Article
Pharmacology & Pharmacy
Manuel Rey-Funes, Daniela S. Contartese, Rafael Pelaez, Josune Garcia-Sanmartin, Judit Narro-Iniguez, Manuel Solino, Juan Carlos Fernandez, Anibal Sarotto, Nicolas S. Ciranna, Juan Jose Lopez-Costa, Veronica B. Dorfman, Ignacio M. Larrayoz, C. Fabian Loidl, Alfredo Martinez
Summary: Hypothermia has a protective effect on the retina in rat models of perinatal asphyxia, correcting abnormalities in electroretinogram and reducing retinal cell apoptosis. Expression of cold-shock proteins is upregulated in hypothermia treated groups, suggesting a potential mechanism for preventing vision disabling sequelae related to asphyxia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Manuel Rey-Funes, Juan Carlos Fernandez, Rafael Pelaez, Manuel Solino, Daniela S. Contartese, Nicolas S. Ciranna, Ronan Nakamura, Anibal Sarotto, Veronica B. Dorfman, Jose M. Zapico, Ana Ramos, Beatriz de Pascual-Teresa, Juan Jose Lopez-Costa, Ignacio M. Larrayoz, Alfredo Martinez, Cesar Fabian Loidl
Summary: The study found that zr17-2 had similar effects to hypothermia in treating asphyctic rats, improving parameters of electroretinography, reducing apoptotic cell numbers, and correcting morphological parameters of the retina. Injection of this small molecule did not have toxicity in the absence of asphyxia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
James DS. Aridas, Tamara Yawno, Amy E. Sutherland, Ilias Nitsos, Flora Y. Wong, Rod W. Hunt, Michael Ditchfield, Michael C. Fahey, Atul Malhotra, Euan M. Wallace, Alistair J. Gunn, Graham Jenkin, Suzanne L. Miller
Summary: This study found that combined use of TH and MLT for neonatal encephalopathy in newborn lambs provides significantly greater neuroprotection than either treatment alone.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Pediatrics
Kasper J. Kyng, Sigrid Kerrn-Jespersen, Kristine Bennedsgaard, Torjus Skajaa, Michael Pedersen, Ida E. Holm, Tine B. Henriksen
Summary: The study indicated that RIPC could reduce brain lactate/N-acetylaspartate ratios at 72 hours after HI, but had no effect on diffusion-weighted imaging, neuropathology scores, neurological recovery, or mortality. RIPC may have a selective metabolic effect by ameliorating lactate accumulation without improving other short-term outcomes.
PEDIATRIC RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Claudio Manna, Valentina Lacconi, Giuseppe Rizzo, Antonino De Lorenzo, Micol Massimiani
Summary: Obstetric and newborn outcomes of ART pregnancies are associated with a significant prevalence of adverse health conditions in mothers and neonates. The observed placental alterations are thought to result from dysregulation of molecular factors and pathways. It is unclear if these alterations are caused by ART itself or by infertility. Inappropriate trophoblast invasion and altered vascular remodeling are implicated in obstetric and perinatal risks in ART pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Chiara Maddaloni, Domenico Umberto De Rose, Marco Perulli, Ludovica Martini, Iliana Bersani, Francesca Campi, Immacolata Savarese, Andrea Dotta, Maria Paola Ronchetti, Cinzia Auriti
Summary: This study compared the levels of presepsin in plasma and urine between newborn infants with perinatal asphyxia and controls. The results showed that the levels of presepsin in blood and urine were consistent in neonates with perinatal asphyxia at any time point. Additionally, perinatal asphyxia was found to increase the levels of serum CRP and procalcitonin.
Article
Multidisciplinary Sciences
Xiaofeng Zhu, Weiwei Chen, Haitang Wang
Summary: In this study, the mechanism of exercise-mediated placental angiogenesis and perinatal outcome was explored using mouse models. The results showed that exercise intervention improved body composition and glucose tolerance in HFD-fed pregnant mice. HFD aggravated placental inflammation and hypoxic conditions, but exercise intervention significantly alleviated these conditions by increasing PPAR gamma expression and inhibiting angiogenesis.
Article
Pediatrics
Alexa C. Stone, Kyle C. Strickland, David T. Tanaka, Jennifer B. Gilner, Monica E. Lemmon, Jeffrey B. Russ
Summary: This study examines the impact of chorioamnionitis on outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) and finds that chorioamnionitis is associated with an increased risk of abnormal EEG patterns and post-neonatal epilepsy, highlighting the crucial role of placental pathology in neuroprognostication for HIE patients.
PEDIATRIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Lisa M. Vallely, Rachel Smith, John W. Bolnga, Delly Babona, Michaela A. Riddell, Alice Mengi, Lucy Au, Cherolyn Polomon, Joshua P. Vogel, William S. Pomat, Andrew J. Vallely, Caroline S. E. Homer
Summary: In this study, 59 stillbirths were identified, with at least one avoidable factor found in 95% of cases. Patient-related factors included poor response to reduced fetal movement and delays in seeking help during labor. Health personnel-related factors included inadequate intrapartum care, delayed diagnosis of breech presentation, and prolongation of the second stage of labor without intervention.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Review
Pediatrics
Marina-Stefania Stroe, Lieselotte Van Bockstal, Allan Valenzuela, Miriam Ayuso, Karen Leys, Pieter Annaert, Sebastien Carpentier, Anne Smits, Karel Allegaert, Adrian Zeltner, Antonius Mulder, Chris Van Ginneken, Steven Van Cruchten
Summary: Animal models provide valuable information on human disease mechanisms and (patho)physiological factors affecting drug development. Nonclinical data is critical for understanding pediatric disease conditions and developing new drug therapies. This study aimed to develop a neonatal Gottingen Minipig model for investigating the impact of systemic hypoxia and therapeutic hypothermia on drug disposition in perinatal asphyxia.
FRONTIERS IN PEDIATRICS
(2023)
Article
Acoustics
Farah Deeba, Ricky Hu, Victoria Lessoway, Jefferson Terry, Denise Pugash, Jennifer Hutcheon, Chantal Mayer, Septimiu Salcudean, Robert Rohling
Summary: Pregnancy complications such as pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are associated with changes in the structure and function of the placenta. Elastography techniques can assess the mechanical properties of the placenta and be used for detecting placenta abnormalities and predicting pregnancy outcomes.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Pediatrics
Lina Chalak, Raymond W. Redline, Amy M. Goodman, Sandra E. Juul, Taeun Chang, Toby D. Yanowitz, Nathalie Maitre, Dennis E. Mayock, Andrea L. Lampland, Ellen Bendel-Stenzel, David Riley, Amit M. Mathur, Rakesh Rao, Krisa P. Van Meurs, Tai-Wei Wu, Fernando F. Gonzalez, John Flibotte, Ulrike Mietzsch, Gregory M. Sokol, Kaashif A. Ahmad, Mariana Baserga, Joern-Hendrik Weitkamp, Brenda B. Poindexter, Bryan A. Comstock, Yvonne W. Wu
Summary: Placental abnormalities were common in newborn infants with hypoxic-ischemic encephalopathy, especially in those born at or after 40 weeks of gestation. The combination of acute and chronic placental abnormalities may contribute to the complex causal pathways of HIE in these infants.
JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Monica Zen, Francisco Schneuer, Thushari Alahakoon, Natasha Nassar, Vincent W. Lee
Summary: Maternal preeclampsia may have an impact on the academic performance of offspring, but this is largely attributed to perinatal and childhood factors. The gestational age at birth may play a more significant role in poor school performance than preeclampsia itself.
JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Agata Tarkowska, Wanda Furmaga-Jablonska, Jacek Bogucki, Janusz Kocki, Ryszard Pluta
Summary: This study investigated the expression of Alzheimer's-disease-related genes in the lymphocytes of newborns after perinatal asphyxia and perinatal asphyxia treated with hypothermia. The results showed decreased expression of amyloid protein precursor and beta-secretase genes in the peripheral lymphocytes of newborns with perinatal asphyxia, while the expression of presenilin 1 and 2 genes increased. Hypothermia treatment did not significantly affect the gene expression patterns.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Fernando F. Gonzalez, Emily Voldal, Bryan A. Comstock, Dennis E. Mayock, Amy M. Goodman, Marie-Coralie Cornet, Tai-Wei Wu, Raymond W. Redline, Patrick Heagerty, Sandra E. Juul, Yvonne W. Wu
Summary: Placental abnormalities were not independently associated with risk of death or neurodevelopmental impairment in subjects with HIE. The relationship between multiple chronic placental lesions and HIE outcomes deserves further study.
Article
Pediatrics
Anne Synnes, Peter J. Anderson, Ruth E. Grunau, Deborah Dewey, Diane Moddemann, Win Tin, Peter G. Davis, Lex W. Doyle, Gary Foster, May Khairy, Chukwuma Nwaesei, Barbara Schmidt
ARCHIVES OF DISEASE IN CHILDHOOD
(2015)
Article
Pediatrics
Brett J. Manley, Robin S. Roberts, Lex W. Doyle, Barbara Schmidt, Peter J. Anderson, Keith J. Barrington, Birgitta Bohm, Agneta Golan, Aleid G. van Wassenaer-Leemhuis, Peter G. Davis
JOURNAL OF PEDIATRICS
(2015)
Article
Clinical Neurology
Ronit M. Pressler, Geraldine B. Boylan, Neil Marlow, Mats Blennow, Catherine Chiron, J. Helen Cross, Linda S. de Vries, Boubou Hallberg, Lena Hellstrom-Westas, Vincent Jullien, Vicki Livingstone, Barry Mangum, Brendan Murphy, Deirdre Murray, Gerard Pons, Janet Rennie, Renate Swarte, Mona C. Toet, Sampsa Vanhatalo, Sarah Zohar
Editorial Material
Pediatrics
Tore Curstedt, Henry L. Halliday, Mikko Hallman, Ola D. Saugstad, Christian P. Speer
Review
Pediatrics
Tore Curstedt, Henry L. Halliday, Christian P. Speer
Article
Medicine, General & Internal
Dirk Bassler, Richard Plavka, Eric S. Shinwell, Mikko Hallman, Pierre-Henri Jarreau, Virgilio Carnielli, Johannes N. Van den Anker, Christoph Meisner, Corinna Engel, Matthias Schwab, Henry L. Halliday, Christian F. Poets
NEW ENGLAND JOURNAL OF MEDICINE
(2015)
Article
Rehabilitation
Aisling Gough, Mark A. Linden, Dale Spence, Henry L. Halliday, Christopher C. Patterson, Lorcan McGarvey
DISABILITY AND REHABILITATION
(2015)
Article
Pediatrics
Lex W. Doyle, Barbara Schmidt, Peter J. Anderson, Peter G. Davis, Diane Moddemann, Ruth E. Grunau, Karel O'Brien, Koravangattu Sankaran, Eric Herlenius, Robin Roberts
JOURNAL OF PEDIATRICS
(2014)
Article
Pediatrics
Lex W. Doyle, Henry L. Halliday, Richard A. Ehrenkranz, Peter G. Davis, John C. Sinclair
JOURNAL OF PEDIATRICS
(2014)
Biographical-Item
Pediatrics
Christian P. Speer, Henry L. Halliday
Editorial Material
Pediatrics
Maximo Vento, Tore Curstedt, Henry L. Halliday, Mikko Hallman, Ola D. Saugstad, Christian P. Speer
Article
Medicine, General & Internal
Sanja Zivanovic, Janet Peacock, Mireia Alcazar-Paris, Jessica W. Lo, Alan Lunt, Neil Marlow, Sandy Calvert, Anne Greenough
NEW ENGLAND JOURNAL OF MEDICINE
(2014)
Article
Medicine, General & Internal
Denis Azzopardi, Brenda Strohm, Neil Marlow, Peter Brocklehurst, Aniko Deierl, Oya Eddama, Julia Goodwin, Henry L. Halliday, Edmund Juszczak, Olga Kapellou, Malcolm Levene, Louise Linsell, Omar Omar, Marianne Thoresen, Nora Tusor, Andrew Whitelaw, A. David Edwards
NEW ENGLAND JOURNAL OF MEDICINE
(2014)
Review
Medicine, General & Internal
Lex W. Doyle, Richard A. Ehrenkranz, Henry L. Halliday
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2014)
Review
Medicine, General & Internal
Lex W. Doyle, Richard A. Ehrenkranz, Henry L. Halliday
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2014)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)