Article
Medical Laboratory Technology
Caroline E. Franks, Jieli Li, Magen Martinez, Christopher W. Farnsworth, Patricia M. Jones, David G. Grenache, Qing H. Meng, Ann M. Gronowski
Summary: This study assessed the utility of 5 quantitative hCG immunoassays for use as tumor markers in trophoblastic and non-trophoblastic disease. Results suggest that all 5 immunoassays are adequate for using hCG as a tumor marker in gestational trophoblastic disease and select germ cell tumors. Further studies are needed to assess the utility of quantitative hCG as a tumor marker in other malignant diseases.
CLINICAL CHEMISTRY
(2023)
Article
Medical Laboratory Technology
Carel J. J. Pretorius, Urs Wilgen, Sandra Klingberg, Anna Zournazi, Linda Sanders, Jacobus P. J. Ungerer
Summary: We compared the diagnostic sensitivity of beta hCG with total hCG assays in testicular cancer patients. Discordant results were common, with isolated increases of hCGt observed in 15.7% of patients and beta hCG in 6.9% of patients. Primary hypogonadism was the most common cause of isolated hCGt increases. Beta hCG decreased more rapidly below its upper reference than hCGt after therapeutic interventions.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Chemistry, Analytical
Hatem Mohamed Elsheikh, Shadia Abdel-Hamid Fathy, Nahed Hassan Ebeid, Khaled Mohamed Sallam, Ahmed Sami El-bayoumy, Nagy Lahzy Mehany, Germine Mohsen Hamdy
Summary: The main objective of this study was to prepare and evaluate primary reagents for the liquid phase human chorionic gonadotropin-radioimmunoassay (HCG-RIA) kit. Polyclonal antibodies were found to be specific and valid, while monoclonal antibodies were more specific. The developed in-house HCG-RIA method showed high sensitivity, specificity, precision, and accuracy, making it suitable for quantifying HCG in human sera for pregnancy monitoring and diagnosis of gestational trophoblastic diseases.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Peripheral Vascular Disease
Ruijuan Wang, Li Chen, Xiaobing Wang, Yanjun Liu
Summary: The aberrant increase of circulating β-human chorionic gonadotropin (?-HCG) at early stages of pregnancy is associated with predicting gestational hypertension. Inflammatory and oxidative stress markers play a significant role in severe pregnancy-induced hypertension during the perinatal stage.
MICROVASCULAR RESEARCH
(2021)
Review
Obstetrics & Gynecology
Jin Peng, Shangge Lv, Lin Liu, Shuai Feng, Naidong Xing
Summary: This systematic review highlights the importance of considering paraneoplastic secretion of beta-HCG in patients with lung neoplasms and positive pregnancy tests. Early recognition and appropriate management can prevent delays in diagnosis and treatment of malignancies in young women.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Review
Oncology
Jennifer King, Nabil Adra, Lawrence H. Einhorn
Summary: Testicular cancer has a high cure rate, with most patients diagnosed at a young age. Research into survivorship issues and newer biomarkers among testicular cancer patients and survivors will continue to advance the field. Further therapeutic options are needed for patients who do not respond to standard treatments.
Article
Cell Biology
Ilaria Dando, Cristian Andres Carmona-Carmona, Nicola Zampieri
Summary: hCG is a hormone that binds to LHR and plays roles in pregnancy and tumor development. Studies have shown conflicting results on the role of hCG in cancer. In vitro experiments without serum showed that hCG could promote cell proliferation in breast cancer cell lines.
Article
Chemistry, Analytical
Xue Wang, Huanyuan Wang, Yingying Sun, Zhe Liu, Na Wang
Summary: This study presents a liquid crystal biosensor using Au nanoparticles for signal amplification to detect HCG antigen in a micro and cost-effective manner. The sensor utilizes the unique properties of LC for HCG detection, providing excellent sensitivity and low detection limits.
Article
Biochemistry & Molecular Biology
Clara Lazzaretti, Valentina Secco, Elia Paradiso, Samantha Sperduti, Claudia Rutz, Annika Kreuchwig, Gerd Krause, Manuela Simoni, Livio Casarini
Summary: The study focused on identifying key residues in LHCGR that are likely evolved in humans to discriminate between specific binding of LH and hCG. Mutations within the receptor's leucine reach repeat 9 and 10 were found to lead to loss of discrimination ability, resembling the modulation of Lhr-mediated signaling patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Kiwamu Noshiro, Takeshi Umazume, Rifumi Hattori, Soromon Kataoka, Takashi Yamada, Hidemichi Watari
Summary: This study found that serum ketone levels peak in the third trimester of pregnancy, but do not directly correlate with neonatal body shape. Weight loss during pregnancy may be related to morning sickness, with a higher pre-pregnancy body mass index leading to greater weight loss.
Article
Medicine, General & Internal
Ping Xiao, Tao Guo, Rutie Yin
Summary: Gestational trophoblastic neoplasia can be misdiagnosed as ectopic pregnancy, with common clinical manifestations including amenorrhea, abnormal vaginal bleeding, and abdominal pain. By conducting HCG testing, ultrasonography, and pathological analysis, the misdiagnosis rate can be reduced and timely treatment can be provided.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Hamideh P. Fallah, Maira S. Rodrigues, Maya Zanardini, Rafael H. Nobrega, Hamid R. Habibi
Summary: The study found that zGnih has a direct effect on spermatogenesis induced by both basal and gonadotropin (Lh and Fsh) in zebrafish testis. Specific concentrations of zGnih can significantly decrease the number of G0/G1 cells after 7 days in culture, with no significant impact on the proportion area of spermatogonia cell types. The research also revealed that zGnih reduces the proliferative activity of type A spermatogonia and increases the mitotic activity of type B spermatogonia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Jhon Fredy Narvaez Valderrama, Vanessa Correa Gil, Viviana B. Alzate, Edison Andres Tavera, Edgar Norena, Jazmin Porras, Juan Carlos Quintana-Castillo, Juan L. Jose Garcia, Francisco P. Jose Molina, Carlos Ramos-Contreras, Julio Bueno Sanchez
Summary: This study investigated the effects of airborne PAHs on hormone production in placental cells. The results showed that PAHs can decrease the levels of beta-hCG and progesterone, potentially leading to abnormal placental development and adverse pregnancy outcomes. This may be attributed to the role of PAHs as endocrine disruptors.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medical Laboratory Technology
Christopher J. Mattiello, Douglas F. Stickle
Summary: We used image analysis to characterize the dose vs response curve of a qualitative serum hCG lateral flow immunoassay, which helped us understand the transition from negative to positive. The results showed that the curve could be described by a simple hyperbola equation, which was useful for verifying the assay's performance characteristics.
CLINICA CHIMICA ACTA
(2023)
Article
Developmental Biology
Ngoc Bich Thi Tran, Thanh Ngoc Cao, Quoc Huy Vu Nguyen, Linh Giang Thi Truong, Linh Manh Tran, Thao Nguyen Tran Nguyen, Tam Minh Le
Summary: This study aimed to determine the predictive value of CA-125 in combination with serum beta-hCG and progesterone in the early detection of EP. The results showed significant differences in levels of CA-125, beta-hCG, and progesterone between the EP and IUP groups, and a combination of these markers had high sensitivity and specificity in the early diagnosis of EP (92.8% and 90.9%, respectively).
Review
Medical Laboratory Technology
Kati Rasanen, Outi Itkonen, Hannu Koistinen, Ulf-Hakan Stenman
CLINICAL CHEMISTRY
(2016)
Review
Medical Laboratory Technology
Ulf-Hakan Stenman
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Kati Rasanen, Elina Lehtinen, Kristiina Nokelainen, Teijo Kuopio, Laura Hautala, Outi Itkonen, Ulf-Hakan Stenman, Hannu Koistinen
MOLECULAR CARCINOGENESIS
(2016)
Article
Oncology
Sonja Lumme, Leena Tenkanen, Hilde Langseth, Randi Gislefoss, Matti Hakama, Par Stattin, Goran Hallmans, Herman Adlercreutz, Pekka Saikku, Ulf-Hakan Stenman, Pentti Tuohimaa, Tapio Luostarinen, Joakim Dillner
Article
Biochemistry & Molecular Biology
Hannu Koistinen, Erik Wallen, Henna Ylikangas, Kristian Meinander, Maija Lahtela-Kakkonen, Ale Narvanen, Ulf-Hakan Stenman
BIOLOGICAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Henna Ylikangas, Johanna M. Mattsson, Ulf-Hakan Stenman, Hannu Koistinen, Antti Poso, Maija Lahtela-Kakkonen
Article
Medical Laboratory Technology
Robert D. Nerenz, Melanie L. Yarbrough, Ulf-Hakan Stenman, Ann M. Gronowski
CLINICAL BIOCHEMISTRY
(2016)
Article
Endocrinology & Metabolism
And Demir, Raimo Voutilainen, Ulf-Hakan Stenman, Leo Dunkel, Kerstin Albertsson-Wikland, Ensio Norjavaara
HORMONE RESEARCH IN PAEDIATRICS
(2016)
Article
Public, Environmental & Occupational Health
Matti Hakama, Sue M. Moss, Ulf-Hakan Stenman, Monique J. Roobol, Marco Zappa, Sigrid Carlsson, Marco Randazzo, Vera Nelen, Jonas Hugosson
JOURNAL OF MEDICAL SCREENING
(2017)
Article
Obstetrics & Gynecology
Elina Keikkala, Sini Koskinen, Piia Vuorela, Hannele Laivuori, Jarkko Romppanen, Seppo Heinonen, Ulf-Hakan Stenman
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Cell Biology
Helene M. Markkanen, Tuula Pekkarinen, Esa Hamalainen, Matti J. Valimaki, Henrik Alfthan, Ulf-Hakan Stenman
GROWTH HORMONE & IGF RESEARCH
(2017)
Article
Medicine, General & Internal
P. Simonen, J. Lehtonen, A. -M. Lampi, V. Piironen, U. -H. Stenman, M. Kupari, H. Gylling
JOURNAL OF INTERNAL MEDICINE
(2018)
Article
Urology & Nephrology
Teemu J. Murtola, Anniina Virkku, Kirsi Talala, Ulf-Hakan Stenman, Kimmo Taari, Teuvo L. J. Tammela, Anssi Auvinen
JOURNAL OF UROLOGY
(2017)
Article
Obstetrics & Gynecology
Mariann Koel, Urmo Vosa, Kaarel Krjutskov, Elisabet Einarsdottir, Juha Kere, Juha Tapanainen, Shintaro Katayama, Sulev Ingerpuu, Viljar Jaks, Ulf-Hakan Stenman, Karolina Lundin, Timo Tuuri, Andres Salumets
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Article
Oncology
Jaakko Nevalainen, Ulf-Hakan Stenman, Teuvo L. Tammela, Monique Roobol, Sigrid Carlssone, Kirsi Talalag, Fritz H. Schroder, Anssi Auvinen
CANCER EPIDEMIOLOGY
(2017)
