期刊
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
卷 28, 期 4, 页码 625-635出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.berh.2014.10.015
关键词
Rheumatoid arthritis; Cholinergic anti-inflammatory pathway; Vagus nerve stimulation
类别
There has been a marked improvement in the treatment of rheumatoid arthritis (RA), but most patients do not achieve disease remission. Therefore, there is still a need for new treatments. By screening an adenoviral short hairpin RNA library, we discovered that knockdown of the nicotinic acetylcholine receptor type 7 (alpha 7nAChR) in RA fibroblast-like synoviocytes results in an increased production of mediators of inflammation and degradation. The a7nAChR is intimately involved in the cholinergic anti-inflammatory pathway (CAP). This led us to study the effects of alpha 7nAChR activation in an animal model of RA, and we could show that this resulted in reduced arthritis activity. Accordingly, stimulation of the CAP by vagus nerve stimulation improved experimental arthritis. Conversely, we found aggravation of arthritis activity after unilateral cervical vagotomy as well as in alpha 7nAChR-knockout mice. Together, these data provided the basis for exploration of vagus nerve stimulation in RA patients as a novel anti-inflammatory approach. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据