Review
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Bo Abrahamsen
Summary: This article summarizes the recent advances in the understanding of vertebral fractures, with a focus on endocrine diseases, prevention, and treatment. It highlights the increased risk of vertebral fractures in patients with endocrine diseases and the current focus on invasive treatments. It also mentions that licensed treatments are effective in reducing the occurrence of vertebral fractures in osteoporosis patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Joeri Nicolaes, Christopher Dyer Smith, Cesar Libanati, Cyrus Cooper, Kim Rose Olsen, Bo Abrahamsen
Summary: This study examines the direct healthcare costs of subjects with vertebral fractures available for identification on routine CT scans. The results show that patients with vertebral fractures incur significantly higher healthcare costs compared to those without fractures. The study also found that the healthcare costs per day at risk were higher in the short term for patients with vertebral fractures, although this difference was not statistically significant, and the long-term healthcare costs were similar to the general population.
Article
Endocrinology & Metabolism
W. F. Lems, J. Paccou, J. Zhang, N. R. Fuggle, M. Chandran, N. C. Harvey, C. Cooper, K. Javaid, S. Ferrari, K. E. Akesson
Summary: Vertebral fractures are independent risk factors for future fractures, and VFA in FLS plays a crucial role in detecting vertebral fractures for secondary fracture prevention. Additional information from VFA may influence treatment initiation and type by providing baseline vertebral fracture data.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
M. Barake, R. El Eid, S. Ajjour, M. Chakhtoura, L. Meho, T. Mahmoud, J. Atieh, A. M. Sibai, G. El-Hajj Fuleihan
Summary: The study revealed that Asia is projected to have the largest proportion of osteoporotic fractures worldwide, while data from the Middle East is scarce. Most patients in Arab League countries with osteoporotic fractures were not tested or treated, with high mortality rates observed at 1 to 3 years post-fracture.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Surgery
Xuan-Qi Zheng, Lu Xu, Jie Huang, Cheng-Gui Zhang, Wan-Qiong Yuan, Chui-Guo Sun, Zhi-Shan Zhang, Chen Wei, Jin-Xi Wang, Steven R. Cummings, Wei-Bo Xia, Sheng-Feng Wang, Si-Yan Zhan, Chun-Li Song
Summary: The incidence and cost of clinically recognized vertebral fractures among people aged 50 years and older in urban China have significantly increased. This indicates the need for more attention to the management of osteoporosis in order to prevent osteoporotic fractures.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Tengfei Song, Fan Sun, Shu Liu, Tianwen Ye
Summary: The study aimed to investigate the safety and effectiveness of percutaneous lordoplasty (PLP) in the treatment of severe osteoporotic vertebral compression fracture (OVCF). The results showed that PLP can effectively reduce pain, improve the quality of life, and correct spinal deformity. The procedure had a low rate of complications. Therefore, PLP may be a safe, cost-effective, and minimally invasive alternative for the treatment of severe OVCF.
FRONTIERS IN NEUROLOGY
(2023)
Review
Orthopedics
Solene Prost, Sebastien Pesenti, Stephane Fuentes, Patrick Tropiano, Benjamin Blondel
Summary: Osteoporosis is a common health issue leading to an increase in vertebral fractures, diagnosed through DEXA scans. Treatment options include conservative measures, surgery, and minimally invasive techniques. The choice of treatment for vertebral fractures depends on symptoms, with options like vertebroplasty or vertebral expansion for radiological deformities and symptoms.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Pengfei Sui, Tong Yu, Shouye Sun, Bo Chao, Cheng Qin, Jingwei Wang, Erwei Wang, Changjun Zheng
Summary: This review describes the advances in minimally invasive materials used for the treatment of vertebral compression fractures and discusses the limitations of these materials and approaches to improve their characteristics. It also reviews the types and clinical efficacy of new vertebral implants. This review provides valuable insights for future research and improves understanding of the application of minimally invasive materials for the treatment of vertebral compression fractures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Kaifeng Ye, Da Zou, Fang Zhou, Weishi Li, Yun Tian
Summary: This study aimed to identify the characteristics of vertebral HU in elderly patients with new osteoporotic vertebral compression fractures (OVCF) after percutaneous kyphoplasty (PKP) treatment. The results showed that lower vertebral HU values were associated with a higher risk of new OVCFs after PKP treatment.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Hiroki Iida, Yoshihito Sakai, Taisuke Seki, Tsuyoshi Watanabe, Norimitsu Wakao, Hiroki Matsui, Shiro Imagama
Summary: The study investigates the impact of bisphosphonate (BP) on mortality post osteoporotic vertebral fracture (OVF), and finds that BP medication is significantly associated with reduced all-cause mortality after OVF.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Catarina Brasil d'Alva, Andre Rodrigues Facanha Barreto, Marcello H. Nogueira-Barbosa, Caio Cesar Cavalcante Arruda, aurea Maila Albuquerque, Debora Mota Cordeiro Praciano, Rodrigo Ponte Viana, Daniel Duarte Gadelha, Antonio Brazil Viana Jr, Ilana Marques Moreira, Francisco Jose Rodrigues de Moura Filho, Ana Flavia Torquato de Araujo Junqueira, Renan Magalhaes Montenegro Jr
Summary: This study aimed to investigate the risk of insufficiency vertebral fractures in patients with HP. 44 women with chronic postsurgical HP were compared to a control group of 44 adult healthy women. Vertebral fractures were analyzed using the Genant's method followed by quantitative vertebral morphometry.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Hiroyuki Inose, Tsuyoshi Kato, Shoichi Ichimura, Hiroaki Nakamura, Masatoshi Hoshino, Daisuke Togawa, Toru Hirano, Yasuaki Tokuhashi, Tetsuro Ohba, Hirotaka Haro, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima, Kunihiko Takahashi, Masato Yuasa, Takashi Hirai, Toshitaka Yoshii, Atsushi Okawa
Summary: Women with fresh OVF are at higher risk for subsequent vertebral fracture within the next year. Severe low back pain and use of soft braces are associated with higher risk of subsequent vertebral fractures. Therefore, more attention may be needed for the occurrence of subsequent vertebral fractures in patients treated with these risk factors after OVFs.
EUROPEAN SPINE JOURNAL
(2021)
Article
Orthopedics
Youzhi An, Lili Li, Xuelin Lin, Zhen Zhang, Zhaoyun Zheng, Chengjiang Wang
Summary: This study aimed to investigate the risk of sandwich vertebral fractures in the treatment of osteoporotic vertebral compression fractures via percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). The study found that PVP had a higher risk of sandwich vertebral fractures compared to PKP, potentially due to the larger amount of bone cement, higher rate of cement leakage, and larger Cobb angle.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Endocrinology & Metabolism
N. Binkley, J. T. Schousboe, L. M. Lix, S. N. Morin, W. D. Leslie
Summary: Prior non-vertebral fractures, such as hip, humerus, pelvis, forearm, and other fractures, are associated with an increased likelihood of previously undiagnosed vertebral fracture, providing useful information for risk stratification and monitoring.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Clinical Neurology
Johan von Heideken, Maura D. Iversen, Paul Gerdhem
EUROPEAN SPINE JOURNAL
(2018)
Article
Clinical Neurology
Tian Cheng, Paul Gerdhem
EUROPEAN SPINE JOURNAL
(2018)
Editorial Material
Orthopedics
Paul Gerdhem
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2018)
Article
Clinical Neurology
P. Elkan, T. Lagerback, H. Moller, Paul Gerdhem
EUROPEAN SPINE JOURNAL
(2018)
Article
Orthopedics
Elias Diarbakerli, Anna Grauers, Aina Danielsson, Paul Gerdhem
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2018)
Article
Clinical Neurology
Greger Lonne, Peter Fritzell, Olle Hagg, Dennis Nordvall, Paul Gerdhem, Tobias Lagerback, Mikkel Andersen, Soren Eiskjaer, Martin Gehrchen, Wilco Jacobs, Miranda L. van Hooff, Tore K. Solberg
Article
Endocrinology & Metabolism
David Buchebner, Patrik Bartosch, Linnea Malmgren, Fiona E. McGuigan, Paul Gerdhem, Kristina E. Akesson
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Orthopedics
Linda Helenius, Elias Diarbakerli, Anna Grauers, Markus Lastikka, Hanna Oksanen, Olli Pajulo, Eliisa Loyttyniemi, Tuula Manner, Paul Gerdhem, Ilkka Helenius
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2019)
Article
Clinical Neurology
David Frojd Revesz, Anastasios Charalampidis, Paul Gerdhem
Summary: The study found similar effectiveness between laminectomy with instrumented fusion and laminectomy alone in degenerative cervical myelopathy. Both groups showed improvement within 1 year with no additional improvement between 1 to 2 years.
EUROPEAN SPINE JOURNAL
(2022)
Review
Orthopedics
Tian Cheng, Elisabet Einarsdottir, Juha Kere, Paul Gerdhem
Summary: Twin and family studies indicate a hereditary component in idiopathic scoliosis, but study heterogeneity is large, and the degree of the heritability is uncertain. Nevertheless, known genetic variants associated with idiopathic scoliosis can still only explain a minor part of heritability.
EFORT OPEN REVIEWS
(2022)
Article
Clinical Neurology
Daniel Fell, Elias Diarbakerli, Paul Gerdhem
Summary: This study evaluates the levels of chromium, cobalt, and titanium after fusion surgery for scoliosis. It finds that the use of stainless steel and titanium implants in spinal fusion surgery is associated with elevated metal ion concentrations several years after surgery.
EUROPEAN SPINE JOURNAL
(2022)
Review
Medicine, General & Internal
Elias Diarbakerli, Olof Thoreson, Martin Bjorklund, Leif E. Dahlberg, Martin Englund, Paul Gerdhem, Joanna Kvist, Maziar Mohaddes, Anneli Peolsson, Ola Rolfson, Birgitta Oberg, Allan Abbott
Summary: The study found that musculoskeletal disorder research in Sweden from 2010 to 2020 was predominantly observational cohort based rather than RCT based. There was skewed allocation of first-tier funding, failing to consider the prevalence/incidence and burden of disease.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Orthopedics
L. Helenius, P. Gerdhem, M. Ahonen, J. Syvanen, J. Jalkanen, A. Charalampidis, Y. Nietosvaara, I. Helenius
Summary: This study aimed to assess if omitting the subfascial drain after correcting adolescent idiopathic scoliosis (AIS) would yield comparable results to using a drain in terms of blood loss, hemoglobin level, and opioid consumption. The results showed that omitting the drain did not lead to increased postoperative hemoglobin levels, but patients without the drain required 30% more opioids during the first 48 hours.
BONE & JOINT JOURNAL
(2022)
Article
Clinical Neurology
Simon Blixt, Sebastian Mukka, Peter Forsth, Olof Westin, Paul Gerdhem
Summary: The aim of this study was to validate the use of the Short Musculoskeletal Function Assessment (SMFA) questionnaire in patients with a spine fracture. The results showed that the SMFA indices are highly correlated with ODI in patients with a spine fracture. Therefore, the SMFA indices can be used as an alternative to assess the outcome in patients with spine fractures.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Victor Gabriel El-Hajj, Aman Singh, Simon Blixt, Erik Edstrom, Adrian Elmi-Terander, Paul Gerdhem
Summary: This study assesses the long-term effects of surgical fixation for cervical spine fractures by examining patient-reported outcome measures (PROMs) at 1, 2, and 5 years postoperatively. The results showed that PROMs remained stable beyond 1 year and the 1-year PROMs accurately predicted the outcomes at 2 and 5 years.
