期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 9, 期 -, 页码 215-222出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.9.25
关键词
multivalent carbohydrates; LecA inhibition; phenylene ethynylene; rigid spacers; Sonogashira reaction
资金
- Dutch Technology Foundation STW
- applied science division of NWO
- Technology Program of the Ministry of Economic Affairs
- European fellowship under the ITN project Carmusys [FP7-MC-ITN-213592]
- COST Action [CM1102]
- Fundacio Credit Andorra
The synthesis of phenylene-ethynylene rods and their use as rigid spacers is described. Alternation of a Sonogashira reaction and silyl group cleavage was used to obtain rigid spacers with even and odd numbers of phenylene units. Preliminary applications of these rods in divalent systems are shown. Inhibition studies with Pseudomonas Aeruginosa lectin LecA showed that the rigid spacer proved greatly beneficial for the inhibitory potency.
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