期刊
BEHAVIOURAL BRAIN RESEARCH
卷 272, 期 -, 页码 83-92出版社
ELSEVIER
DOI: 10.1016/j.bbr.2014.06.045
关键词
Anhedonia; Cytokines; Inflammation; Melanoma tumor; Monoamines; Tail suspension test
资金
- Project Grants of Spanish Ministry of Economy and Competitiveness [PSI2012-35352]
- Basque Government [IT757-13]
Depression is a commonly observed disorder among cancer patients; however, the mechanisms underlying the relationship between these disorders are not well known. We used an animal model to study the effects of tumor development on depressive-like behavior manifestation, proinflammatory cytokine expression, and central monoaminergic activity. Male OF1 mice were inoculated with B16F10 melanoma tumor cells and subjected to a 21-day behavioral evaluation comprising the novel palatable food (NPF) test and tail suspension test (TST). The mRNA expression levels of proinflammatory cytokines, interleukin (IL)-1 beta and IL-6, and tumor necrosis factor-alpha (TNF-alpha), were measured in the hypothalamus and hippocampus and the levels of IL-6 and TNF-alpha were measured in the blood plasma. We similarly determined the monoamine turnover in various brain areas. The tumors resulted in increasing the immobility in TST and the expression level of IL-6 in the hippocampus. These increases corresponded with a decrease in dopaminergic activity in the striatum and a decrease in serotonin turnover in the prefrontal cortex. Similarly, a high level of tumor development produced increases in the brain expression levels of IL-6 and TNF-alpha and plasma levels of IL-6. Our findings suggest that these alterations in inflammatory cytokines and monoaminergic system function might be responsible for the manifestation of depressive-like behaviors in tumor-bearing mice. (C) 2014 Elsevier B.V. All rights reserved.
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