Article
Psychology, Biological
Patrick Anselme
Summary: Motivated behavior is believed to be a dopamine-dependent unconscious process, but seeking behavior under reward uncertainty shows behavioral paradoxes that deviate from the predictions of the incentive salience hypothesis, indicating a combination of appetite-based and effort-based attractions.
BEHAVIOURAL PROCESSES
(2021)
Article
Behavioral Sciences
Cristina E. Maria-Rios, Christopher J. Fitzpatrick, Francesca N. Czesak, Jonathan D. Morrow
Summary: When a neutral stimulus is repeatedly paired with an appetitive reward, two types of conditioned approach responses may develop: sign-tracking, directed towards the cue, and goal-tracking, directed towards the reward location. Sign-tracking is sensitive to incentive value, while goal-tracking is responsive to predictive value. Sign-tracking rats were more sensitive to manipulations of incentive value, while goal-tracking rats were more responsive to changes in cue predictive value. Sign-tracking was sensitive to outcome devaluation, while goal-tracking was not. The results suggest different rules of reinforcement learning for sign- and goal-tracking.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Behavioral Sciences
Mike J. F. Robinson, Qi Shan A. Bonmariage, Anne-Noel Samaha
Summary: Uncertain and intermittent access to rewards can increase reward-seeking behaviors, which is relevant to human conditions such as gambling, eating disorders, and drug addiction.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Huw Jarvis, Isabelle Stevenson, Amy Q. Huynh, Emily Babbage, James Coxon, Trevor T. -J. Chong
Summary: Recent research suggests that the act of investing effort may influence learning. This study tested whether effort modulates teaching signals in a reinforcement learning paradigm. The results showed that effort resulted in more efficient learning from positive outcomes and less efficient learning from negative outcomes. Interestingly, this effect varied across individuals and was more pronounced in those who were more averse to investing effort in the first place. These findings highlight the importance of motivational factors in a common framework of reward-based learning, integrating the computational principles of reinforcement learning with those of value-based decision-making.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Heather J. Pribut, Xavier A. Sciarillo, Matthew R. Roesch
Summary: The insula is an important brain region that plays a crucial role in both normal and impaired behavior and decision-making. This study aimed to investigate the functional role of insula in behavior by lesioning the anterior insula and found that insula damage affects accuracy, reaction times, and sign-tracking behavior.
Article
Neurosciences
Debbie M. Yee, Jennifer L. Crawford, Bidhan Lamichhane, Todd S. Braver
Summary: This study investigated the role of human dACC in integrating motivational incentives and found that dACC modulates cognitive control based on the integrated subjective motivational value, affecting task performance.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Tara L. White, Meghan A. Gonsalves, Chloe Zimmerman, Hannah Joyce, Ronald A. Cohen, Uraina S. Clark, Lawrence H. Sweet, Carl W. Lejuez, Adam Z. Nitenson
Summary: This study introduces a concept called agentic anger, which is a negatively valenced state that motivates action to achieve risky goals. The neurobehavioral model was evaluated through two proof-of-concept studies, revealing the relationship between agentic anger, reward, and personality traits.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Kurt M. Fraser, Heather J. Pribut, Patricia H. Janak, Ronald Keiflin
Summary: Reward seeking requires coordination of motor programs. Midbrain dopamine neurons are critical for reinforcement and learning. Ventral tegmental area (VTA) dopamine neurons imbue actions and cues with motivational value, allowing flexible pursuit, whereas substantia nigra (SNc) dopamine neurons support precise, action-specific learning. This heterogeneous dopamine system supports unique forms of instrumental learning and reward-seeking strategies.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Ali Gheidi, Christopher J. Fitzpatrick, Jordan D. Gregory, Jonathan D. Morrow
Summary: Acetylcholinergic antagonists have shown promise in reducing addiction-related behaviors, but the psychological mechanisms behind their effects remain unclear. This study investigates the selective effects of systemic antagonism of acetylcholine receptors on behavior in rats.
PSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Shaun Yon-Seng Khoo, Alexandra Uhrig, Anne-Noel Samaha, Nadia Chaudhri
Summary: The study investigated the effects of dopamine D1-like and D2-like receptor antagonism on sign-tracking and goal-tracking conditioned responses, finding that D2 receptor activity is crucial for goal-tracking but not for sign-tracking. Additionally, psychomotor sensitization induced by amphetamine did not impact incentive salience attribution.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Shelley M. Warlow, Kent C. Berridge
Summary: The central nucleus of amygdala (CeA) plays a role in mediating both positively-valenced reward motivation and negatively-valenced fear. Stimulation of CeA circuitry can intensify incentive motivation while not affecting hedonic impact of the reward. CeA can promote either incentive motivation or fearful motivation, potentially leading to different outcomes in neuropsychiatric disorders involving aberrant motivational salience.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Janna M. Colaizzi, Shelly B. Flagel, Ashley N. Gearhardt, Michelle A. Borowitz, Rayus Kuplicki, Vadim Zotev, Grace Clark, Jennifer Coronado, Talia Abbott, Martin P. Paulus
Summary: Externalizing behaviors in childhood are associated with impulse control disorders in adulthood, and the underlying bio-behavioral risk factors are not fully understood. Animal studies have shown that the propensity to sign-track is related to externalizing behaviors and deficits in executive control. This study found that sign-tracking in children is associated with attentional and inhibitory control deficits, as well as amygdala activation during reward anticipation. It suggests that youth with a propensity to sign-track may have an increased risk for externalizing disorders, with a reliance on subcortical cue-reactive brain systems.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Jay J. Duckworth, Hazel Wright, Paul Christiansen, Abigail K. Rose, Nicholas Fallon
Summary: Research shows cognitive and neurobiological overlap between sign-tracking and maladaptive behavior. The study investigates the neural correlates of sign-tracking by using an additional singleton task and fMRI. The results suggest that sign-tracking is associated with activation of the 'attention and salience network' in response to reward cues but not reward feedback, demonstrating a distinction between the two in the brain.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Computer Science, Artificial Intelligence
Pawel Ladosz, Lilian Weng, Minwoo Kim, Hyondong Oh
Summary: This paper reviews exploration techniques in deep reinforcement learning and emphasizes their importance in solving sparse reward problems. Various existing exploration approaches are categorized and unsolved challenges are discussed to provide valuable future research directions.
INFORMATION FUSION
(2022)
Article
Computer Science, Artificial Intelligence
Shivam Kalhan, Marta I. Garrido, Robert Hester, A. David Redish
Summary: Dysfunction in learning and motivational systems is believed to contribute to addictive behaviors. Previous models have limitations in explaining the key features of addictive behaviors, but this study proposes a novel mathematical model that combines dopamine's role in learning and motivation to simulate addictive behaviors accurately. The model also explains some key characteristics of addictive behaviors.
Review
Neurosciences
Kent C. Berridge
NATURE REVIEWS NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Hammad A. Khan, Kevin R. Urstadt, Nina A. Mostovoi, Kent C. Berridge
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2020)
Article
Neurosciences
Hannah M. Baumgartner, Shannon L. Cole, Jeffrey J. Olney, Kent C. Berridge
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Kevin R. Urstadt, Kent C. Berridge
Article
Multidisciplinary Sciences
Shelley M. Warlow, Erin E. Naffziger, Kent C. Berridge
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Hannah M. Baumgartner, Jay Schulkin, Kent C. Berridge
Summary: Activation of CRF neurons in the CeA and NAc enhances incentive motivation and promotes reward pursuit and consumption, while activation of CRF neurons in the BNST produces negative valence and aversive effects, suppressing the pursuit and consumption of rewards.
BIOLOGICAL PSYCHIATRY
(2021)
Editorial Material
Neurosciences
Kent C. Berridge
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Psychology, Biological
Ileana Morales, Kent C. Berridge
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Behavioral Sciences
Shelley M. Warlow, Kent C. Berridge
Summary: The central nucleus of amygdala (CeA) plays a role in mediating both positively-valenced reward motivation and negatively-valenced fear. Stimulation of CeA circuitry can intensify incentive motivation while not affecting hedonic impact of the reward. CeA can promote either incentive motivation or fearful motivation, potentially leading to different outcomes in neuropsychiatric disorders involving aberrant motivational salience.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Editorial Material
Neurosciences
Brian A. Baldo, Kent C. Berridge
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Biological
Daniel Dukes, Kathryn Abrams, Ralph Adolphs, Mohammed E. Ahmed, Andrew Beatty, Kent C. Berridge, Susan Broomhall, Tobias Brosch, Joseph J. Campos, Zanna Clay, Fabrice Clement, William A. Cunningham, Antonio Damasio, Hanna Damasio, Justin D'Arms, Jane W. Davidson, Beatrice de Gelder, Julien Deonna, Ronnie de Sousa, Paul Ekman, Phoebe C. Ellsworth, Ernst Fehr, Agneta Fischer, Ad Foolen, Ute Frevert, Didier Grandjean, Jonathan Gratch, Leslie Greenberg, Patricia Greenspan, James J. Gross, Eran Halperin, Arvid Kappas, Dacher Keltner, Brian Knutson, David Konstan, Mariska E. Kret, Joseph E. LeDoux, Jennifer S. Lerner, Robert W. Levenson, George Loewenstein, Antony S. R. Manstead, Terry A. Maroney, Agnes Moors, Paula Niedenthal, Brian Parkinson, Ioannis Pavlidis, Catherine Pelachaud, Seth D. Pollak, Gilles Pourtois, Birgitt Roettger-Roessler, James A. Russell, Disa Sauter, Andrea Scarantino, Klaus R. Scherer, Peter Stearns, Jan E. Stets, Christine Tappolet, Fabrice Teroni, Jeanne Tsai, Jonathan Turner, Carien Van Reekum, Patrik Vuilleumier, Tim Wharton, David Sander
Summary: Research has shown the significant impact of affective processes on human thinking and behavior, raising the question of whether this has led to a new era of affectivism.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Behavioral Sciences
David Nguyen, Erin E. Naffziger, Kent C. Berridge
Summary: The positive impact of rewards, which involve components of pleasure, motivation, and learning, is essential for well-being. Under normal conditions, liking and wanting are coherent, but alterations in neural signaling can lead to their dissociation, which may be detrimental to positive well-being.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Kent C. Berridge, Peter Dayan
Meeting Abstract
Neurosciences
Kent Berridge
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Antoine Bechara, Kent C. Berridge, Warren K. Bickel, Jose A. Moron, Sidney B. Williams, Jeffrey S. Stein
PSYCHOLOGICAL SCIENCE IN THE PUBLIC INTEREST
(2019)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)