期刊
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
卷 28, 期 5, 页码 843-853出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2014.07.018
关键词
Hepatocellular carcinoma; Tumour markers; Early detection; Alpha fetoprotein
Tumour markers could be helpful along the continuum of care for patients with hepatocellular carcinoma; however, there is insufficient data for routine use of most current biomarkers in clinical practice. Therefore, the backbone of early detection, diagnosis and treatment response for hepatocellular carcinoma remains imaging-based. Alpha fetoprotein is the best studied of all biomarkers and may be of benefit for early detection when used in combination with ultrasound. Several other biomarkers, including AFP-L3, DCP, osteopontin, and GP73, are also being evaluated for early detection of hepatocellular carcinoma in phase III biomarker studies. Serum and tissue-based biomarkers and genomics may aid in HCC diagnosis, prognosis, and treatment selection; however, further studies are needed to better characterize their accuracy and potential role in clinical practice. (C) 2014 Elsevier Ltd. All rights reserved.
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