G. Foster, Jo-Maree Courtney, Jessica M. M. Collins, Jake M. M. Cashion, Lachlan S. S. Brown, David W. W. Howells, Gabriele C. C. DeLuca, Alison J. J. Canty, Anna E. E. King, Jenna M. M. Ziebell, Brad A. A. Sutherland
Summary: We discovered a subset of microglia, called pericyte-associated microglia (PEM), that closely associate with pericytes. PEM are present in the brain and spinal cord, and their number is reduced in the superior frontal cortex in Alzheimer's disease (AD). This may contribute to vascular dysfunction in neurodegenerative diseases.
Article
Medicine, Research & Experimental
Laura Ghezzi, Bryan Bollman, Luca De Feo, Laura Piccio, Bruce D. Trapp, Robert E. Schmidt, Anne H. Cross
Summary: Multiple sclerosis (MS) is a CNS demyelinating disease that often leads to unsuccessful remyelination and neuronal/axonal damage. While oligodendroglial cells are responsible for myelin production, remyelination by Schwann cells (SchC) has been observed in spinal cord demyelination. This study investigated the extent of SchC remyelination in the brain and spinal cords of autopsied MS specimens.
LABORATORY INVESTIGATION
(2023)
Review
Chemistry, Inorganic & Nuclear
Ke Chen, Si Sun, Junying Wang, Xiao-Dong Zhang
Summary: The central nervous system is crucial for human health, and the treatment of CNS diseases is essential. Artificial enzymes offer high stability and catalytic activity, showing great potential for treating neuroinflammation and other disorders.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Clinical Neurology
Zhonggui Li, Danyu Lin, Xiaoshuang Xu, Xiaohuan Liu, Jieli Zhang, Kaixun Huang, Feiyifan Wang, Jianfeng Liu, Zhi Zhang, Enxiang Tao
Summary: The objective of this study was to investigate the clinical manifestations, treatment, and prognosis of COVID-19-associated central nervous system (CNS) complications. The study recruited 12 patients with COVID-19-associated CNS complications and analyzed their demographics, clinical manifestations, cerebrospinal fluid properties, electroencephalographic features, neuroimaging characteristics, and treatment outcomes. The study found that inflammatory or immune-related complications were relatively common in COVID-19-associated CNS complications, and most patients recovered well with a few having residual neurological dysfunctions.
JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Louise A. Mesentier-Louro, Barbara Rangel, Laurel Stell, M. Ali Shariati, Roopa Dalal, Abinaya Nathan, Ke Yuan, Vinicio de Jesus Perez, Yaping Joyce Liao
Summary: The study revealed that systemic hypoxia can lead to retinal edema and inflammation, which in turn cause visual disturbances. Results showed a significant increase in immune factors in plasma and retina within 1 hour after hypoxia, along with notable changes in retinal tissue. These inflammatory responses rapidly improved within 24 hours, consistent with the typically mild and transient visual disturbances associated with hypoxia.
Article
Cell Biology
Lydia Ayanwuyi, Nataliya Tokarska, Nikki McLean, Jayne Johnston, Valerie Verge
Summary: Brief electrical nerve stimulation has been shown to have a positive effect on the repair of demyelinating diseases and nerve injuries. It promotes the polarization of macrophages to a pro-repair phenotype, reduces inflammation, increases the number of oligodendroglial lineage cells, elevates myelin protein levels, and enhances phosphorylated neurofilaments to protect axons.
NEURAL REGENERATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J. Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Summary: The study reveals that acetylcholine signals are transmitted through a rapid co-activation mechanism, activating receptors on multiple neurons surrounding the release site. Additionally, while acetylcholine signals are direction-selective locally, they do not show global directionality, facilitating information transfer at a local scale.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Wenjie Zhang, Yuan Chen, Hui Pei
Summary: C1q is an essential component of the complement system, performing non-specific immune functions and playing a crucial role in immune homeostasis and normal physiological functions. In the developing central nervous system, C1q is involved in synapse formation, pruning, and the development of neuronal networks. C1q has a close relationship with microglia and astrocytes and may contribute to the development of CNS disorders. Clinical trials are already underway for CNS disorders, highlighting the potential therapeutic target of C1q.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Shogo Tanabe, Toshihide Yamashita
Article
Cell Biology
Toru Nakanishi, Yuki Fujita, Toshihide Yamashita
CELL DEATH & DISEASE
(2019)
Article
Neurosciences
Shogo Tanabe, Shohei Saitoh, Hisao Miyajinna, Takahide Itokazu, Toshihide Yannashita
Article
Neurosciences
Toru Nakanishi, Yuki Fujita, Takashi Tanaka, Toshihide Yamashita
NEUROSCIENCE LETTERS
(2019)
Article
Multidisciplinary Sciences
Yuki Nakazato, Yuki Fujita, Masamitsu Nakazato, Toshihide Yamashita
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Naoki Sada, Yuki Fujita, Nanano Mizuta, Masaki Ueno, Takahisa Furukawa, Toshihide Yamashita
CELL DEATH & DISEASE
(2020)
Review
Biochemistry & Molecular Biology
Yuki Fujita, Toshihide Yamashita
Summary: Microglia, as the resident immune cells of the central nervous system, not only play important roles in pathophysiological conditions but also interact dynamically with neurons in physiological conditions, influencing their structure and function. These immune cells contact neurons at various points and support developmental functions such as neuronal survival, axon elongation, and synaptic circuit maturation. Recent findings on the functions and signaling pathways involved in the reciprocal interactions between microglia and neurons are reviewed, along with discussions on the altered interactions in disease conditions and the potential role of microglia in developmental brain disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Oluwaseun Fatoba, Takahide Itokazu, Toshihide Yamashita
Summary: The complement system, essential for normal brain development and function, can lead to neuroinflammatory responses, neurodegenerative processes, and cognitive impairment when its components are expressed and activated abnormally in the brain. Complement-mediated neuroinflammatory responses and complement-driven neurodegeneration are increasingly implicated in a wide range of CNS disorders as pathologic insults trigger these processes.
Article
Cell Biology
Wakana Oda, Yuki Fujita, Kousuke Baba, Hideki Mochizuki, Hitoshi Niwa, Toshihide Yamashita
Summary: Inhibiting RGMa can attenuate neuronal loss and inflammation in a mouse model of Parkinson's disease, suggesting that RGMa antibodies could be a potential therapeutic option.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Yuka Honjo, Yuki Fujita, Hitoshi Niwa, Toshihide Yamashita
Summary: Neuropathic pain is a type of pain caused by lesions or diseases of the somatosensory nervous system, and in the maxillofacial region, it can be induced by Netrin-4 and Unc5B.
Article
Cell Biology
Hisao Miyajima, Takahide Itokazu, Shogo Tanabe, Toshihide Yamashita
Summary: Ependymal cells have the potential to enhance regeneration processes by secreting neurotrophic factors, with IL-17A negatively regulating this effect. Conditional knockout of IL-17RA in ependymal cells leads to enhanced axonal growth and functional recovery after spinal cord injury. Manipulation of ependymal cells at a molecular level could be a promising strategy for improving functional recovery.
CELL DEATH & DISEASE
(2021)
Article
Clinical Neurology
Nao Shibuya, Takahide Itokazu, Tsubasa Ueda, Toshihide Yamashita
Summary: In this study, the behavior of recruited neutrophils in the peri-infarct area after stroke was investigated using intravital imaging. Colchicine and an anti-P-selectin antibody were found to be effective in inhibiting neutrophil attachment and infiltration, with colchicine showing potential as a therapeutic strategy for acute ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neurosciences
Masahiro Sawada, Kimika Yoshino-Saito, Taihei Ninomiya, Takao Oishi, Toshihide Yamashita, Hirotaka Onoe, Masahiko Takada, Yukio Nishimura, Tadashi Isa
Summary: This study investigates the morphologic changes in the corticospinal tract (CST) after injury, and reveals that multiple reorganizations of the corticospinal projections to spinal segments contribute to the recovery of hand function after spinal cord injury.
Article
Neurosciences
Toke Jost Isaksen, Toshihide Yamashita
NEUROSCIENCE INSIGHTS
(2020)
Article
Medicine, Research & Experimental
Shin-ichiro Hiraga, Takahide Itokazu, Maki Hoshiko, Hironobu Takaya, Mariko Nishibe, Toshihide Yamashita