Review
Biochemistry & Molecular Biology
Xin Liu, Shao-Jun Tang
Summary: This review aims to summarize the pathology and associated factors of chronic pain among individuals with HIV infection. Research suggests that viral proteins and antiretroviral drugs play a critical role in the interactions between neurons, glial cells, and non-neural cells.
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Amandine Bernard, Flavien Bessaguet, Simon Frachet, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Claire Demiot, Aurore Danigo
Summary: Ramipril has the potential to prevent paclitaxel-induced peripheral neuropathy, and the neuroprotective role of ramipril in this condition is mediated through the involvement of the AT2 receptor.
Article
Multidisciplinary Sciences
Tinei Shamu, Cleophas Chimbetete, Matthias Egger, Tinashe Mudzviti
Summary: This study investigated OPLHIV patients aged 50 and above receiving ART in sub-Saharan Africa, finding high prevalence of hypertension as a common comorbidity, with being unmarried or unemployed being significant predictors of mortality, while better immune competence was protective against mortality.
Article
Biochemistry & Molecular Biology
David a. Karadi, Anna Rita Galambos, Peter P. Lakatos, Joost Apenberg, Sarah K. Abbood, Mihaly Balogh, Kornel Kiraly, Pal Riba, Nariman Essmat, Edina Szucs, Sandor Benyhe, Zoltan V. Varga, Eva Szoko, Tamas Tabi, Mahmoud Al-Khrasani
Summary: The study investigates the antiallodynic effect of telmisartan and losartan, two AT1 blockers, in combination with morphine for neuropathic pain management. The combination therapy shows promising results in improving pain and delaying morphine tolerance development. Further studies are needed to analyze the effect of each component in the combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Kaitlyn E. Egan, Gregory M. Caldwell, Maxim S. Eckmann
Summary: This article is a systematic review of epidemiologic, diagnostic, and therapeutic advancements in human immunodeficiency virus-associated peripheral neuropathy from 2018 to 2020. The recent findings discuss the epidemiology/pathology of HIV neuropathy, diagnostics, and therapeutic interventions.
CURRENT PAIN AND HEADACHE REPORTS
(2021)
Article
Clinical Neurology
Harriet I. Kemp, Jan Vollert, Nicholas W. S. Davies, Graeme J. Moyle, Andrew S. C. Rice
Summary: This study explores the differences in self-reported pain measures between different sensory phenotypes and suggests the potential for stratification trials and targeted therapy in HIV patients.
Article
Biochemistry & Molecular Biology
Michal Klazas, Majdi Saleem Naamneh, Wenhua Zheng, Philip Lazarovici
Summary: The study aimed to investigate the protective effect of gabapentin on Taxol-induced peripheral neuropathy and its impact on intra-epidermal nerve fibers density.
Review
Pediatrics
Julie Jesson, Laura Saint -Lary, Marc Harris Dassi Tchoupa Revegue, John O'Rourke, Claire L. Townsend, Francoise Renaud, Martina Penazzato, Valeriane Leroy
Summary: Abacavir has been shown to be an effective and safe first-line treatment option for infants and children living with HIV, with rare toxic effects and manageable adverse reactions.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Immunology
Ioannis Nikolaidis, Maria-Valeria Karakasi, Christos Bakirtzis, Lemonia Skoura, Dimitrios Pilalas, Marina-Kleopatra Boziki, Olga Tsachouridou, Polychronis Voultsos, Pavlos Nikolaidis, Panagiotis Gargalianos-Kakoliris, Michail Daniilidis, Nikolaos Grigoriadis, Symeon Metallidis, Nikolaos Taskos
Summary: Peripheral neuropathy is common among HIV-positive individuals, with a prevalence of 35.9%. It is associated with age, gender, and disease staging. Antiretroviral therapy does not affect the incidence. Early screening is recommended for HIV patients.
INTERNATIONAL JOURNAL OF STD & AIDS
(2022)
Article
Chemistry, Medicinal
Haritha Pasupulati, Satyanarayana S. V. Padi, Bharathi Koganti, Prasad V. S. R. G. Koganti
Summary: Curcumin administration alleviated paclitaxel-induced nociceptive hypersensitivity in rats by reducing thermal hyperalgesia and mechanical allodynia, possibly through the reduction of pro-inflammatory cytokines and oxidative stress. This study suggests the potential therapeutic effects of curcumin as an antinociceptive agent in the management of paclitaxel-induced neuropathic pain, warranting further clinical studies.
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH
(2021)
Review
Neurosciences
Esraa Aly, Willias Masocha
Summary: HIV infection and antiretroviral therapy can induce HIV-associated neuropathic pain. Cannabis and endocannabinoids may alleviate HIV-NP by acting on cannabinoid receptors. More research is needed to explore non-psychoactive drugs targeting the endocannabinoid system for HIV-NP treatment options.
IBRO NEUROSCIENCE REPORTS
(2021)
Article
Health Policy & Services
Harriet I. Kemp, Donna L. Kennedy, Jan Vollert, Nicholas W. S. Davies, Whitney Scott, Andrew S. C. Rice
Summary: This study investigates the relationship between chronic pain and cognitive impairment in HIV patients, and finds a potential association between chronic pain and cognitive dysfunction. Additionally, differences in pain characteristics are observed between patients with and without cognitive impairment.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Immunology
David M. MacDonald, Gary Collins, Chris H. Wendt, Julian Wolfson, Russell P. Tracy, Frank Rhame, Steven Deeks, Stacey A. Rizza, Zelalem Temesgen, Caryn Morse, Angelike P. Liappis, Irini Sereti, Jason Baker, Ken M. Kunisaki
Summary: The study did not find a beneficial effect of losartan on pneumoprotein concentrations in people living with HIV, but individuals with higher CD4+ counts may experience an improvement in SPD concentration when treated with losartan.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2022)
Article
Infectious Diseases
Abdulsalam M. Yakasai, Sonill Maharaj, Musa S. Danazumi
Summary: This study evaluated the effects of a strength exercise intervention on balance impairment and gait disturbance in individuals living with HIV-associated DSPN. The results showed significant improvement in balance performance and walking ability in the training group, suggesting that strength exercise is beneficial for neuropathy-related balance impairment and gait disturbance in persons living with HIV.
SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE
(2021)
Article
Clinical Neurology
Ashley A. Takeshita, Bruce D. Hammock, Karen M. Wagner
Summary: Chemotherapy induced peripheral neuropathy (CIPN) is a stubborn form of neuropathy, with associated pain as the primary limiting factor in chemotherapy treatment. CIPN is prevalent and can persist long after treatment. The COVID-19 pandemic has added psychological pressures and challenges in providing analgesia for cancer patients.
FRONTIERS IN PAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Thomas S. W. Park, Nemat Khan, Andy Kuo, Janet R. Nicholson, Laura Corradini, Maree T. Smith
Summary: The study characterized a chronic low back pain rat model and found increased expression of somatostatin in the lumbar dorsal root ganglia and spinal cord, indicating a potential role in modulating chronic mechanical lower back pain.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Instruments & Instrumentation
Weizhi Xu, Zonglan Zhao, James Falconer, Andrew K. Whittaker, Amirali Popat, Maree T. Smith, Tushar Kumeria, Felicity Y. Han
Summary: The study found that using a large scCO(2) vessel increased the encapsulation efficiency of ketamine, while pre-loading ketamine into pSi also slightly improved the drug incorporation level. Additionally, the use of a large scCO(2) vessel reduced burst release and extended the release period for PLGA microparticles containing ketamine.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Felicity Y. Han, David A. Brockman, Janet R. Nicholson, Laura Corradini, Maree T. Smith
Summary: The study characterized the chronic phase of the MIA-induced rat model of knee joint OA pain using pharmacological methods. Findings showed that gabapentin and morphine were effective in alleviating OA pain, while amitriptyline and meloxicam were not, consistent with prior research.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Behavioral Sciences
Felicity Y. Han, David A. Brockman, Janet R. Nicholson, Laura Corradini, Maree Therese Smith
Summary: Diabetic ketoacidosis (DKA) is a severe complication of diabetes characterized by insulin deficiency and elevated blood glucose levels. It can lead to significant metabolic disturbances and organ damage, including heart muscle, kidney, and neurological impairment, and can even be life-threatening.
BEHAVIOURAL PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Maree T. Smith, Dehui Kong, Andy Kuo, Mohammad Z. Imam, Craig M. Williams
Summary: This article discusses the limitations and problems associated with strong opioid analgesics and describes international efforts to discover new and safer opioids. It focuses on medicinal chemistry strategies using structurally diverse compounds derived from natural sources as lead molecules and elaborates on the current research status and approaches in the discovery of novel opioid ligands that retain analgesic effects with improved safety and reduced adverse effects, particularly addiction liability.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Minze Zhu, Andrew K. Whittaker, Felicity Y. Han, Maree T. Smith
Summary: Biodegradable polymers have been used as carriers in drug delivery systems for over four decades. They have applications at different scales, from macroscale to nanoscale. These materials have been approved for human use and achieved commercial success. Current research focuses on developing new formulation types for improved drug delivery.
APPLIED SCIENCES-BASEL
(2022)
Article
Instruments & Instrumentation
Weizhi Xu, Faheem Maqbool, Vinod Kumar, James R. Falconer, Cedric S. Cui, Trent M. Woodruff, Karin Borges, Andrew K. Whittaker, Maree T. Smith, Felicity Y. Han
Summary: A sustained-release formulation of ketamine, known as KSL, was developed with high loading and demonstrated prolonged release in mice after intravenous administration. The formulation showed high encapsulation efficiency and drug loading, achieving 100% release in vitro within 8 hours.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dehui Kong, Alaa A. Saqer, Matheus Carpinelli de Jesus, Nemat Khan, Alun Jones, Joanne T. Blanchfield, Maree T. Smith, Craig M. Williams
Summary: Multiple sclerosis-associated central neuropathic pain (MS-CNP) is difficult to alleviate and requires novel treatments. A study found that (R)-alpha lipoic acid (ALA) may have pain relief efficacy, but with poor oral bioavailability. By designing and synthesizing biocompatible ester prodrugs of (R)-ALA, a promising candidate (PD-ALA4 HCl salt) was identified.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Anesthesiology
Maree T. Smith
Article
Pharmacology & Pharmacy
Mohammad Zafar Imam, Andy Kuo, Sussan Ghassabian, Yunxin Cai, Yajuan Qin, Tingyou Li, Maree T. Smith
Summary: CYX-5 is a novel opioid peptide that acts as a G-protein biassed MOP receptor agonist, DOP receptor antagonist, and KOP receptor agonist. It provides pain relief, reduces stool output, and does not cause respiratory depression. The mechanism underlying its constipation effect may involve factors other than beta-arrestin2 recruitment.
PHARMACOLOGICAL REPORTS
(2023)
Review
Oncology
A. E. Smith, A. Muralidharan, M. T. Smith
Summary: Metastatic spread of prostate cancer to the skeleton may result in debilitating bone pain. This review discusses the mechanisms underlying the pathobiology of metastatic prostate cancer induced bone pain and reviews current treatment modalities and pain responses in clinical trials.
Letter
Pharmacology & Pharmacy
Mohammad Zafar Imam, Sussan Ghassabian, Andy Kuo, Yunxin Cai, Yajuan Qin, Tingyou Li, Maree T. Smith
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2023)
Article
Chemistry, Medicinal
Maree T. Smith, Dehui Kong, Andy Kuo, Mohammad Z. Imam, Craig M. Williams
Summary: The opioid crisis has increased the demand for novel opioid analgesics that have superior profiles compared to morphine. This Perspective reviews and discusses the multitargeted opioid ligand strategy for discovering such analgesics. Dual-targeted mu-opioid/delta-opioid (MOP/DOP) ligands with strong DOP antagonist potency and without DOP or kappa-opioid (KOP) agonist activity are promising candidates. Dual-targeted MOP/NOP partial agonists also show potential. The pharmacologic template of cebranopadol, a full agonist at MOP, DOP, and NOP receptors, and a partial agonist at KOP receptor, should be avoided due to its poor therapeutic indices.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Chen Chen, Maree T. Smith
Summary: Chronic pain is a common health problem that is difficult to adequately treat. Recent research suggests that the NLRP3 inflammasome plays a significant role in the pathophysiology of chronic pain, particularly in neuropathic and inflammatory pain conditions.
INFLAMMOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Weizhi Xu, Vinod Kumar, Cedric S. Cui, Xaria X. Li, Andrew K. Whittaker, Zhi Ping Xu, Maree T. Smith, Trent M. Woodruff, Felicity Y. Han
Summary: This study demonstrates the use of poly(lactic-co-glycolic) acid nanoparticles to enhance the oral bioavailability and therapeutic potential of cyclic hexapeptide complement C5a receptor 1 antagonists. The nanoparticles not only facilitate prolonged release of the encapsulated peptide, but also significantly increase its oral bioavailability and pharmacological activity in vivo.
ADVANCED THERAPEUTICS
(2022)