期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 24, 期 2, 页码 147-163出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2011.02.006
关键词
transformation; follicular lymphoma; DLBCL; MYC; transplantation
类别
资金
- National Institutes of Health (NIH) [NIH CA109335, NIH CA122105]
- Dwoskin Family Foundation
Histological transformation of follicular lymphoma (FL) to a more aggressive non-Hodgkin's lymphomas is a pivotal event in the natural history of FL and is associated with poor outcome. While commonly observed in clinical practice and despite multiple studies designed to address its pathogenesis, the biology of this process represents an enigma. In this chapter we present a state of the art review summarizing the definition of histologic transformation, its incidence, pathogenesis, clinical manifestations, treatment and outcome. Furthermore, we specifically emphasize gaps in our knowledge that should be addressed in future studies. (C) 2011 Elsevier Ltd. All rights reserved.
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