Review
Anatomy & Morphology
Aurelien Kerever, Eri Arikawa-Hirasawa
Summary: This review summarizes the current understanding of the extracellular matrix (ECM) niche in the adult subventricular zone (SVZ) of the mammalian brain, with a focus on how basement membrane-like structures called fractones, and their composition of glycosaminoglycans (GAGs), may impact neurogenesis by regulating growth factor signaling pathways.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Biochemistry & Molecular Biology
Aurelien Kerever, Fumina Nagahara, Kazuko Keino-Masu, Masayuki Masu, Toin H. van Kuppevelt, Romain R. Vives, Eri Arikawa-Hirasawa
Summary: The study reveals that inhibiting 6-O-sulfation in fractones by endosulfatases suppresses neurogenesis in the SVZ, and a higher number of neuroblasts are found in the SVZ of young and aged Sulf1/2 DKO mice.
Article
Biochemistry & Molecular Biology
Jana Osacka, Alexander Kiss, Zuzana Bacova, Andrej Tillinger
Summary: Aberrant neurogenesis in the subventricular zone and hippocampus contributes to schizophrenia pathogenesis. The commonly prescribed antipsychotics haloperidol and olanzapine affect neurogenesis. This study investigates the effects of these drugs on cell proliferation and gene expression in vitro and in an animal schizophrenia model. The results suggest that chronic treatment with haloperidol and olanzapine can inhibit gene expression, but olanzapine can reverse the inhibitory effect of another drug in the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Harkanwalpreet Sodhi, Alyssa Panitch
Summary: Glycosaminoglycans play a crucial role in tissue engineering by driving stem cell fate and promoting cell proliferation, and recent studies have explored their use in tissue constructs. The research trends in this area are evaluated, providing insights into future directions.
Review
Biochemistry & Molecular Biology
Anastasia V. Strokotova, Elvira V. Grigorieva
Summary: Glucocorticoids are commonly used to treat various diseases but can cause side effects. Recent studies suggest that the toxic effects of glucocorticoids on key extracellular components in the brain may be an underlying mechanism for these side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Pu-Tien Chiang, Hsin-Hsi Tsai, Ruoh-Fang Yen, Yi-Chieh Tsai, Chi-Han Wu, Ching-Hung Chiu, Li-Kai Tsai
Summary: In this study, we assessed the use of F-18-fluorothymidine (FLT) PET to detect cerebral cell proliferation and found that it is associated with stroke severity and outcomes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alyce J. Mayfosh, Tien K. Nguyen, Mark D. Hulett
Summary: The extracellular matrix plays crucial roles in maintaining tissue structure, immune defense, and acting as a reservoir for bioactive molecules, with heparan sulfate proteoglycans (HSPGs) and their component heparan sulfate being essential in these processes. Understanding the regulation of heparanase and its downstream targets is important for potential therapeutic strategies in inflammatory diseases, atherosclerosis, fibrosis, and cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Andi Chen, Xiaohui Chen, Jianhui Deng, Jianjie Wei, Haitao Qian, Yongxin Huang, Shuyan Wu, Fei Gao, Cansheng Gong, Yanling Liao, Xiaochun Zheng
Summary: Hypoxic-ischemic brain damage (HIBD) is the main cause of neurological dysfunction in neonates. Olfactory cognitive dysfunction is important for feeding, the ability to detect hazardous situations, and social relationships. Dexmedetomidine (DEX) treatment could significantly improve olfactory cognitive dysfunction in neonatal rats with HIBD by promoting neurogenesis in the subventricular zone (SVZ) and enhancing the expression of brain-derived neurotrophic factor (BDNF) in microglia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Bin Sun, Mengran Wang, Anna Hoerder-Suabedissen, Chris Xu, Adam M. Packer, Francis G. Szele
Summary: We demonstrate, for the first time, three-photon microscopy imaging of the SVZ in live mice. This strategy could be useful for intravital visualization of cell dynamics, molecular, and pathological perturbation and regenerative events.
Review
Cell Biology
Tien K. Nguyen, Stephanie Paone, Enoch Chan, Ivan K. H. Poon, Amy A. Baxter, Shane R. Thomas, Mark D. Hulett
Summary: Cardiovascular disease is the leading cause of death and disability worldwide, and atherosclerosis plays a crucial role in its development. Heparanase, as the only mammalian enzyme known to cleave heparan sulfate, has been found to be involved in various physiological and pathological processes, including inflammation and plaque formation. This review focuses on the emerging role of heparanase in atherosclerosis and provides an up-to-date overview of its functions.
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Tonia L. Vincent, Oliver McClurg, Linda Troeberg
Summary: The extracellular matrix (ECM) plays a crucial role in tissue homeostasis and disease, acting as a mechano-sensor and mechano-effector in cartilage. It is involved in perceiving and responding to mechanical load, releasing growth factors for cartilage repair and protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Peter Bober, Sona Tkacikova, Ivan Talian, Peter Urdzik, Silvia Toporcerova, Jan Sabo
Summary: HPV-associated lesions and malignancies have changes in the composition and functionality of the extracellular matrix (ECM), affecting the interactions between infection and disease. A study analyzed urine samples from cervical intraepithelial neoplasia grade 3 (CIN3) patients and healthy controls using label-free quantitative analysis and found significant changes in 48 proteins. The down-regulation of ECM-receptor interaction proteins in the CIN3 group may play a role in the development and progression of cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Nan Yao, Yulin Li, Jinrui Han, Siting Wu, Xin Liu, Qiuyu Wang, Zhiguo Li, Fu-Dong Shi
Summary: This study reveals the detrimental role of microglia in neurogenesis and neurorepair after intraventricular hemorrhage (IVH), with CC chemokine ligand 20 (CCL20) playing a likely role in promoting pro-inflammatory responses and neural injury.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Cell Biology
Vicente Llorente, Pedro Velarde, Manuel Desco, Maria Victoria Gomez-Gaviro
Summary: This review summarizes the latest research on neural stem cells and their canonical niches, including their structure, behaviors, and role in neural diseases.
Article
Zoology
Brandon L. Pearson, DeeAnn M. Reeder, Peter G. Judge
AMERICAN JOURNAL OF PRIMATOLOGY
(2015)
Article
Psychology, Biological
Brandon L. Pearson, Erwin B. Defensor, D. Caroline Blanchard, Robert J. Blanchard
PHYSIOLOGY & BEHAVIOR
(2015)
Article
Multidisciplinary Sciences
Brandon L. Pearson, Jeremy M. Simon, Eric S. McCoy, Gabriela Salazar, Giulia Fragola, Mark J. Zylka
NATURE COMMUNICATIONS
(2016)
Letter
Biochemistry & Molecular Biology
K. S. Henzel, B. L. Pearson, D. Ehninger
MOLECULAR PSYCHIATRY
(2018)
Article
Biochemistry & Molecular Biology
D. P. Ryan, K. S. Henzel, B. L. Pearson, M. E. Siwek, A. Papazoglou, L. Guo, K. Paesler, M. Yu, R. Mueller, K. Xie, S. Schroeder, L. Becker, L. Garrett, S. M. Hoelter, F. Neff, I. Racz, B. Rathkolb, J. Rozman, G. Ehninger, M. Klingenspor, T. Klopstock, E. Wolf, W. Wurst, A. Zimmer, H. Fuchs, V. Gailus-Durner, M. Hrabe de Angelis, K. Sidiropoulou, M. Weiergraeber, Y. Zhou, D. Ehninger
MOLECULAR PSYCHIATRY
(2018)
Review
Behavioral Sciences
Brandon L. Pearson, Jacqueline N. Crawley, David Eilam, Nathan S. Pentkowski, Cliff H. Summers
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2017)
Article
Multidisciplinary Sciences
Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S. Henzel, Sabine M. Hoelter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L. Pearson, Ildiko Racz, Birgit Rathkolb, Devon P. Ryan, Susanne Schroeder, Irina Treise, Raffi Bekeredjian, Dirk H. Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergraeber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Dan Ehninger
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Kan Xie, Devon P. Ryan, Brandon L. Pearson, Kristin S. Henzel, Frauke Neff, Ramon O. Vidal, Magali Hennion, Isabelle Lehmann, Melvin Schleif, Susanne Schroeder, Thure Adler, Birgit Rathkolb, Jan Rozman, Anna-Lena Schuetz, Cornelia Prehn, Michel E. Mickael, Marco Weiergraber, Jerzy Adamski, Dirk H. Busch, Gerhard Ehninger, Anna Matynia, Walker S. Jackson, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Stefan Bonn, Martin Hrabe de Angelis, Dan Ehninger
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Editorial Material
Genetics & Heredity
Brandon L. Pearson, Dan Ehninger
Article
Genetics & Heredity
Brandon L. Pearson, Leonie P. Posselt, Kristin S. Henzel, Dan Ehninger
Article
Immunology
Anna Kobrzycka, Pawel Napora, Brandon L. Pearson, Rystyna Pierzchala-Koziec, Rafal Szewczyk, Marek Wieczorek
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Cell & Tissue Engineering
Katarzyna Nawrotek, Karolina Rudnicka, Justyna Gatkowska, Sylwia Michlewska, Brandon L. Pearson, Przemyslaw Plocinski, Marek Wieczorek
Summary: Epigenetic processes, such as DNA methylation and chromatin modifications, are crucial for establishing reduced growth capacity in the mature nervous system. Tet3, a member of the Tet gene family, plays a key role in promoting injury-induced DNA demethylation and expression of regeneration-associated genes. Encapsulated Tet3 enhances levels of demethylation and outperforms NGF in promoting neurite outgrowth, suggesting a novel approach for treating nerve injuries.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Review
Behavioral Sciences
Amy E. Margolis, Ran Liu, Vasco A. Conceicao, Bruce Ramphal, David Pagliaccio, Mariah L. DeSerisy, Emily Koe, Ena Selmanovic, Amarelis Raudales, Nur Emanet, Aurabelle E. Quinn, Beatrice Beebe, Brandon L. Pearson, Julie B. Herbstman, Virginia A. Rauh, William P. Fifer, Nathan A. Fox, Frances A. Champagne
Summary: Humans are exposed to neurotoxicants in air pollution, which increase the risk for psychiatric outcomes. Prenatal exposure to air pollution increases the risk for behavioral inhibition and irritability, affecting dopamine signaling, hippocampal morphology, neuroinflammation, and brain-derived neurotrophic factor expression. Future studies should incorporate complex exposure measurement methods, neuroimaging, and behavioral characterization to improve child development.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Kan Xie, Helmut Fuchs, Enzo Scifo, Dan Liu, Ahmad Aziz, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Patricia da Silva-Buttkus, Julia Calzada-Wack, Yi-Li Cho, Yushuang Deng, A. Cole Edwards, Lillian Garrett, Christina Georgopoulou, Raffaele Gerlini, Sabine M. Hoelter, Tanja Klein-Rodewald, Michael Kramer, Stefanie Leuchtenberger, Dimitra Lountzi, Phillip Mayer-Kuckuk, Lena L. Nover, Manuela A. Oestereicher, Clemens Overkott, Brandon L. Pearson, Birgit Rathkolb, Jan Rozman, Jenny Russ, Kristina Schaaf, Nadine Spielmann, Adrian Sanz-Moreno, Claudia Stoeger, Irina Treise, Daniele Bano, Dirk H. Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Beverly A. Mock, Paolo Salomoni, Carsten Schmidt-Weber, Marco Weiergraber, Eckhard Wolf, Wolfgang Wurst, Valerie Gailus-Durner, Monique M. B. Breteler, Martin Hrabe de Angelis, Dan Ehninger
Summary: Current concepts about the biology of aging are mainly based on studies aiming at identifying factors that regulate lifespan. However, using lifespan as the only measure for aging may have limited value because it can be restricted by specific pathologies. In this study, large-scale phenotyping was used to analyze various markers in aging male mice. Lifetime profiles were established for each phenotype to determine when age-related changes become detectable relative to young adults. The effects of potential anti-aging interventions were also examined. Importantly, the study included young treated groups of animals, subjected to interventions before detectable age-related changes occurred. Many interventions influenced phenotypes before the onset of detectable age-related changes, but did not alter the rate of phenotypic change. Therefore, these interventions had limited effects on aging. Lifespan can be influenced by both physiological aging and specific pathologies associated with old age. The authors provide a resource for large-scale phenotyping of aging male mice at different time points, analyzing a wide range of phenotypes and molecular markers, including genetic and diet interventions that affect lifespan.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Stephanie Calluori, Rebecca Stark, Brandon L. L. Pearson
Summary: Short tandem repeats (STRs) are repetitive sequences of 1-6 base pairs that can expand or contract, and have been linked to over 50 diseases affecting the central nervous system and muscles. Environmental factors play a role in the development of repeat expansion diseases by inducing DNA damage and repair pathways. Oxidative stress and epigenetic modifications are potential mediators of environmentally induced repeat instability. Further research is needed to identify environmental modulators and their mechanisms of action in order to inform prevention and treatment strategies.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)