期刊
BEHAVIOURAL BRAIN RESEARCH
卷 244, 期 -, 页码 100-106出版社
ELSEVIER
DOI: 10.1016/j.bbr.2013.01.038
关键词
Benzodiazepines; Spatial memory; Modified elevated plus maze; N-G-nitro-L-arginine methyl ester; 7-nitroindazole; Mice
资金
- Polish Ministry of Science and Higher Education [NN 405091740]
The aim of the present study was to examine the effects of nitric oxide synthase (NOS) inhibitors on responses, elicited by benzodiazepines (BZs) in a modified elevated plus-maze task in mice. It was shown that acute doses of diazepam (DZ; 1 and 2 mg/kg) and flunitrazepam (FNZ; 0.05, 0.1 and 0.2 mg/kg) significantly increased the time of transfer latency (TL2) in a retention trial, thus confirming memory impairing effects of BZs. L-NAME (N-G-nitro-L-arginine methyl ester; 200 mg/kg), a non-selective inhibitor of NOS, and 7-NI (7-nitroindazole; 40 mg/kg), a selective inhibitor of NOS, further intensified DZ-induced memory impairment. On the other hand, L-NAME (50,100 and 200 mg/kg) and 7-NI (10,20 and 40 mg/kg) prevented FNZ-induced memory compromising process. The results of this study indicated that suppressed NO synthesis enhanced DZ-induced but prevented FNZ-induced memory impairment. Taken together, these findings could suggest NO involvement in BZs-induced impairment of memory processes. The precise mechanism of these controversial effects, however, remains elusive. (C) 2013 Elsevier B.V. All rights reserved.
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