☆ 4.5 Article

Organocatalytic asymmetric selenofunctionalization of tryptamine for the synthesis of hexahydropyrrolo[2,3-b]indole derivatives

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2013)

期刊

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

卷 9, 期 -, 页码 1559-1564

出版社

BEILSTEIN-INSTITUT

DOI: 10.3762/bjoc.9.177

关键词

catalysis; chiral phosphoric acid; hexahydropyrrolo[2,3-b]indole; indole alkaloids; natural products; selenofunctionalization

类别

Chemistry, Organic

资金

NSFC [21232007]
MOST (973 project) [2010CB833300]
Ministry of Education
CAS

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摘要

A chiral phosphoric acid-catalyzed selenofunctionalization of tryptamine derivatives provides access to 3a-(phenylselenyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole derivatives in high yields and with synthetically useful levels of enantioselectivity (up to 89% ee).

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