Article
Pharmacology & Pharmacy
Laura E. Vossen, Ronja Brunberg, Pontus Raden, Svante Winberg, Erika Roman
Summary: The zebrafish is an important model organism in the research of alcohol-related diseases, and male zebrafish of the AB strain exhibit more severe behavioral impairments than females when exposed to ethanol.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Kati L. Healey, Sandra Kibble, Kira Dubester, Amelia Bell, H. S. Swartzwelder
Summary: Binge patterns of alcohol use among adolescents are associated with a higher risk of developing alcohol use disorders and other psychiatric disorders, such as anxiety and depression. Adverse life events also strongly predict these disorders. Animal models have shown that both binge-like alcohol exposure and stress exposure can increase anxiety-like behaviors. This study investigated the interaction between adolescent intermittent ethanol (AIE) and adult stressors, and found that AIE increased vulnerability to stress-induced anxiety-like behavior in male rats. AIE also produced persistent hippocampal deficits that may contribute to increased anxiety-like behaviors when combined with adult stress.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Psychology, Biological
Jonathan Kent Gore-Langton, David Francis Werner, Linda Patia Spear
Summary: The study validated the behavioral differences in adolescent and adult rats in MCSF, revealing that handling increased risk-taking, females were more exploratory than males, and differences in behavioral components between adolescents and adults.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Neurosciences
Rushi Zou, Linling Li, Li Zhang, Gan Huang, Zhen Liang, Zhiguo Zhang
Summary: Predicting individual pain sensitivity is clinically important, and structural MRI-based morphological connectivity (MC) has been found to be a more accurate method for predicting pain thresholds. The prefrontal cortex plays a crucial role in determining pain sensitivity.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Sitong Li, Xinxin Zhang, Yueqin Liu, Zonghui Shan, Hanxiao Liu, Wei Wu, Yupeng Yang
Summary: Maternal separation in mammals has been found to impact the brain structure and function in various regions, but its effect on visual system development is not well understood. This study used a mouse model and found that maternal separation delayed the opening of the critical period for ocular dominance plasticity in female mice, but not in males. It also extended the closure of the critical period in both sexes. Only female mice that experienced maternal separation maintained a juvenile-like ocular dominance plasticity into adulthood.
NEUROSCIENCE LETTERS
(2022)
Article
Clinical Neurology
Haobo Zhang, Dan Xu, Yulin Wang, Xu Lei
Summary: This study examined the impact of sleep deprivation on reactive aggressive behavior and explored a potential electrophysiological marker for identifying individuals prone to aggressive behavior after sleep deprivation. The results showed that the effects of sleep deprivation on aggressive behavior varied between individuals, and prefrontal gamma power may serve as an effective marker for identifying individuals at risk of aggressive behavior after sleep deprivation.
Article
Psychology, Multidisciplinary
Yunlong Tian, Haoyuan Zheng, Wei Tong, Wen He
Summary: Given the prevalence of relative deprivation among adolescents and its negative impact, this study examined relative deprivation using a person-centered statistical method. The results revealed three distinct groups: low cognitive and emotional relative deprivation (33.78% of adolescents), high cognitive and low emotional relative deprivation (37.79% of adolescents), and high cognitive and emotional relative deprivation (28.43% of adolescents). Adolescents with lower income and lacking parental accompaniment were more likely to be in the high deprivation groups. Compared to the low deprivation group, the high deprivation groups had significant positive effects on physical aggression, relational aggression, and overall aggressive behavior. The classes of relative deprivation influenced both physical and relational aggression, but not verbal aggression. It is important to consider both demographic characteristics and latent classes of relative deprivation when designing interventions for aggressive behaviors.
BEHAVIORAL SCIENCES
(2023)
Article
Neurosciences
Stina Lundberg, Erika Roman, Richard L. Bell
Summary: This study aimed to examine the behavioral profiles of rats selectively bred for high or low alcohol consumption during adolescence. The results showed that there was no common behavioral profile for either high or low alcohol-consuming rat lines, and the effect of sex was minimal. The high alcohol-consuming rats displayed high activity and risk-associated behaviors, while the low alcohol-consuming rats displayed low activity, high shelter-seeking behavior, and open area avoidance.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Zhiting Ren, Richard J. Daker, Liang Shi, Jiangzhou Sun, Roger E. Beaty, Xinran Wu, Qunlin Chen, Wenjing Yang, Ian M. Lyons, Adam E. Green, Jiang Qiu
Summary: This study delves into anxiety barriers in creative cognition, uncovering a neural network associated with creativity anxiety and demonstrating its distinction from networks related to divergent creative ability. Additionally, the research developed a Chinese version of the Creativity Anxiety Scale and showed the replicability of key findings across cultures and languages.
Article
Behavioral Sciences
Christian Samsonsen, Guro Mestvedthagen, Martin Uglem, Eylert Brodtkorb
Summary: This study investigated the subjective perceptions of seizure precipitating factors in 152 acute hospital admissions for seizures and compared them with standardized measurements. The study found that stress, sleep loss, alcohol intake, and missed medication were among the most commonly reported seizure precipitants. These factors often interacted with each other, making it difficult to establish the specific underlying cause of seizures. Improved understanding of the cascade of events preceding a seizure can improve the comprehensive personalized management of uncontrolled epilepsy.
EPILEPSY & BEHAVIOR
(2023)
Article
Green & Sustainable Science & Technology
Jia Ying Tan, Wah Yen Tey, Joongjai Panpranot, Steven Lim, Kiat Moon Lee
Summary: Cellulose fibers isolated from oil palm empty fruit bunches (OPEFB) have been studied as a potential reinforcement for polyvinyl alcohol (PVA) biocomposite. The cellulose-reinforced PVA biocomposite films demonstrated improved mechanical strength, moisture barrier properties, thermal stability, and reduced light transmission rate compared to neat PVA. These findings suggest the potential application of cellulose fibers-reinforced PVA biocomposite films in water-soluble detergent capsules.
Article
Chemistry, Multidisciplinary
Hangyu Zhou, Yuichiro Fujimoto, Masayuki Kanbara, Hirokazu Kato
Summary: This study explores the possibility of applying a simple VR-based reflection method, using avatar and HMD to reduce self-awareness during reflection. The results indicate that individuals with low self-confidence in public speaking skills could benefit more from VR reflection using HMD, while those with negative self-bias could reduce more anxiety by using an avatar.
APPLIED SCIENCES-BASEL
(2021)
Article
Substance Abuse
Kati L. Healey, Sandra A. Kibble, Amelia Bell, George Kramer, Antoniette Maldonado-Devincci, H. S. Swartzwelder
Summary: Adolescent intermittent ethanol (AIE) exposure affects adult behavior in rodents, including learning and memory, social interaction, affective behavior, and ethanol self-administration. AIE also produces non-specific behavioral changes that compromise behavioral efficiency. The study highlights the previously unrecognized sex differences in the effects of AIE on activity, exploratory behavior, and anxiety-like behavior.
Article
Behavioral Sciences
Michael T. Bowen, Olivier George, Dawn E. Muskiewicz, F. Scott Hall
Summary: Understanding the factors that contribute to the escalation of alcohol consumption is crucial for understanding the transition from non/social drinking to AUD and improving treatment. This review discusses how the way ethanol is consumed, as well as individual and environmental factors, contribute to the escalation of ethanol consumption. Additionally, the review examines how these factors are modeled in animals.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Behavioral Sciences
Laurel R. Seemiller, Prescilla Garcia-Trevizo, Carlos Novoa, Lisa R. Goldberg, Samantha Murray, Thomas J. Gould
Summary: Adolescent alcohol exposure leads to lasting behavioral changes, and different mouse strains show varying sensitivity to the effects of alcohol. Strain-specific and shared consequences of adolescent alcohol exposure were found, indicating the role of genetic background in mediating these phenotypes.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Stina Lundberg, Ingrid Nylander, Erika Roman
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Article
Agriculture, Multidisciplinary
L. E. Vossen, E. Roman, A. Jansson
Summary: The study shows that after 48 hours of fasting, house crickets increase shelter use and decrease time spent in exposed areas on the floor. The same trend was observed after 24 hours of fasting. Additionally, a significant reduction in grooming was seen in both fasting treatments.
JOURNAL OF INSECTS AS FOOD AND FEED
(2022)
Article
Biochemistry & Molecular Biology
Nikita Tjernstrom, Tie-Qiang Li, Sarah Holst, Erika Roman
Summary: This study examined the relationship between gambling strategies and behavioral and neural correlates using the rat Gambling Task (rGT). The results showed that rats displayed stable gambling strategies in the rGT, which were associated with brain regions important for reward networks. Additionally, rats with risky gambling strategies differed in brain functional connectivity from those with strategic and intermediate strategies.
Article
Neurosciences
Stina Lundberg, Erika Roman, Richard L. Bell
Summary: This study aimed to examine the behavioral profiles of rats selectively bred for high or low alcohol consumption during adolescence. The results showed that there was no common behavioral profile for either high or low alcohol-consuming rat lines, and the effect of sex was minimal. The high alcohol-consuming rats displayed high activity and risk-associated behaviors, while the low alcohol-consuming rats displayed low activity, high shelter-seeking behavior, and open area avoidance.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Laura E. Vossen, Ronja Brunberg, Pontus Raden, Svante Winberg, Erika Roman
Summary: Through experiments with zebrafish Multivariate Concentric Square Field (zMCSF) and novel tank diving test (NTDT), it was found that there are significant differences in exploratory behavior between wild and AB strain zebrafish, while differences between genders are relatively small. This confirms the effectiveness of zMCSF as a tool for analyzing behavior in adult zebrafish.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Laura E. Vossen, Ronja Brunberg, Pontus Raden, Svante Winberg, Erika Roman
Summary: The zebrafish is an important model organism in the research of alcohol-related diseases, and male zebrafish of the AB strain exhibit more severe behavioral impairments than females when exposed to ethanol.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Cathrine Hultman, Nikita Tjernstrom, Sofia Vadlin, Mattias Rehn, Kent W. Nilsson, Erika Roman, Cecilia Aslund
Summary: Decision-making requires individuals to perceive probabilities and risks. This study explores decision-making strategies among young adults and adult rats, and compares the similarities and differences in their choices.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Agriculture, Multidisciplinary
L. E. Vossen, E. Nilsson, A. Jansson, E. Roman
Summary: Edible insects, particularly the house cricket, are being promoted as a sustainable source of protein, trace minerals, and lipids for animal feed and human food. This study adapts the open field test, a commonly used behavioral assessment tool for vertebrate model species, to measure the locomotory activity and behavior of house crickets in response to different light intensities. The results show promising potential for the use of the open field test as a precise phenotyping tool in the study of house crickets.
JOURNAL OF INSECTS AS FOOD AND FEED
(2023)
Article
Behavioral Sciences
Frida A. A. Lindberg, Erika Roman, Robert Fredriksson
Summary: The study investigated SLC38A10 knockout mice and found a decrease in exploratory behavior but no distinct grouping in principal component analysis. The results suggest that loss of SLC38A10 protein function in mice does not drastically alter behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychiatry
Nikita Tjernstrom, Erika Roman
Summary: This study investigated individual differences and stability in rat gambling task (rGT) strategies, and found that rats with risky choice strategies exhibited higher motor impulsivity and voluntary alcohol intake. There were no differences in sexual behavior among the different rGT groups. Treatment with naltrexone resulted in an overall decrease in motivation in the rGT.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Mikaela M. Ceder, Hannah M. Weman, Ebba Johansson, Katharina Henriksson, Kajsa A. Magnusson, Erika Roman, Malin C. Lagerstrom
Summary: The mRNA expression of the glycine receptor alpha 3 subunit (Glra3) is widely but lowly expressed in the mouse central nervous system. Male mice have higher levels of Glra3 expression in multiple brain areas compared to female mice.
Meeting Abstract
Endocrinology & Metabolism
G. Fanni, C. Kagios, E. Roman, J. Wikstrom, S. Haller, J. Eriksson
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Behavioral Sciences
Oly Sen Sarma, Natalia Frymus, Fredrik Axling, Per-Ove Thornqvist, Erika Roman, Svante Winberg
Summary: This study aimed to expand scientific knowledge on zebrafish husbandry practices by examining the effects of enrichment and fish density on their welfare. The findings showed that keeping zebrafish at lower densities (1 fish/L) increased aggression and cortisol secretion, and had an impact on brain monoamines. However, neither stocking density nor enrichment had clear effects on individual fish behavior in the novel tank diving test. Overall, the optimal stocking density for zebrafish is likely to be in the range of 3-6 fish/L.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Giovanni Fanni, Christakis Kagios, Erika Roman, Magnus Sundbom, Johan Wikstrom, Sven Haller, Jan W. Eriksson
Summary: This study aimed to investigate the effect of Roux-en-Y gastric bypass (RYGB) on brain connectivity, and found that RYGB can alter the connectivity of neural pathways related to reward, inhibitory control, and energy homeostasis. These changes are associated with alterations in hypoglycemic responses and may contribute to the glucose metabolic outcomes of RYGB.
Meeting Abstract
Psychiatry
C. Hultman, N. Tjernstrom, S. Vadlin, M. Rehn, K. W. Nilsson, E. Roman, C. Aslund
EUROPEAN PSYCHIATRY
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
