Review
Cell Biology
Anja Baric, Marina Dobrivojevic Radmilovic
Summary: Stroke is a major cause of mortality and disability globally. Recent studies have shown evidence of diabetes involvement in producing a chronic neuroinflammatory state, affecting recovery of function and cognition after stroke.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Psychiatry
Catherine Jordan, Brian Lawlor, David Loughrey
Summary: Music interventions may be effective in improving symptoms and delaying progression of mild cognitive impairment (MCI) to dementia. However, existing studies have limitations in sample size, consideration of confounding variables, consistency with therapist-led sessions, and focus on depression as the primary outcome measure. Different types of music interventions have diverse effects on cognitive and behavioral symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Nick A. Weaver, Jae-Sung Lim, Janniek Schilderinck, Geert Jan Biessels, Yeonwook Kang, Beom Joon Kim, Hugo J. Kuijf, Byung-Chul Lee, Keon-Joo Lee, Kyung-Ho Yu, Hee -Joon Bae, J. Matthijs Biesbroek
Summary: This study used lesion-symptom mapping to identify infarct locations and white matter disconnections associated with poststroke depressive symptoms (PSDS). The results showed that infarcts in the right amygdala, right hippocampus, and right pallidum were consistently associated with PSDS. Disconnectome-based analyses revealed disconnections in the right parahippocampal white matter, right thalamus and pallidum, and right anterior thalamic radiation were significantly associated with PSDS.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Geriatrics & Gerontology
Yoni C. P. Sep, Anna E. Leeuwis, Lieza G. Exalto, Jooske M. Boomsma, Niels D. Prins, Jurre H. Verwer, Philip Scheltens, Wiesje M. van der Flier, Geert Jan Biessels, TRACE-VCI study group Behalf TRACE VCI Study Grp
Summary: This study examines the association between neuropsychiatric symptoms (NPS) and clinical outcomes in memory clinic patients with possible Vascular Cognitive Impairment (VCI). The findings reveal that NPS are common in this patient group and are associated with institutionalization, mortality, and cognitive deterioration. The association between NPS and clinical outcomes varies depending on the severity of cognitive impairment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Gianluigi Rosario Palmieri, Giovanna De Michele, Margherita Matarazzo, Fabiola Di Dato, Sandra Perillo, Diletta Carmen Paola Dello Iacovo, Nunzia Cuomo, Chiara Pane, Cinzia Valeria Russo, Raffaele Iorio, Giuseppe De Michele, Anna De Rosa
Summary: NMS are common among WD patients, especially those with the neurological form, likely due to the widespread pathological changes throughout the central nervous system.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Weiguo Li, Yasir Abdul, Raghavendar Chandran, Sarah Jamil, Rebecca A. Ward, Mohammed Abdelsaid, Guangkuo Dong, Susan C. Fagan, Adviye Ergul
Summary: This study shows that diabetes does not lead to abnormal cerebrovascularization in female rats, which differs from our findings in male animals in various diabetes models. Deferoxamine preserved recognition memory function in diabetic female rats after stroke. The effects of stroke and deferoxamine on cerebrovascular density and microglial activation also appear to be different in female diabetic rats. Lastly, deferoxamine has detrimental effects on animals and BMVECs under control conditions.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tran Thanh Duy Linh, Yi-Chen Hsieh, Li-Kai Huang, Chaur-Jong Hu
Summary: Population aging poses challenges to the treatment of cognitive impairment or dementia, with vascular dementia being the second leading cause after Alzheimer's disease. There have been fewer drug trials targeting vascular dementia compared to Alzheimer's dementia in the past decade, and investment from international pharmaceutical companies in this area remains insufficient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Xueming Fan, Wei Shen, Liuding Wang, Yunling Zhang
Summary: The study evaluated the efficacy of DL-3-n-butylphthalide (NBP) in treating Poststroke Cognitive Impairment (PSCI) by analyzing 26 studies with a total sample size of 2,571 patients. Results showed that NBP, as monotherapy or combination therapy, significantly improved cognitive function, daily living abilities, and reduced neurological deficits without serious adverse reactions. Further high-quality randomized controlled trials are needed to confirm its efficacy and safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Applied
Kasra Moazzami, Mariana Garcia, An Young, Zakaria Almuwaqqat, Bruno B. Lima, Afif Martini, Mhmtjamil Alkhalaf, Amit J. Shah, Felicia C. Goldstein, Ihab Hajjar, Allan Levey, J. Douglas Bremner, Arshed A. Quyyumi, Viola Vaccarino
Summary: This study found that in patients with coronary artery disease (CAD), higher levels of psychological distress are independently associated with worse cognitive performance, indicating that psychological risk factors play a role in the cognitive trajectories of individuals with CAD.
Article
Medicine, General & Internal
Bora Yoon, Dong Won Yang, Yun-Jeong Hong, Taewon Kim, Seunghee Na, Sang-Mi Noh, Hye Lim Park, Bon D. Ku, Young Soon Yang, Hojin Choi, Jae-Won Jang, Seongheon Kim, Yerim Kim, YongSoo Shim
Summary: This study aims to investigate amyloid pathology development in poststroke cognitive impairment patients and compare their cognitive progression. By observing the cognitive changes and dementia conversion rate between A+ and A- groups, the study aims to provide more information on the impact of A beta on PSCI in clinical practice.
Article
Geriatrics & Gerontology
Masaki Shinohara, Kana Matsuda, Yuichiro Ii, Ken-ichi Tabei, Naoko Nakamura, Yoshinori Hirata, Hidehiro Ishikawa, Hirofumi Matsuyama, Keita Matsuura, Masayuki Maeda, Hidekazu Tomimoto, Akihiro Shindo
Summary: This study investigated the relationship between behavioral and psychological symptoms (BPS) and cerebral small vessel disease (SVD) in patients with mild cognitive impairment (MCI) or mild dementia. The results showed that patients with BPS had worse clinical dementia ratings, reduced psychomotor speed, higher modified CAA-SVD scores, and larger numbers of cerebral microbleeds (CMBs). Therefore, preventing these brain lesions may help mitigate the risk of BPS.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Immunology
Huidi Wang, Mingsi Zhang, Jie Li, Jianhai Liang, Mengjia Yang, Genghong Xia, Yueran Ren, Hongwei Zhou, Qiheng Wu, Yan He, Jia Yin
Summary: This study found a causal relationship between gut microbiota and poststroke cognitive impairment (PSCI), which is likely mediated by inflammation-regulating metabolites including lipopolysaccharide (LPS) and butyrate.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Medicine, Research & Experimental
Weijie Yan, Jiahui Fan, Xia Zhang, Huimeng Song, Rongqi Wan, Wei Wang, Yanling Yin
Summary: The study investigated the impact of SNAP29 reduction on poststroke cognitive impairments using in vitro and in vivo ischemic models. It found that SNAP29 decrease was associated with synaptic dysfunction and cognitive deficits, without affecting neuronal survival. This suggests that strategies targeting SNAP29 could be effective in treating poststroke cognitive impairments.
Review
Clinical Neurology
Tatjana Rundek, Magdalena Tolea, Taylor Ariko, Eric A. Fagerli, Christian J. Camargo
Summary: Vascular cognitive impairment (VCI) is mainly caused by vascular risk factors and cerebrovascular disease, accounting for 20-40% of all dementia diagnoses. Cerebrovascular pathology is the most important contributor to dementia, with interactions with neurodegenerative pathology. Controlling vascular risk factors plays a key role in the prevention and treatment of VCI.
Review
Neurosciences
Camilla Elefante, Giulio Emilio Brancati, Samuele Torrigiani, Salvatore Amadori, Sara Ricciardulli, Gabriele Pistolesi, Lorenzo Lattanzi, Giulio Perugi
Summary: This study systematically reviews the clinical features and therapeutic evidence regarding manic syndromes in different types of dementia. The results indicate that manic symptoms are associated with disease progression in Alzheimer's disease, have a variable relationship with cognitive decline in vascular dementia, and often precede or coincide with cognitive impairment in frontotemporal dementia. Mood stabilizers and electroconvulsive therapy appear to be the most effective treatments, while the benefits of short-term treatment with antipsychotic agents need to be balanced with associated risks. Importantly, low-dose lithium salts may have neuroprotective activity in patients with Alzheimer's disease.
CURRENT NEUROPHARMACOLOGY
(2023)
