Article
Neurosciences
Zijuan Zhang, Hai Li, Yunfang Su, Jinlian Ma, Ye Yuan, Ziyang Yu, Ming Shi, Simai Shao, Zhenqiang Zhang, Christian Holscher
Summary: Research demonstrates that the CCK analogue has neuroprotective effects and improves locomotor function in an acute PD mouse model. It acts by restoring dopaminergic neuron count and synapse number, reducing neuroinflammation and autophagy impairment, and protecting against mitochondrial and ER damage.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Applied
Vincent M. Lombardo, Louise Bernier, Ming Z. Chen, William Farrell, Andrew Flick, Philippe Nuhant, Neal W. Sach, Yong Tao, John Trujillo
Summary: Chiral piperidines are commonly found in approved drugs and drug candidates, but their synthesis faces challenges of scalability and stereochemical control. This research focused on accessing stereochemically pure 3,4-disubstituted piperidines through a classical resolution method, which could have broader utility in pharmaceutical intermediates. The practical synthesis described in this work allows for the production of kilogram quantities of enantiopure precursor, enabling scale-up efforts for toxicology studies.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Oncology
Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi Shen
Summary: This study compared the effects of rotenone and MPTP in two commonly used mouse models of chronic PD. The results showed that the MPTP model accurately reproduced the pathological features of PD, while the rotenone model was more suitable for studying mitochondrial dysfunction and Lewy body formation in PD.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Crystallography
Maya Chochkova, Rusi Rusew, Reni Kalfin, Lyubka Tancheva, Maria Lazarova, Hristina Sbirkova-Dimitrova, Andrey Popatanasov, Krasimira Tasheva, Boris Shivachev, Nejc Petek, Martin Sticha
Summary: Parkinson's disease is a common neurodegenerative disorder with severe side effects associated with current treatments. In this study, a new compound, CA(2-Me)-Am, was synthesized and shown to improve memory performance and neuromuscular coordination in an experimental model of Parkinson's disease.
Article
Pharmacology & Pharmacy
Babita Singh, Shivani Pandey, Mohammad Rumman, Shashank Kumar, Prem Prakash Kushwaha, Rajesh Verma, Abbas Ali Mahdi
Summary: The study showed that Bacopa monnieri extract has neuroprotective and neurorescue effects against MPTP-induced degeneration of dopaminergic neurons, potentially slowing down disease progression and delaying neurodegeneration in Parkinson's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Shendong Jing, Zhenhai Wang, Jun Zhang, Xianfeng Li, Ruifei Huang
Summary: Neferine was shown to have a neuroprotective effect against MPTP-induced Parkinson's in mice by reducing pro-inflammatory cytokines levels and increasing dopamine levels. This indicates that neferine could potentially be used as a drug to treat Parkinson's disease with minimal side effects, pending further trials.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Toxicology
Yi Ren, Dan Ye, Yiping Ding, Ning Wei
Summary: This study investigated the role of RK1 in an in vitro and in vivo model of Parkinson's disease. RK1 was found to alleviate motor deficits, enhance TH expression, and protect against cell apoptosis, oxidative stress and inflammatory response. The neuroprotective effects of RK1 were mediated by the SIRT3/Nrf2/HO-1 signaling pathway.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Chuanqi Chu, Tiantian Li, Leilei Yu, Yiwen Li, Miaoyu Li, Min Guo, Jianxin Zhao, Qixiao Zhai, Fengwei Tian, Wei Chen
Summary: Dietary patterns, specifically a low-protein, high-carbohydrate (LPHC) diet, have potential protective effects on Parkinson's disease (PD) by improving motor deficits, increasing dopamine levels, and normalizing gut bacterial composition. Key mediators in this process include fibroblast growth factor 21 (FGF-21), aromatic amino acids (AAAs), microbial metabolites (TUDCA and taurine), and the gut-microbiota-brain axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Neurosciences
Eduard Bentea, Laura De Pauw, Lise Verbruggen, Lila C. Winfrey, Lauren Deneyer, Cynthia Moore, Giulia Albertini, Hideyo Sato, Ann Van Eeckhaut, Charles K. Meshul, Ann Massie
Summary: Our study revealed age-related protection against proteasome inhibition-induced nigrostriatal degeneration in xCT(-/-) mice, while xCT deletion failed to protect nigral dopaminergic neurons of aged mice against MPTP-induced toxicity. This provides new insights into the role of system x(c)(-) in mechanisms of dopaminergic cell loss and its interaction with aging.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Abdolvahed Narmashiri, Mojtaba Abbaszadeh, Ali Ghazizadeh
Summary: This article provides a comprehensive review and meta-analysis on the effects of MPTP on memory and motor functions in Parkinson's disease. The results show that MPTP not only significantly affects motor functions, but also various mnemonic processes. However, no systematic relationship between the MPTP injection protocol parameters and the extent of induced PD symptoms was found.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Ruixi Yang, Suzhen Ye, Shuping Zhang, Hanjin Huang, Yun Zhang, Yao Yang, Shu Xie, Lin He, Yuwei Yang, Jian Shi
Summary: This study evaluated the association between early anxious behavior and serotonin, dopamine, and their metabolites in a murine model of Parkinson's disease. The results showed that MPTP-induced depletion of serotonin and dopamine levels in different brain regions, with varying correlations to anxious behavior. This suggests that the balance between the serotonin and dopamine systems is disrupted in early Parkinson's disease and may contribute to anxiety behaviors.
Article
Neurosciences
Yun-Mi Kim, Su Yeon Choi, Onyou Hwang, Joo-Yong Lee
Summary: This study investigated the potential neuroprotective effects of exogenous pyruvate in a mouse model of Parkinson's disease. The results showed that sodium pyruvate administration could protect nigral DA neurons from degeneration and alleviate the associated motor deficits, indicating its therapeutic potential for PD and related neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Huidan Weng, Wenjing Song, Kangyue Fu, Yunqian Guan, Guoen Cai, En Huang, Xiaochun Chen, Haiqiang Zou, Qinyong Ye
Summary: This study aimed to investigate the potential mechanism and possible regulatory targets of SIRT4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice. The results indicated that fatty acid binding protein 4 (FABP4) in the peroxisome proliferator-activated receptor (PPAR) signaling pathway is the most promising molecular target of SIRT4 in an MPTP-induced mouse model.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Benchi Cai, Lifan Zhong, Qitong Wang, Wendi Xu, Xi Li, Tao Chen
Summary: This study investigates the neuroprotective mechanisms of curcumin for Parkinson's disease through the microbiota-gut-brain axis, and finds that curcumin alleviates motor deficits and gut dysfunctions by regulating the gut microbiota and short-chain fatty acids.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hao Wu, Xi Liu, Ze-Yu Gao, Ming Lin, Xin Zhao, Yi Sun, Xiao-Ping Pu
Summary: The study demonstrates that the flavonoid icaritin can simultaneously reduce neuroinflammation, oxidative stress, and improve alterations in neuronal energy metabolism to improve Parkinson's disease. By inhibiting NLRP3 inflammasome activity and stabilizing mitochondrial function, icaritin shows therapeutic potential in PD. The results suggest that icaritin interacts with key proteins and molecules related to inflammation, mitochondrial function, and energy metabolism, providing insights into its promising therapeutic effects.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)