Article
Biochemistry & Molecular Biology
Thibault Canceill, Geraldine Jourdan, Philippe Kemoun, Christophe Guissard, Yanad Abou Monsef, Marion Bourdens, Benoit Chaput, Sandrine Cavalie, Louis Casteilla, Valerie Planat-Benard, Paul Monsarrat, Isabelle Raymond-Letron
Summary: Adipose-derived mesenchymal stromal cells (ASC) transplantation is a promising strategy for tissue regeneration. This study aimed to optimize the generation phase of a platelet-lysate-based fibrin hydrogel (PLFH) as a proper carrier for in situ ASC implantation, and comprehensively assess its in vitro properties and in vivo safety profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Olga Bondareva, Jesus Rafael Rodriguez-Aguilera, Fabiana Oliveira, Longsheng Liao, Alina Rose, Anubhuti Gupta, Kunal Singh, Florian Geier, Jenny Schuster, Jes-Niels Boeckel, Joerg M. Buescher, Shrey Kohli, Nora Kloeting, Berend Isermann, Matthias Blueher, Bilal N. Sheikh
Summary: Obesity has organ- and endothelial cell subtype-specific effects on gene expression networks, including lipid handling, metabolic pathways, and inflammatory signaling. These transcriptomic aberrations worsen with sustained obesity and are only partially mitigated by dietary intervention and weight loss. The study provides insights into the impact of obesity on the endothelium and identifies potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Mauro Vasella, Kevin Arnke, Dalia Dranseikiene, Elia Guzzi, Francesca Melega, Gregory Reid, Holger Jan Klein, Riccardo Schweizer, Mark W. Tibbitt, Bong-Sung Kim
Summary: In this study, the feasibility of using methacrylated gelatin (GelMA) as a scaffold for mechanically processed stromal vascular fraction (mSVF) was investigated. The results showed that GelMA maintained cell viability and proliferation, and released growth factors, which had a promoting effect on both mSVF and dermal fibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Weijie Jiao, Chen Liu, Jingxin Shan, Zhiyuan Kong, Xiaohong Wang
Summary: This study successfully constructed small-diameter arterial vessels with living cells, which showed good biocompatibility and morphology. By using a combined mold, bioactive materials, and growth factors, the researchers were able to mimic the structure and function of natural arteries. This research offers a potential solution for clinical small-diameter vessel grafts.
Article
Instruments & Instrumentation
Laura Stahn, Justyna Rasinska, Tilo Dehne, Stefanie Schreyer, Aileen Hakus, Manfred Gossen, Barbara Steiner, Shabnam Hemmati-Sadeghi
Summary: There is currently no causal treatment available for Parkinson's disease (PD), but the use of glial cell line-derived neurotrophic factor (GDNF) shows promise in providing regenerative effects for neurons. This study utilized a non-viral Sleeping Beauty (SB) transposon system to overexpress GDNF in adipose tissue-derived mesenchymal stromal cells (adMSCs) and observed positive immunomodulatory effects and neuroprotective function. However, further improvements in motor performance and testing in other disease models are needed for a comprehensive evaluation of this treatment option.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Suihong Liu, Qingxi Hu, Zhipeng Shen, Sasirekha Krishnan, Haiguang Zhang, Murugan Ramalingam
Summary: The study demonstrated the suitability of a 3D printable formulation for self-standing and vascular supportive structures, which has great potential in organ engineering. The formulated hydrogel showed excellent biocompatibility and vascular supportive behavior, making it possible to manufacture organs with complex shapes and structures.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Jian Qi, Shuxian Zheng, Nan Zhao, Yang Li, Guoliang Zhang, Wei Yin
Summary: This study presents a novel approach for the rapid and efficient fabrication of arc vascular channels. A hydrogel matrix preparation and a vascular core 3D printing method are proposed for the construction of multilevel vascular channels. The prepared vascular channels can be used as research models for vascular diseases, drug delivery, targeted therapy, and microenvironment simulation.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Polymer Science
Madina Sarsenova, Yerik Raimagambetov, Assel Issabekova, Miras Karzhauov, Gulshakhar Kudaibergen, Zhanar Akhmetkarimova, Arman Batpen, Yerlan Ramankulov, Vyacheslav Ogay
Summary: The regeneration of cartilage and osteochondral defects is a challenging problem in orthopedic surgery. Tissue-engineering techniques using growth factors and MSCs in hydrogel scaffolds are promising for osteochondral defect repair. In a rabbit model, a heparin-conjugated fibrin hydrogel with synovium-derived MSCs, TGF-beta 1 and BMP-4 significantly enhanced the regeneration of hyaline cartilage and subchondral bone plate.
Article
Biology
Jianping Li, Zhisheng Ji, Yu Wang, Tiantian Li, Jinghua Luo, Jun Li, Xueshuang Shi, Liming Li, Liumin He, Wutian Wu
Summary: This study investigated the combined treatment of nano-hydrogel and human adipose-derived stem cells for spinal cord injury, showing that this approach can regulate inflammatory reaction, protect neurons and axons, and promote motor function recovery, providing evidence for clinical treatment.
Article
Surgery
Fang Liu, Yu Zhao
Summary: The study aimed to investigate the survival of SVF-gel grafts with or without PRF co-transplantation in a rabbit model. Results showed that PRF did not influence the long-term maintenance of fat volume from SVF-gel grafts, but had anti-inflammatory effects in the early period.
AESTHETIC PLASTIC SURGERY
(2021)
Article
Materials Science, Biomaterials
Hue Thi Le, Atsushi Mahara, Takeshi Nagasaki, Tetsuji Yamaoka
Summary: A drug-loaded tissue-adhesive hydrogel was developed to suppress abnormal proliferation of vascular smooth muscle cells. The hydrogel exhibited adhesive properties to the vascular adventitia and released the drug RPM, which effectively inhibited cell proliferation. Preliminary in vivo tests demonstrated that the graft coated with RPM-loaded hydrogel showed better patency than controls, suggesting its potential clinical application.
BIOMATERIALS ADVANCES
(2023)
Article
Biotechnology & Applied Microbiology
Zohreh Afsartala, Mahmoudreza Hadjighassem, Sadegh Shirian, Somayeh Ebrahimi-Barough, Leila Gholami, Gilda Parsamanesh, Ziba Veisimalekshahi, Latifeh Karimzadehbardeei, Jafar Ai
Summary: The study found that encapsulating exosomes derived from mesenchymal stem cells in collagen and fibrin hydrogels can effectively treat spinal cord injury in rats.
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2023)
Article
Oncology
Zhou Li, Huimin Gan, Anru Liang, Xiyue Wang, Xiaohao Hu, Ping Liang, Guoding Xu, Qianwen Huang, Junjun Li, Hongmian Li
Summary: The combined treatment of SVFG and APRFE can promote the repair of irradiated skin and soft tissue injuries by accelerating angiogenesis, promoting collagen synthesis, and reducing inflammation.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Min Yang, Guixi Liu, Qiao Ying
Summary: In this study, adipose-derived stem cells were induced in vitro to differentiate into myoblasts and epithelial-like cells, and then a tissue engineering urethral material was constructed using cell membrane technology and loaded with VEGF Loop delivered by release technology. The urodynamic functions of the rabbit model with urethral defect were significantly improved.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2022)
Review
Medicine, General & Internal
Letizia Senesi, Francesco De Francesco, Andrea Marchesini, Pier Paolo Pangrazi, Maddalena Bertolini, Valentina Riccio, Michele Riccio
Summary: This systematic review provides an update on the clinical application of Adipose-derived mesenchymal stem cells (ADSC) and stromal vascular fraction (SVF) in the treatment of tendon injury and tendinopathy. The review suggests that ADSC/SVF therapy shows promise in enhancing tendon healing. However, further research and randomized control trials are needed for standardization and consensus on their use.
MEDICINA-LITHUANIA
(2023)
Article
Chemistry, Multidisciplinary
Zhuo Wang, Zhirong Liu, Gengrui Zhao, Zichao Zhang, Xinyang Zhao, Xingyi Wan, Yalong Zhang, Zhong Lin Wang, Linlin Li
Summary: In this study, a flexible, stretchable, and highly transparent TENG is designed and fabricated based on an unsymmetrical PAM/BTO composite film. By adjusting the amount and distribution location of BTO, the output performance of the TENG can be improved. The TENG also functions as a high-sensitivity pressure sensor that can distinguish a spectrum of forces at the low frequency.
Article
Chemistry, Multidisciplinary
Sheng Zhang, Baosen Zhang, Da Zhao, Qi Gao, Zhong Lin Wang, Tinghai Cheng
Summary: A non-destructive sorting method based on bionic soft fingers, utilizing a soft robotic gripper (SRG) and Bend Recovery triboelectric sensor (TES), is proposed. The method enables grasping and size sorting of breakable objects, and a fruit sorting system based on this method achieves high sorting accuracy.
Article
Energy & Fuels
Xiang Li, Yuying Cao, Xin Yu, Yuhong Xu, Yanfei Yang, Shiming Liu, Tinghai Cheng, Zhong Lin Wang
Summary: With the utilization of lightweight rotor materials and suitable wind scoop structures, the breeze-driven triboelectric nano generator can efficiently harvest energy even at low wind speeds, making it ideal for agricultural sensor networks in farmland environments.
Article
Chemistry, Physical
Mingwei Shi, Wei Yang, Zailei Zhang, Man Zhao, Zhong Lin Wang, Xianmao Lu
Summary: This study demonstrates that the self-discharge of SSSCs can be suppressed by using PAAm hydrogels with highly concentrated LiCl electrolytes, leading to enhanced charging efficiency and significantly reduced leakage current.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Multidisciplinary Sciences
Yang Nan, Jiajia Shao, Morten Willatzen, Zhong Lin Wang
Summary: This study investigates the contact electrification mechanism and properties at a water/polymer interface using first-principle calculations. The results suggest that the gap between the highest occupied and lowest unoccupied molecular orbitals of polymers determines the extent of contact electrification. Additionally, the study proposes a new model to explain the transfer of charges at the atomic level.
Article
Chemistry, Physical
Jinyang Zhang, Shiquan Lin, Zhong Lin Wang
Summary: This study examines the interaction between a statically charged luminol droplet and the surrounding electrostatic field, and discovers that the polarity of the droplet's charge affects the reactivity of the chemical luminescence reaction. It provides a strategy for regulating chemical luminescence by charging a dielectric solid.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Sanming Hu, Jing Han, Zhijun Shi, Kun Chen, Nuo Xu, Yifei Wang, Ruizhu Zheng, Yongzhen Tao, Qijun Sun, Zhong Lin Wang, Guang Yang
Summary: Researchers have developed a super-strong, biodegradable, and washable cellulose-based conductive macrofiber for fabricating wearable triboelectric nanogenerators (TENGs). The macrofibers possess high tensile strength, good electrical conductivity, and excellent stability. Fabric-based TENGs made from these macrofibers show promising potential for energy harvesting and biomechanical monitoring.
NANO-MICRO LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Chaoqun Xu, Xianpeng Fu, Chengyu Li, Guoxu Liu, Yuyu Gao, Youchao Qi, Tianzhao Bu, Yuanfen Chen, Zhong Lin Wang, Chi Zhang
Summary: This research presents an autonomous system for rainfall monitoring and wireless transmission powered by raindrop energy. The system utilizes a raindrop-TENG array to both harvest raindrop energy and act as a rainfall sensor, while enabling wireless data transmission.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Polymer Science
Wenjie Wu, Zhong Lin Wang, Liqun Zhang
Summary: Dielectric elastomers (DEs) are special materials that deform in response to an electric field. The current main mechanism suggests that the deformations in DEs are induced by Maxwell stress. However, a new molecular mechanism based on entropy-dominated elasticity has been proposed recently, highlighting its importance in the process.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Xuanli Dong, Ziming Wang, Andy Berbille, Xin Zhao, Wei Tang, Zhong Lin Wang
Summary: This study aims to investigate the optimal parameters for contact-electro-catalysis (CEC) under ultrasonic reaction condition and explore the effect of different dielectric particles on the decolorization of organic solutions. The experimental results showed that the degradation rate of methyl orange (MO) increases with the increase of ultrasonic power, and the highest degradation rate was achieved at the ultrasonic frequency of 40 kHz. Additionally, the reaction temperature and the electric polarity of the catalyst also affect the CEC reactions.
Article
Chemistry, Physical
Kai Han, Jianjun Luo, Jian Chen, Yujin Liu, Jinliang Li, Zhong Lin Wang, Wenjie Mai
Summary: Electroaerodynamics (EAD) force, a propulsion method without combustion emissions, has great potential. By combining lightweight EAD thrusters and high-voltage output triboelectric nanogenerators (TENG), successful propulsion systems can be achieved.
Article
Chemistry, Analytical
Xue Wang, Zhiping Feng, Gaoqiang Zhang, Luna Wang, Liang Chen, Jin Yang, Zhonglin Wang
Summary: Recent advances in flexible pressure sensors have made them promising technologies for human epidermal pulse wave monitoring. A 3 x 1 flexible pressure sensor array was developed using three single-electrode sensors with small area to measure pulse waves at different local positions of the radial artery. The designed single sensor has a small area of 6 x 6 mm² and demonstrates high pressure sensitivity, fast response time, wide frequency range, and stability.
Article
Computer Science, Information Systems
Jiabin Zhang, Erming Su, Chengyu Li, Shuxing Xu, Wei Tang, Leo N. Y. Cao, Ding Li, Zhong Lin Wang
Summary: This study introduces an intelligent artifact-monitoring system (SAMS) based on a porous carbon black (CB)/Ecoflex triboelectric nanogenerator (PCE-TENG) that can monitor collisions in real-time and absorb vibrations during artifact transportation. The system consists of six PCE-TENGs attached to the inner wall of the artifact transport package, allowing collision monitoring and protection in different directions. This research presents a practical strategy for artifact transportation monitoring and package engineering, which could have significant implications for the field.
Article
Chemistry, Multidisciplinary
Zihan Wang, Yuchao Jin, Chengyue Lu, Jiyu Wang, Ziwu Song, Xu Yang, Yidan Cao, Yunlong Zi, Zhong Lin Wang, Wenbo Ding
Summary: This study achieves self-powered infrared wireless communication by integrating a triboelectric nanogenerator (TENG) and an infrared transmitter. The frequency and amplitude features of the infrared signal are leveraged for conveying information through the mechanical motion or structure of the TENG devices. This research is of significant importance for the development of a new generation of sustainable self-powered communications.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Liqiang Zhang, Haifang Cai, Liang Xu, Li Ji, Daoai Wang, Youbin Zheng, Yange Feng, Xudong Sui, Yufeng Guo, Wanlin Guo, Feng Zhou, Weimin Liu, Zhong Lin Wang
Summary: In this study, a new macroscale superlubric triboelectric nanogenerator (SL-TENG) was developed to achieve ultra-low friction and wear under high-contact stress. The SL-TENG showed high power density and output current, and the ultralow friction on the hydrogenated surface was identified as the key factor. The SL-TENG demonstrated the ability to light up LEDs without rectification and enable online friction monitoring and early warning.
