Article
Neurosciences
Fang-Fei Tao, Zi-Yu Wang, Ying Wang, Qian-Ru Lv, Peng-Peng Cai, Hai-Wen Min, Jian-Wei Ge, Chun-Yu Yin, Rui Cheng
Summary: Oxygen therapy plays a vital role in the development of bronchopulmonary dysplasia (BPD), but the effect of hippocampal cyclin-dependent kinase 5 (CDK5) on BPD-associated neurodevelopment deficits is not fully understood. Inhibition of CDK5 overactivation can improve cognitive deficits, neuronal apoptosis, and synaptic plasticity disorders in BPD mice.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Zhe Zhao, Hui Ji, Cong Zhang, Jiamin Pei, Xiangjian Zhang, Yi Yuan
Summary: Through experiments on mice, it was found that ultrasound stimulation can significantly improve the whisker-dependent novel object discrimination ability of mice, enhance neuronal firing activity, and promote the growth rate of dendritic spines without promoting their extinction, resulting in enhanced synaptic plasticity. These results indicate that ultrasound stimulation can improve the learning and memory ability of mice and enhance the neuronal firing activity and synaptic plasticity that are closely related to it. This study provides a research basis for the application of ultrasound stimulation in the treatment of learning and memory-related diseases.
Article
Biochemistry & Molecular Biology
Daniel B. Dorman, Kim T. Blackwell
Summary: Synaptic plasticity, the experience-induced change in connections between neurons, plays a crucial role in learning and memory. This study investigates how spatiotemporal synaptic input patterns produce plasticity under in vivo-like conditions. The findings reveal the robustness of plasticity to trial-to-trial variability of spike timing and derive general rules describing the control of plasticity by spatiotemporal patterns of synaptic inputs.
Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Neurosciences
Shu-Ling Chiu, Chih-Ming Chen, Richard L. Huganir
Summary: The study revealed a novel function of ICA69 in AMPAR trafficking, synaptic plasticity, and animal cognition. ICA69 regulates the distribution and stability of PICK1 in neurons, which impacts AMPAR function in the brain. The genetic deletion of ICA69 selectively impairs NMDAR-dependent LTP and leads to behavioral deficits in spatial and associative learning and memory.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Immunology
Ivan Ballasch, Esther Garcia-Garcia, Cristina Vila, Anna Perez-Gonzalez, Anna Sancho-Balsells, Jessica Fernandez, David Soto, Mar Puigdellivol, Xavier Gasull, Jordi Alberch, Manuel J. Rodriguez, Josep M. Canals, Albert Giralt
Summary: In the last two decades, microglia have been recognized as important contributors to neurological disorders, not only through their immunological functions, but also through their ability to modulate synaptic and neural activity. The Ikzf1 gene, which plays crucial roles in regulating the function of circulating monocytes and lymphocytes, was found to be specifically expressed in adult microglia in the brain. Studies using Ikzf1 deficient mice revealed spatial learning deficits, impaired hippocampal function, and altered microglial morphology, suggesting that Ikzf1 is involved in microglial state and function. Furthermore, altered levels of Ikzf1 were observed in neurological disorder models and Alzheimer's disease patients, indicating its potential role in disease pathology.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Allison M. Burns, Melissa Farinelli-Scharly, Sandrine Hugues-Ascery, Jose Vicente Sanchez-Mut, Giulia Santoni, Johannes Graeff
Summary: Long-term memory formation is influenced by synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Studies have shown that HDAC inhibitors (HDACi) can enhance these processes and act as potential cognitive enhancers. This study explores the effects of combining the HDACi CI-994 with contextual fear conditioning (CFC) in mice and demonstrates that CI-994 treatment improves memory formation by enhancing long-term potentiation in the hippocampus, a brain region involved in fear learning. Furthermore, RNA sequencing analysis reveals that HDACi treatment increases synaptic plasticity-promoting gene expression, specifically in the dentate gyrus of the hippocampus, when paired with CFC. Chromatin immunoprecipitation-sequencing experiments show that the combined action of HDACi application and conditioning is necessary for enhancer histone acetylation in pathways underlying improved memory performance. These findings suggest that systemic administration of HDACi amplifies brain region-specific processes induced by learning.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yulia Dembitskaya, Charlotte Piette, Sylvie Perez, Hugues Berry, Pierre J. Magistretti, Laurent Venance
Summary: The study shows that glucose and lactate play different roles in memory engram and neural computation. Lactate is important for high-stimulation load activity patterns and high attentional load in cognitive tasks, while glucose is sufficient for less demanding neural computation and learning tasks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Ye Wang, Amy K. Y. Fu, Nancy Y. Ip
Summary: In the adult hippocampus, astrocytes, the most common glial cells, play a crucial role in regulating synaptic plasticity. Astrocytes are highly heterogeneous in response to changes in neuronal activity and can modulate synaptic communication through various pathways, ultimately influencing memory performance and cognitive functions. Dysregulation of astrocytic signaling can lead to hippocampal circuit dysfunction and cognitive impairment, as observed in conditions like Alzheimer's disease.
Article
Neurosciences
Ping Liao, Qing-Yun Wu, Sen Li, Kai-Bin Hu, Hui-Lin Liu, Hai-Yan Wang, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wang
Summary: Abscisic acid (ABA) is a hormone found in plants and animals that regulates blood glucose and inflammation. It has therapeutic effects on obesity, diabetes, atherosclerosis, and inflammatory diseases. Studies have shown that ABA can cross the blood-brain barrier and improve learning, memory, and cognitive ability in the central nervous system. Additionally, it plays a crucial role in improving Alzheimer's disease, depression, and anxiety.
Article
Immunology
M. A. Clements, A. J. Kwilasz, S. T. Litwiler, Z. Sents, B. J. Woodall, K. Hayashida, L. R. Watkins
Summary: Intrathecal delivery of IL-10 gene therapy is effective in relieving neuropathic pain, as demonstrated by behavioral tests in rodents. A new maze task, called the Two-Arm Rodent Somatosensory (TARS) task, has been developed to assess the development and resolution of pain behavior. This study provides evidence that intrathecal IL-10 gene therapy can improve neuropathic pain through supraspinally-mediated behavioral tasks.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Chemistry, Multidisciplinary
Kai Chen, Qiuping Hu, Zhongcong Xie, Guang Yang
Summary: This study reveals that surgery leads to neuronal hypoactivity and impairs learning-dependent dendritic spine formation, resulting in deficits in multiple learning tasks. These neuronal and synaptic alterations are mediated by peripheral monocytes through NLRP3 inflammasome-dependent IL-1β production. Decreasing peripheral monocytes or inactivating NLRP3 inflammasomes can reduce IL-1β levels and improve neuronal and behavioral deficits.
Article
Biology
Miguel A. Collado, Randolf Menzel, Daniel Sol, Ignasi Bartomeus
Summary: Recent evidence challenges the perception that insects lack cognitive machinery, as solitary bees have been found to innovate by solving new tasks in a laboratory setting. The propensity to innovate is found to be correlated with exploration, boldness, and activity levels, rather than measured learning capacity.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Neurosciences
Blake Aaron Richards, Konrad Paul Kording
Summary: The study of learning and plasticity has always been driven by the question of how physiological changes can be adaptive and improve performance. Different mechanisms such as Hebbian plasticity and dopamine-gated learning show that synapse changes depend on activity and reward, respectively. By examining the existing literature, we argue that gradients are a unifying idea to explain the mechanisms of neuronal plasticity.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
