Article
Neurosciences
Giovanni Annona, Andrea Tarallo, Valeria Nittoli, Ettore Varricchio, Paolo Sordino, Salvatore D'Aniello, Marina Paolucci
Summary: Brief exposure to gallic acid (GA) induces motor neuron hyperexcitability in zebrafish, likely eliciting behavioral responses through activation of specific neural territories related to odor or chemical stimuli. The excessive excitability of neurons may involve additional signaling pathways, although the underlying molecular mechanisms remain to be elucidated. This suggests that GA acts as an excitatory molecule, capable of inducing specific nerve responses, providing a new perspective on its potential effects.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Physics, Applied
Youngbin Tchoe, Jihwan Lee, Ren Liu, Andrew M. Bourhis, Ritwik Vatsyayan, Karen J. Tonsfeldt, Shadi A. Dayeh
Summary: This review discusses nanoscale interfaces with biological tissue, specifically focusing on the electrochemical monitoring of neuronal activity. Findings include characteristics of nanoelectrode-neuron interfaces and recent advancements in the field.
APPLIED PHYSICS REVIEWS
(2021)
Article
Neurosciences
Marin Manuel
Summary: This study demonstrates that using incorrect DCC frequency for intracellular recordings may lead to an overestimation of cell excitability, underestimation of input resistance, and an artificial overestimation of cell firing. These effects are dependent on the membrane time constant of the recorded cell, requiring special attention especially in large cells with very short time constants.
Article
Neurosciences
Takahiro Aimi, Keiko Matsuda, Michisuke Yuzaki
Summary: Changes in neural activity induced by learning and novel environments can lead to the formation of new synapses in the adult brain. This study discovered that Purkinje cells in the cerebellum can be reinnervated by multiple climbing fibers through increased expression of the synaptic organizer C1ql1 or the receptor Bai3. The results indicate that C1ql1-Bai3 signaling, regulated by neuronal activity, may mediate climbing fiber synaptogenesis in mature Purkinje cells.
Article
Neurosciences
Jessica Di Re, Wei-Chun J. Hsu, Cihan B. Kayasandik, Nickolas Fularczyk, T. F. James, Miroslav N. Nenov, Pooran Negi, Mate Marosi, Federico Scala, Saurabh Prasad, Demetrio Labate, Fernanda Laezza
Summary: The axon initial segment (AIS) is a highly regulated subcellular domain necessary for neuronal firing, with changes in its protein composition and distribution influencing neuronal activity. This study focused on the AKT/GSK3 pathway and found that inhibition of AKT by triciribine had the greatest impact on beta IV spectrin localization and distribution within neurons, leading to increased excitability. These perturbations in signaling mechanisms within the AKT pathway may contribute to neuropsychiatric and neurodegenerative disorders by altering beta IV spectrin distribution and neuronal firing.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Andrew A. George, Jaime M. Vieira, Cameron Xavier-Jackson, Michael T. Gee, John R. Cirrito, Heather A. Bimonte-Nelson, Marina R. Picciotto, Ronald J. Lukas, Paul Whiteaker
Summary: This study reveals the molecular mechanism behind the subnucleus-specific alterations in BFCN excitability caused by the interaction between oAβ(42) and nAChR receptors, as well as confirms the important role of α7β2-nAChR in oAβ(42)-induced cognitive decline.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Katharina Sessler, Vivian Blechschmidt, Ulrich Hoheisel, Siegfried Mense, Lucas Schirmer, Rolf-Detlef Treede
Summary: Fractalkine signaling plays a critical role in the sensitization of dorsal horn neurons induced by repetitive nociceptive stimuli, suggesting it may be a potential target for preventing nonspecific, myofascial low back pain. Blocking fractalkine signaling with neutralizing antibodies prevents spinal sensitization, while intrathecal administration of fractalkine induces similar sensitization patterns as nociceptive stimuli.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Sonia Kartha, Prabesh Ghimire, Beth A. Winkelstein
Summary: Inhibiting spinal sPLA(2) at day 7 after neural injury abolishes behavioral sensitivity, reduces neuronal firing in the spinal cord, and restores neuronal phenotypes. Additionally, it increases intracellular glutamate concentrations and restores spinal expression of certain proteins to their uninjured levels. These findings suggest a role for spinal sPLA(2) in maintaining pain and central sensitization through modulation of glutamate excitotoxicity.
Article
Imaging Science & Photographic Technology
Mariana Potcoava, Donatella Contini, Zachary Zurawski, Spencer Huynh, Christopher Mann, Jonathan Art, Simon Alford
Summary: Light sheet microscopy in live cells requires minimal excitation intensity and resolves three-dimensional (3D) information rapidly. Lattice light sheet microscopy (LLSM) works similarly but uses a lattice configuration of Bessel beams to generate a flatter, diffraction-limited z-axis sheet suitable for investigating subcellular compartments, with better tissue penetration. We developed a LLSM method for investigating cellular properties of tissue in situ.
JOURNAL OF IMAGING
(2023)
