Review
Medicine, General & Internal
Mini Michael, Arvind Bagga, Sarah E. Sartain, Richard J. H. Smith
Summary: Haemolytic uraemic syndrome (HUS) is a group of diseases that cause thrombotic microangiopathy, characterized by non-immune microangiopathic haemolytic anaemia, thrombocytopenia, and acute kidney injury. The most common cause of HUS discussed in this review is Shiga toxin-producing Escherichia coli HUS. Identifying the trigger of thrombotic microangiopathy is crucial for personalized treatment. Complement-mediated HUS, once associated with high mortality, can now be treated with anti-complement therapies. However, the high cost of these therapies limits their use in low-income countries.
Review
Medicine, General & Internal
Dan Pugh, Eoin D. O'Sullivan, Fiona Ai Duthie, Philip Masson, David Kavanagh
Summary: AHUS is a rare disorder characterized by abnormal complement regulatory proteins, leading to kidney failure and death in the past. However, new therapies such as terminal complement inhibition show promising outcomes, although based on very low-quality evidence from single-arm studies. Careful consideration of future data is needed for better understanding of treatment duration and adverse outcomes.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Aakriti Gupta, Harshpal Singh Sachdev, Umesh Kapil, Shyam Prakash, Ravindra Mohan Pandey, Hem Chandra Sati, Lokesh Kumar Sharma, Priti Rishi Lal
Summary: This study investigated anaemia in school going adolescent girls in rural Haryana, India. The results showed that besides iron deficiency and folate or vitamin B-12 deficiency, unknown causes and inflammation contribute to a significant proportion of anaemia. Therefore, in addressing anaemia, in addition to iron and folate supplementation, other nutrition-specific factors such as improving water, sanitation, and hygiene practices should be considered.
PUBLIC HEALTH NUTRITION
(2022)
Article
Medicine, General & Internal
Sebastian Ndlovu, Branislav Czako
Summary: MAHA is a subgroup of haemolytic anaemias characterised by destruction of red blood cells, typically associated with various cancers and malignancies, presenting as an ominous condition requiring prompt identification of symptoms for successful treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Hacer Yapicioglu Yildizdas, Burcu Gok Erdogan, Tugay Tepe, Ozlem Goruroglu, Ferda Ozlu, Mehmet Satar, Nejat Narli
Summary: The study found a high prevalence of vitamin B12 deficiency in pregnant women and newborns. Cord blood vitamin B12 levels were negatively correlated with birth weight and head circumference. Early diagnosis and treatment would benefit both mothers and infants. Awareness of vitamin B12 deficiency in pregnant women and newborns should be increased in Turkey.
NUTRITION RESEARCH
(2022)
Article
Geriatrics & Gerontology
Pin-Chun Wang, Jacobijn Gussekloo, Yasumichi Arai, Yukiko Abe, Jeanet W. Blom, Rachel Duncan, Carol Jagger, Ngaire Kerse, Carmen Martin-Ruiz, Leah Palapar, Wendy P. J. den Elzen
Summary: This study found that factors such as iron deficiency, renal impairment, and chronic inflammation are associated with the presence and onset of anemia in very old adults. Individuals with a combination of these determinants have a higher risk of developing anemia.
Article
Obstetrics & Gynecology
Ozgul Ozgan Celikel, Nilgun Altuntas, Nurkan Aksoy
Summary: This randomized study investigated the effects of early or late clamping of the cord on micro-elements and thyroid hormone levels in newborns. The results showed that newborns in the late clamping group had lower FT4 and FT3 values within the first 24 hours compared to the early clamping group. Additionally, the late clamping group had a significantly higher rate of vitamin B12 values below the normal limit, and there was a positive correlation between maternal and neonatal vitamin B12 levels.
GINEKOLOGIA POLSKA
(2022)
Article
Multidisciplinary Sciences
Kalayu Brhane Mruts, Amanuel Tesfay Gebremedhin, Gizachew A. Tessema, Jane A. Scott, Gavin Pereira
Summary: This study found that both short and longer interbirth intervals were associated with an increased risk of maternal anaemia in sub-Saharan Africa. There was a relatively lower risk of maternal anaemia observed between 24 and 40 months of interbirth intervals.
Article
Obstetrics & Gynecology
Gayani Shashikala Amarasinghe, Thilini Chanchala Agampodi, Vasana Mendis, Krishanthi Malawanage, Chamila Kappagoda, Suneth Buddhika Agampodi
Summary: The study investigated the etiological factors contributing to anemia in pregnant women in Sri Lanka and found that besides iron deficiency remaining the primary cause, minor hemoglobinopathies, B12 deficiency, and other etiologies substantially contribute to anemia in this population. Public health interventions, including screening for minor hemoglobinopathies and multiple micronutrient supplementation in pregnancy, should be considered in the national program for areas where these problems have been identified.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Pathology
J. R. Furundarena, Alasne Uranga, Carmen Gonzalez, Bruno Martinez, June Iriondo, Laida Ondarra, Amaia Arambarri, Ricardo San Vicente, Cristina Sarasqueta, Clara Lombardi, Ane Altuna, Nicolas Rois
Summary: The use of an algorithm incorporating reflex testing based on haemogram results can reduce the demand for unnecessary tests in the investigation of anaemia.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Hematology
Aakriti Gupta, Harshpal Singh Sachdev, Umesh Kapil, Shyam Prakash, Ravindra Mohan Pandey, Priti Rishi Lal
Summary: This study investigated the prevalence and causes of anemia among adolescent girls in a specific region of India. The results showed that deficiency of iron and folate increased with the severity of anemia. The current iron and folic acid program was found to be effective in alleviating moderate and mild anemia among adolescent girls.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Article
Primary Health Care
Zoya Mohammad, Anil Ananthaneni, Andee Fontenot, Poornima Ramadas, Mohammad Nour Salloum
Summary: This article reports a rare case of pseudo-thrombotic microangiopathy (pseudo-TMA) caused by B12 deficiency. The patient initially presented with symptoms suggestive of thrombotic thrombocytopenic purpura (TTP), but was later diagnosed with pseudo-TMA due to B12 deficiency. Timely and accurate diagnosis of pseudo-TMA is crucial to avoid unnecessary procedures and treatments.
Article
Hematology
Ankita Bansal, Vanita Suri, Pooja Sikka, Savita Verma Attri, Neelam Varma, Shiv Sajan Saini, Akshaya Goyal, Pankaj Malhotra
Summary: Iron deficiency anemia is the leading cause of anemia during pregnancy, but there is a lack of comprehensive studies on the etiological factors. This study found that vitamin B12 deficiency is the most common cause of anemia in pregnant women, followed by combined B12 and iron deficiency. More research is needed to understand the implications for nutrient supplementation during pregnancy.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2023)
Article
Biochemistry & Molecular Biology
Huseyin Fatih Gul, Hayrunnisa Bekis Bozkurt, Guluzar Ozbolat, Seda Celik
Summary: This retrospective study aimed to investigate the relationship between 25(OH)D deficiency and iron-deficient anaemia (IDA) in pediatric patients. The results showed a significant correlation between 25(OH)D deficiency and IDA, but 25(OH)D deficiency was not found to be an independent risk factor for IDA.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2021)
Article
Medicine, General & Internal
Hacer Eroglu, Murat Kaytaz, Emre Akkaya, Evin Ademoglu, Sema Genc
Summary: The aim of this study was to evaluate the effects of age, sex, and socio-economic status on nutrient concentrations and blood count parameters in children. The results showed significant differences in hemoglobin, hematocrit, mean corpuscular volume, and red cell distribution across different age groups and between boys and girls. Iron deficiency was more prevalent in boys, while vitamin B12 and folate levels decreased with age. Differences in nutrient levels were also observed among different socio-economic groups.
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2022)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)