期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 25, 期 1, 页码 75-89出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2012.01.005
关键词
LMP-1; EBNA-1; Epstein-Barr virus; lymphoma; lymphoproliferative disorders; cytotoxic T-lymphocyte
类别
资金
- NIH
Epstein-Barr virus (EBV) is a ubiquitous gamma-herpes virus that infects most people but results in life-threatening diseases in only a small subset. Persons who are unable to maintain the virus in its latent state can develop uncontrolled EBV-driven lymphoproliferative disorders and lymphomas. EBV-associated lymphomas are well characterized in patients with known defects in cellular immunity as occurs post-transplantation or HIV/AIDS but are increasingly recognized in patients without overt immunodeficiencies. Improved understanding of the biology of these lymphomas and the role EBV plays in lymphomagenesis offer the opportunity for improved therapies targeted at important signaling pathways and immunotherapy specific against EBV viral antigens. Published by Elsevier Ltd.
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