Review
Obstetrics & Gynecology
Lexus M. Frazier, Lauren E. Bobby, Kristen M. Gawronski
Summary: Buprenorphine and clonidine as monotherapy for the treatment of neonatal abstinence syndrome (NAS) have shown favorable effects by reducing length of NAS treatment and LOS.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Samuel Obeng, Francisco Leon, Avi Patel, Julio D. Zuarth Gonzalez, Lucas Chaves Da Silva, Luis F. Restrepo, Lea R. Gamez-Jimenez, Nicholas P. Ho, Maria P. Guerrero Calvache, Victoria L. C. Pallares, Justin A. Helmes, Sakura K. Shiomitsu, Paul L. Soto, Aidan J. Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Takato Hiranita
Summary: The primary kratom alkaloid mitragynine and its metabolite 7-hydroxymitragynine may produce antinociceptive effects through synergistic actions with adrenergic-alpha(2) receptor (A alpha R-2) and m-opioid receptor (MOR) agonists. Additionally, when combined with A alpha R-2 agonists, mitragynine may also produce hypothermic effects.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Rahimah Hassan, Sasidharan Sreenivasan, Christian P. Mueller, Zurina Hassan
Summary: The study evaluated the potential of prescription medications (methadone, buprenorphine, and clonidine) in alleviating mitragynine withdrawal signs. The results showed that these drugs significantly attenuated the withdrawal symptoms, with no major effects on blood or organ toxicity observed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jamie M. Newton, Emma L. Betts, Lyto Yiangou, Jose Ortega Roldan, Anastasios D. Tsaousis, Gary S. Thompson
Summary: Blastocystis is an opportunistic parasite commonly found in the intestines of humans and other animals, but there is limited knowledge about its biology. Analyzing its metabolites can reveal its role in health and disease. Using methanol as an extraction solvent and bead bashing as a lysis technique, carrying out the procedure at room temperature provides a consistent and efficient method to extract metabolites from Blastocystis for NMR analysis.
Article
Virology
German Gustavo Gornalusse, Lucia N. Vojtech, Claire N. Levy, Sean M. Hughes, Yeseul Kim, Rogelio Valdez, Urvashi Pandey, Christina Ochsenbauer, Rena Astronomo, Julie McElrath, Florian Hladik
Summary: The study results suggest that buprenorphine increases the susceptibility of leukocytes to HIV-1 infection in vitro compared to morphine or methadone, but has no effect on the reactivation of latent HIV. These findings provide insights into how opioids, including those used for MAT, impact HIV infection and reactivation, which can inform treatment decisions for individuals living with HIV or at risk of HIV infection.
Article
Pharmacology & Pharmacy
Zahra Rostamipoor, Masoomeh Nazemi-Rafi, Amirhossein Mirafzal, Shahab Ilka, Masumeh Hosseininasab
Summary: Oral clonidine significantly reduced pain and the need for morphine in opioid-dependent patients with orthopaedic fractures.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matthijs W. van Hoogdalem, Brooks T. McPhail, David Hahn, Scott L. Wexelblatt, Henry T. Akinbi, Alexander A. Vinks, Tomoyuki Mizuno
Summary: Neonatal opioid withdrawal syndrome (NOWS) often occurs in infants born to mothers who used opioids during pregnancy. The pharmacological treatments for NOWS exhibit substantial variability in pharmacokinetics (PK) and pharmacodynamics (PD), with current treatments largely relying on empirical treatment of patient symptoms. Further research on the PK/PD relationship of medications used in the treatment of NOWS is needed.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ana Catarina Matos, Ines Alexandra Marques, Ana Salome Pires, Ana Valentim, Ana Margarida Abrantes, Maria Filomena Botelho
Summary: Breast cancer is a common and deadly disease in women. This systematic review examines the effects of analgesics and local anesthetics on breast cancer cells and animal models. The results show that local anesthetics have anti-tumorigenic properties, while morphine appears to promote tumor growth. More research is needed to understand the controversial effects of each drug and their implications for breast cancer treatment outcomes and prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ziqing Wang, Simone Pisano, Veronica Ghini, Pavel Kaderavek, Milan Zachrdla, Philippe Pelupessy, Morgan Kazmierczak, Thorsten Marquardsen, Jean-Max Tyburn, Guillaume Bouvignies, Giacomo Parigi, Claudio Luchinat, Fabien Ferrage
Summary: Metabolomics is a systematic approach to study metabolites in biological systems, providing information about metabolism and diseases. Metabolites play essential roles in biological processes, interacting with macromolecules, but methods to study these interactions systematically are currently limited.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Anesthesiology
Feliciano C. N. Duarte, Leonardo H. D. C. Ferraro, Alessandra Ferreira, Rioko K. Sakata
Summary: The study aimed to evaluate whether the combination of a low dose of methadone with morphine could reduce opioid consumption and provide faster pain relief. The results showed that the combination provided faster pain control compared to morphine alone, with no significant difference in adverse effects between the groups.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Physiology
Ioannis Georgoulis, Christian Bock, Gisela Lannig, Hans O. Portner, Inna M. Sokolova, Konstantinos Feidantsis, Ioannis A. Giantsis, Basile Michaelidis
Summary: This study investigates the stress memory effect of heat hardening on M. galloprovincialis metabolite profile, aiming to identify the underlying biochemical mechanisms that enhance mussels' thermal tolerance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laela Hayu Nurani, Abdul Rohman, Anjar Windarsih, Any Guntarti, Florentinus Dika Octa Riswanto, Endang Lukitaningsih, Nurrulhidayah Ahmad Fadzillah, Mohamad Rafi
Summary: The study on the authentication of Curcuma species using H-1-NMR spectroscopy and chemometrics has demonstrated the importance of metabolite fingerprinting in the authentication of herbal and medicinal plants.
Article
Neurosciences
Safiye Ozdemir-cezik, Asiye Nurten, Berna Midilli, Basak Guertekin, Nurhan Enginar
Summary: The study found that oxytocin can influence morphine tolerance and dependence, while enhancing signaling of alpha-2 adrenoceptors.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Luke Hipperson, William J. Hadden, Christopher B. Nahm, Anthony J. Gill, Jaswinder S. Samra, Anthony Dona, Anubhav Mittal, Sumit Sahni
Summary: A panel of three metabolites can stratify PDAC patients into good or poor prognosis groups based on overall survival. Patients with abnormal levels of 2 or more metabolites in their urine have significantly lower survival rates. Using urinary metabolites as prognostic biomarkers for PDAC patients shows promise for future research and development.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Psychology, Clinical
Milan Padhan, Rituparna Maiti, Debadatta Mohapatra, Biswa Ranjan Mishra
Summary: This meta-analysis evaluated the efficacy and safety of tramadol in the treatment of opioid withdrawal. The results showed that tramadol was not significantly different from placebo in reducing withdrawal symptoms, and there were no significant differences between tramadol and other comparators.
ADDICTIVE BEHAVIORS
(2023)
Article
Neurosciences
Yonghai Wang, Hongchun Li, Ying Zhao, Feng Qin, Liang Wang, Linhong Jiang, Xiaojie Wang, Rong Chen, Yuman He, Qinfan Wei, Shu Li, Yuanyuan Chen, Yuzhou Xiao, Yanping Dai, Qian Bu, Yinglan Zhao, Jingwei Tian, Hongbo Wang, Xiaobo Cen
Summary: Sevoflurane exposure in the neonatal period causes cognitive impairment and social behavior deficits in adolescent rats. Lipidomics and proteomics analysis revealed the remodeling of lipid metabolism and downregulation of LPCAT1 expression in the hippocampus, suggesting their involvement in neurobehavioral dysfunction.
Article
Environmental Sciences
Hongchuan Li, Rui Jin, Zhaowen Xu, Hongxiang Hu, Yusef Kianpoor Kalkhajeh, Yingying Zhao, Linchuan Zhan
Summary: In this study, the potential of chelate tetrasodium glutamate diacetate (GLDA) combined with Tagetes patula L. to remediate cadmium-contaminated soil was investigated. The results showed that GLDA application significantly increased the biomass and cadmium content of Tagetes patula, indicating the efficacy of GLDA for the remediation of cadmium-contaminated farmlands.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Tongchuan Chen, Yingying Zhao, Qianqian Wang, Wenting Wang, Aimin An
Summary: This paper proposes a Distributed Secondary Compensation Control (DSCC) method to solve the problems of the transmission system controlled by traditional droop control. It improves the dynamic response of the system and its fault ride through capability.
JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Ying-Ying Zhao, Yu-Jie Li, Xiao-Mei Yu, Qin-Ting Su, Li-Wen Wang, Yu-Shu Zhu, Yan-Hui Fu, Guang-Ying Chen, Yan-Ping Liu
Summary: A new bisabolane-type sesquiterpenoid, morincitrinoid A (1), was isolated from the stems and leaves of Morinda citrifolia L., along with five known analogues (2-6), through phytochemical study. The chemical structure of 1 was determined by comprehensive spectral analysis. Compounds 1-6 exhibited significant anti-inflammatory and anti-HIV activities, inhibiting NO production and HIV-1 reverse transcriptase (RT) with comparable or better potency than hydrocortisone, indicating their potential therapeutic value.
NATURAL PRODUCT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Shuai-Bing Liu, Xia Yao, Jun Tao, Jian-Jun Yang, Ying-Ying Zhao, Dong-Wei Liu, Su-Yun Wang, Su-Ke Sun, Xu Wang, Pang-Ke Yan, Nan Wu, Xiao Liu, Xiao-Jian Zhang, Xin Tian, Zhang-Suo Liu
Summary: The aim of this study was to develop a population pharmacokinetic (PK) model for ciprofol and its major metabolite M4, and link it to the population pharmacodynamics (PD) model in subjects with different renal functions. The study found that the PK of ciprofol and M4 could be best described by three-compartment and two-compartment models, respectively. The concentrations of ciprofol and M4 were linked using a linear protein binding model. Hemoglobin and uric acid were identified as covariates affecting the clearance of ciprofol and M4. The developed model provides a comprehensive understanding of the PK and PD of ciprofol.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Physics, Multidisciplinary
Sayantan Mazumdar, Ying Zhao, Xiaodan Zhang
Summary: Perovskite/silicon tandem solar cells (PSTSCs) have the potential to overcome the efficiency limit of single-junction silicon solar cells by combining the wider bandgap of a semitransparent perovskite solar cell (PSC) with the ability of a narrow bandgap silicon solar cell to convert infrared light. However, the actual efficiency of PSTSCs is currently below the theoretical limit, and challenges in stability and upscaling need to be addressed.
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY
(2023)
Article
Environmental Sciences
Zirui Ye, Miao Qi, Yingming Zhao, Wei Wei, X. George Xu
Summary: This study estimated the fetal and pediatric doses from chest CT scans performed during the COVID-19 pandemic. Organ and effective doses were calculated using VirtualDose-CT software. The results showed that fetal absorbed doses ranged from 0.04 to 0.61 mGy depending on the gestational age, and extending the scan range to the abdominal region increased fetal doses by almost 4-fold. The findings provide valuable information for radiologists and patients to minimize unnecessary radiation exposure.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Chemistry, Physical
Liang Yan, Qiao Yuan, Hui Tian, Wanzhong Ren, Lei Wang, Yingchun Zhao
Summary: Mo-Bi based catalysts have attracted attention for the oxidation reaction of isobutene to methacrolein. Most studies focus on the reaction mechanism and catalytic active sites, but fail to reflect the real reaction process on commercial catalyst surfaces. This research demonstrates that fine-tuning the active phase structure can greatly enhance the catalytic performances, providing a new perspective for developing high-performance catalysts.
REACTION KINETICS MECHANISMS AND CATALYSIS
(2023)
Article
Environmental Sciences
Kaixin Zheng, Yufen Wang, Xiaomin Wang, Tingting Zhu, Xueming Chen, Yingxin Zhao, Peizhe Sun, Yindong Tong, Yiwen Liu
Summary: This survey investigated the influence of ultrasound (US) and potassium permanganate (KMnO4) co-pretreatment on anaerobic digestion of waste activated sludge (WAS). The results showed that the co-treatment significantly increased the cumulative methane yield and improved the biodegradability of soluble organics. The analysis also revealed that US + KMnO4 pretreatment enhanced the biochemical methane potential, hydrolysis rate, and relative abundance of functional microorganisms associated with anaerobic digestion.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Lu Jin, Ningyu Ren, Pengyang Wang, Renjie Li, Qifan Xue, Fei Huang, Xiaobo Zhang, Ying Zhao, Xiaodan Zhang
Summary: A secondary anti-solvent strategy is proposed for the first time to further reduce surface defects in conventional surface passivation for perovskite solar cells. This strategy effectively enhances the crystallization quality of 2D perovskite and reduces the surface defect density by nearly two orders.
Article
Environmental Sciences
Yingying Zhao, Meng Su, Xin Meng, Jiying Liu, Faming Wang
Summary: This study evaluated the effects of environmental heat stress and personal cooling strategies on the physiological and perceptual responses of college students wearing personal protective equipment (PPE). The results showed that PPE can help mitigate heat stress, and the use of cooling systems can further reduce heat strain. The perceptual responses improved significantly with the use of personal cooling systems.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Chemistry, Multidisciplinary
Sanjiang Pan, Renjie Li, Jin Wang, Qixing Zhang, Manjing Wang, Biao Shi, Pengyang Wang, Ying Zhao, Xiaodan Zhang
Summary: In this paper, a two-dimensional nanosheet quaternary metal hydroxide catalyst composed of Ni, Fe, Cr, and Mo elements was reported. By in situ electrochemical activation, the catalyst obtained higher metal valence states and many O vacancies, providing excellent catalytic activity and corrosion resistance in overall alkaline seawater electrolysis. The floating solar seawater splitting device showed an efficiency of solar energy to hydrogen of 20.61 +/- 0.77%.
Article
Chemistry, Multidisciplinary
Hongrui Sun, Sanlong Wang, Shanshan Qi, Pengyang Wang, Renjie Li, Biao Shi, Qixing Zhang, Qian Huang, Shengzhi Xu, Ying Zhao, Xiaodan Zhang
Summary: An innovative in-situ etching (ISE) method using methanol is proposed to reduce surface defects in inorganic perovskite solar cells (IPSCs). The treatment with methanol leads to a decrease in surface defects and the passivation of grain boundary defects, resulting in a reduction in trap density and improved charge carrier extraction. The efficiency of the IPSCs is enhanced from 16.00% to 19.34% using this method.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Zheng Ma, Zhen Xing, Yingying Zhao, Yiru Hu
Summary: This paper investigates the influence of freeze-thaw cycles on the dynamic strength properties of silty clay fillers before and after cement improvement, and quantifies the improvement effects of cement improvement. The results show that cement modification significantly improves the dynamic strength parameters of silty clay even after multiple freeze-thaw cycles, providing a useful reference for subgrade improvement along the silty clay railway in northern China.
Article
Materials Science, Multidisciplinary
Ying Zhao, Lian-Cai An, Kai Li, Yong-Ji Gong, Tian-Meng Guo, Fei-Fei Gao, Yang Lei, Quanwen Li, Wei Li, Xian-He Bu
Summary: Hybrid organic-inorganic piezoelectrics have gained attention for their fascinating performance, ease of synthesis, and mechanical flexibility. However, most reported systems contain toxic heavy metals or are unstable due to metal halide bonds. In this research, a stable zero-dimensional hybrid piezoelectric material based on an environmentally friendly anion of SCN- was synthesized. The resulting flexible composite films showed exceptional mechanical energy harvesting properties, outperforming state-of-the-art piezoelectric devices, with excellent durability and stability.
SCIENCE CHINA-MATERIALS
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
