Article
Medicine, General & Internal
Rachel D'Amico, Djhenne Dalmacy, Jenifer A. Akinduro, Madison Hyer, Stephen Thung, Shengyi Mao, Naleef Fareed, Seuli Bose-Brill
Summary: Gestational diabetes (GD) affects pregnancy and increases the risk of type 2 diabetes. The study aimed to explore how often individuals with GD access primary care and type 2 diabetes screening.
Review
Endocrinology & Metabolism
Lana R. Flachs Madsen, Stine Gerdoe-Kristensen, Jeannet Lauenborg, Peter Damm, Ulrik S. Kesmodel, Elsebeth Lynge
Summary: This article reviews the association between gestational diabetes mellitus (GDM) and other diseases, finding evidence of associations with kidney diseases and liver disease, particularly in women with postpartum type 2 diabetes mellitus (T2DM). The association with breast cancer has been extensively studied but with conflicting results. Limited and inconsistent results were found for other cancers and no studies were found on thyroid diseases or short-term/long-term mortality in women with a history of GDM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Tal Schiller, Oren Barak, Yael Winter Shafran, Miri Barak Sacagiu, Lee Cohen, Edi Vaisbuch, Taiba Zornitzki, Alena Kirzhner
Summary: Limited data exists on follow-up, treatment, and outcomes for women with prediabetes before or at the beginning of pregnancy. This study compared women with prediabetes to those with type 2 diabetes mellitus and found similar baseline characteristics, but delayed medical attention in the prediabetes group. The prediabetes group required less treatment for glycemic control and had lower glycosylated hemoglobin levels throughout pregnancy.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Soumyalekshmi Nair, Valeska Ormazabal, Flavio Carrion, Aase Handberg, H. David Mcintyre, Carlos Salomon
Summary: Extracellular vesicles (EVs) play important roles in cell communication and are crucial for regulating molecular cross-talk between different metabolic tissues, influencing insulin sensitivity in both healthy and gestational diabetes mellitus (GDM) pregnancies. The placenta has a vital role in metabolic regulation during pregnancy and placenta-mediated EV cross-talk serves as a central component in GDM pathophysiology. Targeting the placenta and using EVs as therapeutic agents show potential for improving insulin resistance and placental dysfunction in GDM.
Article
Medicine, General & Internal
Daniel Boron, Jakub Kornacki, Pawel Gutaj, Urszula Mantaj, Przemyslaw Wirstlein, Ewa Wender-Ozegowska
Summary: The study aimed to determine whether corin may be a predictor of preeclampsia (PE) in women with long-term pregestational diabetes (PGDM). The results of the study suggest that serum corin assessment may play a role in predicting preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Kaitlyn K. Stanhope, Naima T. Joseph, Marissa Platner, Ciara Hutchison, Shawn Wen, Adrienne Laboe, Katie Labgold, Denise J. Jamieson, Sheree L. Boulet
Summary: In a large public hospital, ICD-10 codes accurately identified cases of pregestational and gestational diabetes with low numbers of false positives.
Article
Peripheral Vascular Disease
Xinyun (Christie) Liang, Anamaria Savu, Deliwe Ngwezi, Sonia Butalia, Padma Kaul, Roseanne O. Yeung
Summary: This study assessed the association between maternal glucose levels in pregnancy and subsequent hypertension and found that increasing glucose levels were associated with an increased risk of hypertension.
Article
Obstetrics & Gynecology
Kartik K. Venkatesh, Xiaoning Huang, Natalie A. Cameron, Lucia C. Petito, Joshua Joseph, Mark B. Landon, William A. Grobman, Sadiya S. Khan
Summary: This study compared trends in pregestational and gestational diabetes in rural and urban areas in the USA and found that pregnant women in rural areas face unique challenges that contribute to disparities in adverse pregnancy outcomes. The frequency of diabetes increased in both rural and urban areas from 2011 to 2019, with rural areas having a higher risk. These findings have implications for delivering equitable diabetes care in pregnancy in rural US communities.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Biology
Karina dos Santos, Eliane Lopes Rosado, Ana Carolina Proenca da Fonseca, Gabriella Pinto Belfort, Leticia Barbosa Gabriel da Silva, Marcelo Ribeiro-Alves, Veronica Marques Zembrzuski, Mario Campos Jr., Lenita Zajdenverg, Michele Drehmer, J. Alfredo Martinez, Claudia Saunders
Summary: In a nutrigenetic trial in Rio de Janeiro, Brazil, the factors influencing hypertensive disorders of pregnancy (HDP) were analyzed. The study found that black skin color, previous preeclampsia, elevated blood pressure in the third trimester, elevated blood pressure in the first trimester, mean blood pressure, and high HbA1c level were significant risk factors for HDP. However, dietetic and genotypic features did not have a significant impact on the outcome.
Article
Endocrinology & Metabolism
Kaat Beunen, Lies Vercauter, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick van den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: This study aimed to characterize and evaluate the risk of long-term glucose intolerance in women with gestational diabetes mellitus (GDM) positive for type 1 diabetes-related autoimmune antibodies (T1D-related autoantibodies) in pregnancy. The results showed that women with autoantibodies had some adverse characteristics during pregnancy and in their newborns. Long-term follow-up revealed that some women developed glucose intolerance, but only a few still had autoantibodies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Veronika Lappe, Gregory Gordon Greiner, Ute Linnenkamp, Anja Viehmann, Heinke Adamczewski, Matthias Kaltheuner, Dietmar Weber, Ingrid Schubert, Andrea Icks
Summary: Screening rates for gestational diabetes mellitus (GDM) in Germany have increased from 40.2% in 2010 to 93.3% in 2020, while the prevalence has increased from 9.4% to 15.1% during the same period. However, the utilization of follow-up care remains low. Factors such as age, education level, insulin prescription, hypertension, and obesity are positively associated with participation in follow-up care.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Heidi Sormunen-Harju, Saila Koivusalo, Mika Gissler, Johanna Metsala
Summary: Maternal obesity is associated with an increased risk of pregnancy complications, and this risk further increases in the second pregnancy. Additionally, first-pregnancy complications can impact the risk of complications in the second pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Pediatrics
Vendula Bartakova, Beata Baratova, Katarina Chalasova, Petr Janku, Katerina Kankova
Summary: This study aimed to compare anthropometric and developmental abnormalities and/or morbidity in offspring of mothers with gestational diabetes mellitus (GDM) to control offspring. The study found that offspring of GDM mothers had delayed psychomotor development in early childhood, but caught up to the control group by 5 years of age. Children with macrosomia had a higher weight-for-height percentile and were more frequently ill than those with normal birth weight. Offspring of obese mothers had worse verbal language skills in early childhood and a higher weight-for-height percentile.
Article
Cardiac & Cardiovascular Systems
Victor J. M. Zeijen, Lida Feyz, Rajiv Nannan Panday, Kevin Veen, Jorie Versmissen, Isabella Kardys, Nicolas M. Van Mieghem, Joost Daemen
Summary: This study found that renal denervation can safely maintain long-term blood pressure-lowering effects for at least five years, with stable antihypertensive drug usage over time.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Oncology
Geert Spierenburg, Peter Grimison, Christine Chevreau, Silvia Stacchiotti, Sophie Piperno-Neumann, Axel Le Cesne, Virginia Ferraresi, Antoine Italiano, Florence Duffaud, Nicolas Penel, Severine Metzger, Sylvie Chabaud, Lizz van der Heijden, David Perol, Michiel A. J. van de Sande, Jean-Yves Blay, Hans Gelderblom
Summary: Long-term analysis of nilotinib for advanced D-TGCT showed approximately half of patients experienced progression and required additional treatment after 8.5 years, while some patients maintained disease control after limited treatment duration.
EUROPEAN JOURNAL OF CANCER
(2022)