Article
Behavioral Sciences
Hannah G. Sexton, Nathan A. Olszewski, Mary-Louise Risher
Summary: Adolescence is a period characterized by increased social behavior, risk taking, and novelty seeking. Exposure to chronic adolescent unpredictable stress can lead to maladaptive behaviors and increase susceptibility to alcohol and substance abuse. The PPAR gamma agonist rosiglitazone may be an effective therapeutic for attenuating certain risk taking and novelty seeking behaviors in females.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Ege Kingir, Cem Sevinc, Gunes Unal
Summary: Chronic oral ketamine prevents the reduction of daily activity and loss of desire caused by chronic unpredictable mild stress. This preventive effect is achieved by altering neuronal activation in the lateral habenula and nucleus accumbens shell.
Review
Neurosciences
Dmitrii D. Markov
Summary: Despite numerous studies, the etiological and pathophysiological mechanisms of depression are still poorly understood. Chronic unpredictable mild stress is the most commonly used model, while the sucrose preference test is commonly used for assessing anhedonia. However, the reproducibility of the model and the relationship between animal and human anhedonia need further investigation.
Article
Behavioral Sciences
Maria Camila Acero-Castillo, Maria Camila Ardila-Figueroa, Silvia Botelho de Oliveira
Summary: The study evaluated the effect of Chronic Social Isolation (CSI) on male Wistar rats, showing that exposure to CSI leads to anhedonic-type behavior and an anxiogenic profile. It was also demonstrated that resocialization does not reverse these behaviors.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Fenfang Tian, Dan Liu, Jin Chen, Wei Liao, Weibo Gong, Rongzhong Huang, Liang Xie, Faping Yi, Jian Zhou
Summary: The study explored the impact of chronic stress on pituitary protein expression in rats, identifying specific proteins linked to susceptibility to depression, anxiety, and resilience. This research provides important insights into the neurochemical mechanisms underlying vulnerability and resistance to stress-induced anxiety or depression.
FRONTIERS IN GENETICS
(2021)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Multidisciplinary Sciences
Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Hilda Amekyeh, Benjamin Kingsley Harley, Augustine Tandoh, Prince Dagadu Okyere, Eric Woode
Summary: The hydroethanolic leaf extract of Pseudospondias microcarpa has a significant antidepressant-like effect and can reverse behavioral changes induced by chronic mild stress.
Article
Cell Biology
Francesca Marchisella, Kerstin Camile Creutzberg, Veronica Begni, Alice Sanson, Luis Eduardo Wearick-Silva, Saulo Gantes Tractenberg, Rodrigo Orso, Erika Kestering-Ferreira, Rodrigo Grassi-Oliveira, Marco Andrea Riva
Summary: Epidemiological studies have shown that environmental insults and maternal stress during pregnancy increase the risk of several psychiatric disorders in the offspring. Converging lines of evidence from humans, as well as from rodent models, suggest that prenatal stress (PNS) interferes with fetal development, ultimately determining changes in brain maturation and function that may lead to the onset of neuropsychiatric disorders. From a molecular standpoint, transcriptional alterations are thought to play a major role in this context and may contribute to the behavioral phenotype by shifting the expression of genes related to excitatory and inhibitory (E/I) transmission balance. Nevertheless, the exact neurophysiological mechanisms underlying the enhanced vulnerability to psychopathology following PNS exposure are not well understood. In the present study, we used a model of maternal stress in rats to investigate the distal effects of PNS on the expression of genes related to glutamatergic and GABAergic neurotransmissions. We inspected two critical brain regions involved in emotion regulation, namely, the prefrontal cortex (PFC) and the amygdala (AMY), which we show to relate with the mild behavioral effects detected in adult rat offspring. We observed that PNS exposure promotes E/I imbalance in the PFC of adult males only, by dysregulating the expression of glutamatergic-related genes. Moreover, such an effect is accompanied by increased expression of the activity-dependent synaptic modulator gene Npas4 specifically in the PFC parvalbumin (PV)-positive interneurons, suggesting an altered regulation of synapse formation promoting higher PV-dependent inhibitory transmission and increased overall circuit inhibition in the PFC of males. In the AMY, PNS more evidently affects the transcription of GABAergic-related genes, shifting the balance toward inhibition. Collectively, our findings suggest that the E/I dysregulation of the PFC-to-AMY transmission may be a long-term signature of PNS and may contribute to increase the risk for mood disorder upon further stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Psychiatry
Jiawen Huang, Chongkun Shen, Ran Ye, Yafei Shi, Weirong Li
Summary: The study evaluated depression behavior in female adult SD rats by combining early maternal separation (MS) and adolescent chronic unpredictable mild stress (CUMS). Rats in the MS+CUMS group showed more severe depression-like and anxiety-like behaviors compared to the MS group, possibly due to impaired synaptic plasticity. Additionally, fewer neurons and downregulated synaptic protein expressions were observed in the hippocampus of rats in the MS+CUMS group.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Chen Meng, Siyuan Feng, Zikai Hao, Chen Dong, Hong Liu
Summary: The study revealed that exposure to antibiotics could lead to reduced body weight and liver health in rats under chronic unpredictable mild stress, alleviate anxiety and depression-like behaviors, and cause changes in the composition of gut microbiota. Additionally, short-term antibiotics exposure increased the level of 5-hydroxytryptamine in the brain.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Corey A. Calhoun, Christine Lattouf, Victoria Lewis, Heidi Barrientos, S. Tiffany Donaldson
Summary: This study used female Long-Evans rats bred for high and low anxiety-like behavior to investigate the relationship between anxiety and depression. The results showed that high anxiety rats exhibited more swimming and less floating behavior in the forced swim test, and had lower body weight. Additionally, after chronic mild stress, high anxiety rats showed increased mobility and decreased food consumption.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Janine V. Olthuis, Kara Thompson, Margo C. Watt, Sherry H. Stewart
Summary: High anxiety sensitivity (AS) is associated with functional impairment through a chained indirect pathway involving anxiety symptoms and depression symptoms, but not through unhealthy coping behaviours. This cross-sectional study highlights the importance of reducing AS and addressing depressive symptoms for improving clients' functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Weibo Gong, Wei Liao, Chui Fang, Yanchen Liu, Hong Xie, Faping Yi, Rongzhong Huang, Lixiang Wang, Jian Zhou
Summary: Chronic stress leads to hyperactivity of the HPA axis in depression and anxiety, but the common and unique molecular dysregulations have not been well-explored. Proteomic analysis identified dysregulated proteins potentially associated with vulnerability and adaptability to stress-induced depression or anxiety in different groups. The findings suggest that the regulation system of the rat hypothalamic proteome is differently affected by the same chronic stress.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Psychology, Biological
Mirna Guadalupe Martinez-Damas, Alma Delia Genis-Mendoza, Veronica Perez-de la Cruz, Gabriel Daniel Canela-Tellez, Ismael Jimenez-Estrada, Jose Humberto Nicolini-Sanchez, Lucio Antonio Ramos-Chavez, Silvia Garcia, Magally Ramirez-Ramirez, Ramon Mauricio Coral-Vazquez
Summary: Studies suggest that flavonoid-rich cocoa products, such as (-)-Epicatechin (Epi), can reduce anxiety and depression symptoms. This study aimed to evaluate the impact of Epi on resilience to depression-like behavior in a murine model, finding that Epi could induce resilience to stress-induced depression in mice. Additionally, the study proposes that muscle response to Epi treatment may be influenced by metabolism type and kynurenine aminotransferases (KATs) could play a role in modulating this response.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Public, Environmental & Occupational Health
Md. Reza-A Rabby, Md. Saiful Islam, Maisha Tahsin Orthy, Ahmad Tousif Jami, M. Tasdik Hasan
Summary: This study aimed to assess the prevalence and associated factors of depression symptoms, anxiety, and stress among undergraduate entrance admission-seeking students in Bangladesh. The results showed a high prevalence of depression, anxiety, and stress symptoms, calling for in-depth exploratory investigations and the design of adequate low-intensity interventions to support this young population.
FRONTIERS IN PUBLIC HEALTH
(2023)