Article
Biochemistry & Molecular Biology
Miriam Gonzalez-Gomez, Ricardo Reyes, Ma del Carmen Damas-Hernandez, Xiomara Plasencia-Cruz, Ibrahim Gonzalez-Marrero, Rafael Alonso, Aixa R. Bello
Summary: The study found that prolonged exposure to the environmental estrogenic substance bisphenol-A (BPA) can negatively affect the reproductive axis, resulting in accelerated sexual maturation and a shorter fertile life in offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Rosa Ventura-Martinez, Jose Jesus Mares-Sanchez, Jose Aviles-Herrera, Guadalupe Esther Angeles-Lopez, Myrna Deciga-Campos, Maria Eva Gonzalez-Trujano, Francisco Javier Lopez-Munoz
Summary: This study aimed to evaluate the antinociceptive interaction between metamizole and hesperidin in a visceral pain model, and the results showed a synergistic interaction between them when used in combination.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Plant Sciences
Behrooz Khakpour Taleghani, Behnaz Ghaderi, Mohammad Rostampour, Edris Mahdavi Fekjur, Farkhonde Hasannejad, Malek Moien Ansar
Summary: This study found that the extract of CE has potential anti-nociceptive effects, which may be mediated by opioidergic and GABAergic systems.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Yin Xinqiang, Jing Yuanyuan, You Zhipeng, Ke Jie, Tan Xiao, Hu Yumeng, Zhu Chenxi, Duan Shiyu, Yi Mingpeng, Zhu Yanlin, Chen Sihan, Yan Hao
Summary: Inflammatory pain is a key clinical symptom of inflammatory diseases, with pro-inflammatory cytokine signaling playing a crucial role. Dorsomorphin may inhibit inflammatory mediators by suppressing the p38 MAPK/c-fos pathway, thus exerting its analgesic effect.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Weber Melo Nascimento, Joao Ricardhis Saturnino Oliveira, Rebeca Xavier Cunha, Daywison Silva Rodrigues Gamboa, Ana Paula Sant'Anna Silva, Vera Lucia de Menezes Lima
Summary: This study confirmed the anti-inflammatory effects of I. suffruticosa leave aqueous extract and its ability to act on different parts of the inflammation process, validating its popular use.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinhe Liu, Ning Wang, Jinyan Wang, Fei Luo
Summary: The study found that acute inflammatory pain significantly prolonged subjective duration in the 0.6-2.4 second range, and this effect persisted for several days post-injection. However, pain did not affect time perception in the 2-8 second range.
Article
Psychology, Biological
Johannes B. Finke, Xinwei Zhang, Debora Plein, Thomas M. Schilling, Hartmut Schachinger, Mauro F. Larra
Summary: The study found that administering cognitive tasks and painful physical stressors simultaneously did not lead to strong interference, but rather specific additive effects, particularly regarding cardiovascular reactivity.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Plant Sciences
Crispin D. Sesaazi, Emanuel L. Peter, Andrew G. Mtewa
Summary: The ethanol extract of Schkuhria pinnata aerial parts demonstrated anti-nociceptive activity in mice by reducing writhes and increasing pain threshold, supporting its traditional use in pain management. Further research focusing on identifying active fractions and compounds responsible for this activity is suggested.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Jose Antonio Guerrero-Solano, Mirandeli Bautista, Josue Vidal Espinosa-Juarez, Luis Alfonso Moreno-Rocha, Gabriel Betanzos-Cabrera, Liana Claudia Salanta, Minarda De la O. Arciniega, Elena G. Olvera-Hernandez, Osmar Antonio Jaramillo-Morales
Summary: Pharmacological treatment of pain often leads to undesirable effects, so it is important to explore natural, safe, and effective alternatives. Pomegranate has been used as a preventive and therapeutic agent for its antinociceptive effect, and different parts of the fruit display unique pharmacological activities. This study evaluated the antinociceptive effect of pomegranate extracts and juices from three varieties, and found that they had promising pharmacodynamic properties for the treatment of pain.
Article
Medicine, General & Internal
Xu Liu, Jiang-Tao Zhang, Yue Hu, Wen-Qi Shan, Zhi-Hong Wang, Qing-Yue Fu, Dan-Ni Fu, Jiang Ji, Tong Liu
Summary: A new acute itch mouse model was established by injecting low-dose formalin into the neck or cheek of mice, revealing that activation of TRPA1 channel is a key factor in inducing itch in this model. This model may be effective for screening potential anti-itch drugs.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Francisco D. Rodriguez, Manuel Lisardo Sanchez, Rafael Covenas
Summary: Harmful alcohol use, known as alcohol use disorders (AUDs) in the DSM-5 classification, has various negative effects on individuals and their social and familial environments. Alcohol addiction is characterized by compulsive drinking and negative emotional states during withdrawal, often leading to relapses. The complexity of AUD involves multiple factors, including the use of other psychoactive substances. Ethanol and its metabolites directly impact tissues and may disrupt brain neurotransmission, immunity, and cell repair pathways. The review focuses on the role of neurotensin (NT) in alcohol addiction and the potential use of nonpeptide ligands to modulate the NT system in animal models of harmful drinking behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Guadalupe Del Carmen Baeza-Flores, Jorge Elias Torres-Lopez, Crystell Guadalupe Guzman-Prieigo
Summary: The purpose of this study was to evaluate the antinociceptive effect of ampicillin using the formalin test in rats. The results showed that ampicillin reduced the nociceptive response induced by formalin, with better efficacy observed after repeated treatment. The study also suggested that ampicillin may induce antinociception through the upregulation of GLT-1.
Article
Behavioral Sciences
Guadalupe Garcia, Vladimir A. Martinez-Rojas, Janet Murbartian
Summary: TREK-1 channels play a crucial role in acute and persistent nociceptive hypersensitivity, with selective blockade or activation affecting pain behaviors. The activity of TREK-1 at peripheral and spinal sites can reduce neuronal excitability in a formalin-induced nociception model.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Guidong Dai, Benpeng Li, Yuping Xu, Zhiji Li, Fuchun Mo, Chaoqian Wei
Summary: The combination of matrine with paracetamol exerts analgesic synergistic interactions in a mouse acetic acid-induced writhing model, providing a possible therapeutic alternative for the clinical management of inflammatory pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
K. H. Janbaz, N. Aslam, I. Imran, Q. Jabeen
Summary: The aqueous-ethanol crude extract of Salsola imbricata showed significant anti-inflammatory, analgesic and antipyretic activities in rat models, supporting its traditional use in folk medicine.
JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS
(2021)
Article
Behavioral Sciences
Kristin E. Smith, Mona Boules, Katrina Williams, Elliott Richelson
BEHAVIOURAL BRAIN RESEARCH
(2012)
Review
Biology
Paul J. Linser, Kristin E. Smith, Terri J. Seron, Marco Neira Oviedo
JOURNAL OF EXPERIMENTAL BIOLOGY
(2009)
Article
Gastroenterology & Hepatology
Kristin S. Inman, Amanda A. Francis, Nicole R. Murray
WORLD JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Medical Laboratory Technology
Pai C. Kao, Qiao Jun Han, Shuyi Liu, Xiu Jun Li, Kristin S. Inman, Nicholas Chia
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2016)