期刊
BEHAVIOURAL BRAIN RESEARCH
卷 235, 期 1, 页码 55-66出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2012.07.022
关键词
PTSD; Stress effects; Avoidance; Dendritic spines; Cardiovascular disease
资金
- U.S. Army Medical Research and Materiel Command
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
We evaluated repeated exposures of mice to a trained aggressor mouse as a model (adapted from social stress models of traumatic stress) for aspects of post-traumatic stress disorder (PTSD). Using a cage-within-cage resident-intruder protocol, subject C57BL/6J mice were exposed to aggressors for 6 h daily for 5 or 10 days. At one to three random times during each 6-h session, subjects were exposed directly to aggressor for 1 min or 10 bites, whichever came first. Behavioral, physiological, and histological changes associated with aggressor-exposure were assessed for up to 6 weeks. During aggressor exposure, subjects displayed less territorial behavior, gained weight, and increased body temperature. One day after the last aggressor exposure, inflammatory cardiac histopathologies were prevalent; after 10 days, only mild myocardial degeneration with fibrosis or fibroplasias was evident, while controls showed almost no cardiac abnormalities at any time. After 4 weeks, the medial prefrontal cortex of control mice showed increased dendritic spine density, but aggressor-exposed mice showed no increase. Behaviors affected by aggressor exposure were evaluated in a partition test wherein the subject mouse is separated from the aggressor by a fenestrated partition that permits sensory cues to pass but prevents direct physical interaction. For up to 4-6 weeks after the last aggressor exposure, subjects showed prolonged grooming, freezing, retarded locomotion and no tail rattling. PTSD and its co-morbidities are often consequent to repeated aggravated social assaults (e.g., combat) and manifest socially over time, suggesting the relevance of this repeated aggressor-exposure model to clinical aspects of PTSD. Published by Elsevier B.V.
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