Article
Gastroenterology & Hepatology
Gangarao Davuluri, Nicole Welch, Jinendiran Sekar, Mahesha Gangadhariah, Khaled Alsabbagh Alchirazi, Maradumane L. Mohan, Avinash Kumar, Sashi Kant, Samjhana Thapaliya, McKenzie Stine, Megan R. McMullen, Rebecca L. McCullough, George R. Stark, Laura E. Nagy, Sathyamangla V. Naga Prasad, Srinivasan Dasarathy
Summary: Despite the high clinical significance of sarcopenia in alcohol-associated cirrhosis, the mechanisms of ethanol-induced impaired protein homeostasis are poorly understood. This study identified PP2A as a key mediator in ethanol-induced dysregulation of protein balance, suggesting potential therapeutic approaches targeting the PI3K gamma-PP2A axis.
Article
Biochemistry & Molecular Biology
Rachel Aruldas, Laura Buczek Orenstein, Sade Spencer
Summary: Repeated cocaine exposure induces changes in AMPK and pAMPK in different brain regions and cellular compartments, with some differences between acute withdrawal and ongoing cocaine treatment. Pretreatment with metformin, an indirect AMPK activator, enhances acute cocaine-induced locomotor activity but blocks the development of sensitization. These findings provide insights into the dynamics of AMPK activation in subcellular compartments and support the potential use of metformin for the treatment of cocaine use disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Takayoshi Tajima, Hiroaki Hoshii, Yoshinori Kohmura
Summary: This paper describes the research and development of a practical and efficient process for making the AMPK activator ASP4132, which includes efficient telescoping processes and effective removal of byproducts, resulting in a significant yield improvement.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Oncology
Jia Hao, Zhen Yang, Jian Li, Lifeng Han, Yi Zhang, Tao Wang
Summary: This study aimed to discover natural AMPK activators through virtual screenings, resulting in the identification of (-)-catechin and licochalcone A as the most potent compounds for AMPK activation.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Neurosciences
Weiwei Yu, Ziyi Wu, Xingyue Li, Mengmeng Ding, Ying Xu, Ping Zhao
Summary: This study evaluated the effect of sevoflurane exposure on developmental neurotoxicity and mood disorders, and found that sevoflurane induced depressive-like behavior, which was reversed by ketamine. The results showed that ketamine mediated ERK1/2 phosphorylation by regulating A2AR protein expression, increasing the production of synaptic-associated proteins, enhancing synaptic plasticity in the hippocampus, and ameliorating the depressive-like behavior induced by sevoflurane inhalation.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chunyang Du, Yan Zhu, Yan Yang, Lin Mu, Xue Yan, Ming Wu, Chenming Zhou, Haijiang Wu, Wei Zhang, Yanhui Wu, Guoyu Zhang, Yue Hu, Yunzhuo Ren, Yonghong Shi
Summary: CTRP3 plays a role in lipid metabolism and necroinflammation in renal tubular cells by inhibiting SREBP-1 expression, increasing PPAR-α and ABCA1 expression, and inhibiting NLRP3-mediated inflammation and MLKL-dependent necroinflammation. It also activates the AMPK pathway to provide protection.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Neurosciences
Jianhong Li, Bingxue Zhang, Weiwei Jia, Minguang Yang, Yuhao Zhang, Jiayong Zhang, Le Li, Tingting Jin, Zhifu Wang, Jing Tao, Lidian Chen, Shengxiang Liang, Weilin Liu
Summary: Electroacupuncture treatment can enhance aerobic glycolysis (AG) and glucose metabolism in Alzheimer's disease (AD) by activating AMP-activated protein kinase (AMPK), leading to improved cognitive function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Physiology
Qing-xiang Zhao, Yi-hao Wang, Si-cong Wang, Song Xue, Zhen-xin Cao, Tao Sun
Summary: This study found that PDX can affect autophagy flux via AMPK signaling in LRP patients, showing pro-resolving properties and powerful analgesic effects.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Food Science & Technology
Ta-Chin Lin, Chia-Wen Lu, Kai-Fu Chang, Chung-Jen Lee
Summary: The study found that Juniperus communis (JCo) extract has anti-inflammatory and antioxidant effects, which can improve acute kidney injury and increase the survival rate of animals.
FOOD SCIENCE & NUTRITION
(2022)
Article
Oncology
Janki M. Desai, Aniruddha S. Karve, Gary A. Gudelsky, Mruniya Gawali, William Seibel, Larry Sallans, Biplab DasGupta, Pankaj B. Desai
Summary: This study characterized the pharmacokinetics and metabolism of a potential drug, SBI-0206965, for the treatment of glioblastoma. The results showed that SBI-0206965 has adequate brain permeability but low oral bioavailability, possibly due to rapid hepatic metabolism. These findings will facilitate the further development of SBI-0206965 or other related compounds for the treatment of glioblastoma and other brain tumors.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Biochemistry & Molecular Biology
Linglian Kong, Chuanpi Xiao, Hai Lin, Johan Buyse, Xianlei Li, Zhigang Song
Summary: The study showed that CB1 is mainly expressed in the hypothalamus of broilers, and 72-hour DEX exposure can regulate the CB1 system and AMPK signaling pathway in the broiler hypothalamus. Treatment with DEX for 24 hours and 72 hours increased the mRNA levels of hypothalamic AMPK alpha 2 and GR.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Psychiatry
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan
Summary: The combined therapy of REMSD and fluoxetine protects rats against depression-induced damage and apoptosis in the hippocampus via modulating the A1 adenosine receptor level, suggesting a potential treatment strategy for depression.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Panfeng Wang, Yuntong Zhang, Yan Xia, Dayuan Xu, Hongrui Wang, Dong Liu, Shuogui Xu, Yongming Sun
Summary: The treatment with miR-139-5p enhanced functional recovery and reduced pain hypersensitivity in mice with SCI, possibly through targeting Mst1.
NEUROCHEMICAL RESEARCH
(2021)
Article
Environmental Sciences
Huijie Chen, Yue Zhang, Xue Qi, Xu Shi, Xiaodan Huang, Shi-Wen Xu
Summary: This study described the exacerbating effect of low selenium diet on autophagy in chicken kidney treated with bisphenol A (BPA), and elucidated the involvement of nitric oxide (NO) and AMPK/mTOR signaling pathways. These findings will enhance our understanding of the nephrotoxicity of BPA and the detoxification effect of selenium in chickens.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
T. B. Beena, Mathew. A. Jesil, K. B. Harikumar
Summary: The major cause of colorectal cancer (CRC) related mortality is its metastasis. Signaling pathways, such as the sonic hedgehog (Shh) pathway, and AMP-activated protein kinase (AMPK) play important roles in CRC development and progression. This review explores the interconnection between high-fat diet consumption, Shh pathway activation, and the progression of CRC, as well as the potential regulatory role of AMPK in controlling CRC complexity and lipid levels.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Letter
Anesthesiology
Penghui Wei, Haotian Ye, Jianjun Li, Jian-jun Yang
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Editorial Material
Anesthesiology
Haotian Ye, Penghui Wei, Jian-jun Yang
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Medicine, General & Internal
Hua Wei, Xinhui Du, Huaping Zhao, Peipei Sun, Jianjun Yang
Summary: The study aimed to assess the role of propofol on osteosarcoma and explore the possible mechanisms. The results showed that propofol could inhibit the proliferation and invasion of osteosarcoma and increase the sensitivity of doxorubicin. The experimental results also demonstrated that propofol could induce ER stress and exert an anti-tumor effect.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Jie Guo, Di Qiu, Han-wen Gu, Xing-ming Wang, Kenji Hashimoto, Guang-fen Zhang, Jian-jun Yang
Summary: The perioperative administration of ketamine reduces postoperative depression and pain scores but increases the risk of adverse effects.
MOLECULAR PSYCHIATRY
(2023)
Article
Medical Informatics
Cheng-Mao Zhou, Ying Wang, Jian-Jun Yang, Yu Zhu
Summary: Machine learning can predict gastric cancer patients' prognosis, but no studies have explored predicting gastric cancer death based on machine learning using related inflammatory factor variables. In this study, six machine learning algorithms were applied to predict total gastric cancer death after surgery, and the neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and age were found to be the most important factors.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Clinical Neurology
Sai Chen, Jin-Jin Yang, Yue Zhang, Lei Lei, Di Qiu, Hui-Min Lv, Zhen-Tao Sun, Kenji Hashimoto, Jian-Jun Yang
Summary: This study investigated the effects of a single-dose of esketamine during anesthesia induction on emergence delirium (ED) in preschool children after minor surgery. The study found that the use of esketamine was associated with a higher incidence and score of ED, as well as a longer post-anesthesia care unit stay. However, there were no significant differences in other outcomes between the two groups. Therefore, the use of esketamine in preschool children for minor surgery should be noticed.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Yu-zhu Gao, Xin-miao Wu, Zhi-qiang Zhou, Pan-miao Liu, Jian-jun Yang, Mu-huo Ji
Summary: Accumulating evidence suggests that many sepsis survivors experience long-term cognitive impairments after hospital discharge, causing reduced quality of life and burden for their families. This study utilized a mouse model and various techniques to investigate the role of NRG1/ErbB4 signaling, PV interneurons, and hippocampal neural oscillations in memory decline after repeated LPS injections. The results demonstrated that dysfunction of NRG1/ErbB4 signaling in the hippocampus may contribute to the long-term memory decline observed in the systemic inflammation mouse model. Targeting NRG1/ErbB4 signaling in the hippocampus could be a promising approach for preventing and treating this memory decline.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Han-Wen Gu, Guang-Fen Zhang, Pan-Miao Liu, Wei-Tong Pan, Yuan-Xiang Tao, Zhi-Qiang Zhou, Jian-Jun Yang
Summary: Neuropathic pain severely affects patients' quality of life, but the neuronal circuit mechanisms associated with this disorder remain poorly understood. Recent research has found that a projection from the lateral hypothalamus to the lateral habenula participates in nerve injury-induced nociceptive hypersensitivity. These findings contribute to understanding neuropathic pain and provide potential targets for treatment.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Xiao-Hui Tang, Yu-Gang Diao, Zhuo-Yu Ren, Yan-Yu Zang, Guang-Fen Zhang, Xing-Ming Wang, Gui-Fang Duan, Jin-Chun Shen, Kenji Hashimoto, Zhi-Qiang Zhou, Jian-Jun Yang
Summary: Mouse models of depression-like behavior showed decreased levels of GABA and increased levels of glutamate in the hippocampus. Ketamine treatment reversed these alterations by increasing GABA levels and decreasing glutamate levels. These effects were mediated by changes in enzymes and transporters on GABAergic neurons and astrocytes.
Article
Neurosciences
Xinmiao Wu, Yuzhu Gao, Cuina Shi, Jianhua Tong, Daqing Ma, Jinchun Shen, Jianjun Yang, Muhuo Ji
Summary: Activated microglia and release of pro-inflammatory cytokines cause neuroinflammation and cognitive impairments, but the underlying molecular mechanisms are unknown.
Article
Neurosciences
Ling Zhang, Yu-Zhu Gao, Chun-Jie Zhao, Jiang-Yan Xia, Jian-Jun Yang, Mu-Huo Ji
Summary: This study reveals that active MMP-9 mediates PNN remodeling, leading to reduced synaptic input and abnormal gamma oscillations in hippocampal CA1, ultimately contributing to cognitive impairments in SAE induced by LPS injection. Treatment with the MMP-9 inhibitor SB-3CT can rescue most of these abnormalities.
Article
Multidisciplinary Sciences
Ya-Wei Ji, Zi-Lin Shen, Xue Zhang, Kairan Zhang, Tao Jia, Xiangying Xu, Huizhen Geng, Yu Han, Cui Yin, Jian-Jun Yang, Jun-Li Cao, Chunyi Zhou, Cheng Xiao
Summary: The study focuses on the role of ventral pallidum (VP)-derived cholinergic circuits in hyperalgesia and depression-like behavior in a chronic pain mouse model. The cholinergic circuits are activated by pain-like stimuli and become hyperactive during persistent pain. Acute stimulation of these circuits reduces pain threshold, while inhibition of the circuits elevates pain threshold. Modulation of the VP-derived cholinergic pathway for multiple days regulates depression-like behavior in chronic pain. Therefore, these circuits are implicated in comorbid hyperalgesia and depression-like behavior in a chronic pain mouse model.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Ting-ting Zhu, He Wang, Han-wen Gu, Ling-sha Ju, Xin-miao Wu, Wei-tong Pan, Ming-ming Zhao, Jian-jun Yang, Pan-miao Liu
Summary: Inflammatory depression is closely related to neuroinflammation. Melanin-like polydopamine nanoparticles (PDA NPs) were synthesized using nano-based drug delivery technology to overcome the low permeability of current anti-inflammatory drugs. PDA NPs, with abundant phenolic hydroxyl groups, showed excellent antioxidative properties and were effective in treating lipopolysaccharide-induced inflammatory depression in mice. PDA NPs reduced inflammation, restored synaptic loss, and exhibited good biocompatibility.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Letter
Anesthesiology
Penghui Wei, Min Jia, Pan-miao Liu, Liying Meng, Jianjun Li, Jian-jun Yang
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Wen Duan, Cheng-Mao Zhou, Jin-Jin Yang, Yue Zhang, Ze-Ping Li, Da-Qing Ma, Jian-Jun Yang
Summary: This study investigated the association between the duration of intraoperative hypotension and the incidence of postoperative delirium (POD) in elderly patients undergoing thoracic and orthopedic surgery. The results showed that a duration of hypotension of 5 minutes or longer was closely related to an increased incidence of POD.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
