Article
Neurosciences
Shole Jamali, Shahram Zarrabian, Abbas Haghparast
Summary: The study demonstrated that Orx1Rs in the mPFC regulate the reward-related effects of morphine- and food-induced reward behaviors.
Article
Neurosciences
Darrell Eacret, Crystal Lemchi, Jasmine I. Caulfield, Sonia A. Cavigelli, Sigrid C. Veasey, Julie A. Blendy
Summary: This study investigates the influence of chronic short sleep on opioid reward using a mouse model. The results show that recovery sleep after chronic sleep disruption lessens voluntary opioid intake, but does not affect conditioned reward associated with morphine.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Cesar Huerta, Raul G. Paredes, Teresa Morales, Mario Daniel Caba-Flores, Enrique Meza, Mario Caba
Summary: This study aims to establish whether rabbits can be conditioned using CPP protocol by conducting experiments with caloric restriction. It demonstrates for the first time that rabbits can be conditioned using CPP paradigm through food-induced place preference, opening up new opportunities to study positive affective states in a species with important behavioral and physiological differences from rodents.
Article
Neurosciences
Wei Xu, Yuman He, Jiamei Zhang, Hongchun Li, Xuemei Wan, Menglu Li, Yonghai Wang, Rui Xu, Haoluo Zhang, Yanping Dai, Haxiaoyu Liu, Linhong Jiang, Ying Zhao, Xiaobo Cen
Summary: The study demonstrates that simvastatin can prevent the reinstatement of cocaine-induced conditioned place preference without affecting its acquisition, likely due to its administration during extinction phase. Lipidomic analysis reveals that the nucleus accumbens is the most affected brain region by simvastatin, with alterations in fatty acids, phospholipids, and triacylglycerol metabolism. Simvastatin reverses most effects on phospholipids induced by cocaine and reshapes lipid metabolic pathways in specific brain regions, ultimately facilitating cocaine extinction and preventing relapse.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Adel Kashefi, Carlos Tomaz, Shole Jamali, Ali Rashidy-Pour, Abbas Ali Vafaei, Abbas Haghparast
Summary: The study showed that CBD administration had a significant impact on extinction and reinstatement of MPH-induced conditioning place preference (CPP) in rats, suggesting its potential as a method to alleviate symptoms of drug addiction.
BRAIN RESEARCH BULLETIN
(2021)
Article
Cell Biology
Justin N. Siemian, Miguel A. Arenivar, Sarah Sarsfield, Cara B. Borja, Charity N. Russell, Yeka Aponte
Summary: Research shows that a subpopulation of LH GABAergic neurons expressing leptin receptors specifically drives appetitive behaviors in mice, while their ablation does not affect weight gain and food intake. Both groups of neurons in the LH can modulate reward-related behaviors, but only LHVGAT neurons impact feeding, and LHLEPR neurons can discriminate conditioned cues in Pavlovian paradigms.
Article
Behavioral Sciences
Mahsa Anooshe, Kiana Nouri, Saeideh Karimi-Haghighi, Zahra Mousavi, Abbas Haghparast
Summary: The study found that Cannabidiol (CBD) has an inhibitory effect on Methamphetamine-induced conditioned place preference, with a more potent impact in the acquisition phase. This suggests that CBD could be a beneficial compound for treating drug abuse, but further research is needed to fully understand its effectiveness.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Ferdos Zamanirad, Mojdeh Fattahi, Haleh Amirteymori, Zahra Mousavi, Abbas Haghparast
Summary: Targeting the orexin system, particularly in the ventral tegmental area (VTA), has been shown to be a promising approach for treating drug addiction. Modulating the orexin system in the VTA can facilitate the extinction process of drug-related memories and prevent their relapse.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Behavioral Sciences
Archana Durairaja, Ceylan-Scarlett Steinecke, Markus Fendt
Summary: The study found that orexin 1 receptor antagonist impairs cognitive flexibility in a sex-dependent manner, affecting females more than males. Consumption of the reward used in the ASST was not affected by the antagonist, indicating a specific impact on cognitive flexibility rather than reward response.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Saurabh S. Kokane, Brandon D. Butler, Josimar Hernandez Antonio, Ross J. Armant, Adam C. Hoch, Clinton S. Coelho, Blake N. Brady, Houda H. Chamseddine, Linda I. Perrotti
Summary: Women show a faster progression, increased consumption, more positive subjective effects, and higher relapse rates during abstinence in cocaine addiction. Estradiol is a key mediator of these effects, and ERK1/2 and mTOR play a role in the underlying neurobiological mechanisms.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Neurosciences
Sunny Zhihong Jiang, Sean Sweat, Sam P. Dahlke, Kathleen Loane, Gunner Drossel, Wenqin Xu, Hugo A. Tejeda, Charles R. Gerfen, Lee E. Eiden
Summary: The study reveals the crucial role of NCS-Rapgef2 signaling to ERK in dopamine D1 receptor-expressing neurons of the NAc in cocaine-induced locomotor sensitization and conditioned place preference, while showing no impact in corticolimbic areas. Ablation of cocaine-dependent ERK activation by eliminating NCS-Rapgef2 suggests a new cAMP-dependent signaling pathway for cocaine-induced behavioral adaptations independent of PKA/CREB signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Olga Rodriguez-Borillo, Lorena Rosello-Jimenez, Julian Guarque-Chabrera, Maria Palau-Batet, Isis Gil-Miravet, Raul Pastor, Marta Miquel, Laura Font
Summary: After cocaine exposure, increased cFos activity was observed in the granular cell layer at the top of the posterior vermis (lobules VIII and IX) in mice, and this activity was positively correlated with cFos expression in the medial prefrontal cortex. These findings suggest that certain regions of the cerebellum may be involved in the regulation of cocaine-conditioned behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Psychiatry
Arash Khanegheini, Masoumeh Khani, Shahram Zarrabian, Shahrokh Yousefzadeh-Chabok, Behrooz Khakpour Taleghani, Abbas Haghparast
Summary: The study looked at the potential interaction between CBD and METH during the sensitization phase on the rewarding effect of METH, with results indicating that CBD may reduce the motivation for METH seeking. Additionally, the study found that prior exposure to METH and the use of CBD could create sensitization to METH CPP even at sub-threshold doses of METH.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Laila Asth, Lia P. Iglesias, Rayssa C. Brianis, Anna P. Marcal, Nicia P. Soares, Daniele C. Aguiar, Fabricio A. Moreira
Summary: This study examined the effects of monoamine stabilizers and aripiprazole on cocaine-induced behaviors. The results showed that aripiprazole could prevent cocaine-induced hyperlocomotion, but also impaired spontaneous locomotion, while (-)-OSU6162 had a minor effect. (-)-OSU6162 also played a role in preventing the acquisition of cocaine-induced conditioned place preference.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Review
Behavioral Sciences
E. Theresa Bjorness, W. Robert Greene
Summary: Dopamine, orexin, and adenosine systems play dual roles in reward and sleep/arousal. Drug abuse may influence both reward and sleep/arousal mechanisms. Cocaine can cause acute sleep loss and abnormal recovery patterns under chronic exposure conditions. Experimentally induced sleep disturbance may increase cocaine seeking behavior.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biochemical Research Methods
Anand Joshi, Brian Parris, Yongzhen Liu, Christian Heidbreder, Phillip M. Gerk, Matthew Halquist
BIOMEDICAL CHROMATOGRAPHY
(2017)
Article
Pharmacology & Pharmacy
Anand Joshi, Matthew Halquist, Zacharoula Konsoula, Yongzhen Liu, J. P. Jones, Christian Heidbreder, Phillip M. Gerk
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2017)
Article
Medicine, Research & Experimental
Walter Ling, Vijay R. Nadipelli, Naoko A. Ronquest, Victoria A. Albright, Arnie P. Aldridge, Susan M. Learned, Vishaal Mehrad, Christian Heidbreder
CONTEMPORARY CLINICAL TRIALS
(2019)
Article
Substance Abuse
Walter Ling, Vijay R. Nadipelli, Caitlyn T. Solem, Naoko A. Ronquest, Yu-Chen Yeh, Susan M. Learned, Vishaal Mehra, Christian Heidbreder
JOURNAL OF ADDICTION MEDICINE
(2019)
Article
Medicine, General & Internal
Barbara R. Haight, Susan M. Learned, Celine M. Laffont, Paul J. Fudala, Yue Zhao, Amanda S. Garofalo, Mark K. Greenwald, Vijay R. Nadipelli, Walter Ling, Christian Heidbreder, James L. Andersen, Genie L. Bailey, Scott Robert Bartley, Michael J. Biunno, Brent Boyett, Jesse M. Carr, Eduardo Cifuentes, Sandra Daniela Duarte-Sckell, Otto R. Dueno, Boyde J. Harrison, David R. Hassman, Kent Steven Hoffman, Valentin Isacesu, Saleem Ishaque, Rishi Kakar, Kyle Kampman, Richard D. Knapp, George Konis, Jelena Kunovac, Joseph A. Kwentus, Lawrence S. Levinson, Shishuka Malhotra, Vishaal Mehra, Ricky Stuart Mofsen, Marvin Lane Peyton, Gita G. Pujari, Rakesh Ranjan, Daniel Rutrick, Gregory Seal, Scott Daniel Segal, Rajinder Shiwach, Haydn Mikel Thomas, Peter Paul Ventre, Amit K. Vijapura, David P. Walling, Katharina L. Wiest
Article
Pharmacology & Pharmacy
Anne Andorn, Jay Graham, John Csernansky, John W. Newcomer, Sunita Shinde, Gilbert Muma, Christian Heidbreder, Maurizio Fava
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2019)
Article
Medicine, General & Internal
Rahul Dhanda, Della Varghese, Vijay R. Nadipelli, Maurizio Fava, Namita Joshi, Caitlyn T. Solem, James A. Graham, Susan M. Learned, Christian Heidbreder
PATIENT PREFERENCE AND ADHERENCE
(2019)
Article
Substance Abuse
Walter Ling, Vijay R. Nadipelli, Arnie P. Aldridge, Naoko A. Ronquest, Caitlyn T. Solem, Howard Chilcoat, Victoria Albright, Courtney Johnson, Susan M. Learned, Vishaal Mehra, Christian Heidbreder
JOURNAL OF ADDICTION MEDICINE
(2020)
Article
Substance Abuse
Brent Boyett, Katharina Wiest, Lori D. McLeod, Lauren M. Nelson, Warren K. Bickel, Susan M. Learned, Christian Heidbreder, Paul J. Fudala, Anne Le Moigne, Yue Zhao
Summary: The psychometric evaluation of the OC-VAS on a large OUD patient population provides evidence supporting its use in measuring the severity of opioid craving and predicting opioid use.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Pharmacology & Pharmacy
Celine M. Laffont, Eliford Ngaimisi, Mathangi Gopalakrishnan, Vijay Ivaturi, Malcolm Young, Mark K. Greenwald, Christian Heidbreder
Summary: This study analyzes the relationship between buprenorphine plasma exposure and clinical efficacy in individuals with opioid use disorder (OUD). The findings suggest that maintaining buprenorphine plasma concentrations at 2-3 ng/ml optimizes treatment outcomes in most patients, while certain subgroups may require higher concentrations. The study also identifies demographic, genetic, and social factors that modulate treatment response and retention.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Substance Abuse
Christian Heidbreder, Paul J. Fudala, Mark K. Greenwald
Summary: This article reviews the discovery and early development stages of buprenorphine, the key steps that led to its approval as a drug product, and the regulatory approval of several buprenorphine-based medications for the treatment of opioid use disorder. The article discusses the progressive improvements in availability and efficacy of opioid use disorder treatment through regulatory and policy evolution, while also highlighting the challenges that still exist in improving treatment quality, integrating treatment into routine care and reducing disparities in access to treatment.
DRUG AND ALCOHOL DEPENDENCE REPORTS
(2023)
Article
Pharmacology & Pharmacy
Anne C. Andorn, Barbara R. Haight, Sunita Shinde, Paul J. Fudala, Yue Zhao, Christian Heidbreder, Susan M. Learned, Norma Lynn Fox, Vijay R. Nadipelli, David Hassman, Daniel Rutrick
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2020)
Article
Psychology, Clinical
Walter Ling, Vijay R. Nadipelli, Caitlyn T. Solem, Naoko A. Ronquest, Yu-Chen Yeh, Susan M. Learned, Vishaal Mehra, Christian Heidbreder
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2020)
Article
Substance Abuse
Walter Ling, Vijay R. Nadipelli, Caitlyn T. Solem, David Farabee, Naoko A. Ronquest, Brian Perrochet, Susan M. Learned, Chinmay G. Deshpande, Christian Heidbreder
SUBSTANCE ABUSE AND REHABILITATION
(2019)
Article
Pharmacology & Pharmacy
Vijay Ivaturi, Mathangi Gopalakrishnan, Jogarao V. S. Gobburu, Weiyan Zhang, Yongzhen Liu, Christian Heidbreder, Celine M. Laffont
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2017)