Article
Neurosciences
Chung-Wei Hsu, Sabrina Wang
Summary: The study suggests that activation of OX-A neurons can promote resilient behaviors under stressful situations in a learned helplessness (LH) animal model of depression, and that OX-A and OX-B neuropeptides exhibit dissimilar functions in LH behaviors.
Article
Clinical Neurology
Silvia Breviario, Julia Senserrich, Eva Florensa-Zanuy, Emilio Garro-Martinez, Alvaro Diaz, Elena Castro, Angel Pazos, Fuencisla Pilar-Cuellar
Summary: The study found that the activity and protein expression of MMP-9 are significantly elevated in brain areas relevant to depression, while nectin-3 levels are lower in these areas. The immobility time in the tail suspension test is positively correlated with cortical MMP-9 activity and negatively correlated with nectin-3 levels. These findings support the role of MMP-9 in the pathophysiology of depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Dane Donegan, Christoph M. Kanzler, Julia Buescher, Paulius Viskaitis, Ed F. Bracey, Olivier Lambercy, Denis Burdakov
Summary: Skilled arm movements require adaptation based on sensory errors, and studies in mice show that forelimb motor adaptation is regulated by the hypothalamic orexin/hypocretin neurons (HONs). By studying goal-oriented mouse-robot interactions, distinct HON signals were found during forelimb movements and motor adaptation. Temporally-delimited optosilencing of these movement-associated HON signals impaired sensory error-based motor adaptation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Joao Paulo Bras, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Silvia Monari, Mandy Meijer, Jocelyn Grosse, Mario Adolfo Barbosa, Susana Gomes Santos, Carmen Sandi, Maria Ines Almeida
Summary: This study suggests that male rats with high-CORT stress responsiveness exhibit increased anhedonia and passive coping responses in adulthood following peripubertal stress exposure. Additionally, exposure to peripubertal stress leads to increased hippocampal TNF-alpha expression, which correlates with passive coping responses. Furthermore, peripubertal stress has long-term effects on hippocampal microglia, particularly in high-CORT stress-responsive rats.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Behavioral Sciences
Batoul Mirbolouk, Kambiz Rohampour, Mohammad Rostampour, Adele Jafari, Behrooz Khakpour-Taleghani
Summary: This study evaluated the role of Orx1R in depressive behaviors using the CMS model, showing that chronic Orx1R antagonism alleviates depressive behaviors induced by CMS and improves PSD-95 expression in PFC.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Article
Neurosciences
Changjing Zhang, Leilei Zhu, Shuaifei Lu, Mengyuan Li, Ming Bai, Yucheng Li, Erping Xu
Summary: This study is the first to demonstrate the antidepressant-like effects of FMN in a CORT-induced mice model of depression, suggesting it as a potential candidate for treating depression.
Article
Neurosciences
Vijayakumar Mavanji, Jennifer A. Teske, Catherine M. Kotz, Giuseppe Pellizzer
Summary: Orexin-A (OXA) is a hypothalamic neuropeptide that regulates wakefulness, appetite, reward processing, muscle tone, motor activity, and other physiological processes. It increases the excitability of the sensorimotor system, which leads to an increase in awake time, muscle tone, and spontaneous physical activity (SPA).
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
Magali Hernandez, Guillaume Harle, Robert Lalonde, Catherine Strazielle
Summary: The study investigated the long-term effects of excessive glucocorticoids on the developing brain and found that it can have negative impacts on motor structures such as the cerebellum. While CORT exposure resulted in increased motor activity in some sensorimotor functions, it did not significantly affect spatial learning.
NEUROSCIENCE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Daiane B. Fraga, Anderson Camargo, Gislaine Olescowicz, Dayane Azevedo Padilha, Francielle Mina, Josiane Budni, Patricia S. Brocardo, Ana Lucia S. Rodrigues
Summary: Both ascorbic acid and ketamine can rapidly alleviate CORT-induced depressive-like behaviors and improve hippocampal synaptic markers.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhi-ying Gao, Tian-yu Chen, Ting-ting Yu, Li-ping Zhang, Si-jie Zhao, Xiao-yang Gu, Ying Pan, Ling-dong Kong
Summary: Paternal stress exposure may contribute to depression in offspring, and cinnamaldehyde could be a potential intervention for intergenerational inheritance of depression.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Yunyun Song, Jiannan Li, Huiming Li, Min Cai, Danmin Miao
Summary: Orexin, a promising target for anti-depression treatment, has been found to be involved in comorbid diseases of depression. Despite the abnormal activity of orexin neurons in depression, the neuro-circuit mechanism of orexin remains unclear. The ventral tegmental area (VTA), as an important downstream factor of orexin neurons, is considered crucial in the mechanism of depression, but the role of VTA orexinergic afferents in depression is still not clear. This study showed that VTA orexinergic afferents participate in the mechanism of depression, with the orexin-1 receptor playing a major role.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu Wu
Summary: Chronic stress can induce depressive-like behavior and inhibit adult hippocampal neurogenesis. Chronic corticosterone treatment decreases the proliferation and survival of neural stem cells, impairs the migration of newborn neurons, and increases neuronal autophagy. Inhibiting hyperactive neuronal autophagy can reverse the decrease in neuronal brain-derived neurotrophic factor levels, rescue neurogenesis, and exert antidepressant effects.
Article
Pharmacology & Pharmacy
Ruohong Lin, Linlin Liu, Marta Silva, Jiankang Fang, Zhiwei Zhou, Haitao Wang, Jiangping Xu, Tiejun Li, Wenhua Zheng
Summary: Hederagenin, a triterpenoid saponin extracted from Fructus Akebiae, has been proposed to have potential therapeutic effects in depression. This study found that Hederagenin protected PC12 cells against corticosterone-induced damage through activation of the PI3K/AKT pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Hailah M. ALmohaimeed, Zuhair M. Mohammedsaleh, Ashwaq H. Batawi, Maha Jameal Balgoon, Osama Ibrahim Ramadan, Hasan Ahmed Baz, Soad Al Jaouni, Nasra Naeim Ayuob
Summary: Cinnamomum cassia and Zingiber officinale in combination exhibit synergistic effects in improving blood glucose levels, reducing neuroinflammation, enhancing antioxidant capacity, and alleviating depressive-like behaviors in diabetic rats. This combination therapy shows superior efficacy compared to single administration of either ginger or cinnamon, providing a promising alternative or complementary supplement for managing diabetes and its neurological and psychiatric complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Christian Holscher
Summary: GLP-1 and GIP receptor agonists have shown protective effects on synapses and synaptic transmission in the treatment of AD and PD. Through animal models and clinical trials, these receptor agonists have demonstrated good effects in preventing cognitive decline, synaptic loss, and neuron death. By enhancing the ability to cross the blood-brain barrier, dual-GLP-1/GIP receptor agonists have shown superior protective properties in the prevention and treatment of AD and PD.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hongyan Cai, Jing Qiao, Siru Chen, Junting Yang, Christian Holscher, Zhaojun Wang, Jinshun Qi, Meina Wu
Summary: This study reveals that MCU knockdown in hippocampal neurons can improve the memory performance of APP/PS1/tau mice. The results suggest that MCU knockdown can improve the synapse structure and function, alleviate inflammation, and restore mitophagy, indicating its potential as a therapeutic approach for AD.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Medical Informatics
Alok Joshi, Stephen Todd, David P. Finn, Paula L. McClean, Kongfatt Wong-Lin
Summary: This study analyzed the prescribing practices of antidepressant medications for dementia patients in hospitals in England and Wales, revealing complex interactions between prescribed drug types, dementia subtypes, and depression.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2022)
Article
Psychology, Biological
Jaishree Jalewa, Juanita Todd, Patricia T. Michie, Deborah M. Hodgson, Lauren Harms
Summary: This study investigates the neurobiology of MMN as a preclinical biomarker of schizophrenia and the effects of developmental risk factors, maternal infection and adolescent cannabis use, on rat MMR amplitude. The findings suggest that male rats exposed to these risk factors show reduced MMR in specific auditory contexts, providing a model for MMN impairments in schizophrenia.
Review
Neurosciences
Niklas Reich, Christian Holscher
Summary: Currently, there is a lack of disease-modifying treatments for Alzheimer's and Parkinson's disease. However, GLP-1 mimetics have shown neuroprotective effects in preclinical studies, making them a promising treatment option for these diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Niklas Reich, Christian Holscher
Summary: This review examines the role of acylated ghrelin in the regulation of memory and fear behavior, as well as its impact on specific brain areas and neurotransmitter systems. It also discusses the neurogenesis and signaling pathways associated with acylated ghrelin in the hippocampus, and its involvement in conditioned taste aversion, novelty learning, and memory formation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Mathematical & Computational Biology
Chandan K. Behera, Alok Joshi, Da-Hui Wang, Trevor Sharp, KongFatt Wong-Lin
Summary: By computationally modeling neural circuits and analyzing dynamical systems, this study found that neural circuits with different structures can perform the same function, indicating the degeneracy of neural circuits. However, it is still unclear whether neural circuits with interacting neuromodulator sources can degenerate while maintaining the same neuromodulatory function. This study addresses this question by simulating neural circuits of neuromodulators serotonin and dopamine, local interneurons, and their interactions under reward/punishment-based conditioning tasks.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Yogesh Kumar Meena, Hubert Cecotti, Braj Bhushan, Ashish Dutta, Girijesh Prasad
Summary: In this study, a multimodal Hindi language eye-gaze-assisted learning system based on a virtual keyboard was used to reduce tracking errors and detect children with dyslexia. The results showed that the workload and usability of the system were substantially different for children with dyslexia, and different classifiers were successfully able to distinguish dyslexic children based on typing speed on different words. This work highlights the importance of inclusive virtual keyboards and demonstrates their potential for detecting dyslexia.
IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS
(2023)
Article
Clinical Neurology
Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Holscher
Summary: The study found that DA5-CH was more effective than semaglutide in a PD model, reducing rotational behavior, alleviating dopamine depletion and inflammation response, protecting dopaminergic neurons, and reducing levels of α-synuclein.
PARKINSONS DISEASE
(2022)
Article
Computer Science, Artificial Intelligence
Hongmei He, John Gray, Angelo Cangelosi, Qinggang Meng, T. Martin McGinnity, Jorn Mehnen
Summary: This work systematically explores the key aspects of human-centered AI (HAI) for trustworthy robots and autonomous systems (TRAS). It identifies the five key properties that a TRAS must have: safety, security, health, easy to use, and compliance with laws and ethics. It highlights the need for more scientific attention to the risks posed by advanced AI in TRAS and examines the challenges of implementing TRAS. The paper provides a new acceptance model and emphasizes the contribution of human-level intelligence to humanity.
IEEE TRANSACTIONS ON COGNITIVE AND DEVELOPMENTAL SYSTEMS
(2022)
Article
Biochemical Research Methods
Jie Hao, Jiawei Zou, Jiaqiang Zhang, Ke Chen, Duojiao Wu, Wei Cao, Guoguo Shang, Jean Y. H. Yang, KongFatt Wong-Lin, Hourong Sun, Zhen Zhang, Xiangdong Wang, Wantao Chen, Xin Zou
Summary: Cell-state transition analysis using single-cell RNA-sequencing can reveal additional information in time-resolved biological phenomena. However, current methods are limited to short-term evolution of cell states based on gene expression derivative. This study presents scSTAR, a method that overcomes this limitation by constructing a paired-cell projection between different biological conditions with arbitrary time spans, leading to more accurate predictions and new discoveries in aging and cancer research.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Neurosciences
Vahab Youssofzadeh, Sujit Roy, Anirban Chowdhury, Aqil Izadysadr, Lauri Parkkonen, Manoj Raghavan, Girijesh Prasad
Summary: This study analyzed magnetoencephalography (MEG) data to examine the cortical engagement during mental imagery tasks. They found that beta power decrements can be used as markers to map and decode cortical engagement and classify different task types with high accuracy.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Zijuan Zhang, Ziyang Yu, Ye Yuan, Jing Yang, Shijie Wang, He Ma, Li Hao, Jinlian Ma, Zhonghua Li, Zhenqiang Zhang, Christian Hölscher
Summary: Synaptic impairment and loss are important in Alzheimer's disease (AD), and can cause cognitive dysfunction and memory loss. In this study, a novel CCK analogue was found to improve synaptic plasticity, spatial learning, and memory in an AD mouse model. This effect was achieved through the activation of the PI3K/Akt and PKA/CREB-BDNF/TrkB signaling pathways, leading to protection of synapses and cognition.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Genetics & Heredity
Hong-Yan Cai, Si-Ru Chen, Yu Wang, Juan-Juan Jiao, Jun Qiao, Christian Holscher, Zhao-Jun Wang, Sheng-Xiao Zhang, Mei-Na Wu
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disease that worsens with age. Dysregulation of long non-coding RNAs (lncRNAs) and the associated competing endogenous RNA (ceRNA) network may be linked to the occurrence and development of AD. RNA sequencing identified 358 differentially expressed genes (DEGs), including 302 differentially expressed mRNAs (DEmRNAs) and 56 differential expressed lncRNAs (DElncRNAs). The constructed ceRNA network includes 4 lncRNAs, 4 microRNAs, and 2 mRNAs. Functional enrichment analysis revealed the involvement of DEmRNAs in AD-related biological functions. Co-expressed DEmRNAs in humans and mice were validated using real-time quantitative polymerase chain reaction (qRT-PCR). The findings provide insights into AD-related pathological mechanisms and can contribute to improving AD diagnosis and treatment.
Article
Neurosciences
Theodora Panagaki, Elisa B. Randi, Csaba Szabo, Christian Holscher
Summary: The study confirms the protective effects of incretin signaling in managing neuronal degeneration in Parkinson's disease, and further explains the observed effects of incretin-based therapies in PD patients. The dual incretin analog shows superior anti-apoptotic effects compared to the glucagon-like peptide-1 analog.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)