15-Hydroxyprostaglandin Dehydrogenase Generation of Electrophilic Lipid Signaling Mediators from Hydroxy Ω-3 Fatty Acids

15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways

(2015) Nathaniel W. Snyder et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase

(2014) R. L. Charles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts

(2013) Luis Villacorta et al.   CARDIOVASCULAR RESEARCH

15-Hydroxyprostaglandin Dehydrogenase-derived 15-Keto-prostaglandin E2Inhibits Cholangiocarcinoma Cell Growth through Interaction with Peroxisome Proliferator-activated Receptor-γ, SMAD2/3, and TAP63 Proteins

(2013) Dongdong Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1

(2013) D Lu et al.   ONCOGENE

Conjugated Linoleic Acid Is a Preferential Substrate for Fatty Acid Nitration

(2012) Gustavo Bonacci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

15-Lipoxygenase Metabolites of Docosahexaenoic Acid Inhibit Prostate Cancer Cell Proliferation and Survival

(2012) Joseph T. O’Flaherty et al.   PLoS One

15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy

(2011) Hye-Kyung Na et al.   BIOCHEMICAL PHARMACOLOGY

Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses

(2011) Sueleyman Bilal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

11-Oxoeicosatetraenoic Acid Is a Cyclooxygenase-2/15-Hydroxyprostaglandin Dehydrogenase-Derived Antiproliferative Eicosanoid

(2011) Xiaojing Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Formation and Signaling Actions of Electrophilic Lipids

(2011) Francisco J. Schopfer et al.   CHEMICAL REVIEWS

Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

(2011) Emilia Kansanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitro-Oleic Acid Inhibits Angiotensin II–Induced Hypertension

(2010) Jifeng Zhang et al.   CIRCULATION RESEARCH

Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids

(2010) Francisco J. Schopfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids

(2010) Cosima Arnold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioenergetic Metabolites Regulate Base Excision Repair-Dependent Cell Death in Response to DNA Damage

(2010) J.-b. Tang et al.   MOLECULAR CANCER RESEARCH

Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids

(2010) Alison L Groeger et al.   Nature Chemical Biology

Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives

(2009) F.J. Schopfer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells

(2009) Emilia Kansanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Selectivity of 5-Hydroxyeicosanoid Dehydrogenase and Its Inhibition by 5-Hydroxy- 6-Long-Chain Fatty Acids

(2009) P. Patel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

15-oxo-Eicosatetraenoic Acid, a Metabolite of Macrophage 15-Hydroxyprostaglandin Dehydrogenase That Inhibits Endothelial Cell Proliferation

(2009) C. Wei et al.   MOLECULAR PHARMACOLOGY

Accumulation of 15-deoxy-Δ12,14-prostaglandin J2adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction

(2008) Joo Yeun Oh et al.   BIOCHEMICAL JOURNAL

NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non-Small Cell Lung Cancer

(2008) D. Hughes et al.   Cancer Prevention Research

Expression of 15-PGDH is downregulated by COX-2 in gastric cancer

(2008) Z. Liu et al.   CARCINOGENESIS