期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 22, 期 4, 页码 483-487出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.beha.2009.08.005
关键词
acute myeloid leukaemia; cancer stem cells; embryonic stem cells; expression; leukaemic stem cells; xenotransplantation
类别
资金
- NCI NIH HHS [R01 CA116606-05, R01 CA055029, R01 CA116606, R01 CA055029-18] Funding Source: Medline
Leukaemia stem cells (LSCs) are responsible for sustaining and propagating malignant disease, and, as such, are promising targets for therapy. Studies of human LSCs have served an important role in defining the major tenets of the cancer stem cell model, which centre on the frequencies of cancer stein cells, their potential hierarchical organisation and their degree of maturation. LSCs in acute myeloid leukaemia (AML) have recently been studied using mouse syngeneic models of leukaemia induced by MLL oncogenes. These studies have revealed that LSCs are more analogous to progenitor cells and employ embryonic stem cell-like genetic programmes for their maintenance, prompting a refinement of the original cancer stem cell model with important implications for design of therapies to selectively target LSCs. (c) 2009 Elsevier Ltd. All rights reserved.
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